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| 1 | Ehanced efficacy of DNA vaccination against Her -2/neu tumor antigen by genetic adjuvants 显示文摘 | Chang SY Lee KC Ko SY | 2004 | Int Cancer2004，111，1： | 1 |
| 2 | Nail-splinting technique for ingrown nails:the therapeutic effects and the proper removal time of the splint显示文摘 | Kim YJ Ko JH Choi KC | 2003 | Dermatol Surg2003，29，7： | 1 |
| 3 | Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein显示文摘AIM: To test whether oral L-81 treatment could im-prove the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver. METHODS: Genetically diabetic (db/db) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db/db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mecha-nism, HepG2 cells were treated with L-81 and the effects on apolipoprotein B (apoB) secretion and mRNA level of the MTP gene were assessed.RESULTS: Treatment of db/db mice with L-81 sig-nificantly reduced and nearly normalized their body weight, hyperphagia and polydipsia. L-81 also markedly decreased the fasting plasma glucose level, improved glucose tolerance, and attenuated the elevated levels of plasma cholesterol and triglyceride. At the effective dosage, little toxicity was observed. Treatment of HepG2 cells with L-81 not only inhibited apoB secretion, but also signif icantly decreased the mRNA level of the MTP gene. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. CONCLUSION: L-81 represents a promising candidate in the development of a selective insulin-mimetic mol-ecule and an anti-diabetic agent. | Wo-Shing Au Li-Wei Lu Sidney Tam Otis King Hung Ko Billy KC Chow Ming-Liang He Samuel S Ng Chung-Man Yeung Ching-Chiu Liu Hsiang-Fu Kung Marie C Lin | 2009 | World Journal of Gastroenterology2009，15，24： | 1 |
| 4 | Tracheal rupture complicating emergent endotracheal intabation显示文摘 | Fan CM Ko PC Taai KC | 2004 | AmJ Emerg Med2004，22，4： | 1 |
| 5 | Enhanced efficacy of DNA vaccination against Her-2/neu tumor antigen by genetic adjuvants显示文摘 | Chang SY Lee KC Ko SY | 2004 | Int J C ancer2004，111，1： | 1 |
| 6 | Mammotome verse ATEC: a comparison of two breast vaccum biopsy techniques under sonographic guidance显示文摘 | Hahn M Kagan KO Siegmann KC | 2010 | Arch Gynecol Obstet2010，281，2： | 1 |
| 7 | Mammotome versusATEC:a comparison of two breast vacuum biopsy techniques under sonographic guidance 显示文摘 | Hahn M Kagan KO Siegmann KC | 2010 | Arch Gynecol Obstet2010，281，2： | 1 |
| 8 | Pain and complications of directional vacuumassisted stereotactic biopsy: comparison of the Mammotome and Vacora techniques 显示文摘 | Hahn M Kagan KO Siegmann KC | 2011 | Breast J2011，17，5： | 1 |
| 9 | Mammotome versus ATEC : a comparison of two breast vacuum biopsy techniques under sonographic guidance 显示文摘 | Hahn M Kagan KO Siegmann KC | 2010 | Arch Gynecol Obstet2010，281，2： | 1 |
| 10 | Small-molecule inhibitors of c-myc transcriptional factor suppress proliferation显示文摘 | Jeong KC Ahn KO Yang CH | 2010 | Mol Biosyst2010，6，8： | 1 |
| 11 | Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniaein Taiwan显示文摘 | Yu WL Ko WC Cheng KC | 2006 | Clin Infect Dis2006，42，： | 1 |
| 12 | 3-OH flavone inhibition of epidermal growth factor-induced proliferation through blocking prostaglandin E2 production 显示文摘 | Shen SC Ko CH Hsu KC | 2004 | Int J Cancer2004，108，： | 1 |
| 13 | Ehanced efficacy of DNA vaccination against Her-2/neu tumor antigen by genetic adjuvants 显示文摘 | Chang SY Lee KC Ko SY | 2004 | Int Cancer2004，111，1： | 1 |
| 14 | Association between rmpA and magA genes and elinica], s,ndromes caused by KlebsieUa pneamoni- ae in Taiwan显示文摘 | Yu WL Ko WC Cheng KC | 2006 | Clin Infect Dis2006，42，10： | 1 |
| 15 | Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan显示文摘 | Yu WL Ko WC Cheng KC | 2006 | Clin Infect Dis2006，42，10： | 1 |
| 16 | Glutathione deficiency in type 2diabetes impairs cytokine responses and control of intracellular bacteria显示文摘 | Tan KS Lee KO Low KC | 2012 | J Clin Invest2012，122，6： | 1 |
| 17 | Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes显示文摘 | Yu WL Ko WC Cheng KC | 2008 | Diagn Microbiol Infect Dis2008，62，1： | 1 |
| 18 | Supporting Intelligent Context-Awareness in Ubiquitous Sensor Network with RFID显示文摘 | Ko KC Lee DW Ko YB | 2005 | Korea Computer2005，，00： | 1 |
| 19 | Dentification and characterization of a novel cold-adapted esterase from a metagenomic library of mountain soil显示文摘 | Ko KC Rim SO Han Y | 2012 | Journal of Industrial Microbiology and Biotechnology2012，39，5： | 1 |
| 20 | Strategy for screening metagenomic resources for exocellulase activity using a robotic, high-throughput screening system显示文摘 | Ko KC Han Y Cheong DE | 2013 | Journal of Microbiological Methods2013，94，3： | 1 |
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