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| 1 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 2 | Decline of Tetanus Antitoxin Level with Age in Taiwan 显示文摘 | Wu C J Ko HC Lee HC | 2009 | J Formos Med Assoc2009，108，5： | 1 |
| 3 | Long term outcomes of gamma knife radiosurgery for typical trigeminal neural- gia minimum 5--year follow--up显示文摘 | Lee JK Choi HJ Ko HC | 2012 | J Korean Neuro- surg Soc2012，51，5： | 1 |
| 4 | Modulation of drug-metabolizing enzymes by extracts of a herbal medicine Evodia rutaecarpa in C57BL/6J mice显示文摘 | Ueng YF Ko HC Chen CF | 2002 | Life Sci2002，71，11： | 1 |
| 5 | Propofol versus midazolam for up per gastrointestinal endoscopy in cirrhotic patients: a meta-analysis of randomized controlled trims 显示文摘 | Tsai HC Lin YC Ko CL | 2015 | PLoS 0ne2015，10，11： | 1 |
| 6 | Gestationai diabetes mellitus in Korea:prevalence and prediction of glucose intolerance at early postpartum显示文摘 | Jang HC Yim CH Han KO | 2003 | Diabetes Res Clin Pratt2003，61，2： | 1 |
| 7 | Physiologic indirect response models characterize diverse typesof pharmacodynamic effects 显示文摘 | Jusko WJ Ko HC | 1994 | Clin Pharmacol Ther1994，56，： | 1 |
| 8 | Comparison of maturation,fertilizaation, development, and gene expression of mouse oocytes grown in vitro and in vivo显示文摘 | Kim DH Ko DS Lee HC | 2004 | J Assist Teprod Genet2004，21，7： | 1 |
| 9 | Gestational diabetes mellitus in Korea:prevalence and prediction of glucose intolerance at early postpartum显示文摘 | Jang HC Yim CH Han KO | 2003 | Diabetes Res Clin Pract2003，61，： | 1 |
| 10 | Decline of tetanus antitoxin level with age in taiwan显示文摘 | Wu CJ Ko HC Lee HC | 2009 | J Formos Med Assoc2009，108，5： | 1 |
| 11 | Langerhans cell sarcoma arising from Langerhans cell histiocytosis:a case report显示文摘 | Lee JS Ko GH Kim HC | | 0，，： | 1 |
| 12 | Dermoscopy can be use-ful in differentiating scalp psoriasis from seborrhoeic derma-titis显示文摘 | Kim GW Jung HJ Ko HC | 2011 | BrJ Dermatol2011，164，3： | 1 |
| 13 | In vitro and in vivo activity of meropenem and sulbactam against a multidrug-resistant Acinetobacter baumannii strain显示文摘 | Ko WC Lee HC Chiang SR | 2004 | J Antimicrob Chemother2004，53，： | 1 |
| 14 | Successful treatment of xan-thoma disseminatum with combined lipid lowering agents显示文摘 | Kim WJ Ko HC Kim BS | 2012 | AnnDermatol2012，24，3： | 1 |
| 15 | Training finger indi- viduation with a mechatronic-virtual reality system leads to im- proved fine motor control post-stroke 显示文摘 | Thielbar KO Lord TJ Fischer HC | 2014 | J Neuroeng Rehabil2014，11，： | 1 |
| 16 | Coronary artery bypass graft surgery vs percutaneoua interventions in coronary revascularizationA systematic review显示文摘 | Deb S Wijeysundera HC Ko DT | 2013 | JAMA2013，310，19： | 1 |
| 17 | Comparison of corpus callosotomy and vagus nerve stimulation in children with Lennox-Gastaut syndrome显示文摘 | You S J Kang HC Ko TS | 2008 | Brain Dev2008，30，3： | 1 |
| 18 | Varying postprandial abdominovagal and cardiovagal activity in normal subjects 显示文摘 | Chang CS Ko CW Lien HC | 2010 | Neurogastroenterol Motil2010，22，： | 1 |
| 19 | Long term outcomes of gamma knife radiosurgery for typical trigeminal neuralgia minimum 5 -- year follow-- up显示文摘 | Lee JK Choi HJ Ko HC | 2012 | J Korean Neurosurg Soc2012，51，5： | 1 |
| 20 | Emotion recognition using EEG signals with relative power values and Bayesian network 显示文摘 | Ko KE Yang HC Sim KB | 2009 | International Journal of Control Automation and Systems2009，7，5： | 1 |
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