|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula显示文摘BACKGROUND Perianal fistulae are either primary(idiopathic)or secondary[commonly associated with Crohn’s disease,(CD)].It is assumed,although not proven,that the pathophysiology differs.AIM To systematically compare the clinical phenotypes,cytokine and phosphoprotein profiles of idiopathic and CD-related perianal fistulae.METHODS Sixty-one patients undergoing surgery for perianal fistula were prospectively recruited(48 idiopathic,13 CD)into a cohort study.Clinical data,including the Perineal Disease Activity Index(PDAI)and EQ-5D-5L were collected.Biopsies of the fistula tract,granulation tissue,internal opening mucosa and rectal mucosa were obtained at surgery.Concentrations of 30 cytokines and 39 phosphoproteins were measured in each biopsy using a magnetic bead multiplexing instrument and a chemiluminescent antibody array respectively.Over 12000 clinical and 23500 laboratory measurements were made.RESULTS The PDAI was significantly higher(indicating more active disease)in the CD group with a mean difference of 2.40(95%CI:0.52-4.28,P=0.01).Complex pathoanatomy was more prevalent in the CD group,namely more multiple fistulae,supralevator extensions,collections and rectal thickening.The IL-12p70 concentration at the internal opening specimen site was significantly higher(median difference 19.7 pg/mL,99%CI:0.2-40.4,P=0.008)and the IL-1RA/IL-1βratio was significantly lower in the CD group at the internal opening specimen site(median difference 15.0,99%CI=0.4-50.5,P=0.008).However in the remaining 27 cytokines and all 39 of the phosphoproteins across the four biopsy sites,no significant differences were found between the groups.CONCLUSION CD-related perianal fistulae are more clinically severe and anatomically complex than idiopathic perianal fistulae.However,overall there are no major differences in cytokine and phosphoprotein profiles. | James B Haddow Omar Musbahi Thomas T MacDonald Charles H Knowles | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，4： | 2 |
| 2 | Performance of Neural Network: Mapping Forests Using GIS and Remotely Sensed Data 显示文摘 | Skidmore A Turner B Brinkhof W Knowles E | 1997 | ISPRS Journal of Photogrammetric Engineering & Remote Sensing1997，63，： | 2 |
| 3 | Mechanism of action of Bocillus thuringiensis in- secticidalδ-endotoxins 显示文摘 | Knowles B H | 1994 | Advances in Insect Physiology1994，24，： | 1 |
| 4 | Dietary supplementation and respiratory muscle performance in patients with COPD 显示文摘 | Knowles JB Fauban M Wiggs B J | 1988 | Chest1988，93，5： | 1 |
| 5 | Biochar for the miti- gation of nitrate leaching from soil amended with biosolids显示文摘 | Knowles O A Robinson B H Contangelo A | 2011 | Science of the Total Environment2011，409，17： | 1 |
| 6 | Preparation of shikimate-5-phosphoate显示文摘 | KNOWLES P F SPRINSON D B | 1970 | Methods in Enzymology1970，17，： | 1 |
| 7 | Strength of concrete-filled steel tubular columns显示文摘 | Knowles R B Park R | 1969 | Journal of Strnctural Division ASCE1969，95，2： | 1 |
| 8 | Intestinal absorption of calcium dihydrophosphate and calci- um citrate compared by two methods显示文摘 | SCHUETTE S A KNOWLES J B | 1988 | Am J Clin Nutr1988，47，5： | 1 |
| 9 | Intestinal absorption of Ca(He PO4)2 and Ca citrate compared by two methods显示文摘 | Schuette S A Knowles J B | 1988 | Am Clin Nutrition1988，47，： | 1 |
| 10 | Biochar for the miti- gation of nitrate leaching from soil amended with biosolids显示文摘 | Knowles O A Robinson B H Contangelo A | 2011 | The Sci- ence of the Total Environment2011，409，： | 1 |
| 11 | Molecular cloning of an insect aminopeptidase N that serves as a receptor for Bacillus thuringiensis Cry1A(c)toxin显示文摘 | Knight P J K Knowles B H Ellar D J | 1995 | J Biol Chemistry1995，270，17： | 1 |
| 12 | Experimental evaluation of a cylindrical parabolic solar collector显示文摘 | Ramsey J W Gupta B P Knowles G R | 1977 | ASME Journal of Heat Transfer1977，，： | 1 |
| 13 | Biochar for the mitigation of nitrate leaching from soil amended with biosolids显示文摘 | Knowles O A Robinson B H Contangelo A | | Science of the Total Environment0，，： | 1 |
| 14 | Quantitation of cellular components of the enteric nervous system in the normal human gastrointestinal tract-report on behalf of the Gastro 2009 International Working Group显示文摘 | Knowles CH Veress B Kapur RP | 2011 | Neurogastroenterol Motil2011，23，2： | 1 |
| 15 | Exploiting tumorspecific defects in the interferon pathway with a previously unknownoncolytic virus显示文摘 | Stojdl DF Lichty B Knowles S | 2000 | Nat Med2000，6，7： | 1 |
| 16 | Biochar for the mitigation of nitrate leaching from soil amended with biosolids显示文摘 | Knowles O A Robinson B H Contangelo A | 2011 | Science of the Total Environment2011，409，17： | 1 |
| 17 | The Receptor forBacillus thuringiensis CrylA (c) delta-Endotoxin in the BrushBorder Membrane of the Lepidopteran Manduca sexta isAminopeptidase N显示文摘 | KNIGHT P J KNOWLES B H ELLAR D J | 1994 | Mol Microbiol1994，11，： | 1 |
| 18 | Disruption of the AKT pathway inhibits metastasis in an orthotopic model of head and neck squamous cell carcinoma 显示文摘 | Knowles JA Golden B Yan L | 2011 | Laryngoscope2011，121，11： | 1 |
| 19 | Immunosurgery of mouse blastocyte显示文摘 | Knowles B | 1975 | Proc Nat Acad Sci USA1975，72，12： | 1 |
| 20 | Monoclonal antibody defining a stagespecific mouse embryonic antigen (SSEA-1)显示文摘 | Solter D Knowles B B | 1978 | Proc Natl Acad Sci USA1978，75，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员