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| 1 | The role of sphingosine-1-phosphate in bone remodeling and osteoporosis显示文摘Osteoporosis is a systemic bone disease that affects more than 200 million people worldwide and is caused by the disruption of the equilibrium between osteoclastic bone resorption and osteoblastic bone formation. Sphingosine-1-phosphate(S1 P) is a natural,bioactive sphingolipid that has been shown to play a major role in cardiovascular and immunological pathologies by regulating biological and cellular processes, including migration, differentiation, proliferation and survival. Recent studies also suggest a central role for S1 P in bone diseases, including osteoporosis;however, the effects of S1 P, particularly in bone metabolism, remain to be further elucidated. In this review, we summarize the available literature on the role of S1 P in bone metabolism with a focus on osteoporosis. On the cellular level, S1 P acts as an osteoclast-osteoblast coupling factor to promote osteoblast proliferation and bone formation. Moreover, the recruitment of osteoclast precursors to resorption sites is regulated by the interplay of S1 P gradients and S1 P receptor expression. From a clinical perspective, increasing evidence suggests that systemically elevated S1 P blood levels may serve as an independent risk factor for osteoporosis-related fractures. Taken together, S1 P signaling is a potential therapeutic target and may serve as a novel biomarker in patients with systemic bone disease. | Justus M.Grewe Paul-Richard Knapstein Antonia Donat Shan Jiang Daniel JSmit Weixin Xie Johannes Keller | 2022 | Bone Research2022，10，2： | 5 |
| 2 | Cervicalcarci-noma: standard and pharmaco kinetic analysis of time-intensitycurves for assessment of tumor angiogenesis and patients urvival显示文摘 | Hawighorst H Knapstein PG? Knopp MV | 1999 | MAGMA1999，8，1： | 1 |
| 3 | Cervical carcinoma:standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival显示文摘 | Hawighorst H Knapstein PG Knopp MV | 1999 | MAGMA1999，8，1： | 1 |
| 4 | Cervical carcinoma:standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival显示文摘 | Hawighorst H Knapstein PG Knopp MV | 1999 | MAGMA1999，8，1： | 1 |
| 5 | Angiogenesis of cervix carcinoma:contrast enhanced dynamic MRI,histologic quantification of capillary density and lymphatic system infiltration显示文摘 | Hawighorst H Knapstein PG Knopp MV | 1998 | Radiology1998，38，1： | 1 |
| 6 | Angiogenesis of uterine cervical carainoma:characterization by pharmacokinetic magnetic resonance parameters and histological microvessel density with correlation to lymphatic involvement显示文摘 | Hawighorst H Knapstein PG Weikel W | 1997 | Cancer Res1997，57，21： | 1 |
| 7 | Staging of invasive cervical carcinoma and of pelvic lymph nodes by high resolution MRI with a phased-array coil in comparison with pathological findings显示文摘 | Hawighorst H Schoenberg SO Knapstein PCB | 1998 | Comput Assist Tomogr1998，22，1： | 1 |
| 8 | Cervical carcino ma:standard and pharmacokinetic analysis of time-intensity curve for asessment of tumors angiogenesis and patient survival显示文摘 | Hawishorst H Knapstein PG Knopp MV | 1999 | MAGMA1999，8，1： | 1 |
| 9 | Cervical carcinoma:comparionof standard and pharmacokinetic MR imaging显示文摘 | Hawighorst H Knapstein PG Weikel W | 1996 | Radiology1996，201，2： | 1 |
| 10 | Staging of invasive cervical carcinoma and of pelvic lgmph nodes by high resolution MRI with a phased-array coilin com- parison with pathological finding显示文摘 | Hawighorst H Schoenberg SO Knapstein PG | 1998 | J Cornput Assist To- mogr1998，22，1： | 1 |
| 11 | Staging of invasive cervical carcinoma and of pelvic lymph nodes by high resolution MRI with a phased-array coil in comparison with pathological findings 显示文摘 | Hawighorst H Schoenberg SO Knapstein PG et a1 | 1998 | J Comput Assist Tomogr1998，22，1： | 1 |
| 12 | Cercival carcinoma:comparison of standard and pharmacokinetic MR imaging显示文摘 | Hawighorst H Knapstein PG Weikel W | 1996 | Radiology1996，201，： | 1 |
| 13 | Utrine cervical carcinoma: comparison of standard and pharmacokkinetic analysis of time-intensity curves for assessment of trmor angiogenesis and patient survival显示文摘 | Hawighorst H Knapstein PG Knopp MV | 1998 | Canceu Res1998，58，16： | 1 |
| 14 | Cervical carcinoma : standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival magnetic resonance materials in显示文摘 | Hawighorst H Knapstein PG Knopp MV | 1999 | Biol Phys Med1999，8，1： | 1 |
| 15 | Uterine cervical carcinoma: comparison of standard and pharmaeokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival显示文摘 | Hawighorst H Knapstein P G Knopp M V | 1998 | Cancer Res1998，58，16： | 1 |
| 16 | The impact of treatment for genital cancer on quality of life and body im- age - results of a prospective longitudinal 10 -year study 显示文摘 | Hawighorst - Knapstein S Fusshoeller C Franz C | 2004 | Gynecol Oncol2004，94，2： | 1 |
| 17 | Antiviral triple therapy with boceprevir in a chronic hepatitis C haemodialysis patient awaiting kidney re-transplantation显示文摘 | Johanna Knapstein Peter R. Galle Tim Zimmermann | 2014 | Digestive and Liver Disease2014，，1： | 1 |
| 18 | Angiogenesis of uterine cervical carcinoma: charaterization by pharmacokinetic magnetic resonance parameters and histological microvessel density with correlation to lymphatic involvement显示文摘 | Hawighorst H Knapstein PG Weikel W | 1997 | Cancer Res1997，57，： | 1 |
| 19 | Angiogenesis of uterine cervical carcinoma:characterization by pharmacokinetic magnetic resonance parameters and histological microvessd density with correlation to lymphatic involvement显示文摘 | Hawighorst H Knapstein PG Weikd W | 1997 | Cancer Rec1997，57，： | 1 |
| 20 | Uterine Cervical Carcinoma:Comparison of Standard and Pharmacokinetic Analysis of Time-intensity Curves for Assessment of Tumor Angiogenesis and Patient Survival显示文摘 | Hawughorst H Knapstein PG Knopp MV | 1998 | Cancer Res1998，58，3： | 1 |
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