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| 1 | Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma显示文摘AIM To conduct a cohort study of 101 patients with hepatocellular carcinoma (HCC) presenting to a tertiary care medical referral center in Germany between 1997 and 1999.METHODS AND RESULTS Data were retrospectively analyzed by chart review. In 95cases (72 males and 23 females) sufficient data were available for analysis. Twenty-five (29%)of 8.5 patients were HBsAg or anti-HBc positive,21/85 (25%) were anti-HCV positive, and 6/85(7%) were positive for both HBV and HCV-markers. Age was significantly lower in HBV-positive patients than in the other two groups.Thirty-one (34%) of 90 patients had histories of alcohol abuse, In 79/ 94 (84%) patients,cirrhosis was diagnosed. Of these cirrhotic patients, 29/79 (37%) belonged to Child-Pugh's group (CHILD) A, 32/79 (40%) to CHILD B, and 18/79 (23%) to CHILD C. AFP was elevated in 61/91 (67%) patients. A single tumor nodule was found in 38/94 (40%), more than one nodule in 31/94 (34%), and 25/94 (26%) had a diffusely infiltrating tumor, i.e. the tumor margins could not be seen on imaging procedures. Portal vein thrombosis was present in 19/ 94 (20%).Imaging data consistent with lymph node metastases were found in 10/92 (11%), while distant metastases were found in 8/93 (9%).According to Okuda 28/94 (30%) were grouped to stage Ⅰ, 53/94 (56%) were grouped to stage Ⅱ, and 13/94 (14%) were grouped to stage Ⅲ.Survival data were available for 83 patients. The Kaplan-Meier estimate for median survival was 8.4 months. Factors influencing survival were the Okuda score, the presence of portal vein thrombosis, and the presence of ascites. The presence of non-complicated liver cirrhosis by itself, distant metastases, or infection with hepatitis viruses did not influence survival. AFP positivity by itself did not influence survival,though patients with an AFP value greater than 100μg/L did experience shortened survival.Treatment besides tamoxifen or supportive care was associated with prolonged survival. The influence of therapy on survival was most pronounced in Okuda stage Ⅱ patients. There was longer survival in those Okuda stage Ⅱpatients who were treated with percutaneous ethanol injection.CONCLUSION Even in a Iow incidence area such as Germany, the majority of HCC is caused by viral hepatitis and therefore potentially preventable. Reflecting the high proportion of advanced stage tumors in our patients, the median survival was poor. Patients who received active therapy had a longer survival. | Christian Rabe Tillmann Pilz Christoph Klostermann Marc Berna Hans H.Schild Tilman Sauerbruch Wolfgang H.Caselmann | 2001 | World Journal of Gastroenterology2001，7，2： | 60 |
| 2 | Slow saccades and other eye movement disorders in spinocerebellar atrophy type 1显示文摘 | Klostermann W Heide W | 1997 | J Neurol1997，244，： | 1 |
| 3 | Crossed R1 response of the blink reflex in peripheral facial palsy显示文摘 | Klostermann W Wessel K | 1995 | Electromyogr Clin Neurophysiol1995，35，： | 1 |
| 4 | Multifunctional nature of UV-irradiated nanocrystalline anatase thin films for biomedical applications显示文摘 | Rupp F Haupt M Klostermann H | 2010 | Acta Biomater2010，6，12： | 1 |
| 5 | Crossed R1 response of the blink reflex in peripheral facial palsy显示文摘 | Klostermann W Wessel K | 1995 | Eleetromyogr Clin Neuro physiol1995，35，： | 1 |
| 6 | Analysis of acrylamide and mechanisms of its formation in deep- flied products 显示文摘 | Gertz C Klostermann S | 2002 | European Journal of Lipid Science and Technology2002，104，： | 1 |
| 7 | The ehemorepulsive activity of the axonal guidance signal semaphorin D requires dimerization显示文摘 | Klostermann A Lohrum M Adams R H | 1998 | J Biol Chem1998，273，： | 1 |
| 8 | Alcoholism and intimate partner violence:Effects on children's psychosocial adjustment显示文摘 | Klostermann K M L Kelley | 2009 | Int J Environ Res Public Health2009，6，12： | 1 |
| 9 | Analysis of acrylamide and mechanisms of its formation in deep-fried products显示文摘 | Gertz C Klostermann S | 2002 | European Journal of Lipid Science and Technology2002，104，11： | 1 |
| 10 | The Adaptive Capacity Wheel: a method to assess the inherent charac- teristics of institutions to enable the adaptive capacity of society 显示文摘 | Gupta J Termeer C Klostermann J | 2010 | Environmental Science & Policy2010，13，6： | 1 |
| 11 | Analysis of acrylamide and mechanisms of its formation in deep-fried products显示文摘 | Gertz C Klostermann S | 2002 | European Journal of Lipid Science and Technology2002，104，： | 1 |
| 12 | Candidate genes for physical performance in the horse 显示文摘 | SCHRODER W KLOSTERMANN A DISTLET O | 2011 | Vet J2011，190，1： | 1 |
| 13 | Precancerous lesions of the uterine cer- vix : Mor-phology and molecular pathology显示文摘 | Horn LC Klostermann K | 2011 | Pathologe2011，32，2： | 1 |
| 14 | Opening the networks with Parlay/OSA: standards and aspects behind the APIs显示文摘 | MOERDIJK A J KLOSTERMANN L | 2003 | IEEE Network Magazine2003，17，3： | 1 |
| 15 | L1-CAM as a target for treatment of cancer with monoclonal antibodies显示文摘 | Weidle UH Eggle D Klostermann S | | 0，，12： | 1 |
| 16 | Incidence of adjacent vertebral fractures in patients treated with balloon kyphoplasty:two years prospective follow-up显示文摘 | Pflugmacher R Schroeder RJ Klostermann CK | | 0，，08： | 1 |
| 17 | HPV - associated al- teration of the vulvar and vagina 显示文摘 | Horn LC Klostermann K Hautmann S | 2011 | Pathologe2011，18，6： | 1 |
| 18 | Human CD4^+CD25^+ Tcells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production显示文摘 | Bellinghausen I Klostermann B Konp J | 2003 | J Allergy Clin Immunol2003，111，4： | 1 |
| 19 | Basilar branch disease presenting with progressive pure motor stroke显示文摘 | Kaps M Klostermann W Wessel K | 1997 | Acta Neurol Scand1997，96，5： | 1 |
| 20 | Preliminary report: circulating levels of the adipokine vaspin in gestational diabetes mellitus and preeclampsia 显示文摘 | Stepan H Kralisch S Klostermann K | 2010 | Metabolism2010，59，： | 1 |
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