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| 1 | Real-life chromoendoscopy for dysplasia surveillance in ulcerative colitis显示文摘AIM To evaluate the use of chromoendoscopy for surveillance of ulcerative colitis in a real-life community hospital setting.METHODS Patients with extensive ulcerative colitis, having disease duration of more than 8 years and who presented between the years of 1999 to 2013, were offered enrolment in this single cohort prospective study. All participants underwent standard bowel preparation with sodium phosphate and chromoendoscopy. Two expert endoscopists, novice to chromoendoscopy, evaluated each segment of the colon with standarddefinition colonoscopes after spray application of 0.4% indigo carmine. All observed lesions were recorded and evaluated before being removed and/or biopsied. In addition, nontargeted biopsies were taken from each segment of the colon. The dysplasia detection rate and dysplasia detection yield were ascertained. RESULTS A total of 21 neoplastic lesions(2 carcinomas, 4 of high-grade dysplasia and 15 of low-grade dysplasia) and 27 nondysplastic lesions were detected in 16 of the total 67 patients(70% male; median disease duration: 17 years; median age at diagnosis: 25 years; 92% aminosalicylate-treated). The dysplasia detection rate was 10.5%(7/67 patients). The dysplasia detection yield was 20.8%(10/48) for targeted biopsies and 3.5%(11/318) for nontargeted biopsies. The sensitivity and specificity for the macroscopic evaluation of neoplasia using chromoendoscopy were 48% [95% confidence interval(CI): 26%-70%] and 96%(95%CI: 93%-98%), respectively. The positive predictive and negative predictive values were 42%(95%CI: 27%-59%) and 97%(95%CI: 95%-98%), respectively. A total of 19/21 dysplastic lesions were detected in mucosa with histologic inflammation.CONCLUSION Chromoendoscopy seems to be of value for dysplasia surveillance of ulcerative colitis in a community hospital setting. The yield of non-targeted biopsies is negligible. | Pasquale Klepp Anita Tollisen Arne Roseth Milada Cvancarova Smastuen Solveig N Andersen Morten Vatn Bjorn A Moum Stephan Brackmann | 2018 | World Journal of Gastroenterology2018，24，35： | 3 |
| 2 | Cuff integrity after arthroscopic versus open rotator cuff repair:a prospective study显示文摘 | Bishop J Klepps S Lo IK | 2006 | J Shoulder Elbow Surg2006，15，3： | 1 |
| 3 | Minimum 5-year follow-up of anterior column structural allografts in the thoracic and lumbar Spine显示文摘 | Molinari RW Bridwell KH Klepps SJ | 1999 | Spine1999，24，10： | 1 |
| 4 | Prospective comparison of flexibility radiographs in adolescent idiopathic scoliosis 显示文摘 | Klepps S J Lenke LG Bridwell KH | 2001 | Spine ( Phila Pa 1976)2001，26，5： | 1 |
| 5 | Endocrine treatment,with or without radiotherapy,in locally advanced prostate cancer (SPCG-7/SFUO-3):an open randomised phase Ⅲ trial显示文摘 | Widmark A Klepp O Solberg A | | 0，，9660： | 1 |
| 6 | Longitudinal tracking of adolescent smoking,physical activity,and food choice behaviors显示文摘 | Kelder SH Perry CL Klepp LI | 1994 | Am J Public Health1994，84，： | 1 |
| 7 | Virulence factors of the Mycobacterium tuberculosis complex显示文摘 | Forrellad MA Klepp LI Gioffr A | 2013 | Virulence2013，4，1： | 1 |
| 8 | Acoustic pyrmeter: picture windows to boiler performance显示文摘 | Yori LG Dams H Kleppe J A | 1991 | Power1991，135，8： | 1 |
| 9 | Prospective compari-son of flexibility radiographs in adolescent idiopathic scoliosis显示文摘 | Klepps SJ Lenke LG Bridwell KH | 2001 | Spine(Phila Pa 1976)2001，26，5： | 1 |
| 10 | Desiccation cracking of soil barriers 显示文摘 | Kleppe J H Olson R E | 1985 | Hydraulic Barriers in Soil and Rock ASTM1985，，： | 1 |
| 11 | Adolescents' proxy reports of parents' socioeconomic status: How valid are they? 显示文摘 | LIEN N FRIESTAD C KLEPP K I | 2001 | J Epidemiol Community Health2001，，55： | 1 |
| 12 | Adapt acoustic pyrometer to measure flue-gas flow显示文摘 | Kleppe J A | 1995 | Power1995，8，： | 1 |
| 13 | Acoustic pyrometers: picture windows to boiler performance显示文摘 | Yorl L G Dams F H Kleppe J A | 1991 | Power1991，8，： | 1 |
| 14 | The Knee elbow position in lumbar discsurgery-review of complication显示文摘 | Eie N Solgaad T Klepp H | 1983 | Spine1983，8，8： | 1 |
| 15 | Spinal cord anesthesia of the baboon comparison with man and implications of spinal cord blood flow during thoracic aortic cross-clamping显示文摘 | Svensson LG Klepp P Hinder RA | 1986 | A Afr J Surg1986，24，： | 1 |
| 16 | Digitoxin medication and cancer:case control and internal dose-response studies显示文摘 | Haux J Klepp O Spigset O | 2001 | BMC Cancer2001，111，： | 1 |
| 17 | Country and destination image:different or similar image concepts显示文摘 | Mossberg L I Kleppe | 2005 | The Service Industries Journal2005，25，4： | 1 |
| 18 | Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association 显示文摘 | Kleppe R Toska K Haavik J | 2001 | J Neurochem2001，77，4： | 1 |
| 19 | Endocrine treatment,with or without radiotherapy,in locally advanced prostate cancer (SPCG-7/SFUO-3):an open randomised phase Ⅲ trial显示文摘 | Widmark A Klepp O Solberg A | | 0，，9660： | 1 |
| 20 | Efficiency of nitrification in trickling filters using different filter media显示文摘 | LEKANG O I KLEPPE H | 2000 | Aquac Eng2000，21，： | 1 |
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