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| 1 | MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus显示文摘AIM To investigate the micro RNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.METHODS High throughput screening using Taq Man~ Array Human Micro RNA quantitative PCR was used to determine expression levels of 754 micro RNAs in distal esophageal mucosa(1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett's esophagus using argon plasma coagulation vs pretreatment mucosa, posttreatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett's esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted m RNA target pathway analysis was used to investigate the functional involvement of differentially expressed micro RNAs.RESULTS Forty-four micro RNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen micro RNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine micro RNAs(mi R-424-5p, mi R-127-3p, mi R-98-5p, mi R-187-3p, mi R-495-3p, mi R-34c-5p, mi R-223-5p, mi R-539-5p, mi R-376a-3p, mi R-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These micro RNAs were also more highly expressed in Barrett's esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in the regulation of cell survival signalling pathways. Three micro RNAs(mi R-187-3p, mi R-135b-5p and mi R-31-5p) were expressed at higher levels in postablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These mi RNAs were expressed at similar levels in preablation Barrett's esophagus mucosa, matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in regulating the expression of proteins that contribute to barrier function.CONCLUSION Neosquamous mucosa arising after ablation of Barrett's esophagus expresses micro RNAs that may contribute to decreased barrier function and micro RNAs that may be involved in the regulation of survival signaling pathways. | Loveena Sreedharan George C Mayne David I Watson Timothy Bright Reginald V Lord Alfiya Ansar Tingting Wang Jakob Kist David StJ Astill Damian J Hussey | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 2 | Fiber optic sectrum analyzer显示文摘 | Kist R Sohler W | 1983 | J Lightwave Tech1983，1，2： | 2 |
| 3 | Acute renal insufficiency and renal replacement therapy after pediatric cardiopulmonary bypass surgery显示文摘 | Kist van Holthe tot Echten JE Goedvolk CA Doornaar MB | 2001 | Pediatr Cardiol2001，22，： | 1 |
| 4 | Secondary Resistance Among 554 Isolates of Helicobacter pylori After Failure of Therapy显示文摘 | M. Heep M. Kist S. Strobel D. Beck N. Lehn | 2000 | European Journal of Clinical Microbiology and Infections Diseases2000，，7： | 1 |
| 5 | Estimation of ifosfamide /cisplatinum-induced renal toxicity by urinary protem analysis显示文摘 | Rossi RM Kist C Wutster U | 1994 | Pediatr Nophrol1994，8，： | 1 |
| 6 | Venlafaxine and bupropion combination therapy in a case of treatment-resistant depression显示文摘 | Fatemi SH Emamian ES Kist DA | 1999 | Ann Pharmacother1999，33，6： | 1 |
| 7 | Minimally ablative resurfacing with the confluent 2,790 nm erbium: YSGG la- ser:a pilot study on safety andefficacy 显示文摘 | Walgrave SE Kist DA Noyaner-Turley A | 2012 | Lasers Surg Med2012，44，2： | 1 |
| 8 | Purkinje Cell Size Is Reduced in Cerebellum of Patients with Autism显示文摘 | S. Hossein Fatemi Amy R. Halt George Realmuto Julie Earle David A. Kist Paul Thuras Amelia Merz | 2002 | Cellular and Molecular Neurobiology2002，，2： | 1 |
| 9 | Helicobacter pylori activates mitogen-activated protein kinase cascades and induces expression of the proto-oncogenes c-fos and c-jun显示文摘 | Meyer-ter-Vehn T Covacci A Kist M | 2000 | J Biol Chem2000，275，16： | 1 |
| 10 | Acute and Chronic Administration of the Branched-Chain Amino Acids Decreases Nerve Growth Factor in Rat Hippocampus显示文摘 | Giselli Scaini Lis Mairá Mello-Santos Camila B. Furlanetto Isabela C. Jeremias Francielle Mina Patrícia F. Schuck Gustavo C. Ferreira Luiza W. Kist Talita C. B. Pereira Maurício R. Bogo Emilio L. Streck | 2013 | Molecular Neurobiology2013，，3： | 1 |
| 11 | Effect of pulsed dye laser and intense pulsed light source on the dermal extracellular matrix remodeling显示文摘 | Zelickson B Kist D | 2000 | Lasers Surg Med2000，，12： | 1 |
| 12 | Secondary resistance among 554 isolates of Helicobaeter pylori after failure of therapy显示文摘 | Heep M Kist M Strobl S | 2000 | Eur J Clin Microbio Infect Dis2000，19，7： | 1 |
| 13 | Shortest paths in stochastic networks显示文摘 | Lioyd-Smith B Kist A A | 2004 | IEEE2004，4，： | 1 |
| 14 | Histological and ultrastructurul evaluation of the effects of a radiofrequencybased nonablative dermal remodeling device:a pilot study显示文摘 | ZELICKSON B D KIST D BERNSTEIN E | 2004 | Arch Dermatol2004，140，2： | 1 |
| 15 | Pulsed dye laser and photoderm treatment stimulates production of type-Ⅰ collagen and collagenase transcripts in papillary dermis fibroblasts显示文摘 | Zelickson BD Kist DA | 2001 | Lasers Surg Med2001，，13： | 1 |
| 16 | Antiviral potential of interferon-omega on hepatitis B virus replication in human hepatoma cells 显示文摘 | HAGELSTEIN J KIST A STREMMEL W | 1998 | Arzneimittelforschung1998，48，3： | 1 |
| 17 | Impact of ELISA and immunoblot as diagnostic tools one year after eradication of helicobacter pylori in a multicentre treatment study显示文摘 | Kist M Strobel S Kirchner T | 1999 | FEMS Immunol Med Microbiol1999，24，2： | 1 |
| 18 | Bacterial genetic fingerprint: a reliable factor in the study of the epidemiology of human Campylobacter enteritis显示文摘 | STEINBRUECKNER B RUBERG F KIST M | 2001 | Clin Microbiol2001，39，： | 1 |
| 19 | Antiviral potential of interferonomega on hepatitis B virus replication in human hepatoma cells显示文摘 | Hagelstein J Kist A Stremmel W Galle PR | 1998 | Arzneimittelforschung1998，48，： | 1 |
| 20 | Twin anemia-polycythemia sequence: diagnostic criteria, classification, perinatal management and outcome显示文摘 | Slaghekke F Kist WJ Oepkes D | 2010 | Fetal Diagn Ther2010，27，4： | 1 |
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