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| 1 | Unpowered Knee Exoskeleton Reduces Quadriceps Activity during Cycling显示文摘自行车是一种环保且具有娱乐性的交通方式。为了减少自行车运动的能量消耗同时不消耗额外的能源,我们提出利用扭力弹簧对膝关节伸展进行支撑。我们开发了一个基于嵌入式扭转弹簧与交叉四杆机构的膝关节外骨骼原型机。在研究过程中,通过分析8名健康男性参与者以恒定功率骑行测试的数据,对原型机性能进行了评估。记录参与者在200 W和225 W带有加速系统的骑行训练机运动时两个腿部股直肌的表面肌电图(EMG)。然后,通过连续小波变换在时间频率上分析这些数据。在相同的骑行速度和腿部节奏下,肌电的中值功率谱频率随骑行负荷的增加而增加。在相同的骑行载荷下,外骨骼机器人可使中值功率谱频率降低。外骨骼机器人不消耗电能,不传递净正机械功,可减轻股四头肌的活动。此项基础研究可应用于骑行辅助可穿戴设备的进一步开发。 | Ronnapee Chaichaowarat Jun Kinugawa Kazuhiro Kosuge | 2018 | Engineering2018，4，4： | 4 |
| 2 | An oral fluoropyrimidine agent S-1 induced interstitial lung disease:A case report显示文摘A 66-year-old Japanese man with pancreatic cancer received eleven courses of gemcitabine monotherapy.The tumor responded to gemcitabine until metastatic liver tumors progressed.Subsequently,he was treated with S-1,an oral fluoropyrimidine anticancer agent,as salvage chemotherapy.Forty-two days after initiating S-1,he presented with dyspnea and fever.Chest computed tomography showed diffuse interstitial lesions with thickening of the alveolar septa and ground glass opacity.Serum KL-6 level was elevated to 1,230 U/mL and he did not use any other drugs except insulin.Thus,the development of interstitial lung disease(ILD)was considered to be due to S-1.Arterial blood oxygen pressure was 49.6 Torr in spite of oxygen administration(5 L/min).Steroid therapy improved his symptoms and the interstitial shadows on chest radiograph.Although S-1-induced ILD has mostly been reported to be mild,clinicians should be aware that S-1 has the potential to cause fatal ILD. | Hiromichi Yamane Masahide Kinugawa Shigeki Umemura Yasuhiro Shiote Kenichiro Kudo Toshimitsu Suwaki Haruhito Kamei Nagio Takigawa Katsuyuki Kiura | 2011 | World Journal of Clinical Oncology2011，2，7： | 3 |
| 3 | Application of the Distributed Database (Data-Free-Way) ou the Analysis of Mechanical Properties in Neutron lrradiated 316 Stainless Steel 显示文摘 | Fujita M Kinugawa J Tsuji H | 2000 | Fusion Engineering and Design2000，，5152： | 2 |
| 4 | Cellular basis for the acute inhibitory effects of IL-6 and TNF- alpha on excitation-contraction coupling 显示文摘 | Sugishita K Kinugawa K Shimizu T | 1999 | J Mol Cell Cardiol1999，31，8： | 1 |
| 5 | Evidence of a role for lactadherin in Alzheimer disease显示文摘 | Boddaert J Kinugawa K Lambert 7C | 2007 | Am J Pathol2007，170，： | 1 |
| 6 | AngiotensinⅡtype 1 receptor blocker attenuates myocardial remodeling and preserves diastolic function in diabetic heart显示文摘 | TSUTSUI H MATSUSHIMA S KINUGAWA S | 2007 | Hypertens Res2007，30，5： | 1 |
| 7 | Mitochondrial oxidative stress and dysfunction in myocardial remodelling显示文摘 | Tsutsui H Kinugawa S Matsushima S | | 0，，03： | 1 |
| 8 | Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy显示文摘 | Kinugawa K Yonekura K Ribeiro RC | 2001 | Circ Res2001，89，7： | 1 |
| 9 | Direct evidence for increased hydroxyl radicals originated from superoxide in the failing myocardium显示文摘 | Ide T Tsutsui H Kinugawa S | 2000 | Circ Res2000，86，4： | 1 |
| 10 | Neurohumoral profiles in patients with hypertrophic cardiomyophthy:differences to hypertension left ventricular hypertrophy显示文摘 | Ogino K Ogura K Kinugawa T | 2004 | Circ J2004，68，5： | 1 |
| 11 | Signaling pathways responsible for fetalvgene induction in the failin human heart:evidence for altered thyroid hormone receptor gene expression显示文摘 | Kinugawa K Minobe WA Wood WM | 2001 | Circulation2001，103，8： | 1 |
| 12 | Thyroid hormone induces cardiac myocyte hyper- trophy in a thyroid hormone receptor alphal-speeific manner that requires TAK1 and p38 mitogen-activated protein kinase显示文摘 | KINUGAWA K JEONG M Y BRISTOW M R | 2005 | Mol Endocrinol2005，19，： | 1 |
| 13 | Mitochondrial oxidative stress, DNA damage, and heart failure 显示文摘 | Tsutsui H Ide T Kinugawa S | 2006 | Antioxid Redox Signal2006，8，910： | 1 |
| 14 | Mitochondrial oxidative stress,DNAdamage,and heart failure显示文摘 | Tsutsui H Ide T Kinugawa S | 2006 | Antioxid Redox Signal2006，8，910： | 1 |
| 15 | Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy 显示文摘 | Kinugawa K Yonekura K Ribeiro RC | 2001 | Circ Res2001，89，7： | 1 |
| 16 | Protection by exogenously added coenzyme Q9 against free radical-induced injuries in human liver cells显示文摘 | Kusumoto C Kinugawa T Morikawa H | 2010 | J Clin Biochem Nutri2010，46，3： | 1 |
| 17 | Transient left ventricular apical ballooning in a patient with bicuspid aortic valve created a left ventricular thrombus leading to acute renal infarction 显示文摘 | Sasaki N Kinugawa T Yamawaki M | 2004 | Circ J2004，68，5： | 1 |
| 18 | Monotypic epithelioid angiomyolipoma of the kidney : a case report 显示文摘 | Morioka M Kinugawa K Funabiki S | 2006 | Int J Urol2006，13，9： | 1 |
| 19 | 查看详情显示文摘 | Yoshikawa M Fujimoto K Kinugawa H Kitao T Ogata N | | 0，，： | 1 |
| 20 | Mitochondrial oxidative stress, DNA da- mage, and heart failure 显示文摘 | Tsutsui H Ide T Kinugawa S | 2006 | Antioxid Redox Signal2006，8，910： | 1 |
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