|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 脑组织TNFɑ过度表达对神经胶质细胞及脑缺血梗死灶体积的影响显示文摘目的:探讨脑组织肿瘤坏死因子ɑ(TNFɑ)过度表达对小胶质细胞、星形胶质细胞激活及脑缺血梗死灶体积的影响。方法:用TNFɑ、胶质纤维酸性蛋白(GFAP)、髓磷脂、整合素ɑM(OX42)免疫组化染色观察SD大鼠与转小鼠TNFɑ基因大鼠未缺血脑组织的TNFɑ表达及3种神经胶质细胞穴星形胶质细胞、小胶质细胞与少突神经胶质细胞雪的激活状态。采用线栓法制作大鼠大脑中动脉闭塞模型,SD大鼠与转小鼠TNFɑ基因大鼠缺血1h再灌注72h后,先行神经功能缺损程度评分,再断头取脑四氯氮唑(TTC)染色计算脑梗死体积。结果:转小鼠TNFɑ基因大鼠与SD大鼠相比,未缺血脑组织见TNFɑ表达,且星形胶质细胞、小胶质细胞与少突神经胶质细胞呈肥大和增生性变化;缺血1h再灌注72h后神经功能缺损程度评分显著增高,脑梗死灶体积显著增大。结论:未缺血时脑组织TNFɑ的表达可明显激活3种神经胶质细胞,TNFɑ的过度表达可使脑缺血时神经功能明显恶化及脑梗死体积明显增加,提示TNFɑ的过度表达可明显加剧缺血性脑损伤。 | 李义召 曹秀玲 王凤山 程艳娜 孙若鹏 于进 朱虹 Pettigrew LC Kindy MS | 2004 | 山东大学学报(医学版)2004，42，5： | 2 |
| 2 | Ocular manifestation and their associated factors among HIV/AIDS patients receiving highly active antiretroviral therapy in Southern Ethiopia显示文摘AIM:To assess the pattern of ocular manifestation and associated factors among human immunodeficiency virus(HIV)/acquired immunodeficiency syndrome(AIDS) patients on highly active antiretroviral therapy(HAART) at Hawassa University Referral Hospital, Southern Ethiopia. METHODS:A cross sectional study was conducted from January 2014 to April 2015. After obtaining informed written consent, 240 adult HIV/AIDS patients on HAART were randomly selected regardless of their ophthalmic symptoms, WHO status or CD4 count. Data were collected using structured questionnaires and ophthalmologic clinical examination. Data were entered and analyzed using SPSS version 20.0 software. RESULTS:The mean duration of HAART was 62.5mo. The prevalence of HIV related ocular manifestation was 14.2%. Seborrheic blepharitis(5%) was the most common ocular manifestation, followed by squamoid conjunctival growth(3.8%). The rate of ocular manifestation was significantly higher among study participants who had CD4+ count <200 cells/μL(AOR=3.83; 95%CI:1.315-11.153), low duration of HAART(AOR=3.0; 95%CI:1.305-6.891) and who had primary school education [odds ratio(OR) =2.8; 95%CI:1.105-7.099]. Prevalence of visual impairment and blindness was 10.9% and 5.8%, respectively.CONCLUSION:HAART may be the reason for the decline in the prevalence of ocular manifestation in HIV/AIDS patients in the study area. Ophthalmologic screening of HIV/AIDS patients, especially those with CD4 counts of <200/μL cells and in the first five years of HAART followup is recommended to reduce visual impairment and/or blindness. | Anteneh Amsalu Kindie Desta Demiss Nigussie Demoze Delelegne | 2017 | International Journal of Ophthalmology(English edition)2017，10，5： | 2 |
| 3 | GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism显示文摘 | Li Y Perry T Kindy MS | 2009 | Proc Natl Acad Sci USA2009，106，： | 1 |
| 4 | The alternative and terminal pathways of complement mediate post-traumatic spinal cord inflam- mation and injury 显示文摘 | Qiao F Atkinson C Kindy MS | 2010 | Am J Pathol2010，177，6： | 1 |
| 5 | Characterization of constitutive human serum amyloid A protein (SAA4) an apolipoprotein显示文摘 | DE BEER M C YUAN T KINDY M S | 1995 | J Lipid Res1995，36，3： | 1 |
| 6 | Mitochondrial manganese superoxide dismutasc prevents neural apop rtosis and reduces ischcmic brain injury: supp ression of peroxynitrite production, lipid pcroxidation, and mitochondrial dysfunction 显示文摘 | KELLER JN KINDY MS Holtsberg FW | 1998 | Neurosci1998，18，2： | 1 |
| 7 | A Sequential Injection Method for the Determination of Aluminum in Drinking Water Using Fluorescence Enhancement of the Aluminum - morin Complex in Micellar Media显示文摘 | KINDY S M Z SULIMAN F O SALAMA S B | 2003 | Microchemical Journal2003，74，： | 1 |
| 8 | The ahemative and terminal pathways of complement mediate post-traumatic spinal cord inflammation and injury显示文摘 | Oiao F Atkinson C Kindy MS | 2010 | Am J Pathol2010，6，： | 1 |
| 9 | Tyrosine phosphorylation of microtubule-associated protein kinase after transient ischemia in the gerbil brain显示文摘 | Campos-González R Kindy MS | 1992 | J N eurochem1992，59，5： | 1 |
| 10 | Oxidized high-density lipopro- tein induces neuron death显示文摘 | Keller JN Hanni KB Kindy MS | 2000 | Exp Neurol2000，161，： | 1 |
| 11 | 转小鼠TNFB基因大鼠脑缺血时细胞凋亡、c-JUN、p-JUN与p-JNK表达的研究显示文摘目的:探讨肿瘤坏死因子B(TNFB)过度表达时对细胞凋亡、c-JUN、p-JUN与p-JNK表达的影响。方法:采用线栓法制作大鼠大脑中动脉闭塞模型,用TNFB、TUNEL、c-JUN、p-JUN与p-JNK免疫组化染色观察SD大鼠与转小鼠TNFB基因大鼠缺血1h再灌注24h时的细胞凋亡、c-JUN、p-JUN与p-JNK的表达。结果:与SD大鼠相比,转小鼠TNFB基因大鼠缺血1h再灌注24h后,脑组织凋亡细胞显著增多,c-JUN、p-JUN与p-JNK过度表达显著,以上指标变化均显著高于SD大鼠。结论:TNFB的过度表达加剧缺血性脑损伤,其机制可能为c-JUN、p-JUN与p-JNK的过度表达。 | 李义召 曹秀玲 卢林 王凤山 程艳娜 孙若鹏 JIN Yu HONG Zhu Pettigrew LC Kindy MS | 2005 | 山东大学学报(医学版)2005，43，12： | 1 |
| 12 | Microencapsulation to reduce mechanical loss of micrespheres: implications in myocardial cell therapy显示文摘 | AI Kindi AH Asenjo JF Ge Y | 2011 | Eure J Cardio-Thorac Surg2011，39，2： | 1 |
| 13 | GLP-1 receptor stimulation preservesprimary cortical and dopaminergic neurons in cellular and rodentmodels of stroke and Parkinsonism 显示文摘 | Li Y Perry T Kindy MS | 2009 | Proc Natl Acad Sci USA2009，106，4： | 1 |
| 14 | An Evaluation of Surface Roughness Parameters Measurement Using Vision-- based Data 显示文摘 | Al Kindi G A Shirinzadeh B | | International Journal of Machine Tools and Manufacture0，47，34： | 1 |
| 15 | Inhibitors of cathepsin B improve memory and reduce β-amyioid in transgenic Alzheimcr disease mice expressing the wild-type, but not the Swedish Mutant, β-secretase site of the amyloid precursor protein显示文摘 | Hook V Kindy M Hook G | 2008 | J Biol Chem2008，283，： | 1 |
| 16 | Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptor显示文摘 | Bruce AJ Boling W Kindy MS | | 0，，： | 1 |
| 17 | Feasibility assessment of vision - based surface roughness parameters acquisition for different types of machined specimens显示文摘 | Al- kindi Ghassan A Shirinzadeh Bijan | 2009 | Image and Vision Computing2009，27，： | 1 |
| 18 | Inhibition of Alzheimer's amyloidosis by peptides that prevent beta sheet conformation显示文摘 | Kindy MS Baumann M | 1996 | Biochem Biophys Res Commun1996，226，3： | 1 |
| 19 | Overexpression of murine TNFα gene increases infarct volume in focal cerebral ischemia stroke显示文摘 | Li YZ Holtz ML Kindy MS | 2002 | Stroke2002，33，1： | 1 |
| 20 | Focal cerebral ischemia inthe TNF-alpha-transgenic rat显示文摘 | Pettigrew LC Kindy MS Scheff S | 2008 | Neuroinflammation2008，235，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员