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| 1 | 脑组织TNFɑ过度表达对神经胶质细胞及脑缺血梗死灶体积的影响显示文摘目的:探讨脑组织肿瘤坏死因子ɑ(TNFɑ)过度表达对小胶质细胞、星形胶质细胞激活及脑缺血梗死灶体积的影响。方法:用TNFɑ、胶质纤维酸性蛋白(GFAP)、髓磷脂、整合素ɑM(OX42)免疫组化染色观察SD大鼠与转小鼠TNFɑ基因大鼠未缺血脑组织的TNFɑ表达及3种神经胶质细胞穴星形胶质细胞、小胶质细胞与少突神经胶质细胞雪的激活状态。采用线栓法制作大鼠大脑中动脉闭塞模型,SD大鼠与转小鼠TNFɑ基因大鼠缺血1h再灌注72h后,先行神经功能缺损程度评分,再断头取脑四氯氮唑(TTC)染色计算脑梗死体积。结果:转小鼠TNFɑ基因大鼠与SD大鼠相比,未缺血脑组织见TNFɑ表达,且星形胶质细胞、小胶质细胞与少突神经胶质细胞呈肥大和增生性变化;缺血1h再灌注72h后神经功能缺损程度评分显著增高,脑梗死灶体积显著增大。结论:未缺血时脑组织TNFɑ的表达可明显激活3种神经胶质细胞,TNFɑ的过度表达可使脑缺血时神经功能明显恶化及脑梗死体积明显增加,提示TNFɑ的过度表达可明显加剧缺血性脑损伤。 | 李义召 曹秀玲 王凤山 程艳娜 孙若鹏 于进 朱虹 Pettigrew LC Kindy MS | 2004 | 山东大学学报(医学版)2004，42，5： | 2 |
| 2 | GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism显示文摘 | Li Y Perry T Kindy MS | 2009 | Proc Natl Acad Sci USA2009，106，： | 1 |
| 3 | The alternative and terminal pathways of complement mediate post-traumatic spinal cord inflam- mation and injury 显示文摘 | Qiao F Atkinson C Kindy MS | 2010 | Am J Pathol2010，177，6： | 1 |
| 4 | Mitochondrial manganese superoxide dismutasc prevents neural apop rtosis and reduces ischcmic brain injury: supp ression of peroxynitrite production, lipid pcroxidation, and mitochondrial dysfunction 显示文摘 | KELLER JN KINDY MS Holtsberg FW | 1998 | Neurosci1998，18，2： | 1 |
| 5 | The ahemative and terminal pathways of complement mediate post-traumatic spinal cord inflammation and injury显示文摘 | Oiao F Atkinson C Kindy MS | 2010 | Am J Pathol2010，6，： | 1 |
| 6 | Tyrosine phosphorylation of microtubule-associated protein kinase after transient ischemia in the gerbil brain显示文摘 | Campos-González R Kindy MS | 1992 | J N eurochem1992，59，5： | 1 |
| 7 | Oxidized high-density lipopro- tein induces neuron death显示文摘 | Keller JN Hanni KB Kindy MS | 2000 | Exp Neurol2000，161，： | 1 |
| 8 | 转小鼠TNFB基因大鼠脑缺血时细胞凋亡、c-JUN、p-JUN与p-JNK表达的研究显示文摘目的:探讨肿瘤坏死因子B(TNFB)过度表达时对细胞凋亡、c-JUN、p-JUN与p-JNK表达的影响。方法:采用线栓法制作大鼠大脑中动脉闭塞模型,用TNFB、TUNEL、c-JUN、p-JUN与p-JNK免疫组化染色观察SD大鼠与转小鼠TNFB基因大鼠缺血1h再灌注24h时的细胞凋亡、c-JUN、p-JUN与p-JNK的表达。结果:与SD大鼠相比,转小鼠TNFB基因大鼠缺血1h再灌注24h后,脑组织凋亡细胞显著增多,c-JUN、p-JUN与p-JNK过度表达显著,以上指标变化均显著高于SD大鼠。结论:TNFB的过度表达加剧缺血性脑损伤,其机制可能为c-JUN、p-JUN与p-JNK的过度表达。 | 李义召 曹秀玲 卢林 王凤山 程艳娜 孙若鹏 JIN Yu HONG Zhu Pettigrew LC Kindy MS | 2005 | 山东大学学报(医学版)2005，43，12： | 1 |
| 9 | GLP-1 receptor stimulation preservesprimary cortical and dopaminergic neurons in cellular and rodentmodels of stroke and Parkinsonism 显示文摘 | Li Y Perry T Kindy MS | 2009 | Proc Natl Acad Sci USA2009，106，4： | 1 |
| 10 | Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptor显示文摘 | Bruce AJ Boling W Kindy MS | | 0，，： | 1 |
| 11 | Inhibition of Alzheimer's amyloidosis by peptides that prevent beta sheet conformation显示文摘 | Kindy MS Baumann M | 1996 | Biochem Biophys Res Commun1996，226，3： | 1 |
| 12 | Overexpression of murine TNFα gene increases infarct volume in focal cerebral ischemia stroke显示文摘 | Li YZ Holtz ML Kindy MS | 2002 | Stroke2002，33，1： | 1 |
| 13 | Focal cerebral ischemia inthe TNF-alpha-transgenic rat显示文摘 | Pettigrew LC Kindy MS Scheff S | 2008 | Neuroinflammation2008，235，1： | 1 |
| 14 | Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury:suppression of peroxynitrite production,lipid peroxidation,and mitochondrial dysfunction显示文摘 | Keller JN Kindy MS Holtsberg FW | 1998 | J Neurosci1998，18，： | 1 |
| 15 | Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNFreceptors显示文摘 | Bruce AJ Boling W Kindy MS | 1996 | Nat Med1996，2，7： | 1 |
| 16 | Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation 显示文摘 | Soto C Kindy MS Baumann M | 1996 | Biochem Biophys Res Commun1996，226，3： | 1 |
| 17 | Mitochondrial manganses superoxide dismutase prevents neuronal apoptosis and reduces ischemic brain injury:suppression of peroxynitrite production,lipid peoxidatin,and itochondrial dysfunction显示文摘 | KELLER JN KINDY MS HOLSBERG FW | 1998 | J Cereb Blood Flow Metab1998，18，： | 1 |
| 18 | Heparin prevents vascular smooth muscle cell progression through the G1 phase of the cell cycle显示文摘 | Reilly CF Kindy MS Brown KE | 1989 | J Biol Chem1989，264，12： | 1 |
| 19 | GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism显示文摘 | Li Y Perry T Kindy MS | 2009 | Proc Nod Acad Sci USA2009，106，4： | 1 |
| 20 | Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor显示文摘 | Gray DS Bruce-Keller AJ Kindy MS | 1998 | Cereb Blood Folw Metab1998，18，12： | 1 |
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