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| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | On the macroparticle flux from vacuum arc cathode spots显示文摘 | Anders S Anders A Kin M Y | 1993 | IEEE Trans On Plasma Science1993，21，： | 2 |
| 3 | Comparative radiation impact on biota and man in the area affected by the accident at the Chernobyl nuclear power plant显示文摘 | ALEXAKHIN R M GERAS′KIN S A | 2005 | J Environ Radioact2005，80，： | 1 |
| 4 | Non-lnvasive Measurement of Glucose by Metabolic Heat Conformation Method 显示文摘 | Cho O K Kin Y Hiroshi M | 2004 | Clinical Chemistry2004，50，10： | 1 |
| 5 | Biomechanical evaluation of kyphoplasty and vertebroplasty with calcium phosphate cement in a simulated osteoporotic compression fracture显示文摘 | Tomita S Kin A Yazu M | | 0，，02： | 1 |
| 6 | Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma显示文摘 | Torimura T Ueno T Kin M | | 0，，05： | 1 |
| 7 | Autocrine motility factor enhances hepatoma cell invasion across the basement membrane through activation of beta1 integrins显示文摘 | Torimura T Ueno T Kin M | 2001 | Hepatology2001，34，1： | 1 |
| 8 | Drug discovery from natural products显示文摘 | Vincent P G James M Kin S L | 2006 | J Ind Microbiol Biotechnol2006，33，7： | 1 |
| 9 | Mechanism of two-dimension electron gas formation in AlxGa1-xN/GaN heterostructures显示文摘 | Jang H W Jeon C M Kin K H | 2002 | Applied Physics Letters2002，81，7： | 1 |
| 10 | Synthesis of Triazine-Based Polyimide Nanocomposites with Flower-Like ZnO by Microwave-Assisted Solvothermal Technique显示文摘 | Turgay Se?kin Nilufer K?v?lc?m Süleyman K?ytepe | 2013 | Polymer-Plastics Technology and Engineering2013，，13： | 1 |
| 11 | Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine显示文摘 | KIN H ZATTA J A LOFYE T M | 2005 | Cardiovasc Res2005，67，： | 1 |
| 12 | Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine 显示文摘 | KIN H ZATTA A J LOFYE M T | 2005 | Cardiovasc Res2005，67，： | 1 |
| 13 | The effect of hydrogen peroxide on a CST under cesium ion exchange conditions显示文摘 | KIN S H PHILIP M ANTHONY R G | 2003 | Separation Science and Technology2003，38，1213： | 1 |
| 14 | Effect of silicate fertilizer on reducing methane emission during rice cultivation显示文摘 | All M A Lee C H Kin P J | 2008 | Biology and Fertility of Soils2008，44，59： | 1 |
| 15 | Analysis of the fine-scale population structure of “candidatus accumulibacter phosphatis” in enhanced biological phosphorus removal sludge,using fluorescence in situ hybridization and flow cytometric显示文摘 | KIM J M LEE H J KIN S Y c(al | 2010 | Appl Environ Microbiol2010，76，12： | 1 |
| 16 | The impact of hepatic portoenterostomy on liver transplantation for the treatment of biliary atresia:Early failure adversely affects outcome显示文摘 | Alexopoulos SP Merrill M Kin C | 2012 | Pediatr Transplantation2012，16，4： | 1 |
| 17 | An accurate active shape model for facial feature extraction显示文摘 | KWOK W W KIN M L KIT C N | | 0，，15： | 1 |
| 18 | Porous pyridine based polyimide–silica nanocomposites with low dielectric constant显示文摘 | Nilufer K?v?lc?m Turgay Se?kin Süleyman K?ytepe | 2013 | Journal of Porous Materials2013，，4： | 1 |
| 19 | SHBG levels correlate with insulin ,:sistanee in postmenopausal women 显示文摘 | &kin F Bastemir M Alkis E el al | 2009 | Eur J Intern Med2009，20，： | 1 |
| 20 | HPV oligonucleotide microar- ray--based detection of HPV genotypes in cervical neoplasti- elestions显示文摘 | Kin CJ Jeong JK Park M | 2003 | Gynecol Oncol2003，89，2： | 1 |
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