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| 1 | TNF-α Induces Transient Resistance to Fas-Induced Apoptosis in Eosinophilic Acute Myeloid Leukemia Cells显示文摘Tumor necrosis factor α (TNF-α) has been recognized as an activator of nuclear factor κB (NF-κB), a factor implicated in the protection of many cell types from apoptosis. We and others have presented evidence to suggest that Fas-induced apoptosis may be an important aspect of the resolution of inflammation, and that delayed resolution of inflammation may be directly associated with NF-κB-dependent resistance to Fas. Because TNF-α activates NF-κB in many cell types including inflammatory cells such as eosinophils, we examined effects of TNF-α signaling on the Fas-mediated killing of an eosinophilic cell line AML14. While agonist anti-Fas (CH11) treatment induced apoptosis in AML14 cells, no significant cell death occurred in response to TNF-α alone. Electrophoretic mobility shift assay (EMSA) revealed that TNF-α induced NF-κB transactivation in AML14 cells in a time- and dose-dependent fashion, and subsequent supershift assays indicated that the translocated NF-κB was the heterodimer p65 (RelA)/p50. Pre-treatment of cells with TNF-α dramatically decreased the CH11-induced cell death in a transient fashion, accompanied by suppression of activation of caspase-8 and caspase-3 activation. Inhibition of NF-κB transactivation by inhibitors, BAY 11-7085 and parthenolide, reversed the suppression of Fas-mediated apoptosis by TNF-α. Furthermore, TNF-α up-regulated X-linked inhibitor of apoptosis protein (XIAP) transiently and XIAP levels were correlated with the temporal pattern of TNF-α protection against Fas-mediated apoptosis. This finding suggested that TNF-α may contribute to the prolonged survival of inflammatory cells by suppression of Fas-mediated apoptosis, the process involved with NF-κB transactivation,anti-apoptotic XIAP up-regulation and caspase | Yimin Qin Sogyong Auh Lyubov Blokh Catherine Long Isabelle Gagnon Kimm J. Hamann | 2007 | Cellular & Molecular Immunology2007，4，1： | 19 |
| 2 | Association of resting heart rate and hypertension stages on all-cause and car- diovascular mortality among elderly Koreans: the Kangwha Cohort Study显示文摘BackgroundElevated 休息心率和高血压独立地增加死亡的风险。然而,他们在高血压的阶段的死亡上的联合效果根据在老人口之中的更新的临床的指南是跟随的 unclear.MethodsWe Kangwha 县的 6100 个居民( 2600 男性和 3500 女性)的一个队,朝鲜,1985年3月从 55~99 个60岁的孩子 ,为为 20.8 年的所有原因和心血管的死亡直到2005年12月31日。死亡数据通过电话和访问被收集(到 1991 ) ,并且被死亡记录与国家统计办公室匹配证实(1992 − 2005 ) 。危险比率被放松第八个联合公民定义的心率和高血压为所有原因和心血管的死亡计算用在为使 factors.ResultsThe 危险比率惊讶控制以后的比例的危险模型与放松心率 > 联系了的考克斯的委员会标准;80 beats/min 与有 61-79 beats/min 的心率的 normotensives 相比在高血压的人是更高的,与 1.43 的危险比率价值(95% CI:1.00 − 1.92 ) 在为 prehypertension 的所有原因死亡上, 3.01 (95% CI:1.07-8.28 ) 在为 prehypertension 的心血管的死亡上,并且 8.34 (95% CI:2.52 − 28.19 ) 为舞台 2 高血压。增加的风险(HR:3.54, 95% CI:1.16-9.21 ) 与两个在那些之中被观察休息心率 ≥在有共存的 women.ConclusionsIndividuals 的心血管的死亡上的 80 beats/min 和 prehypertension 提高了休息甚至在 prehypertension,心率和高血压与独自放松心率或高血压提高与那些相比为所有原因和心血管的死亡有更大的风险。这些调查结果建议那提高的休息心率不应该在老高血压的病人被认为是一个不太严肃的风险因素。 | Mikyung Ryu Gombojav Bayasgalan Heejin Kimm Chung Mo Nam Heechoul Ohrr | 2016 | Journal of Geriatric Cardiology2016，13，7： | 7 |
| 3 | Childhood obesity显示文摘 | Joan C Han Debbie A Lawlor Sue YS Kimm | 2010 | The Lancet2010，，9727： | 2 |
| 4 | Lot sizing and scheduling-survey and extensions(Invited review) 显示文摘 | DREXL A KIMMS A | 1997 | European Journal of Operation Research1997，99，2： | 1 |
| 5 | Finding circles by an array of accumulators 显示文摘 | C Kimme D Balland J Sklansky | 1975 | Communications of the ACM1975，18，2： | 1 |
| 6 | The role of dietary fiber in the development and treatmentof childhood obesity显示文摘 | KIMM S Y | 1996 | Pediatrics1996，96，5： | 1 |
| 7 | Finding circles by an array of accumulators 显示文摘 | C Kimme D Balland J Sklansky | 1972 | Commun ACM1972，15，1： | 1 |
| 8 | MMTV insertional mutagenesis identifies genes,gene families and pathways involved in mammary cancer显示文摘 | Theodorou V Kimm MA Boer M | | 0，，06： | 1 |
| 9 | A case - control study on seaweed consumption and the risk of breast cancer 显示文摘 | YangYJ NamSJ KongG KimM K | 2010 | British Journal of Nutrition2010，103，9： | 1 |
| 10 | Effect of AC electric fields on the stabilization of premixed Bunsen flames 显示文摘 | KIMM K CHUNG S H KIM H H | 2010 | Proceedings of the Combustion Institute2010，33，1： | 1 |
| 11 | Childhood obesity-2010 : pro- gress and challenges 显示文摘 | Han JC Lawlor DA Kimm SYS | 2010 | Lancet2010，375，9727： | 1 |
| 12 | Current insights into inherited bone marrow failure syndromes显示文摘 | ChungNG KimM | 2014 | Korean J Pediatr2014，57，8： | 1 |
| 13 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 14 | Detection of VX contamination in soil through solid - phase microextraction sampling and gas chromatography/mass spectrometry of the VX degradation product bis (diisopropyl aminoethyl) disulfide显示文摘 | HOOK G L KIMM G KOCH D | 2003 | Journal of Chromatography A2003，992，12： | 1 |
| 15 | A genetic algorithm for multi-level, multi-machine lot sizing and scheduling 显示文摘 | Kimms A | 1999 | Computers and Operations Reaserch1999，26，8： | 1 |
| 16 | Relation be- tween the changes in physical activity and body mass index dur- ing adolescence: a multicentre longitudinal study显示文摘 | KIMM S Y GLYNN N W OBARZANEK E | 2005 | Lancet2005，23，29： | 1 |
| 17 | Low serum bilirubin level as an inde- pendent predictor of stroke incidence : a prospective study in Kore-an men and women显示文摘 | Kimm H Yun JE Jo J | 2009 | Stroke2009，40，11： | 1 |
| 18 | Approximate nucleolus-based revenue sha- ring in airline alliances 显示文摘 | KIMMS A CETINER D | 2012 | European Journal of Operational Re- search2012，220，2： | 1 |
| 19 | Etevated NADPH Oxidase Activity Contributes to Oxidative Stress and Cell Death in Huntington's Disease 显示文摘 | VALENCIA A SAPP E KIMM J | 2013 | Human Molecular Genetics2013，22，6： | 1 |
| 20 | Effect of enamel etching time on roughness and bond strength 显示文摘 | Barkmeier WW Erickson RL Kimmes NS | 2009 | Oper Dent2009，34，2： | 1 |
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