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| 1 | Neuroprotective effects of bovine colostrum on intracerebral hemorrhage-induced apoptotic neuronal cell death in rats显示文摘Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism. Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyl-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death. | Sung Eun Kim ll Gyu Ko Mal Soon Shin Chang Ju Kim Young Gwan Ko Hanjin Cho | 2012 | Neural Regeneration Research2012，7，22： | 2 |
| 2 | Animal plant warfare and secondary metabolite evolution显示文摘The enduring discussion,why plants produce secondary metabolites with pharmacologically and toxicologically active towards mammals traces back to the eminent role of medicinal plants in the millennia-old history of manhood.In recent years,the concept of an animal plant warfare emerged,which focused on the co-evolution between plants and herbivores.As a reaction to herbivory,plants developed mechanical defenses such as thorns and hard shells,which paved the way for adapted animal physiques.Plants evolved further defense systems by producing chemicals that exert toxic effects on the animals that ingest them.As a result of this selective pressure,animals developed special enzymes,e.g.cytochrome P450 monooxigenases(CYP450)that metabolize xenobiotic phytochemicals.As a next step in the evolutionary competition between plants and animals,plants evolved to produce non-toxic pro-drugs,which become toxic only after ingestion by animals through metabolization by enzymes such as CYP450.Because these sequestered evolutionary developments call to mind an arms race,the term animal plant warfare has been coined.The evolutionary competition between plants and animals may help to better understand the modes of action of medicinal plants and to foster the efficient and safe use of phytotherapy nowadays. | Steffen WÖLL Sun Hee KIM Henry Johannes GRETEN Thomas EFFERTH | 2013 | Natural Products and Bioprospecting2013，3，1： | 2 |
| 3 | Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus 显示文摘 | Koherman OG Kim DD Shen L Ruggles JA Nielsen LL Fineman MS | 2005 | Am J Health Syst Pharm2005，62，2： | 1 |
| 4 | A complex of the IL-1 homo-logue IL-lF7b and IL-18-binding protein reduces IL-18 activity显示文摘 | Bufler P Azam T Gamboni-Robertson F Reznikov LL Ku-mar S Dinarello CA Kim SH | 2002 | Proc Natl Acad Sci USA2002，99，13： | 1 |
| 5 | The antitumor histone deacety-lase inhibitor suberoylanilide hydroxamic acid exhibits anti-in-flammatory properties via suppression of cytokines显示文摘 | Leoni F Zaliani A Bertolini G Porro G Pagani P Pozzi P Dona G Fossati G Sozzani S* Azam T Bufler P Fantuzzi G Goncharov I Kim SH Pomerantz BJ Reznikov LL SiegmundB Dinarello CA Mascagni P | 2002 | ProcNatl Acad Sci USA2002，99，： | 1 |
| 6 | Chronic exposure to GLP-1R agonists promotes homologous GLP-I receptor desensitization in vitro but does not attenuate GLP-1R- dependent glucose homeostasis in vivo 显示文摘 | Baggio LL Kim JG Drucker DJ | 2005 | Diabetes2005，53，： | 1 |
| 7 | Analysis of the polar flagellar gene sys- tem of Vibrio parahaemolyticus 显示文摘 | Kim YK McCarter LL | 2000 | J Bacteriol2000，182，13： | 1 |
| 8 | Cross-regulation in Vibr/o parahaemolyt/cus : compensatory activation of polar flagellar genes by the lateral flagellar regulator LafK显示文摘 | Kim YK McCarter LL | 2004 | J Bacteriol2004，186，12： | 1 |
| 9 | Opacification of urinary bladder and ureter at CT urography: effect of a log-rolling procedure and postvoiding residual bladder urine volume 显示文摘 | Kim S Wang LL Heiken JP | 2008 | Radiology2008，247，： | 1 |
| 10 | IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma显示文摘 | Reznikov LL Kim SH Westcott JY | 2000 | Proc Natl Acad Sci USA2000，97，5： | 1 |
| 11 | Safety of laser in situkeratomileusis performed under ultra - thin corneal flap 显示文摘 | Lin RT Lu S Wang LL Kim ES Bradley J | 2003 | J Refract Surg2003，19，2： | 1 |
| 12 | Modulation of astrocyte inducible nitric oxide synthase and cytokine expression by in-terferon beta is associated with induction and inhibition of in-terferon gamma-activated sequence binding activity显示文摘 | Hua LL Kim MO Brosnan CF | 2002 | J Neurochem2002，83，5： | 1 |
| 13 | Modulation of astrocyte inducible nitric oxide synthase and cytokine expression by interferon beta is associated with induction and inhibition of interferon gamma-activated sequence binding activity 显示文摘 | Hua LL Kim MO Brosnan CF | 2002 | J Neurochem2002，83，5： | 1 |
| 14 | Development and characterization of a GLP-l-albumin conjugate which retains the ability to activate the GLP-I receptor in vivo 显示文摘 | Kim JG Baggio LL Bridon DP | 2003 | Diabetes2003，52，3： | 1 |
| 15 | Galectin - 3 increases gastric cancer cell motility by up - regulating fascin - 1 expression 显示文摘 | Kim SJ Choi Ll Cheong TC | 2010 | Gastroenterology2010，138，3： | 1 |
| 16 | Development and characterization of a glucagons-like peptide 1-albumin conjugate 显示文摘 | Kim JG Baggio LL Bridon DP | 2003 | Diabetes2003，52，： | 1 |
| 17 | Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from β -aminoamides bearing subsituted triazolopiperazines显示文摘 | Kim D Kowalchick JE Brockunier LL | 2008 | J Med Chem2008，51，3： | 1 |
| 18 | Discov-ery of potent and selective dipeptidyl peptidase IV inhibitors de-rived from p-aminoamides bearing subsitutedtriazolopiperazines显示文摘 | KIM D KOWALCHICK J E BROCKUNIEH LL | 2008 | J Med Chem2008，51，3： | 1 |
| 19 | An outbreak of viral haemorrhagic pneumonia (tentative name) of rabbits in Korea 显示文摘 | Park N Y Chong C Y Kim J H et :ll | 2007 | J Korean Vet Med Assoc2007，23，9： | 1 |
| 20 | Development and characterization of a glucagon-like peptide 1-albumin conjugate:the ability to activate the glucagon-like peptide 1 receptor in vivo显示文摘 | Kim JG Baggio LL Bridon DP | 2003 | Diabetes2003，52，3： | 1 |
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