|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 多奈哌齐治疗重度阿尔茨海默病患者:双盲、平行分组、安慰剂对照研究显示文摘Background: The cholinesterase inhibitor donepezil is used to treat mild-to-moderate Alzheimer’s disease. Its efficacy in severe dementia has not been assessed and is controversial. Our aim was to ascertain the effectiveness of donepezil in patients with severe Alzheimer’s disease, by focusing primarily on cognition and activities of daily living. Methods: We did a 6-month, double-blind, parallel-group, placebo-controlled study in 248 patients with severe Alzheimer‘s disease (mini mental state examination score 1-10) who were living in assisted care nursing homes ran by trained staff in Sweden. We assigned patients oral donepezil (5 mg per day for 30 days then up to 10 mg per day thereafter, n=128) or matched placebo (n=120). Our primary endpoints were change from baseline to month 6 in the severe impairment battery (SIB) and modified Alzheimer’s Disease Cooperative Study activities of daily living inventory for severe Alzheimer’s disease (ADCS-ADL-severe). We analysed outcomes for patients with data at baseline and at one or more other timepoints (modified intent-to-treat population) with last observation carried forward used to replace missing data. Findings: 95 patients assigned donepezil and 99 patients assigned placebo completed the study. Patients treated with donepezil improved more in SIB scores and declined less in ADCS-ADL-severe scores at 6 months after initiation of treatment compared with baseline than did controls (least squares [LS] mean difference, 5.7, 95%CI 1.5-9.8; p=0.008, and 1.7, 0.2-3.2; p=0.03, respectively). The incidence of adverse events was comparable between groups (donepezil 82%[n=105] vs placebo 76%[n=91]), with most being transient and mild or moderate in severity. More patients discontinued treatment because of adverse events in the donepezil group (n=20) than in the placebo group (n=8). Interpretation: Donepezil improves cognition and preserves function in individuals with severe Alzheimer’s disease who live in nursing homes. | Winblad B. Kilander L. Eriksson S. 周永(译) | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 2 |
| 2 | Testing health information of students and adults 显示文摘 | Kilander HF | 2001 | Journal of School Health2001，71，8： | 1 |
| 3 | Observed associate on between the HAl mutation D222G in the 2009 pandemic influenza A(H1Nll virus and severe clinical outcome, Norway 2009- 2010显示文摘 | Kilander A Rykkvin R Dudman SG | 2010 | Euro Surveill2010，15，19： | 1 |
| 4 | Local and sys-temic immune responses to rectal administration of recombinantcholera toxin B subunit in humans显示文摘 | Jertborn M Nordstr? m I Kilander A | 2001 | Infect Immun2001，69，6： | 1 |
| 5 | Cancer death is related to high palmitoleic acid in serum and to polymorphisms in the SCD-1 gene in healthy Swedish men显示文摘 | L Byberg L Kilander E W Lemming | 2014 | American Journal of Clinical Nutrition2014，99，3： | 1 |
| 6 | Adenovirus-mediated gene therapy using human p21WAF-1/Cip-1 to prevent wound healing in a rabbit model of glaucoma filtration surgery显示文摘 | Perkins TW Faha B Ni M Kiland JA Poulsen GL Antelman D | 2002 | Arch Ophthalmol2002，120，7： | 1 |
| 7 | Hypertension is related to cognitive impairment:a 20-year follow-up of 999 men显示文摘 | Kilander L Nyman H Boberg M | | 0，，03： | 1 |
| 8 | Energy dissipation and mac- ro instabilities in a stirred square tank investigated using an LE PIV approach and LDA measurements 显示文摘 | Kilander J Rasmuson A | 2005 | Chemical Engineering Science2005，60，24： | 1 |
| 9 | Early predictors of glu- cocorticoid treatment failure in severe and moderately severe attacks o1 ulcerative colitis 显示文摘 | Lindgren SC Flood LM Kilander AF | 1998 | Eur J Gastroenterol Hepatol1998，10，10： | 1 |
| 10 | Hypertension is related to cognitive impairment: a 20-year follow-up of 999 men显示文摘 | Kilander L Nyman H Boberg M | 1998 | Hypertension1998，31，3： | 1 |
| 11 | Hypertension is Related to Cognitive Impairment, A20 year follow-up of 999 Men显示文摘 | Kilander L Nyman H Boberg M | 1998 | Hypertension1998，31，： | 1 |
| 12 | Hypertension is related to cognitive impairment: a 20-year follow-up of 999 men显示文摘 | Kilander L Nyman H Boberg M | 1998 | Hypertension1998，31，： | 1 |
| 13 | Hypertension is related to cognitive impairment : a 20-year follow-up of 999 men 显示文摘 | Kilander L Nyman H Boberg M | 1998 | Hypertension1998，31，3： | 1 |
| 14 | Hypertension is re- lated to cognitive impairment: a 20-year follow-up of 999 men显示文摘 | Kilander L Nyman H Boberg M | 1998 | Hypertension1998，31，3： | 1 |
| 15 | Inorganic-organic hybrid coatings with mixed metal oxides 显示文摘 | Ballard R L Njus J M Kiland B R | 2001 | European Polymer Journal2001，37，2： | 1 |
| 16 | Is smoking a risk factor for collagenous colitis?显示文摘 | Lina Vigren Klas Sj?berg Cecilia Benoni Curt Tysk Johan Bohr Anders Kilander Lasse Larsson Magnus Str?m Henrik Hjortswang | 2011 | Scandinavian Journal of Gastroenterology2011，，11： | 1 |
| 17 | Hypertension is related to cognitive impairment:a 20-year follow-up of 999 men显示文摘 | Kilander L Nyman H Boberg M | 1998 | Hypertension1998，31，： | 1 |
| 18 | Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men显示文摘 | Giedraitis V Kilander L Degerman-Gunnarsson M | 2009 | Dement Geriatr Cogn Disord2009，27，： | 1 |
| 19 | Determinants of costs of care for patients with Alzheimer's disease显示文摘 | J nsson L Eriksdotter J?nhagen M Kilander L | 2006 | International Journal of Geriatric Psychiatry2006，21，5： | 1 |
| 20 | The association between low diastolic blood pressure in middle age and cognitive function in old age, A populatin-based study显示文摘 | Kilander L Nyman H Boberg M | 2000 | Age and Aging2000，29，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员