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| 1 | Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis显示文摘Objective:To investigate the effect of pomegranate peel aqueous extract(PGE) on the development of secondary experimental echinococcosis and on the viability of Echinococcux granulosus protoscoleces,and the immunomodulatory properties of PGE.Methods:Swiss mice were inoculated intraperitoneally with viable protoscoleces.Then,PGE was orally administered daily during cystic echinococcosis development.Cyst development and hepatic damage were macroscopically and histologically analyzed.The production of nitric oxide and TNF-α was assessed in plasma and the hepatic expression of iNOS.TNF-α,NF-κB and CD68 was examined.Moreover,protoscoleces were cultured and treated with different concentrations of PGE.Results:It was observed that in vitro treatment of protoscoleces caused a significant decrease in viability in a PGE-dose-dependent manner.In vivo,after treatment of cystic echinococcosis infected mice with PGE,a significant decrease in nitric oxide levels(P<0.000 1)and TNF-α levels(P<0.001) was observed.This decline was strongly related to the inhibition of cyst development(rate of hydatid cyst growth inhibition=63.08%) and a decrease in CD68 expression in both the pericystic layer of hepatic hydatid cysts and liver tissue(P<0.000 1).A significant diminution of iNOS,TNF-α and NF-κB expression was also observed in liver tissue of treated mice(P<0.000 1).Conclusions:Our results indicate an antihydatic scolicidal effect and immunomodulatory properties of PGE,suggesting its potential therapeutic role against Echinococcuss granulosus infection. | Moussa Labsi Lila Khelifi Dalila Mezioug Imene Soufli Chafia Touil-Boukoffa | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，3： | 5 |
| 2 | 光激酶C基因突变导致的大头精子畸形是阿尔及利亚男性不育症的最常见遗传因素显示文摘克氏综合征和Y染色体微缺失是过去针对男性不育症仅有的两项基因检测分析技术。北非男性经常出现两种罕见的畸形精子症:大头和圆头精子畸形,推荐进行AURKC和DPYl9L2基因检测。对阿尔及利亚男性不育患者进行以上基因检测,评估两种畸形精子症的患病率,并与克氏综合征和Y染色体微缺失的频率进行比较。我们对阿尔及利亚君士坦丁市的IbnRochd医院辅助生殖中心进行不育症咨询的599名患者进行了回顾性研究,其中404人存在精液参数异常现象。14人和7人分别患有典型的大头精子畸形或圆头精子畸形,进而对这些患者进行了AURKC和DPYl9L2基因分析显示,11名大头精子畸形患者存在4URKC基因突变(79%),相当于所有精液异常人群的2.7%。而5名圆头精子畸形患者,相当于1.2%的不育症患者,均存在DPYl9L2基因缺失。通过比较,我们预测该人群中克氏综合症和Y染色体微缺失的患病率分别是1.6%和0.23%。我们的研究表明AURKC基因突变较克氏综合症更常见,它是导致北非男性不育的主要遗传因素。此外,本文也预测了AURKC和DP"觋2基因缺陷发生率分别是Y染色体微缺失发生率的10倍和5倍。 | Leyla Ounis Abdelali Zoghmar Charles Coutton Leila Rouabah Maroua Hachemil Delphine Martinez Guillaume Martinez Ines Bellil Douadi Khelifi Christophe Arnoult Julien Faure Sebti Benbouhedja Abdelkader Rouabah Pierre F Ray | 2015 | Asian Journal of Andrology2015，17，1： | 5 |
| 3 | Test Bench for the Mechanical Distribution of Predators to Control Insect Pests显示文摘 | M. Khelifi F. Pare M. Aider | 2011 | Journal of Environmental Science and Engineering2011，5，11： | 4 |
| 4 | Analysis of the security of perceptual image Hashing based on non-negative matrix factorization 显示文摘 | Fouad Khelifi | 2010 | IEEE Signal Processing Letters2010，17，1： | 1 |
| 5 | Allelic variation of HMW and LMW glutenin subunits, HMW secalin subunits and 75K gamma-secalins of hexaploid triticale显示文摘 | N. Amiour M. Dardevet D. Khelifi A. Bouguennec G. Branlard | 2002 | Euphytica2002，，2： | 1 |
| 6 | Allelie variation of HMW and LMW glutenin subunits, HMW secalin subunits and 75k gamma-secalin of hexaploid triticale 显示文摘 | Amiour N Dardevet M Khelifi D | 2002 | Euphytica2002，123，： | 1 |
| 7 | Response surface meth- odology enzymes and metabolites characterization显示文摘 | Ayed L Khelifi E Jannet H B | 2010 | Chem Eng J2010，165，： | 1 |
| 8 | Identification of some wheat pro- teins separated by a two-step acid polyacrylamide gel electrophore- sis and sodium dodecyl sulfate-palyacrylamide gel electrophoresis technique显示文摘 | Branlard G Khelifi D Lookhart G | 1992 | Cereal chemistry1992，69，6： | 1 |
| 9 | Homology-dependent methylation in primate repetitive DNA显示文摘 | Meunier J Khelifi A Navratil V | 2005 | Pro Natl Acad Sci USA2005，102，： | 1 |
| 10 | Aerobic decolourization of the indigo dye-containing textile wastewater using continuous combined bioreactors显示文摘 | KHELIFI E GANNOUN H TOUSHAMI Y | | 0，，02： | 1 |
| 11 | Design of a Mechanical Release System of Predator Insects to Control the Colorado Potato Beetle, Leptinotarsa Decemlineata (Say)显示文摘 | Sylvain de Ladurantaye Mohamed Khelifi | 2012 | Journal of Environmental Science and Engineering(B)2012，1，6： | 1 |
| 12 | Daxx is required for stress-induced cell death and JNK activation显示文摘 | Khelifi AF D'Alcontres MS Salomoni P | 2005 | Cell Death Differ2005，12，7： | 1 |
| 13 | Analysis of the security of per- ceptual image hashing based on non-negative ma- trix factorization 显示文摘 | KHELIFI F JIANG J | 2010 | IEEE Signal Processing Letters2010，17，1： | 1 |
| 14 | Usability meanings and interpretations in ISO standards 显示文摘 | ABran A Khelifi A Suryn W | 2003 | Software Quality Journal2003，11，： | 1 |
| 15 | Prompt gamma neutron activation analysis of bulk concrete samples with an Am-Be neutron source显示文摘 | KHELIFI R IDIRI Z OMARI L | 1999 | Applied Radiation and Isotopes1999，51，： | 1 |
| 16 | Mo- lecular epidemiology of human astrovirus and adenovirus serotypes 40/41 strains related to acute diarrhea in Tunisian children显示文摘 | Sdiri - Loulizi K Gharbi - Khelifi H de Rougemont A | 2009 | J Med Virol2009，81，11： | 1 |
| 17 | HOPPSIGEN : a database of human and mouse processed pseudogenes 显示文摘 | Khelifi A Duret L Mouchiroud D | 2005 | Nucleic Acids Res2005，33，1： | 1 |
| 18 | Aerobic decolouriza- tion of the indigo dye2containing textile wastewater using continuous combined bioreactors 显示文摘 | Khelifi E Gannoun H Touhami Y | 2008 | Journal of Hazard- ous Materials2008，152，： | 1 |
| 19 | Perceptual Image Hashing Based on Virtual Watermark Detection显示文摘 | KHELIFI F JIANG Jianmin | 2010 | IEEE Transactions on Image Processing2010，19，： | 1 |
| 20 | Effect of polymer crystallinity in P3HT∶PCBM solar cells on band gap trap states and apparent recombination order显示文摘 | SPOLTORE D OOSTERBAAN W D KHELIFI S | 2013 | Advanced Energy Materials2013，3，4： | 1 |
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