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| 1 | Nitrogen in Relation to Photosynthetic Capacity and Accumulation of Osmoprotectant and Nutrients in Brassica Genotypes Grown Under Salt Stress显示文摘Different strategies of the application of nutrients are required to overcome the adverse effects of mustard (Brassica juncea L.) in response to NaCl stress. The objective of the present study was to determine if different added levels of nitrogen (N) in growth medium could alleviate the adverse effects of salt stress on photosynthetic capacity and accumulation of osmoprotectants and nutrients. 14 days mustard seedlings of salt-sensitive (cv. Chuutki) and salt-tolerant (cv. Radha) genotypes were fed with: (i) 0 mmol L-1 NaCl + 0 mg N kg-1 sand (control), (ii) 90 mmol L-1 NaCl + 30 mg N kg-1 sand, (iii) 90 mmol L-1 NaCl + 60 mg N kg-1 sand, (iv) 90 mmol L-1 NaCl + 90 mg N kg-1 sand and (v) 90 mmol L-1 NaCl + 120 mg N kg-1 sand. Under the condition of salinity stress, N application caused a significant ameliorative effect on both genotypes with respect to growth attributes [fresh weight (FW) and dry weight (DW)] and physio-biochemical parameters [percent water content (WC), net photosynthetic rate (PN), stomatal conductance (gs), total chlorophyll (Chl), carbonic anhydrase (CA) activity and malondialdehyde (MDA), nitrogen (N), potassium (K) and sodium (Na) contents, and K/Na ratio] and yield attributes (number of pods/plant, seeds/pod and seed yield/plant). The salt-tolerant genotype exhibited maximum value for growth, physio-biochemical and yield attributes at 60 mg N kg-1 sand than that of salt-sensitive genotype. These results suggest that application of N may ameliorate most of the attributes and prove to be a physiological remedy to increase the tolerance against the ill effects of salt stress in Brassicas. | Manzer H Siddiqui Firoz Mohammad M Nasir Khan Mohamed H Al-Whaibi Ali H A Bahkali | 2010 | Agricultural Sciences in China2010，9，5： | 14 |
| 2 | Abdominal applications of diffusion-weighted magnetic resonance imaging: Where do we stand?显示文摘Diffusion-weighted imaging (DWI) is one of the magnetic resonance imaging (MRI) sequences providing qualitative as well as quantitative information at a cellular level. It has been widely used for various applications in the central nervous system. Over the past decade, various extracranial applications of DWI have been increasingly explored, as it may detect changes even before signal alterations or morphological abnormalities become apparent on other pulse sequences. Initial results from abdominal MRI applications are promising, particularly in oncological settings and for the detection of abscesses. The purpose of this article is to describe the clinically relevant basic concepts of DWI, techniques to perform abdominal DWI, its analysis and applications in abdominal visceral MR imaging, in addition to a brief overview of whole body DWI MRI. | Ajaykumar C Morani Khaled M Elsayes Peter S Liu William J Weadock Janio Szklaruk Jonathan Russell Dillman Asra Khan Thomas L Chenevert Hero K Hussain | 2013 | World Journal of Radiology2013，5，3： | 12 |
| 3 | Global secretome analysis identifies novel mediators of bone metastasis显示文摘骨头是稳固的肿瘤的远转移的一个最普通的地点。分泌蛋白质被知道影响在变形癌症房间和骨头基质之间的病理学的相互作用。为了包括地介绍,分泌了与骨头转移联系的蛋白质,我们使用了量、非量的集体 spectrometry 全球性分析改变从多重种类和癌症的变形能力打的骨头的九根细胞线的 secretomes。由比较父母房间和他们的骨头的 secretomes 变形衍生物,我们识别了特别地在这些房间线与骨头转移被联系的分泌蛋白质。我们然后合并了大临床的转移数据集的生物信息的分析获得强烈与临床、试验性的骨头转移被联系的几个功能的班的候选人小说骨头转移蛋白质的一张表。选择蛋白质的功能的确认显示在 vivo,骨头转移能被高表示支持(1 ) 唾液的 cystatins CST1, CST2,和 CST4;(2 ) plasminogen 使活跃之物小块地和 PLAU;或(3 ) 骨胶原功能蛋白质 PLOD2 和 COL6A1。总的来说,我们的学习揭开了骨头转移并且因此的几个新分泌调停人证明 secretome 分析是为新奇 biomarkers 和候选人的鉴定的一个强大的方法治疗学的目标。 | Maria Andres Blanco Gary LeRoy Zia Khan Ma a Ale kovi Barry M Zee Benjamin A Garcia Yibin Kang | 2012 | Cell Research2012，22，9： | 12 |
| 4 | Antibacterial efficacy of the seed extracts of Melia azedarach against some hospital isolated human pathogenic bacterial strains显示文摘Objective:To investigate the antibacterial potential of the polar and non-polar extracts of the seeds of Melia azedarach(M.azedarach) L.(Meliaceae) against eighteen hospital isolated human pathogenic bacterial strains.Methods:Petrol,benzene,ethyl acetate,methanol,and aqueous extracts at five different concentrations(1,2,5,10 and 15 mg/mL) were evaluated.Disk diffusion method was followed to evaluate the antibacterial efficacy.Results:All extracts of the seeds demonstrated significant antibacterial activity against tested pathogens.Among all extracts,ethyl acetate extract revealed the highest inhibition comparatively.The present study also favored the traditional uses reported earlier.Conclusions:Results of this study strongly confirm that the seed extracts of M.azedarach could be effective antibiotics,both in controlling gram-positive and gram-negative human pathogenic infections. | Abdul Viqar Khan Qamar Uddin Ahmed M Ramzan Mir Indu Shukla Athar Ali Khan | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 11 |
| 5 | Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis显示文摘AIM:To investigate the significance of Thrombospondin-1 (TSP-1) expression and its relationship with angiogenesis during experimental fibrosis. METHODS:Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine (DEN). The serial sections from liver tissues were stained with anti-CD34 and anti-TSP-1 antibodies before being quantitated by light microscopy. RESULTS:Our results showed that of TSP-1 expression gradually increases according to the severity of fibrosis (GroupⅠvs group Ⅱ, Group Ⅲ and Group Ⅳ;Group Ⅱ vs group Ⅲ and group Ⅳ;group Ⅲ vs group Ⅳ, P < 0.05). Moreover, TSP-1 expression was found to be correlated with angiogenesis (P < 0.05). CONCLUSION:The correlative evidence of the link between TSP-1 and fibrosis or angiogenesis provided by this study suggests that besides its role as a strong promoter of transforming growth factor-β1 (TGF-β1), TSP-1 might have an additional role in liver fibrogenesis by stimulating angiogenesis and this protein could be a potential target to prevent fibrogenesis in chronic inflammatory diseases of the liver. | Gülsüm zlem Elpek Güzide Ayse Gkhan Sevgi Bozova | 2008 | World Journal of Gastroenterology2008，14，14： | 7 |
| 6 | Association between facet joint osteoarthritis and the Oswestry Disability Index显示文摘AIM:To investigate the correlation of facet joint osteoarthritis(FJOA) at lumbar levels L4/L5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS:The study involved lumbar MRIs of 591 patients with a mean age of 47.3 years.The MRIs of the lumbar spine were performed on a 1.5 Tesla scanner(Magnetom Avanto,Siemens AG,Erlangen,Germany) using a dedicated receive only spine coil.After initial blinding,each dataset was evaluated by 2 board certified radiologist with more than 5 years experience in musculoskeletal imaging.In total 2364 facet joints were graded.Degenerative changes of the facet joints were evaluated according to the 4-point scale as proposed by Weishaupt et al Functional status was assessed using the ODI.The index is scored from 0 to 100 and interpreted as follows:0%-20%,minimaldisability; 20%-40%,moderate disability; 40%-60%,severe disability; 60%-80%,crippled; 80%-100%,patients are bedbound.Spearman's coefficient of rank correlation was used for statistical analysis,with significance set at P < 0.05.RESULTS:In total 2364 facet joints at lumbar levels L4/5 and L5/S1 were analysed in 591 individuals.FJOA was present in 97%(L4/L5) and 98%(L5/S1).At level L4/5(left/right) 17/15(2.9%/2.5%) were described as grade 0,146/147(24.7%/24.9%) as grade 1,290/302(49.1%/51.1%) as grade 2 and 138/127(23.4%/21.5%) as grade 3.At level L5/S1(left/right) 10/11(1.7%/1.9%) were described as grade 0,136/136(23.0%/23.0%) as grade 1,318/325(53.8%/55.0%) as grade 2 and 127/119(21.5%/20.1%) as grade 3.Regarding the ODI scores,patients' disability had a minimum of 0% and a maximum of 91.11% with an arithmetic mean of 32.77% ± 17.02%.The majority of patients(48.39%) had moderate functional disability(21%-40%).There was no significant correlation between FJOA and ODI on both sides of lumbar level L4/5 and on the left side of lumbar level L5/S1.A weak positive correlation was evaluated between ODI and FJOA on the right side of lumbar level L5/S1.CONCLUSION:The missing correlation of FJOA and ODI confirms our clinical experience that imaging alone is an insufficient approach explaining low back pain.Clinical correlation is imperative for an adequate diagnostic advance in patients with low back pain. | Adel Maataoui Thomas J Vogl Marcus Middendorp Konstantinos Kafchitsas M Fawad Khan | 2014 | World Journal of Radiology2014，6，11： | 6 |
| 7 | 鸡源产气荚膜梭菌重组酶聚合酶扩增检测方法的建立显示文摘为建立鸡源产气荚膜梭菌(Clostridium perfringens)的快速诊断方法,本研究以产气荚膜梭菌α-毒素的编码基因plc为基础设计、合成引物和探针,并以real-time PCR的方法进行验证,建立了鸡源产气荚膜梭菌的重组酶聚合酶扩增(RPA)检测方法。该方法可在38℃、25 min内对产气荚膜梭菌的α-毒素编码序列进行快速特异性扩增,最低检测限量可达1×10^1copies/μL,灵敏度良好。以此方法检测实验室保存的临床样本,其检测结果与real-time PCR的检测结果一致。上述结果表明,本研究建立的real-time RPA方法在检测鸡源产气荚膜梭菌时具有操作简单、快速灵敏的特点,适用于鸡源产气荚膜梭菌的临床检测。 | 许笑 王艳华 M Umar Zafar Khan 王恒 蔡建平 | 2019 | 中国兽医科学2019，49，12： | 6 |
| 8 | 植物叶缘锯齿发育的研究进展显示文摘叶缘锯齿是叶片重要的形态特征之一,受到多种叶缘发育因子的调控。笔者回顾了国内外研究成果,详细分析了植物激素、CUC2(CUP SHAPED COTYLEDONE2)和MicroRNA对叶缘锯齿发育的影响,总结了植物中各叶缘因子的表达与功能,并探讨了叶缘锯齿形成的分子机制及其意义。分析表明,在复杂的叶缘发育调控网络中,生长素与CUC2对叶缘的调控起到非常重要的作用,大部分叶缘因子的调控功能依赖于生长素和CUC2。最后,展望了叶缘锯齿发育未来的研究方向与发展趋势,并对其以后的应用领域进行了预测。 | 李晓屿 Ralf Müller-Xing Shahid Khan 郑玉彩 李玉花 邢倩 | 2019 | 中国农学通报2019，35，1： | 6 |
| 9 | Tumor lysis syndrome: A clinical review显示文摘Tumor lysis syndrome is an oncometabolic emergency resulting from rapid cell death. Tumor lysis syndrome can occur as a consequence of tumor targeted therapy or spontaneously. Clinicians should stratify every hospitalized cancer patient and especially those receiving chemotherapy for the risk of tumor lysis syndrome. Several aspects of prevention include adequate hydration, use of uric acid lowering therapies, use of phosphate binders and minimization of potassium intake. Patients at high risk for the development of tumor lysis syndrome should be monitored in the intensive care unit. Established tumor lysis syndrome should be treated in the intensive care unit by aggressive hydration, possible use of loop diuretics, possible use of phosphate binders,use of uric acid lowering agents and dialysis in refractory cases. | Aibek E Mirrakhimov Prakruthi Voore Maliha Khan Alaa M Ali | 2015 | World Journal of Critical Care Medicine2015，4，2： | 5 |
| 10 | Correlation of lumbar lateral recess stenosis in magnetic resonance imaging and clinical symptoms显示文摘AIM To assess the correlation of lateral recess stenosis(LRS) of lumbar segments L4/5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS Nine hundred and twenty-seven patients with history of low back pain were included in this uncontrolled study.On magnetic resonance images(MRI) the lateral recesses(LR) at lumbar levels L4/5 and L5/S1 were evaluated and each nerve root was classified into a 4-point grading scale(Grade 0-3) as normal,not deviated,deviated or compressed.Patient symptoms and disability were assessed using ODI.The Spearman's rank correlation coefficient was used for statistical analysis(P < 0.05).RESULTS Approximately half of the LR revealed stenosis(grade 1-3;52% at level L4/5 and 42% at level L5/S1) with 2.2% and 1.9% respectively reveal a nerve root compression.The ODI score ranged from 0%-91.11% with an arithmetic mean of 34.06% ± 16.89%.We observed a very weak statistically significant positive correlation between ODI and LRS at lumbar levels L4/5 and L5/S1,each bilaterally(L4/5 left:rho < 0.105,P < 0.01;L4/5 right:rho < 0.111,P < 0.01;L5/S1 left:rho 0.128,P < 0.01;L5/S1 right:rho < 0.157,P < 0.001).CONCLUSION Although MRI is the standard imaging tool for diagnosing lumbar spinal stenosis,this study showed only a weak correlation of LRS on MRI and clinical findings.This can be attributed to a number of reasons outlined in this study,underlining that imaging findings alone are not sufficient to establish a reliable diagnosis for patients with LRS. | Annina SplettstoBer M Fawad Khan Bernd Zimmermann Thomas J Vogl Hanns Ackermann Marcus Middendorp Adel Maataoui | 2017 | World Journal of Radiology2017，9，5： | 4 |
| 11 | Magnetic resonance imaging-based interpretation of degenerative changes in the lower lumbar segments and therapeutic consequences显示文摘Intervertebral disc degeneration and facet joint osteoarthritis of the lumbar spine are, among others, wellknown as a cause of low back and lower extremity pain. Together with their secondary disorders they set a big burden on health care systems and economics worldwide. Despite modern imaging modalities, such as magnetic resonance imaging, for a large proportion of patients with low back pain(LBP) it remains difficult to provide a specific diagnosis. The fact that nearly all the lumbar structures are possible sources of LBP, may serve as a possible explanation. Furthermore, our clinical experience confirms, that imaging alone is not a sufficient approach explaining LBP. Here, the Oswestry Disability Index, as the most commonly used measure to quantify disability for LBP, may serve as an easy-toapply questionnaire to evaluate the patient's ability to cope with everyday life. For therapeutic purposes, among the different options, the lumbar facet joint intraarticular injection of corticosteroids in combination with an anaesthetic solution is one of the most frequently performed interventional procedures. Although widely used the clinical benefit of intra-articular steroid injections remains controversial. Therefore, prior to therapy, standardized diagnostic algorithms for an accurate assessment, classification and correlation of degenerative changes of the lumbar spine are needed. | Adel Maataoui Thomas J Vogl M Fawad Khan | 2015 | World Journal of Radiology2015，7，8： | 4 |
| 12 | Effects ofsulfur dioxide on the development of powdery mildew of cucumber 显示文摘 | Khan M R Khan M W | 1998 | Environ Exper Bot1998，40，： | 3 |
| 13 | Simulation in endoscopy:Practical educational strategies to improve learning显示文摘In gastrointestinal endoscopy, simulation-based training can help endoscopists acquire new skills and accelerate the learning curve. Simulation creates an ideal environment for trainees, where they can practice specific skills, perform cases at their own pace, and make mistakes with no risk to patients. Educators also benefit from the use of simulators, as they can structure training according to learner needs and focus solely on the trainee. Not all simulation-based training,however, is effective. To maximize benefits from this instructional modality,educators must be conscious of learners' needs, the potential benefits of training,and associated costs. Simulation should be integrated into training in a manner that is grounded in educational theory and empirical data. In this review, we focus on four best practices in simulation-based education: deliberate practice with mastery learning, feedback and debriefing, contextual learning, and innovative educational strategies. For each topic, we provide definitions,supporting evidence, and practical tips for implementation. | Rishad Khan Michael A Scaffidi Samir C Grover Nikko Gimpaya Catharine M Walsh | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，3： | 3 |
| 14 | Surface plasmon polariton at the interface of dielectric and graphene medium using Kerr effect显示文摘We theoretically investigate the control of surface plasmon polariton(SPP) generated at the interface of dielectric and graphene medium under Kerr nonlinearity. The controlled Kerr nonlinear signal of probe light beam in a dielectric medium is used to generate SPPs at the interface of dielectric and graphene medium. The positive, negative absorption, and dispersion properties of SPPs are modified and controlled by the control and Kerr fields. A large amplification(negative absorption) is noted for SPPs under the Kerr nonlinearity. The normal/anomalous slope of dispersion and propagation length of SPPs is modified and controlled with Kerr nonlinearity. This leads to significant variation in slow and fast SPP propagation. The controlled slow and fast SPP propagation may predict significant applications in nano-photonics, optical tweezers, photovoltaic devices, plasmonster, and sensing technology. | Bakhtawar Muhammad Haneef B A Bacha H Khan M Atif | 2018 | Chinese Physics B2018，27，11： | 3 |
| 15 | Petrography and geochemistry of Jumara Dome sediments, Kachchh Basin: Implications for provenance, tectonic setting and weathering intensity显示文摘In the Kachchh Mainland, the Jumara Dome mixed carbonate-siliciclastic succession is represented by the Jhurio and Patcham formations and siliciclastic-dominating Chari Formation(Bathonian to Oxfordian). The Jumara Dome sediments were deposited during sea-level fluctuating, and were interrupted by storms in the shallow marine environment. The sandstones are generally medium-grained, moderately sorted, subangular to subrounded and of low sphericity. The sandstones are mineralogically mature and mainly composed of quartzarenite and subarkose. The plots of petrofacies in the Qt-F-L, Qm-F-Lt, Qp-Lv-Ls and Qm-P-K ternary diagrams suggest mainly the basement uplift source(craton interior) in rifted continental margin basin setting. The sandstones were cemented by carbonate, iron oxide and silica overgrowth. The Chemical Index of Alteration values(73% sandstone and 81% shale) indicate high weathering conditions in the source area. Overall study suggests that such strong chemical weathering conditions are of unconformity with worldwide humid and warm climates during the Jurassic period. Positive correlations between Al2O3 and Fe2O3, TiO2, Na2O, MgO, K2O are evident. A high correlation coefficient between Al2O3 and K2O in shale samples suggests that clay minerals control the major oxides. The analogous contents of Si, Al, Ti, LREE and TTE in the shale to PAAS with slightly depleted values of other elements ascribe a PAAS like source(granitic gneiss and minor mafics) to the present study. The petrographic and geochemical data strongly suggest that the studied sandstones/shales were deposited on a passive margin of the stable intracratonic basin. | Ahmad A.H.M Noufal K.N Masroor Alam M Tavheed Khan | 2014 | Chinese Journal Of Geochemistry2014，33，1： | 3 |
| 16 | 肾髓质癌中SMARCB1蛋白表达缺失的独特机制:20例形态学和分子分析显示文摘肾髓质癌是一种罕见但极具侵袭性的肾癌,其发生在具有镰状红细胞病或罕见具有其他血红蛋白病的患者。SMARCB1是SWI/SNF染色质重塑复合物的核心亚基,该蛋白表达缺失是肾髓质癌的主要诊断特征。然而,SMARCB1蛋白表达缺失的分子机制尚不清楚。作者回顾性分析了两家机构于1996~2017年期间诊断的20例肾髓质癌。所有患者均有镰状红细胞病,所有肿瘤免疫组化显示有SMARCB1蛋白表达缺失。用3色探针荧光原位杂交(FISH)检测SMARCB1位点状态,并用靶向二代测序平台检测SMARCB1在体细胞内结构的变化情况。20例患者的FISH分析显示,11例(55%)同时存在半合子缺失和SMARCB1易位,6例(30%)SMARCB1纯合子缺失,3例(15%)虽然有SMARCB1蛋白缺失却无结构或拷贝数的改变。 | 魏建国(摘译) 袁晓露(审校) Jia L Carlo M I Khan H | 2019 | 临床与实验病理学杂志2019，35，8： | 3 |
| 17 | 心脏病及非心脏病患者降低舒张压的效果:收缩压干预试验结果分析显示文摘收缩压和舒张压低于何种阈值时心血管事件增多仍然不明确。应用收缩压干预试验(systolic blood pressure intervention trial,SPRINT)的数据,研究者评估了1519例心血管病患者和7574位非心血管病者的收缩压和舒张压与心血管事件之间的关系。 | 刘青 叶鹏 Khan NA Rabkin SW Zhao Y McAlister FA Park JE Guan M Chan S Humphries KH | 2018 | 中华高血压杂志2018，26，6： | 3 |
| 18 | 车辆悬架系统的自适应模糊控制(英文)显示文摘悬架是用来支持车身的系统,通过隔离道路干扰使得乘客感觉舒适、并确保车辆稳定.为此研究了全车模型悬架系统在下列几种控制方式下的性能:被动控制、半主动控制、自适应标准可加性模型(SAM)下的主动控制.全车模型可以为车辆悬架系统提供一些必要的性能参数,如车身偏移、车轮偏移和悬架偏斜.乘坐的舒适性和车辆的操控性决定了所需悬架系统的性能.乘坐的舒适性取决于车身偏移和乘客座位的偏移,而车辆的稳定由其他自由度(如俯仰和滚转)决定.半主动和主动悬架控制的设计通过MATLAB/SIMULINK加以实现,充分考虑了不规则的路面,并以此验证半主动控制和SAM主动控制的性能.实验结果表明,SAM主动控制能够改善乘坐的舒适性和车辆的操控性. | Khan Laiq Umair Khan M | 2012 | 中国科学技术大学学报2012，42，9： | 3 |
| 19 | An evaluation of OSOM BV blue test in the diagnosis of bacterial vaginosis显示文摘Objective:To determine the prevalence of bacterial vaginosis(BV) in patients with vaginal discharge and evaluate the efficacy of OSOM BV blue test in diagnosis.Methods:OSOM BV blue test,a rapid diagnostic test based on the principle of detection of bacterial sialidase activity in vaginal fluid specimens was conducted.A total of 405 patients in the reproductive age group(15- 45 years) having vaginal discharge were included in the study along with 10 healthy age-matched controls.Two high vaginal swabs were collected aseptically from each patient.One swab was used to make smear for gram staining,and the other was for OSOM BV blue test.Amine test and vaginal pH test were taken as well.Results:The prevalence of bacterial vaginosis was 60.7%. OSOM BV blue test showed good efficacy,as compared with gram staining in diagnosing BV.The sensitivity and specificity of OSOM BV blue test were 97.6%and 97.5%respectively.Amsel’s criteria diagnosed 180(44.4%) cases of BV and had sensitivity and specificity of 67.1%and 90.6%respectively.Thus the performance of OSOM BV blue was better than the methods based on Amsel’s criteria.Conclusions:OSOM BV blue test is an efficacious bed side test,helpful in rapidly making an accurate diagnosis of BV in setups lacking laboratory facilities or expert microbiologists. | Fatima Shujatullah Haris M Khan Razia Khatoon Tamkin Rabbani Abida Malik | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 3 |
| 20 | Reducing the morbidity from extravasation injuries显示文摘 | Khan M S Holmes J D | 2002 | Ann Plast Surg2002，48，6： | 3 |
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