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| 1 | Nature:揭示干细胞惊人异质性显示文摘论文作者George Daley教授说:"这是一项非常基础的研究,但它阐明了多能性状态广泛性。我们捕获了干细胞不同状态的详细分子谱。"研究人员通过采用多种变量如不同的化学物质、培养环境和遗传敲除来扰乱多能干细胞,研究人员探究了它们的发育景观。随后,他们分析了每个细胞的遗传组成,观察了每个细胞多能状态的微小波动。他们发现内部、化学和环境信号影响干细胞方式的许多细微差异,揭示出了复杂的发育调控因子"决策"回路。 | Roshan M.Kumar Patrick Cahan Alex K.Shalek Rahul Satija A.Jay Daley Keyser Hu Li Jin Zhang Keith Pardee David Gennert John J.Trombetta Thomas C.Ferrante Aviv Regev George Q.Daley James J. Collins | 2014 | 岭南现代临床外科2014，14，6： | 10 |
| 2 | A Bayesian approach for integrating multilevel priors and data for aerospace system reliability assessment显示文摘This paper investigates Bayesian methods for aerospace system reliability analysis using various sources of test data and expert knowledge at both subsystem and system levels.Four scenarios based on available information for the priors and test data of a system and/or subsystems are studied using specific Bayesian inference techniques.This paper proposes the Bayesian melding method for integrating subsystem-level priors with system-level priors for both system-and subsystem-level reliability analysis.System and subsystem reliability outcomes are compared under different scenarios.Computational challenges for posterior inferences using the sophisticated Bayesian melding method are addressed using Markov Chain Monte Carlo(MCMC) and adaptive Sampling Importance Re-sampling(SIR) methods.A case study with simulation results illustrates the applications of the proposed methods and provides insights for aerospace system reliability analysis using available multilevel information. | Jian GUO Zhaojun LI Thomas KEYSER | 2018 | Chinese Journal of Aeronautics2018，31，1： | 5 |
| 3 | Model Identification of a Micro Air Vehicle显示文摘This paper is focused on the model identification of a Micro Air Vehicle (MAV) in straight steady flight condition. The identification is based on input-output data collected from flight tests using both frequency and time domain techniques. The vehicle is an in-house 40 cm wingspan airplane. Because of the complex coupled, multivariable and nonlinear dynamics of the aircraft, linear SISO structures for both the lateral and longitudinal models around a reference state were derived. The aim of the identification is to provide models that can be used in future development of control techniques for the MAV. | Jorge Nio Flavius Mitrache Peter Cosyn Robin De Keyser | 2007 | Journal of Bionic Engineering2007，4，4： | 5 |
| 4 | Identification and substrate prediction of new Fragaria x ananassa aquaporins and expression in different tissues and during strawberry fruit development显示文摘The newly identified aquaporin coding sequences presented here pave the way for further insights into the plant–water relations in the commercial strawberry(Fragaria x ananassa).Aquaporins are water channel proteins that allow water to cross(intra)cellular membranes.In Fragaria x ananassa,few of them have been identified hitherto,hampering the exploration of the water transport regulation at cellular level.Here,we present new aquaporin coding sequences belonging to different subclasses:plasma membrane intrinsic proteins subtype 1 and subtype 2(PIP1 and PIP2)and tonoplast intrinsic proteins(TIP).The classification is based on phylogenetic analysis and is confirmed by the presence of conserved residues.Substrate-specific signature sequences(SSSSs)and specificity-determining positions(SDPs)predict the substrate specificity of each new aquaporin.Expression profiling in leaves,petioles and developing fruits reveals distinct patterns,even within the same(sub)class.Expression profiles range from leaf-specific expression over constitutive expression to fruit-specific expression.Both upregulation and downregulation during fruit ripening occur.Substrate specificity and expression profiles suggest that functional specialization exists among aquaporins belonging to a different but also to the same(sub)class. | Britt Merlaen Ellen De Keyser Marie-Christine Van Labeke | 2018 | Horticulture Research2018，5，1： | 2 |
| 5 | The European stroke scale显示文摘 | Hantson L DJ Weardt W De Keyser J | 1994 | Stroke1994，25，： | 2 |
| 6 | 第16章 温带气旋:气象学100年来的研究核心显示文摘1919年在气象学上是重要的一年,不仅因为美国气象学会成立于这一年,同时还有其他两个原因。其中之一是J.皮叶克尼斯关于温带气旋结构的论文于1919年发表,建立了著名的挪威气旋模型。也是在那一年,一系列会议的举办促进了温带气旋研究所需的国际合作和科学交流组织的形成,这必然包括跨越国界的空间尺度。本章主要描述针对温带气旋的形成、演变和动力过程,它们构成的锋,以及伴随而来的急流和风暴路径进行科学探究的历史。我们将这些现象统称为气象学的核心,因为在此期间,其在促进气象学研究方面发挥着核心作用。这个成果丰硕的世纪使得温带气旋研究成为可能,是因为1)解决不良预报的实际挑战具有巨大的社会经济影响,2)理论、观测和诊断(包括动力模式)的结合提供了改进的物理解释和概念模型,以及3)强有力的国际合作。气旋的概念框架产生于对气旋分类和理解的渴望;它们包括挪威气旋模型和Shapiro-Keyser气旋模型。理解气旋动力学的挑战引申出诸如准地转、斜压不稳定、半地转和锋生等理论框架。预测爆发性温带气旋的挑战尤其带来了新的理论发展,如位势涡度(PV)理论和上游效应。对可预报性的局限性的更深层次的认识源于混沌决定论的演变。最后,观测的洞察力成就了详细的气旋和锋面结构、风暴路径及雨带分类。 | 大卫·舒尔茨 LANCE F.BOSART BRIAN A.COLLE HUW C.DAVIES CHRISTOPHER DEARDEN DANIEL KEYSER OLIVIA MARTIUS PAUL J.ROEBBER W.JAMES STEENBURGH HANS VOLKERT ANDREW C.WINTERS 张萌(编译) 贾朋群(编译) | 2019 | 气象科技进展2019，9，S01： | 2 |
| 7 | 应用ICF扩大慢性神经性疾病中健康问题范围的研究显示文摘目的确定能够显示慢性神经功能障碍(多发性硬化症、帕金森氏病和神经肌肉疾病)患者有关健康问题的ICF类目。方法采用Delphi研究方法,由三方面与疾病相关的人组成专家小组,即患者及其代理人、医疗和非医疗卫生专业人士(n=98)。小组要求根据《国际功能,残疾和健康分类》(ICF)反映有关特定疾病的健康问题,选择相关类目。小组成员将这些类目与简明残疾记录量表(MRD)和残疾及其影响量表(DIP)两种测量工具中的指标作比较。结果选择出68项ICF类目相关性最大,分别属于四个ICF领域。患者/代理人和卫生专业人员两者评价的类目无显著性差异。疾病小组的一致性很高。三个特定疾病小组的选择在'身体功能和结构'领域存在差异,但如果扩大纳入标准则可以达成共识。所选择的ICF项目涵盖了几乎所有测量项目。最大的差异表现在'参与'和'环境因素'领域选择的类目。结论与广泛应用于神经学领域的健康状态测量相比,在研究健康问题时所选择的ICF类目更为广泛,特别是涉及ICF的'参与'和'环境因素'领域时。 | Klaske WYNIA Berrie MIDDEL Jitse P. van DIJK Han de RUITER Willem LOK Jacques Ha de KEYSER Sijmen A. REIJNEVELD 王朴(译) 张君梅(译) 荀芳(译) 邱卓英(审校) 李建军(审校) | 2008 | 中国康复理论与实践2008，14，12： | 2 |
| 8 | Heterogeneous chemistry of HONO on liquid sulfuric acid : A new mechanism of chlorine activation on stratospheric sulfate aerosols 显示文摘 | Zhang R Y Leu M-T Keyser L F | 1996 | The Journal of Physical Chemistry1996，10，： | 1 |
| 9 | Features for Image Retrieval: An Experimental Comparison 显示文摘 | Deselaers T Keysers D Ney H | 2008 | Information Retrieval(S1386-4564)2008，11，2： | 1 |
| 10 | Antipernulear factor compared with the so called 'antikeratin' antibodies to human epidermis filaggrin,in the diagnosis of arthritis显示文摘 | Vincent c de Keyser F Masson-Bessiere C | 1999 | Ann Rheum Dis1999，58，1： | 1 |
| 11 | Increased serum neuronspecific enolaseconcentrations in patients with hyperglycemic cortical ischemic stroke显示文摘 | Suiter G Elting JW De Keyser J | 1998 | Neurosci Lett1998，253，1： | 1 |
| 12 | Use of the barthel index and modified rankin scale in acute stroke trials显示文摘 | Sulter G Steen C Keyser JD | | 0，，08： | 1 |
| 13 | Use of the Barthel index and modi- fied Rankin Scaleim acute stroke scale in acute seroke trial 显示文摘 | Suher G Steen C De Keyser J | 1999 | Stroke1999，30，8： | 1 |
| 14 | Postexposure application of Fas receptor small-interfering RNA to suppress sulfur mustard-induced apoptosis in human airway epithelial cells:implication for a therapeutic approach显示文摘 | Keyser BM Andres DK Nealley E Holmes WW Benton B Paradiso D | 2013 | J Pharmacol Exp Ther2013，344，1： | 1 |
| 15 | Use of the Barthel index and modified Rankin scale in acute stroke trials显示文摘 | Sulter G Steen C de Keyser J | 1999 | Stroke1999，30，： | 1 |
| 16 | Audiovisual mirror neurons and action recognition 显示文摘 | Keysers C Kohler E Umiha MA | 2003 | Exp Brain Res2003，153，4： | 1 |
| 17 | PCR-based DGGE fingerprinting and identification of methanogens detected in three different types of UASB granules显示文摘 | KEYSER M WITTHUHN R C LAMPRECHT C | | 0，，： | 1 |
| 18 | Diferentiated thyroid cancer in chil- dren显示文摘 | De Keyser LF Van Herle AJ | 1985 | Head Neck Surg1985，8，： | 1 |
| 19 | Monosynaptic reflexes in the superficial forearm flexors in man and their clinical significance 显示文摘 | Deschuytere J Rosselle N de Keyser C | 1976 | J Neurol Neurosurg Psychiat1976，39，6： | 1 |
| 20 | Efficiency evaluation of a DNA extraction and purification protocol on archival formalin-fixed and paraffin embedded tissue显示文摘 | Farrugia A Keyser C Ludes B | 2009 | Forensic Sci Int: Genetics2009，194，1： | 1 |
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