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| 1 | Clostridium difficile infections in China显示文摘Clostridium difficile (C. difficile) infection has become one of the major hospital-associated infections in West-ern countries in the last two decades. However, there is limited information on the status of C. difficile infection inChinese healthcare settings. Given the large and increasing elderly population and the well-recognized problem ofover-prescribing of broad spectrum antibiotics in China, it is critical to understand the epidemiology and potentialrisk factors that may contribute to C. difficile infection in China. A literature review of available published studies,including those in Chinese language-based journals, was conducted. A review of the currently available literaturesuggested the presence of C. difficile infections in China, but also suggested that these infections were not particu-larly endemic. This finding should lead to better designed and greatly expanded studies to provide a more reliableepidemiologically-based conclusion on the actual status of C. difficile infection in China, including the identifica-tion of any associated risk factors. Such information is ultimately valuable to develop appropriate strategies to pre-vent C. difficile infection and the vast negative impact of such infections in China and other developing countries. | Ke Jin a,b,c,Shixia Wang c,d,Zuhu Huang a,b,c,Shan Lu b,c,daDepartment of Infectious Diseases,bJiangsu Province Key Laboratory in Infectious Diseases,cChina-US Vaccine ResearchCenter,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China d Department of Medicine,University of Massachusetts Medical School,Worcester,MA 01655,USA. | 2010 | The Journal of Biomedical Research2010，24，6： | 14 |
| 2 | Effects of disinhibition on spatiotemporal pattern of neuronal first recruitment in neuronal networks显示文摘The propagation of neuronal activities is a key feature to understanding information processing in networks. The analysis based on first-spikes of bursts in turn plays an important role in the research of neuronal activity propagation. Our focus here is to investigate how spatiotemporal patterns of neuronal first-spikes are affected by disinhibition. Multi-electrode arrays were used to record stimulation-evoked bursts of multiple neurons in randomly cultured neuronal networks. Both the precise timing of and the rank relationships between first-spikes were analyzed. Compared with evoked bursts in the network's native state, the precise first-spike latencies in its dis-inhibited state are more consistent and the propagation of its bursting activities is much faster. Additional points of interest are that disinhibited neuronal networks can be evoked to generate stable and distinguishable neuronal first recruitment spatiotemporal patterns specific to the stimulation site, and that the disinhibition may cause the original spatiotemporal patterns to change in a heterogeneous manner with regards to different propagation pathways. | Liangbin Pana,b,c,1, Xindong Songa,b,c,1, Guangxin Xiang a,b,c, Jing Zhua,b,c, Jing Cheng a,b,c,d,a Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China b Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China c National Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Beijing 102206, China d State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 6 |
| 3 | Immobilized enzymes in analytical themistry显示文摘 | Gray D N Keys M H Watson B | 1997 | Anal Chem A1997，，49： | 1 |
| 4 | Post-collisional magmatism in the central East African orogen: The Maevarano suite of north Madagascm显示文摘 | Goodenough K M Thomas R J De Waele B Key R M Schofield D I Bauer W Tucker R D Kafahatelo J M Rabrimanana M Ralison A V Randriamananjma T | 2010 | Lithos2010，116，12： | 1 |
| 5 | On the interaction ofarchitecture and algorithm in the domain-based parallelization of anunstructured-grid incompressible flow code显示文摘 | KAUSHIK D K KEYES D E SMITH B F | 1998 | Contemporary Math-ematics1998，218，： | 1 |
| 6 | The Manufacture of anhydrous ethyl alcohol显示文摘 | Keyes D B | 1929 | Industrial and Engineering Chemistry1929，21，11： | 1 |
| 7 | Fluorinated organics in the bi osphere显示文摘 | Key B D Howell R D Criddle C S | 1997 | Environmental Science& Technology1997，31，9： | 1 |
| 8 | Evaluating Fabric Smoothness Appearance with a Laser Profilometer 显示文摘 | XU B CUMINATO D F and KEYES N M | 1998 | textile Re- search Journal1998，68，12： | 1 |
| 9 | Fluorinated organics in the biosphere显示文摘 | Key B D Howell R D Criddle C S | 1997 | Environ Sci Technol1997，31，： | 1 |
| 10 | A prototype example of sensor fusion used for a sitting analysis 显示文摘 | Keys L D Schimdt N J Phillips B E | 1990 | Image Processing and Remote Sensing1990，，4： | 1 |
| 11 | Peptic ulcerand mental disorders among adults in the community;The role of nicotine and alcohol use disorders显示文摘 | Goodwin R D Keyes K M Stein M B | 2009 | Psy-chosom Med2009，71，4： | 1 |
| 12 | Precipitation extremes and the impacts of climate change on stormwater infrastructure in Washing- ton State显示文摘 | Rosenberg E A Keys P W Booth D B | 2010 | Climatic Change2010，102，12： | 1 |
| 13 | Immobilized enzymes in analytical chemistry显示文摘 | Gray D N Keyes M H Watson B | 1977 | Anal Chem1977，49，12： | 1 |
| 14 | Fluorinated organics in the biosphere显示文摘 | Key B D Howell R D Criddle C S | 1997 | Enironmental Ssience & Technology1997，31，9： | 1 |
| 15 | Evaluating fabric smoothness appearance with a laser profilometer显示文摘 | XU B CUMINATO D F KEYES N M | 1998 | Textile Research1998，30，2： | 1 |
| 16 | Fluorinated organics in the biosphere显示文摘 | Key B D Howell R D Criddle C S | 1997 | Environmental Science & Technology1997，31，9： | 1 |
| 17 | Fluorinated organics in the biosphere显示文摘 | KEY B D HOWELL R D CRIDDLE C S | 1997 | Environ Sci Technol1997，31，9： | 1 |
| 18 | Fluorinated organics in the biosphere显示文摘 | Howell R D | 1997 | Environ Sci Technol1997，31，： | 1 |
| 19 | Fluorinated Organics in the Biosphere 显示文摘 | Key B D Howell R D Criddle C S | 1997 | Environ Sci Technol1997，31，9： | 1 |
| 20 | Fundamental study of the thermal desorption of toluene from montmorillonite clay particles 显示文摘 | Keyes R B Silcox G D | 1994 | Environ Sci Technol1994，28，5： | 1 |
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