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| 1 | HBV infection decreases risk of liver metastasis in patients with colorectal cancer:A cohort study显示文摘AIM:To evaluate the effect of hepatitis B virus (HBV) infection on liver metastasis of colorectal cancer.METHODS:A total of 1298 colorectal cancer patients were recruited from January 2001 to March 2005 in this study.Enzyme-linked immunosorbent assay was used to test serum HBV markers for colorectal cancer.Patients were divided into study (infection) group and control (non-infection) group.Clinical features of patients in two groups were compared.RESULTS:Liver metastasis was found in 319 out of the 1298 colorectal cancer patients.The incidence of liver metastasis was significantly lower in study group than in control group (14.2% vs 28.2%,P < 0.01).HBV infection significantly decreased the risk of liver metastasis [hazard ratio (HR):0.50,95% confidence interval (95% CI):0.38-0.66],but the incidence of extrahepatic metastasis was significantly higher in study group than in control group (31.9% vs 17.0%,P < 0.01).The HR was the lowest in chronic hepatitis B group (HR:0.29,95% CI:0.12-0.72).The number of liver metastatic lesions was significantly less in study group than in control group with a higher surgical resection rate.However,no significant difference was found in survival rate between the two groups (P=0.95).CONCLUSION:HBV infection decreases the risk of liver metastasis in patients with colorectal cancer and elevates the surgical resection rate of liver metastatic lesions. | Hai-Bo Qiu Zhao-Lei Zeng Zhi-Qiang Wang Hui-Yan Luo Rajiv Prasad Keshari Zhi-Wei Zhou Rui-Hua Xu Li-Yi Zhang | 2011 | World Journal of Gastroenterology2011，17，6： | 19 |
| 2 | 三维培养药敏实验测定的胃癌药物敏感性与多药耐药基因蛋白表达的关系显示文摘背景与目的:目前胃癌化疗疗效尚不理想,通过预测个体肿瘤对药物的敏感性来指导临床治疗,以提高疗效,早已成为化疗界瞩目的问题。本研究通过三维培养药敏实验测定胃癌的药物敏感性,并通过测定多药耐药基因表达产物水平,分析两者之间的关系。方法:应用三维培养体外药敏实验技术,测定表阿霉素、顺铂、草酸铂、5-FU、泰素帝、伊立替康6种单药和5-FU+表阿霉素+顺铂、5-FU+伊立替康、5-FU+草酸铂、5-FU+泰素帝+顺铂4组联合用药对22例胃癌组织的抑制率,并计算敏感率;应用逆转录聚合酶链反应(RT-PCR)和免疫组化法检测胃癌组织中MDR1、MRP1、ABCG2基因蛋白的表达。结果:单药组中5-FU对胃癌组织的抑制率和敏感率最高,分别为29.8%和50.0%;联合用药组抑制率最高为5-FU+泰素帝+顺铂(59.8%),敏感率最高为5-FU+表阿霉素+顺铂(77.3%);联合用药组抑制率和敏感率均高于单药组(P<0.05)。胃癌组织中MDR1、MRP1、ABCG2mRNA的阳性率分别为90.9%、54.5%、77.3%,MDR1、MRP1、ABCG2蛋白的阳性率分别为36.4%、54.5%、36.4%;多药耐药蛋白高表达与胃癌对表阿霉素的耐药有相关性(P<0.05)。结论:胃癌组织中多药耐药基因MDR1、MRP1、ABCG2蛋白高表达与胃癌组织对表阿霉素的耐药有关,提示这三种耐药基因可能参与介导表阿霉素的耐药。 | 袁庶强 周志伟 梁永钜 符立梧 陈功 Rajiv Prasad Keshari 张丽仪 | 2009 | 癌症2009，28，4： | 9 |
| 3 | Diagnostic assays developed for the control of foot-andmouth disease in India显示文摘Foot-and-mouth disease(FMD) is a highly contagious and economically devastating disease of livestock, primarily affecting cattle, buffalo and pigs. FMD virus serotypes O, A and Asia1 are prevalent in India and systematic efforts are on to control and eventually eradicate the disease from the country. FMD epidemiology is complex due to factors like co-circulation, extinction, emergence and re-emergence of genotypes/lineages within the three serotypes, animal movement, diverse farm practices and large number of susceptible livestock in the country. Systematic vaccination, prompt diagnosis, strict biosecurity measures, and regular monitoring of vaccinal immunity and surveillance of virus circulation are indispensible features for the effective implementation of the control measures. Availability of suitable companion diagnostic tests is very important in this endeavour. In this review, the diagnostic assays developed and validated in India and their contribution in FMD control programme is presented. | Gaurav Kumar Sharma Sonalika Mahajan Rakesh Matura Saravanan Subramaniam Rajeev Ranjan Jitendra Biswal Manoranjan Rout Jajati Keshari Mohapatra Bana Bihari Dash Aniket Sanyal Bramhadev Pattnaik | 2015 | World Journal of Virology2015，4，3： | 2 |
| 4 | Magnetic and ferroelectric properties of Zn and Mn co-doped BaTiO_3显示文摘This paper reports an approach to obtaining multiferroic properties in co-doped(Zn:Mn) Ba Ti O3 near room temperature.Interestingly,an unusual magnetic hysteresis loop is observed in the co-doped compositions in which the central portion of the loop is squeezed.However,in the composition Ba0.9Zn0.1Ti0.9Mn0.1O3,a broad magnetic hysteresis loop is observed.Such a magnetic effect is attributed to the coexistence of antiferromagnetic and ferromagnetic exchange interactions in the system.The observation of the above type of magnetic properties is likely to be due to the presence of exchange interactions between Mn ions.A lossy-type of ferroelectric hysteresis loop is also observed in co-doped ceramic compositions near room temperature. | Sangram Keshari Das Binod Kumar Roul | 2015 | Chinese Physics B2015，24，6： | 2 |
| 5 | Reactive Oxygen Species-Induced Activation of ERK and p38 MAPK Medi- ates PMA-induced NETs Release from Human Neutrophils 显示文摘 | Ravi S Keshari AnupamVerma Manoj K Barthwal | 2013 | Jour- nal of Cellular Biochemistry2013，114，： | 1 |
| 6 | Increased my eloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis显示文摘 | Kothari N Keshari RS Bogra J | 2011 | J Crit Care2011，26，4： | 1 |
| 7 | Hydrogeochemical evaluation of high-fluoride ground waters a case study from Mehsana District, Gujarat, India 显示文摘 | Dhiman S D Keshari K | 2006 | Hydrological Sciences2006，51，6： | 1 |
| 8 | Isolated flavonoids from Ficus racemosa stem bark possess antidiabetic,hypolipidemic and protective effects in albino Wistar rats显示文摘 | KESHARI A K KUMAR G KUSHWAHA P S | 2016 | Journal of ethnopharmacology2016，181，： | 1 |
| 9 | Cytokines induced neutrophil extracellular traps formation:implication for the inflammatory disease condition显示文摘 | Keshari RS Jyoti A Dubey M | 2012 | PLoS ONE2012，7，48： | 1 |
| 10 | Characterization of intervertebral disc degeneration by high-resolution magic angle spinning (HR-MAS) spectroscopy显示文摘 | Keshari KR Zektzer AS Swanson MG | 2005 | Magn Reson Med2005，53，3： | 1 |
| 11 | Correlation of HR MAS spectroscopy derived metabolite concentrations with colla gen and proteoglycan levels and Thompson grade in the degener ative disc显示文摘 | Keshari KR Lotz jC Kurhanewicz J etal | 2005 | Spine2005，30，23： | 1 |
| 12 | Cytokines induced neu- trophil extracellular traps formation: implication for the inflamma- tory disease condition显示文摘 | Keshari RS Jyoti A Dubey M | 2012 | PLoS One2012，7，48： | 1 |
| 13 | Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition显示文摘 | Keshari RS Jyoti A Dubey M | 2012 | PLoS One2012，7，48： | 1 |
| 14 | Cytokines induced neutrophil extracellulartraps formation: implication for the inflammatory disease condition显示文摘 | Keshari RS Jyoti A Dubey M | 2012 | PLoS One2012，7，48： | 1 |
| 15 | Correlation of HR-MAS spectroscopy derived metabolite concentrations with collagen and proteoglycan levels and Thompson grade in the degenerative disc 显示文摘 | Keshari KR Lotz JC John K | 1976 | Spine1976，30，30： | 1 |
| 16 | Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils显示文摘 | Keshari R S Verma A Barthwal M K | 2013 | Journal of Cellular Biochemistry2013，114，： | 1 |
| 17 | An operational model for estimating Regional Evapotranspiratinn through Surface Energy Partitioning (RESEP) 显示文摘 | Ambast S k Keshari A K Gosain A K | 2002 | International Journal of Remote Sensing2002，23，22： | 1 |
| 18 | Satellite remote sensing to support management of irrigation systems: concepts and approaches显示文摘 | Ambast S K Keshari A K Gosain A K | 2002 | Irrigation and Drainage2002，51，1： | 1 |
| 19 | Satellite re mote sensing to support management of irrigation sys terns: concepts and approaches 显示文摘 | Ambast S K Keshari A K Gosain A K | 2002 | Irrigation and Drainage2002，51，1： | 1 |
| 20 | Repeated photoporation with graphene quantum dots enables homogeneous labeling of live cells with extrinsic markers for fluorescence microscopy显示文摘In the replacement of genetic probes,there is increasing interest in labeling living cells with high-quality extrinsic labels,which avoid over-expression artifacts and are available in a wide spectral range.This calls for a broadly applicable technology that can deliver such labels unambiguously to the cytosol of living cells.Here,we demonstrate that nanoparticle-sensitized photoporation can be used to this end as an emerging intracellular delivery technique.We replace the traditionally used gold nanoparticles with graphene nanoparticles as photothermal sensitizers to permeabilize the cell membrane upon laser irradiation.We demonstrate that the enhanced thermal stability of graphene quantum dots allows the formation of multiple vapor nanobubbles upon irradiation with short laser pulses,allowing the delivery of a variety of extrinsic cell labels efficiently and homogeneously into live cells.We demonstrate high-quality time-lapse imaging with confocal,total internal reflection fluorescence(TIRF),and Airyscan superresolution microscopy.As the entire procedure is readily compatible with fluorescence(super resolution)microscopy,photoporation with graphene quantum dots has the potential to become the long-awaited generic platform for controlled intracellular delivery of fluorescent labels for live-cell imaging. | Jing Liu Ranhua Xiong Toon Brans Saskia Lippens Eef Parthoens Francesca Cella Zanacchi Raffaella Magrassi Santosh K.Singh Sreekumar Kurungot Sabine Szunerits Hannelore Bové Marcel Ameloot Juan C.Fraire Eline Teirlinck Sangram Keshari Samal Riet De Rycke Gaëlle Houthaeve Stefaan C.De Smedt Rabah Boukherroub Kevin Braeckmans | 2018 | Light(Science & Applications)2018，7，1： | 1 |
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