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| 1 | Myelin Oligodendrocyte Glycoprotein-IgG Contributes to Oligodendrocytopathy in the Presence of Complement, Distinct from Astrocytopathy Induced by AQP4-IgG显示文摘Immunoglobulin G against myelin oligodendrocyte glycoprotein(MOG-Ig G) is detectable in neuromyelitis optica spectrum disorder(NMOSD) without aquaporin-4 Ig G(AQP4-Ig G), but its pathogenicity remains unclear.In this study, we explored the pathogenic mechanisms of MOG-Ig G in vitro and in vivo and compared them with those of AQP4-Ig G. MOG-Ig G-positive serum induced complement activation and cell death in human embryonic kidney(HEK)-293 T cells transfected with human MOG. In C57 BL/6 mice and Sprague-Dawley rats, MOG-Ig G only caused lesions in the presence of complement. Interestingly, AQP4-Ig G induced astroglial damage, while MOGIg G mainly caused myelin loss. MOG-Ig G also induced astrocyte damage in mouse brains in the presence ofcomplement. Importantly, we also observed ultrastructural changes induced by MOG-Ig G and AQP4-Ig G. These findings suggest that MOG-Ig G directly mediates cell death by activating complement in vitro and producing NMOSDlike lesions in vivo. AQP4-Ig G directly targets astrocytes,while MOG-Ig G mainly damages oligodendrocytes. | Ling Fang Xinmei Kang Zhen Wang Shisi Wang Jingqi Wang Yifan Zhou Chen Chen Xiaobo Sun Yaping Yan Allan G. Kermode Lisheng Peng Wei Qiu | 2019 | Neuroscience Bulletin2019，35，5： | 13 |
| 2 | Changes in ABA turnover and sensitivity that accompany dormancy termination of yellow-cedar ( Chamaecyparis nootkatensis ) seeds 显示文摘 | Schmitz N Abrams S R Kermode A R | 2002 | Journal of Experimental Botany2002，53，366： | 1 |
| 3 | Obesity is a determinant of asthma control independent of inflammation and lung mechanics显示文摘 | Farah CS Kermode JA Downie SR | 2011 | Chest2011，140，3： | 1 |
| 4 | The trasition from seed development to germination:a key role for desiccation显示文摘 | KERMODE | 1986 | Horticulture Science1986，21，： | 1 |
| 5 | Rating the burn scar显示文摘 | Sullivan T Smith J Kermode J | 1990 | J Burn Care Rehabil1990，11，3： | 1 |
| 6 | Measurement of serum TSH and thyroid hormones in the management of treatment of thyroid carcinoma with radioiodine显示文摘 | Edmonds C J Hayes S Kermode J C | 1977 | British Journal of Radiology1977，50，599： | 1 |
| 7 | Role of abscisic acid in seed dormancy显示文摘 | Kermode A R | 2005 | J Plant Growth Regul2005，24，8： | 1 |
| 8 | The house of fiction: Interviews with seven English novelists 显示文摘 | Kermode Frank | 1963 | Partisan Review1963，30，1963： | 1 |
| 9 | Vulnerable but feeling safe= HIV risk among male rural-to-urban migrant workers in Chengdu, Chi- na显示文摘 | Li L Morrow M Kermode M | 2007 | AIDS Care2007，19，10： | 1 |
| 10 | Seed dor- mancy cycling in Arabidopsis : chromatin remodelling and g- ulation of DOG1 in response to seasonal environmental signals显示文摘 | FOOTITT S MULLER K KERMODE A R eta| | 2015 | Plant Journal2015，81，3： | 1 |
| 11 | Comparison between prostaglandin E1 and epoprostenol (prostacyclin) in infants after heart surgery 显示文摘 | Kermode J Butt W Shann F | 1991 | Br Heart J1991，66，： | 1 |
| 12 | Rat- ing the burn scar 显示文摘 | Sullivan T Smith J Kermode J | 1990 | Burn Care Rehabil1990，11，3： | 1 |
| 13 | Rating the burn scar 显示文摘 | Sullivan T Smith J Kermode J | 1990 | J Burn Care Res1990，11，3： | 1 |
| 14 | Role of abscisic acid in seed dormancy显示文摘 | Kermode A R | 2005 | Journal of Plant Growth Regulation2005，24，： | 1 |
| 15 | Heterogeneity of blood-brain barrier changes in multiple sclerosis:a MRI study with gadolinium-DTPA enhancement显示文摘 | Kermode AG Tofts PS Thompson A J | 1990 | Neurology1990，40，： | 1 |
| 16 | Role of abscisic acid in seed dormancy 显示文摘 | Kermode A R | 2005 | J Plant Grow Regulat2005，24，： | 1 |
| 17 | Patterns of disease activity in multiple sclerosis:a clinical and magnetic resonance imaging study显示文摘 | Thompson A J Kermode AG MacManus DG | 1990 | BM J1990，300，： | 1 |
| 18 | Rating the burn scar显示文摘 | Sullivan T Smith J Kermode J | | 0，，03： | 1 |
| 19 | New therapeutic approaches to combat arterial thrombosis:better drugs for old targets,novel targets,and future prospects显示文摘 | Choi J Kermode JC | 2011 | Mol Interv2011，11，2： | 1 |
| 20 | Institutional Control of Interpretation显示文摘 | FRANK KERMODE | 1979 | Salmagundi1979，43，： | 1 |
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