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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Attenuation of mitochondrial,but not cytosolic,Ca^(2+) overload reduces myocardial injury induced by ischemia and reperfusion显示文摘瞄准:mitochondrial Ca2+ 的变细([Ca2+] m ) ,然而并非 cytosolic Ca2+([Ca2+] c ) ,超载改进可收缩的恢复。我们假设了那变细[Ca2+] m,然而并非[Ca2+] c,超载对 ischemia/reperfusion-induced 损害授与 cardioprotection。方法:从孤立的酒的老鼠心,房间生存能力,和在孤立的老鼠短暂的电子上导致的 Ca2+ 的梗塞尺寸室的 myocytes 被测量。我们决定了 BAPTAAM 的效果,一座Ca2+螯岩山,在废除两个的超载的集中[Ca2+] c 并且[Ca2+] m ,和钌红,Ca2+的 mitochondrial uniporter 的一个禁止者搬运,在废除超载的集中[Ca2+] m ,然而并非[Ca2+] c ,在 ischemia/reperfusion 导致的心脏的损害上。结果:两个的变细[Ca2+] m 并且[Ca2+]由 BAPTAAM 的 c ,和变细[Ca2+] m ,然而并非[Ca2+] c ,由钌红的超载,减少了心脏的损害观察,显示重要性[Ca2+]在响应 ischemia/reperfusion 的 cardioprotection 和可收缩的恢复的 m 。结论:学习用一条原因效果途径提供了不含糊的证据那变细[Ca2+] m,然而并非[Ca2+] c,超载为对 ischemia/reperfusion-induced 损害的 cardioprotection 负责。我们也证实了以前的观察那变细[Ca2+] m,然而并非[Ca2+] c,旁边钌红改进可收缩的恢复追随者 ischemia/reperfusion。 | Chun-mei CAO Wing-yee YAN Jing LIU Kenneth WL KAM Shi-zhong ZHAN James SK SHAM Tak-ming WONG | 2006 | Acta Pharmacologica Sinica2006，27，7： | 4 |
| 3 | Intravenous immunoglobulin does not reduce left ventricular remodeling in patients with myocardial dysfunction during hospitalization after acute myocardial infarction显示文摘 | Lars Gullestad Stein ?rn Kenneth Dickstein Christian Eek Thor Edvardsen Svend Aakhus Erik T. Askevold Annika Michelsen Bj?rn Bendz Rita Sk?rdal Hans-J?rgen Smith Arne Yndestad Thor Ueland P?l Aukrust | 2012 | International Journal of Cardiology2012，，： | 1 |
| 4 | The neuronal microRNA system显示文摘 | Kenneth SK | 2006 | Nat Rev Neurosci2006，7，12： | 1 |
| 5 | Acute testicular ischemia results in germ cell specific apoptosis in the rat显示文摘 | Turner TT Tung Kenneth SK Tomosnasa H | 1997 | Biol Reprod1997，57，6： | 1 |
| 6 | MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells 显示文摘 | Thales Papagiannakopoulos Alice Shapiro Kenneth SK | 2008 | Caneker Res2008，68，19： | 1 |
| 7 | Non - human primates used in studies of periodontal disease pathogenesis: a review of the literature 显示文摘 | Schon PH Kenneth SK | 1993 | J Periodontol1993，64，： | 1 |
| 8 | Acute testicular ischemia results in germ cell-specific apoptosis in the rat显示文摘 | Turer TT Tung kenneth SK Tomomasa H | | 0，，： | 1 |
| 9 | Penicillium marneffei : a pathogen on our doorstep显示文摘 | Ferdinandos SK Marina SM Kenneth MM | 2004 | J R Soc Med2004，97，8： | 1 |
| 10 | Estrogen receptor-α mediates the detrimental effects of neonatal diethylstilbestrol(OES) exposure in the murine reproductive tract显示文摘 | John F Cousea B Kenneth SK | 2004 | Toxicology2004，205，12： | 1 |
| 11 | Positron emission tomog- raphy with selected mediastinoscopy compwered to routine mediastinoscopy offers cost and clinical outcome benefits for preoperative staging of non small cell lung cancer 显示文摘 | Kelvin K Kenneth SK Amanda JB | 2005 | Eur J Nucl Med Mol Imaging2005，32，9： | 1 |
| 12 | Attenuation of IL-8 expression in C6-deficent rabbit after acute myocaedial ischeia/reperfusion显示文摘 | Kenneth SK James LP Elaine JT | 1998 | J Mol CellCardiol1998，30，： | 1 |
| 13 | Major depressive disorder显示文摘 | Maurizio F Kenneth SK | 2000 | Neuron2000，28，： | 1 |
| 14 | Fundamental principles affecting the outcomes of therapy for osseous lesions显示文摘 | Kenneth SK Paul BR | 2000 | Periodontol2000，22，： | 1 |
| 15 | Estrogen receptor and human disease显示文摘 | Bonnie JD Kenneth SK | 2006 | J clinical investigation2006，116，3： | 1 |
| 16 | An Official American Thoracic Society Statement:Treatment of Fungal Infections in Adult Pulmonary and Critical Care Patients显示文摘 | Andrew HL Kenneth SK George AS | 2011 | Am J Respir Crit Care Med2011，183，： | 1 |
| 17 | Estrogen receptor-α mediates the detrimental effects of neonatal diethylstilbestrol (OES) exposure in the murine reproductive tract显示文摘 | John F Cousea B Kenneth SK | 2004 | Toxicology2004，205，12： | 1 |
| 18 | Arylacetamide kappa-opioid receptor agonists produce a tonic and use-dependent block of tetrodotoxin-sensitive and-resistant sodium currents in colon sensory neurons 显示文摘 | Joshi SK Kenneth L Bielefeldt K | 2003 | JPET Neurons2003，307，1： | 1 |
| 19 | Introducing Ref Seq and Locus Link: curated human genome resourxces at the NCBI 显示文摘 | Kim DP Kenneth SK Hugues S | 2000 | Trends Genet2000，16，1： | 1 |
| 20 | The relationship between social support and major depression cross-sectional longituainal and genetic per-spectives显示文摘 | Tracey DW Kenneth SK | 2000 | J New Ment Dis2000，188，5： | 1 |
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