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| 1 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 2 | Software piracy: Is it related to level of moral judgment?显示文摘 | Jeanne M. Logsdon Judith Kenner Thompson Richard A. Reid | 1994 | Journal of Business Ethics1994，，11： | 2 |
| 3 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 4 | Using Office hours wisely 显示文摘 | JANA L PRESSLER CAROLE A KENNER | 2009 | Nurse Educator2009，，5： | 1 |
| 5 | Revised recommenda- tions on screening for chloroquine and hydroxychloroquine reti- nopathy显示文摘 | Marmor M F Kenner U Lai T Y | 2011 | Ophthalmology2011，118，2： | 1 |
| 6 | Concepts of fecal streptococci in stream pollution显示文摘 | Geldreich E E Kenner B A | 1969 | Journal Water Pollution Control Federation1969，41，8： | 1 |
| 7 | Developing a culture of emer- gency preparedness education in nursing 显示文摘 | Kenner Carole A Pressler Jana L | 2014 | Nurse Educ2014，39，1： | 1 |
| 8 | Ability of the no-reflow phenomenon during an acute myocardial infarction to predict left ventricular dysfunction at one-month follow-up显示文摘 | Kenner MD Zajac EJ Kondos GT | 1995 | Am J Cardiol1995，76，： | 1 |
| 9 | Grooved titanium surfaces orient growth and migration of cells from human gingival explants 显示文摘 | Brunette DM Kenner GS Gould TRL | 1983 | J Dent Res1983，62，10： | 1 |
| 10 | Transition from hospital to home for parents ofpreterm infants显示文摘 | Boykova M Kenner C | 2012 | J Perinat Neonatal Nurs2012，26，1： | 1 |
| 11 | Ability of the no refow phenomenon during an acute myocardial infarction to predict left ventricular dyfunction at one month follow up显示文摘 | Kenner MD Zajac EJ Kondos GT | 1995 | Am J Cardiol1995，76，12： | 1 |
| 12 | Regulation of growth factor induced signaling by protein- tyrosine- phosphatase 显示文摘 | Byon JC Kenner KA Kusari AB | 1997 | Pro Soc Exp BiolMed1997，216，10： | 1 |
| 13 | Ability of the no-reflow phenomenon during an acute myocardial infarction to predict left ventricular dysfunction at one-month follow-up显示文摘 | Kenner MD Zajac E J Kondos GT | 1995 | Am J Cardiol1995，76，12： | 1 |
| 14 | Re-evaluating the Concept of Working Time:An Analysis of Recent Case Law显示文摘 | | 2004 | Industrial Relations Journal2004，35，6： | 1 |
| 15 | The transition from tube to nipple in the premature newborn 显示文摘 | Fernandez DP Rosales VM Kenner C | 2007 | Newborn and Infant Nursing Reviews2007，7，2： | 1 |
| 16 | Age-associated ironaccumulation in bone : implications for postmenopausal os-teoporosis and a new target for prevention and treatment bychelation 显示文摘 | Liu G Men P Kenner GH | 2006 | Biometals2006，19，： | 1 |
| 17 | Second-trimestermaternal serum marker screening : maternal serum alpha-fetoprotein, beta-human chorionic gonadotropin, estriol, andtheir various combinations as predictors of pregnancy outcome显示文摘 | Yaron Y Cherry M Kenner R L | 1999 | Am J Obstet Gynecol1999，181，4： | 1 |
| 18 | Drafts and Fragments and the Structure of the Cantos显示文摘 | Kenner Hugh | 1963 | Agenda1963，，： | 1 |
| 19 | Therapeutic effects ofan oral chelator targeting skeletal tissue damage in experi-mental postmenopausal osteoporosis in rats 显示文摘 | Liu G Men P Kenner GH | 2008 | Hemo-globin2008，32，： | 1 |
| 20 | Stat5 tetramer formation is associated with leukemogenesis显示文摘 | Moriggl R Sexl V Kenner L | 2005 | Cancer Cell2005，7，1： | 1 |
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