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| 1 | New discovery of fossil cycad-like plants from the Middle Jurassic of West Liaoning,China显示文摘 | WANG Yongdong ZHANG Wu ZHENG Shaolin SAIKI Keni'chi LI Nan | 2005 | Chinese Science Bulletin2005，50，16： | 8 |
| 2 | An oncolytic adenovirus delivering TSLC1 inhibits Wnt signaling pathway and tumor growth in SMMC-7721 xenograft mice model显示文摘Tumor suppressor in lung cancer-1(TSLC1)was first identified as a tumor suppressor for lung cancer,and frequently downregulated in various types of cancers including hepatocellular carcinoma(HCC).The Wnt pathway plays a critical role in tumorigenesis,migration,and invasion in HCC.However,the function of TSLC1 in modulating Wnt signaling in HCC is unclear.In this study,we evaluated the effect of TSLC1-armed oncolytic adenovirus(S24-TSLC1)on the Wnt/β-catenin pathway,cell viability,invasion and migration abilities of HCC in vitro and the growth of SMMC-7721-xenografted tumor in mice model.We detected the expression of TSLC1 in tumor samples and HCC cell lines.The results showed that TSLC1 expression was low in HCC,but high in pericarcinomatous tissue and normal cells,which implied that TSLC1 is a tumor suppressor of liver cancer.S24-TSLC1 exhibited an antitumor effect on HCC cell growth in vitro,but did little damage to normal liver cells.Overexpression of TSLC1 downregulated the transcriptional activity of TCF4/β-catenin and inhibited the mRNA or protein expression of Wnt target genes cyclinD1 and c-myc.S24-TSLC1 also inhibited the invasion and migration of HCC cells.Animal experiments further confirmed that S24-TSLC1 significantly inhibited tumor growth of the SMMC-7721-xenografted tumor.In conclusion,TSLC1 could downregulate the Wnt signal pathway and suppress HCC cell growth,migration and invasion,suggesting that S24-TSLC1 may be a potent antitumor agent for future clinical trials in liver cancer treatment. | Yigang Wang Panpan Huang Yanping Hu Keni Guo Xiaoyuan Jia Biao Huang Xinyuan Liu Xianglei He Fang Huang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 2 |
| 3 | Effects of antidepressajats on the production of cyiokines 显示文摘 | Kenis G Maes M | 2002 | Int J Neuropsychopharmacol2002，5，4： | 1 |
| 4 | In vivo immunomodulatory effects of clozapine in schizophrenia显示文摘 | Maes M Bosmans E Kenis G | 1997 | Schizo Res1997，26，： | 1 |
| 5 | Nitrate reductase transcript is expressed in the primary response of maize to environmental nitrate显示文摘 | G. Gowri Juana D. Kenis Bj?rn Ingemarsson Margaret G. Redinbaugh Wilbur H. Campbell | 1992 | Plant Molecular Biology1992，，1： | 1 |
| 6 | Microstructure and Properties of Nippon Fire- Resistant Steels显示文摘 | Ska W Keny F S | 1999 | Journal of Materials Engineering and Perform- ance1999，10，8： | 1 |
| 7 | The epigenetics of aging and neurodegeneration显示文摘 | Lardenoije R Iatrou A Kenis G | 2015 | Prog Neurobiol2015，131，： | 1 |
| 8 | On the performance of membraneless laminar flow-based fuel cells显示文摘 | Ranga S. Jayashree Seong Kee Yoon Fikile R. Brushett Pedro O. Lopez-Montesinos Dilip Natarajan Larry J. Markoski Paul J.A. Kenis | 2010 | Journal of Power Sources2010，，11： | 1 |
| 9 | Modes of Network Governance:Structure,Management,and Effectiveness显示文摘 | Provan K G Kenis P | 2008 | Journal of PublicAdministration Research and Theory2008，，18： | 1 |
| 10 | Gene therapy-directed osteegenesis: BMP-7 transduced human fibroblasts form bone in vivo显示文摘 | PAUL H KENI G RENNY T | 2000 | Hum Gene Ther2000，11，8： | 1 |
| 11 | Automated whole-breast ultrasound:advancin the performance of breast cancer screening显示文摘 | Keny KM Riehwald GA | 2011 | Semin Ultrasound CTMR2011，32，4： | 1 |
| 12 | Modes of Network Governance:Structure,Man-agement,and Effectiveness显示文摘 | Provan K Kenis P | 2008 | Journal Administration Researchand Theory2008，18，2： | 1 |
| 13 | The demoga Phieand Morphologieal features of rotator cuff Disease: a comparison of a symptomatic and ymptomatic shoulder显示文摘 | Keny amaguchi William D Middleton | 2006 | JBJS2006，88，： | 1 |
| 14 | Evaluation of gas production potential from marine gas hydrate deposits in Shenhu area of South China Sea显示文摘 | Li Gang Moridis G J Zhang Keni | 2010 | Energy & Fuels2010，24，11： | 1 |
| 15 | Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction显示文摘 | Chouliaras L van den Hove D L Kenis G | 2012 | Neurobiol Aging2012，33，8： | 1 |
| 16 | The 100 classic papers of pediatric orthopaedic surgery: a bibliometric analysis显示文摘 | Kavanagh RG Kelly JC Keny PM | 2013 | J Bone Joint Surg Am2013，，95： | 1 |
| 17 | Ex- perimental and theoretical scaling laws for transverse diffusive broadening in two-phase laminar flows in microchannels 显示文摘 | ISMAGILOV R F STROOCK A D KENIS P J A | 2000 | Applied Physics Letters2000，76，17： | 1 |
| 18 | How organizational field networks shape interorganizational tie - formation rates 显示文摘 | Kenis P Knoke D | 2002 | Academy of Management Review2002，27，2： | 1 |
| 19 | Modes of network governance: structure management and effectiveness显示文摘 | Provan K G Kenis P | 2008 | Journal of Public Administration Research and Theory2008，18，2： | 1 |
| 20 | The extended direct endonasal transsphenoidal approach for nonadenomatous suprasellar tumor 显示文摘 | Dusick JR Esposito F Keny DF | 2005 | J Neurosurg2005，102，5： | 1 |
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