|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association between Ambient Air Pollution and Hospital Emergency Admissions for Respiratory and Cardiovascular Diseases in Beijing: a Time Series Study显示文摘Objective To investigate the association between ambient air pollution and hospital emergency admissions in Beijing. Methods In this study, a semi-parametric generalized additive model(GAM) was used to evaluate the specific influences of air pollutants(PM10, SO2, and NO2) on hospital emergency admissions with different lag structures from 2009 to 2011, the sex and age specific influences of air pollution and the modifying effect of seasons on air pollution to analyze the possible interaction. Results It was found that a 10 μg/m3 increase in concentration of PM10 at lag 03 day, SO2 and NO2 at lag 0 day were associated with an increase of 0.88%, 0.76%, and 1.82% respectively in overall emergency admissions. A 10 μg/m3 increase in concentration of PM10, SO2 and NO2 at lag 5 day were associated with an increase of 1.39%, 1.56%, and 1.18% respectively in cardiovascular disease emergency admissions. For lag 02, a 10 μg/m3 increase in concentration of PM10, SO2 and NO2 were associated with 1.72%, 1.34%, and 2.57% increases respectively in respiratory disease emergency admissions. Conclusion This study further confirmed that short-term exposure to ambient air pollution was associated with increased risk of hospital emergency admissions in Beijing. | ZHANG Ying WANG Shi Gong MA Yu Xia SHANG Ke Zheng CHENG Yi Fan LI Xu NING Gui Cai ZHAO Wen Jing LI Nai Rong | 2015 | Biomedical and Environmental Sciences2015，28，5： | 18 |
| 2 | Effects of Inlet Circumferential Fluctuation on the Sweep Aerodynamic Performance of Axial Fans/Compressors显示文摘Swept blades have been widely used in the transonic fan/compressor of aircraft engines with the aids of 3D CFD simulation since the design concept of controlling the shock structure was firstly proposed and successfully tested by Dr.Wennerstrom in the 1980s.However,some disadvantage phenomenon has also been induced by excessively 3D blade geometries on the structure stress insufficiency,vibration and reliability.Much confusion in the procedure of design practice leading us to recognize a new view on the flow mechanism of sweep aerodynamical induction: the new radial equilibrium established by the influence of inlet circumferential fluctuation(CF) changes the inlet flows of blading and induces the performance modification of axial fans/compressors blade.The view is verified by simplified models through numerical simulation and circumferentially averaged analysis in the present paper.The results show that the CF source items which originate from design parameters,such as the spanwise distributions of the loading and blading geometries,contribute to the changing of averaged incidence spanwise distribution,and further more affect the performance of axial fans/compressors with swept blades. | Xingmin Gui Fang Zhu Ke Wan Donghai Jin | 2013 | Journal of Thermal Science2013，22，5： | 8 |
| 3 | A novel ubiquitin carboxyl terminal hydroase is involved in toad oocyte maturation显示文摘p28, a 28kD protein from toad (Bufo bufo gargarizans) oocytes, was identified by using p13suc1-agaroseaffinity chromatography. Sequence homology analysis of the full-length cDNA of p28 (Gene Bank accessionnumber: AF 314091) indicated that it encodes a protein containing 224 amino-acids with about 55% iden-tities and more than 70% positives to human, rat or mouse UCH-L1, and contains homological functionaldomains of UCH family. Anti-p28 monoclonal antibody, on injecting into the oocytes, could inhibit theprogesterone-induced resumption of meiotic division in a dose-dependent manner. The recombinant proteinp28 showed similar SDS/PAGE behaviors to the native one, and promoted ubiquitin ethyl ester hydrolysis,a classical catalytic reaction for ubiquitin carboxyl terminai hydrolases (UCHs). The results in this paperreveal that a novel protein, p28, exists in the toad oocytes, is a UCH L1 homolog, was engaged in theprocess of progesterone-induced oocyte maturation possibly through an involvement in protein turnover anddegradation. | ZHAO GUI SUN1,2,3,*, WEI HUA KONG2,*, YAN JUN ZHANG2, SHAN YAN1, JI NING LU1, ZHENG GU1, FENG LIN1, JIA KE TSO1,**1 National Laboratory of Contraceptives and Devices Research, Shanghai Institute of Planned ParenthoodResearch, Shanghai 200032, China2 Colle | 2002 | Cell Research2002，12，4： | 8 |
| 4 | Influence of Non-Axisymmetric Terms on Circumferentially Averaged Method in Fan/Compressor显示文摘The governing equations are derived by circumferentially averaging the three-dimensional(3D) Navier-Stokes equations,which are solved using a time marching finite volume approach.Both Euler throughflow model and Navier-Stokes(N-S) throughflow model are employed to investigate the performance and flow fields of a highly loaded transonic single-stage fan ATS-2 and a four-stage fan.The results are compared with the experimental and three-dimensional computational results.It shows that the throughflow models can provide reasonable performance characteristics and N-S throughflow model gives better predictions in endwall regions.A throughflow computation n in which all the non-axisymmetric terms are included has been performed at off-design condition and the radial distributions of the flow field can be well described. | Ke Wan Hailiang Jin Donghai Jin Xingmin Gui | 2013 | Journal of Thermal Science2013，22，1： | 7 |
| 5 | Synthesis and anticancer activities of porphyrin induced anticancer drugs显示文摘鉴于性质卟啉在肿瘤有选择地是累积, ftorafur 被绑定修改改进它指向的肿瘤并且减少它的副作用的卟啉块。这些新奇卟啉衍生物和金属混合物与令人满意的产量在温和条件下面被综合,并且所有这些新混合物的构造被描绘由紫外,红外, MS, 1H NMR 系列和基本分析。他们的反癌症活动被 MTT 试金评估;结果显示混合物 4a-c 的反癌症活动象 ftorafur 的一样两次高。 | Dong Hong Li Jun Lin Diao Ke Gui Yu Cheng He Zhou | 2007 | Chinese Chemical Letters2007，18，11： | 6 |
| 6 | A successful case of combined liver and kidney transplantation for autosomal dominant polycystic liver and kidney disease显示文摘Withadvancesintransplantation,multiorgantransplantationhasbecomeatreatmentofchoiceforendstageorganfailurewhichcannotberever... | HE Xiao Shun, HUANG Jie Fu, CHEN Gui Hua, ZHENG Ke Li and YE Xiao Ming | 1999 | World Journal of Gastroenterology1999，5，1： | 5 |
| 7 | Study protocol:A cross-sectional study on psychology and behavior investigation of Chinese residents,PBICR显示文摘Objective:This study protocol identifies the basic research route and framework of psychological and behavioral surveys among Chinese residents,aims establishing a database through a multicenter,large-sample cross-sectional survey in China to provide strong data support for research development in various fields and a more comprehensive and systematic understanding of the physical and mental health status of the public.Method:The study was conducted from June 20,2022 to August 31,2022,using stratified sampling and quota sampling methods,a total of 148 cities,202 districts and counties,390 townships/towns/sub-districts,and 780 communities/villages(excluding Hong Kong,Macao,and Taiwan)from 23 provinces,5 autonomous regions,and 4 municipalities directly under the central government in China were selected.The questionnaire was distributed one-on-one and face-to-face to the public by trained investigators,and the questionnaire included eight aspects:personal basic information,personal health status,family basic information,social environment in which they were located,psychological level scale,behavioral level scale,other scales,and attitude towards social hot issues.Data analysis will be performed after questionnaire return.Results:Data collection is ongoing.These findings will support physical and mental health research and strategy development in China and even globally,guiding policy-makers and health care organizations to reform their programs to ensure the best interests of residents and their families. | Yu-Jia Wang Ayidana Kaierdebieke Si-Yuan Fan Rui-Feng Zhang Meng-Jie Huang Han Li Xiao-Nan Sun Qi-Yu Li Wen-Jia Meng Wen-Yu Wu Zhi Lin Jing-Yao Liu Xin-Pei Wang Yun-Chou Wu Jing-Qi Tang Yi-Ke Sun Ke Chen Pu Ge Wai-Kit Ming Casper Zhang Zheng Feei Ma Lei Feng Xin-Yue Zhang Yu-Yao Niu Yu-Pei Yan Yi-Le Jin Guang-Ze Gao Shuang Dai Yu-Liu Li Yue Tan Yi-Wei Wu Qi Zhang Gui Gui Xian-Li Pan Yan-Ming Liao Xian-Qi Zhao Ya-Ting Zhang Hui-Yi Chen Yue-Wei Qiu Xiao-Min Fu Jiang-Ling Zhou Dan Li Ke-Han Li Meng-Wei Xu Zhe Wang Yue-Qi Wang Yong Ma Xin-Ying Sun Yi-Bo Wu | 2022 | Psychosomatic Medicine Research2022，4，3： | 3 |
| 8 | Recent advances in asymmetric synthesis with CO2显示文摘Carbon dioxide(CO2)is an important and appealing C1 building block in chemical synthesis due to its nontoxicity,abundance,availability and sustainability.Tremendous progress has been achieved in the chemical transformation of CO2 into high valueadded organic chemicals.However,the asymmetric synthesis with CO2 to form enantioenriched molecules,especially the catalytic process,has lagged far behind.The enantioselective incorporation of CO2 into organic compounds is highly desirable,as the corresponding chiral products,such as carboxylic acids and amino acids,are common structural units in a vast array of natural products and biologically active compounds.Herein,we discuss recent progress toward the enantioselective incorporation of CO2 into organic molecules,which mainly rely on three strategies:1)kinetic resolution or desymmetrization of epoxides with CO2 to form chiral cyclic carbonates and polycarbonates;2)nucleophilic attack of O-or N-nucleophiles to CO2 in tandem with asymmetric C–O bond formation to prepare chiral cyclic carbonates and carbamates;3)direct enantioselective nucleophilic attack of organometallic reagents to CO2 with asymmetric C–C bond formation.Finally,challenges and future outlook in this area are also presented. | Chuan-Kun Ran Xiao-Wang Chen Yong-Yuan Gui Jie Liu Lei Song Ke Ren Da-Gang Yu | 2020 | Science China Chemistry2020，63，10： | 2 |
| 9 | Efficacy study of CyberKnife stereotactic radiosurgery combined withCIK cell immunotherapy for advanced refractory lung cancer显示文摘 | Yuan-Yuan Wang Yi-Shan Wang Tao Liu Ke Yang Gui?Qing Yang Han-Chen Liu Shan-Shan Wang Jia-Lin Yang | 2013 | Experimental and Therapeutic Medicine2013，，2： | 2 |
| 10 | Optical and Radiative Properties of Aerosols during a Severe Haze Episode over the North China Plain in December 2016显示文摘The optical and radiative properties of aerosols during a severe haze episode from 15 to 22 December 2016 over Beijing, Shijiazhuang, and Jiaozuo in the North China Plain were analyzed based on the ground-based and satellite data, meteorological observations, and atmospheric environmental monitoring data. The aerosol optical depth at 500 nm was < 0.30 and increased to > 1.4 as the haze pollution developed. The ?ngstr?m exponent was > 0.80 for most of the study period. The daily single-scattering albedo was > 0.85 over all of the North China Plain on the most polluted days and was > 0.97 on some particular days. The volumes of fine and coarse mode particles during the haze event were approximately 0.05–0.21 and 0.01–0.43 μm3, respectively—that is, larger than those in the time without haze. The daily absorption aerosol optical depth was about 0.01–0.11 in Beijing, 0.01–0.13 in Shijiazhuang, and0.01–0.04 in Jiaozuo, and the average absorption ?ngstr?m exponent varied between 0.6 and 2.0. The aerosol radiative forcing at the bottom of the atmosphere varied from –23 to –227, –34 to –199, and –29 to –191 W m–2 for the whole haze period, while the aerosol radiative forcing at the top of the atmosphere varied from –4 to –98, –10 to –51,and –21 to –143 W m–2 in Beijing, Shijiazhuang, and Jiaozuo, respectively. Satellite observations showed that smoke,polluted dust, and polluted continental components of aerosols may aggravate air pollution during haze episodes. The analysis of the potential source contribution function and concentration-weighted trajectory showed that the contribution from local emissions and pollutants transport from upstream areas were 190–450 and 100–410 μg m^(–3), respectively. | Yu ZHENG Huizheng CHE Leiku YANG Jing CHEN Yaqiang WANG Xiangao XIA Hujia ZHAO Hong WANG Deying WANG Ke GUI Linchang AN Tianze SUN Jie YU Xiang KUANG Xin LI Enwei SUN Dapeng ZHAO Dongsen YANG Zengyuan GUO Tianliang ZHAO Xiaoye ZHANG | 2017 | Journal of Meteorological Research2017，31，6： | 2 |
| 11 | Robust prediction of hourly PM_(2.5) from meteorological data using LightGBM显示文摘Retrieving historical fine particulate matter(PM_(2.5))data is key for evaluating the long-term impacts of PM_(2.5) on the environment,human health and climate change.Satellite-based aerosol optical depth has been used to estimate PM_(2.5),but estimations have largely been undermined by massive missing values,low sampling frequency and weak predictive capability.Here,using a novel feature engineering approach to incorporate spatial effects from meteorological data,we developed a robust Light GBM model that predicts PM_(2.5) at an unprecedented predictive capacity on hourly(R^(2)=0.75),daily(R^(2)=0.84),monthly(R^(2)=0.88)and annual(R^(2)=0.87)timescales.By taking advantage of spatial features,our model can also construct hourly gridded networks of PM_(2.5).This capability would be further enhanced if meteorological observations from regional stations were incorporated.Our results show that this model has great potential in reconstructing historical PM_(2.5) datasets and real-time gridded networks at high spatial-temporal resolutions.The resulting datasets can be assimilated into models to produce long-term re-analysis that incorporates interactions between aerosols and physical processes. | Junting Zhong Xiaoye Zhang Ke Gui Yaqiang Wang Huizheng Che Xiaojing Shen Lei Zhang Yangmei Zhang Junying Sun Wenjie Zhang | 2021 | National Science Review2021，8，10： | 2 |
| 12 | Next-generation Sequencing Study of Pathogens in Serum from Patients with Febrile Jaundice in Sierra Leone显示文摘Objective People in Western Africa suffer greatly from febrile jaundice, which is caused by a variety of pathogens. However, yellow fever virus(YFV) is the only pathogen under surveillance in Sierra Leone owing to the undeveloped medical and public health system there. Most of the results of YFV identification are negative. Elucidation of the pathogen spectrum is required to reduce the prevalence of febrile jaundice. Methods In the present study, we used Ion Torrent semiconductor sequencing to profile the pathogen spectrum in archived YFV‐negative sera from 96 patients in Sierra Leone who presented with unexplained febrile jaundice. Results The most frequently identified sequencing reads belonged to the following pathogens: cytomegalovirus(89.58%), Epstein‐Barr virus(55.21%), hepatitis C virus(34.38%), rhinovirus(28.13%), hepatitis A virus(20.83%), coxsackievirus(10.42%), Ebola virus(8.33%), hepatitis E virus(8.33%), lyssavirus(4.17%), leptospirosis(4.17%), chikungunya virus(2.08%), Crimean‐Congo hemorrhagic fever virus(1.04%), and hepatitis B virus(1.04%). Conclusion The distribution of sequencing reads suggests a broader spectrum of pathogens for consideration in clinical diagnostics and epidemiological surveillance in Sierra Leone. | ZHANG Yi YE Fei XIA Lian Xu ZHU Ling Wei IDRISSA Laybohr Kamara HUANG Ke Qiang ZHANG Yong LIU Jun BRIMA Kargbo WANG Ji LIANG Mi Fang SONG Jing Dong MA Xue Jun WU Gui Zhen | 2019 | Biomedical and Environmental Sciences2019，32，5： | 2 |
| 13 | Characterization of an early gene encoding for dUTPase in Rana grylio virus 显示文摘 | Zhao Z Ke F Gui J F | 2007 | Virus Res2007，123，2： | 1 |
| 14 | A multi-center,open-label,randomized,parallel-controlled phase II study comparing pharmacokinetic,pharmacodynamics and safety of ripertamab(SCT400)to rituximab(Mab Thera?)in patients with CD20-positive B-cell non-Hodgkin lymphoma显示文摘Objective:This multi-center,open-label,randomized,parallel-controlled phaseⅡstudy aimed to compare the pharmacokinetics(PK),pharmacodynamics(PD)and safety profile of ripertamab(SCT400),a recombinant antiCD20 monoclonal antibody,to rituximab(MabThera^(■))in patients with CD20-positive B-cell non-Hodgkin lymphoma(NHL).Methods:Patients with CD20-positive B-cell NHL who achieved complete remission or unconfirmed complete remission after standard treatment were randomly assigned at a 1:1 ratio to receive a single dose of ripertamab(375mg/m^(2))or rituximab(MabThera^(■),375 mg/m^(2)).PK was evaluated using area under the concentration-time curve(AUC)from time 0 to d 85(AUC_(0-85d)),AUC from time 0 to week 1(AUC0-1 w),AUC from time 0 to week 2(AUC_(0-2 w)),AUC from time 0 to week 3(AUC_(0-3 w)),AUC from time 0 to week 8(AUC_(0-8 w)),maximum serum concentration(C_(max)),terminal half-life(T_(1/2)),time to maximum serum concentration(T_(max))and clearance(CL).Bioequivalence was confirmed if the 90%confidence interval(90%CI)of the geometric mean ratio of ripertamab/rituximab was within the pre-defined bioequivalence range of 80.0%-125.0%.PD,immunogenicity,and safety were also evaluated.Results:From December 30,2014 to November 24,2015,a total of 84 patients were randomized(ripertamab,n=42;rituximab,n=42)and the PK analysis was performed on 76 patients(ripertamab,n=38;rituximab,n=38).The geometric mean ratios of ripertamab/rituximab for AUC_(0-85d),ATC_(0-inf),and Cmaxwere 96.1%(90%CI:87.6%-105.5%),95.9%(90%CI:86.5%-106.4%)and 97.4%(90%CI:91.6%-103.6%),respectively.All PK parameters met the pre-defined bioequivalence range of 80.0%-125.0%.For PD and safety evaluation,there was no statistical difference in peripheral CD 19-positive B-cell counts and CD20-positive B-cell counts at each visit,and no difference in the incidence of anti-drug antibodies was observed between the two groups.The incidences of treatment-emergent adverse events and treatment-related adverse events were also comparable between the two groups.Conclusions:In this study,the PK,PD,immunogenicity,and safety profile of ripertamab(SCT400)were similar to rituximab(MabThera^(■))in Chinese patients with CD20-positive B-cell NHL. | Xiaohong Han Mingzhi Zhang Huaqing Wang Qingyuan Zhang Wei Li Miaowang Hao Yuhuan Gao Jie Jin Hanyun Ren Yun Tang Xiaonan Hong Xiaoyan Ke Hang Su Lin Gui Jianmin Luo Liangzhi Xie Wenlin Gai Yuankai Shi | 2022 | Chinese Journal of Cancer Research2022，34，6： | 1 |
| 15 | Characterization of an Early Gene Encoding for dUTPase in Rana grylio Virus显示文摘 | Zhao Z Ke F Gui J F | 2007 | Virus Research2007，123，： | 1 |
| 16 | Characterization of an early gene encoding for dUTPase in Rana grylio virus 显示文摘 | ZHAO Z KE F GUI J F | 2007 | Virus Research2007，123，2： | 1 |
| 17 | ART1 and putrescine contribute to rice aluminum resistance via OsMYB30 in cell wall modification显示文摘Cell wall is the first physical barrier to aluminum(Al)toxicity.Modification of cell wall properties to change its binding capacity to Al is one of the major strategies for plant Al resistance;nevertheless,how it is regulated in rice remains largely unknown.In this study,we show that exogenous application of putrescines(Put)could significantly restore the Al resistance of art1,a rice mutant lacking the central regulator Al RESISTANCE TRANSCRIPTION FACTOR 1(ART1),and reduce its Al accumulation particularly in the cell wall of root tips.Based on RNA-sequencing,yeast-onehybrid and electrophoresis mobility shift assays,we identified an R2R3 MYB transcription factor OsMYB30 as the novel target in both ART1-dependent and Put-promoted Al resistance.Furthermore,transient dual-luciferase assay showed that ART1 directly inhibited the expression of OsMYB30,and in turn repressed Os4CL5-dependent 4-coumaric acid accumulation,hence reducing the Al-binding capacity of cell wall and enhancing Al resistance.Additionally,Put repressed OsMYB30 expression by eliminating Alinduced H2O2accumulation,while exogenous H2O2promoted OsMYB30 expression.We concluded that ART1 confers Put-promoted Al resistance via repression of OsMYB30-regulated modification of cell wall properties in rice. | Li Jun Gao Xiang Pei Liu Ke Ke Gao Meng Qi Cui Hui Hui Zhu Gui Xin Li Jing Ying Yan Yun Rong Wu Zhong Jie Ding Xue Wei Chen Jian Feng Ma Nicholas PHarberd Shao Jian Zheng | 2023 | Journal of Integrative Plant Biology2023，65，4： | 1 |
| 18 | Characterization of an early gene encoding for dUTPase in Rana grylio virus 显示文摘 | Zhao Z Ke F Gui J Zhang Q | 2007 | Virus Res2007，123，2： | 1 |
| 19 | Recent insights into aquatic viruses: Emerging and reemerging pathogens, molecular features, biological effects, and novel investigative approaches显示文摘Aquatic viruses are naturally present in the aquatic environment and the number of viruses is staggering.Various multicellular organisms in aquatic ecosystems may be infected,cross-species transmitted,manipulated,and killed by aquatic viruses,which can lead to cascading ecological effects.The viruses in unicellular aquatic organisms can alter interactions between host individuals,and are essential in effecting or maintaining the dynamics of aquatic microbial communities,horizontal gene transfer,biodiversity,and modulating ecological processes globally.Meanwhile,hosts also impact viral abundance and diversity.Microbial diversity drives multifunctionality in ecosystems,while viruses shape complex microbial communities and are crucial for ecosystem functioning.This review focuses on molecular,genetic,evolutionary,and ecosystemic advances related to emerging and reemerging aquatic viruses,presents the contexts,novel tools,and investigative approaches pertaining to the study of aquatic virology,and discusses the mechanisms by which viruses affect aquatic ecosystems.The paper provides an efficient and broadly-based blueprint for improving understanding of aquatic viruses. | Qi-Ya Zhang Fei Ke Lang Gui Zhe Zhao | 2022 | Water Biology and Security2022，1，4： | 1 |
| 20 | Somatic embryogenesis and plant regeneration in Eleutherococcus senticosus 显示文摘 | Gui Y Guo Z Ke S | 1991 | Plant Cell Rep1991，9，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员