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| 1 | Expression of IGF-Ⅱ,p53,p21 and HBxAg in precancerous events of hepatocarcinogenesis induced by AFBI and/or HBV in tree shrews显示文摘INTRODUCTIONIn order to study the relationship between oncogeneexpression and HCC generation,we observed theprecancerous hepatic GGT loci,IGF-Ⅱ,p53 andp21 expression during hepatocarcinogenesis of treeshrew induced by hepatitis B virus (HBV) and/oraflatoxin B1 (AFB1). | Qin LL Su JJ Li Y Yang C Ban KC Yian RQ | 2000 | World Journal of Gastroenterology2000，6，1： | 37 |
| 2 | 室内氡与肺癌关系研究显示文摘目的 直接调查居室水平氡浓度对居民肺癌危险度的影响 ,并与由矿工受照结果推导的结论相比较。方法 在甘肃省平凉、庆阳两地区进行病例 对照研究。该地区居民稳定而室内氡水平较高。肺癌病例必须是在 1994年 1月至 1998年 4月期间诊断 ,年龄在 30~ 75岁之间 ,居住在平凉和庆阳两地区的居民。根据人口调查资料随机选取对照 ,对照要在年龄、性别、地区方面与病例相匹配。在过去 5~ 30年期间 ,凡住过两年以上的房间都布放了氡探测器。氡测量涵盖了 77%的照射周期。结果 病例居室的平均氡浓度为 2 30 4Bq m3 (n =76 8) ,对照为 2 2 2 2Bq m3 (n =16 5 9)。居民肺癌危险度随室内氡水平的增高有所上升 (P <0 0 0 1)。根据线性模型 ,对全部研究个体而言 ,在 10 0Bq m3 情况下 ,附加比值比 (EOR)为 0 19(95 %CI:0 0 5 ,0 47)。对测量涵盖了 10 0 %照射周期的个体 ,为 0 31(95 %CI:0 10 ,0 81)。在对照射的不确定度进行调整后 ,估算值可增加70 %。结论 研究结果证明室内水平氡照射会增加肺癌危险度 。 | 王作元 Lubin JH 王陇德 张守志 Boice JD Jr 崔宏星 张淑蓉 Conrath SC 夏英 尚兵 Brenner A 雷苏文 Metayer KC 曹吉生 Chen KW 雷淑杰 Kleinerman RA | 2002 | 中华放射医学与防护杂志2002，22，3： | 28 |
| 3 | Helicobacter pylori colonization of the oral cavity:Amilestone discovery显示文摘Over the past several years, the severity of Helicobacter pylori(H. pylori) infections has not significantly diminished. After successful eradication, the annual H. pylori recurrence rate is approximately 13% due tooral H. pylori infection. Established clinical diagnostic techniques do not identify an oral etiologic basis of H. pylori prior to gastric infection. There has been disagreement as to whether oral infection of H. pylori exists or not, with no definite conclusion. In medical practice, negative results with the urea breath test suggest that the stomach infection of H. pylori is cured in these patients. In fact, patients can present negative urea breath test results and yet exhibit H. pylori infection due to oral infection. The present paper provides evidence that H. pylori oral infection is nonetheless present, and the oral cavity represents a secondary site for H. pylori colonization. | John KC Yee | 2016 | World Journal of Gastroenterology2016，22，2： | 13 |
| 4 | Identification of tumor associated single-chain Fv by panning and screening antibody phage library using tumor cells显示文摘AIM:To study the feasibility of panning and screeningphage-displaying recombinant single-chain variablefragment (ScFv) of anti-tumor monoclonal antibodiesfor fixed whole cells as the carriers of mAb-bindingantigens.ME,ODS: The recombinant phage displaying librariesfor anti-colorectal tumor mAb MC3Ab, MC5Ab andanti-gastric tumor mAb MGD1 was constructed.Panning and screening were carried outby means ofmodified fixation of colorectal and gastric tumor cellsexpressed the mAb-binding antigens. Concordance ofbinding specificity to tumor cells between phageclones and parent antibodies was analyzed. Thephage of positive clones was identified withcompetitive ELISA, and infected by E.coli HB2151 toexpress soluble ScFv.RESULTS:The ratio of positive clones to MC3-ScF-MC5-ScFv and MGD1-ScFv were 60 %, 24 % and 30 %. MC3-ScFv had Mr 32 000 confirmed by Western blot. Thespecificity to antigen had no difference between 4positive recombinant phage antibodies and MC3Ab.CONCLUSION:The modified process of fixing wholetumor cells is efficient, convenient and feasible to panand screen the phage-displaying ScFv of anti-tumormonoclonal antibodies. | Nie, YZ He, FT Li, ZK Wu, KC Cao, YX Chen, BJ Fan, DM | 2002 | World Journal of Gastroenterology2002，8，4： | 12 |
| 5 | 原发性冻结肩的类固醇注射部位显示文摘之前对冻结肩的研究已经阐明了影像的增强和关节囊的厚度增加,并且在肩袖间隙,前关节囊和腋窝凹处还有高代谢活性病灶。这个研究对比了将皮质类固醇注射入不同部位的短期疗效,包括盂肱关节的关节间隙,肩峰下或者两个部位。 | 傅雄伟 顾旭东 Cho CH Kim du H Bae KC | 2016 | 中国康复2016，31，5： | 11 |
| 6 | 中国部分农村地区6~23月龄婴幼儿贫血患病率及其与膳食多样性的关系显示文摘目的了解中国部分农村地区6~23月龄婴幼儿贫血情况及影响因素。方法利用2016—2017年中国10个省、自治区的20个县进行的“母子健康综合项目”基线调查资料,对1736名6~23月龄婴幼儿及看护人数据进行统计分析。结果6~23月龄婴幼儿贫血患病率为58.1%,其中轻、中度贫血比例较高,分别为24.7%和30.1%。多因素分析显示,相比于18~23月龄婴幼儿,6~11月龄(OR=2.10,95%CI:1.61~2.74),12~17月龄(OR=1.64,95%CI:1.28~2.11)婴幼儿患贫血的风险增加。非独生子女(OR=1.26,95%CI:1.03~1.56)、看护人民族为彝族(OR=1.64,95%CI:1.11~2.43)或其它少数民族(OR=1.72,95%CI:1.33~2.21)、未达到最低膳食多样性(OR=1.40,95%CI:1.10~1.77)是婴幼儿贫血的危险因素;过去1个月服用营养包是婴幼儿贫血的保护因素(OR=0.68,95%CI:0.54~0.86)。结论中国部分农村地区婴幼儿贫血问题属于重度公共卫生问题,关注小月龄、非独生子女及少数民族婴幼儿,为其提供种类丰富的辅食是改善婴幼儿贫血的关键。 | 陈春屹 Ashish KC 黄玥 王银平 高雅晴 周虹 | 2020 | 中国生育健康杂志2020，31，3： | 11 |
| 7 | Doppler study of hepatic vein in cirrhotic patients:Correlation with liver dysfunction and hepatic hemodynamics显示文摘AIM: To elucidate the significance of Doppler measurements of hepatic vein in cirrhotic patients and to correlate with liver dysfunction and hepatic hemodynamics. METHODS: One hundred patients with liver cirrhosis and 60 non-cirrhotic controls were studied. Doppler waveforms were obtained from right hepatic vein and flow velocity measured during quiet respiration. Doppler measurements were also obtained from portal trunk, right portal vein and proper hepatic artery. RESULTS: Hepatic vein waveforms were classified into three classical patterns. Flat waveform was uncommon. Mean hepatic vein velocity was significantly higher in cirrhotic patients (12.7 ± 6.4 vs 5.1 ± 2.1 and 6.2 ± 3.2 cm/s; P < 0.0001). The poorer the grade of cirrhosis, the higher was the mean velocity. Maximum forward velocity was never greater than 40 cm/s in controls. Degree of ascites was found to be highly correlated with mean velocity. “Very high” group (≥ 20 cm/s) presented clinically with moderate to massive ascites. Correlations between right portal flow and mean velocity was significant (P < 0.0001, r = 0.687). CONCLUSION: Doppler waveforms of hepatic vein, which is independent of liver dysfunction, should be obtained during normal respiration. Mean hepatic vein velocity reflects the change in hepatic circulation associated with progression of liver cirrhosis. It can be used as a new parameter in the assessment of liver cirrhosis. | KC Sudhamshu Shoiichi Matsutani Hitoshi Maruyama Taro Akiike Hiromitsu Saisho | 2006 | World Journal of Gastroenterology2006，12，36： | 8 |
| 8 | 运动对新发脂肪肝和已存在脂肪肝的影响显示文摘非酒精性脂肪性肝病(NAFLD)是指非饮酒所致的肝脏过多脂肪堆积,往往常见于超重、肥胖或罹患糖尿病、高胆固醇血症或高甘油三酯血症的个体。NAFLD是目前最常见的慢性肝脏疾病之一,影响了30%以上的一般人群,已成为一个严重的公共卫生负担。在全世界范围内,随着肥胖的流行,该综合征的患病率不断增加。当前,尚没有一种药物或手术获批用于治疗NAFLD。一些研究总结称,减重是唯一经证实的治疗NAFLD的有效方案。 | Sung KC Ryu S Lee JY | 2016 | 胃肠病学和肝病学杂志2016，25，12： | 7 |
| 9 | Child-Pugh-Turcott versus Meld score for predicting survival in a retrospective cohort of black African cirrhotic patients显示文摘AIM: To compare the performance of the Child-Pugh-Turcott (CPT) score to that of the model for end-stage liver disease (MELD) score in predicting survival of a retrospective cohort of 172 Black African patients with cirrhosis on a short and mid-term basis.METHODS: Univariate and multivariate (Cox model) analyses were used to identify factors related to mortality. Relationship between the two scores was appreciated by calculating the correlation coefficient. The Kaplan Meier method and the log rank test were used to elaborate and compare survival respectively. The Areas Under the Curves were used to compare the performance between scores at 3, 6 and 12 mo.RESULTS: The study population comprised 172 patients, of which 68.9% were male. The mean age of the patient was 47.5 ± 13 years. Hepatitis B virus infection was the cause of cirrhosis in 70% of the cases. The overall mortality was 31.4% over 11 years of follow up. Independent factors significantly associated with mortality were: CPT score (HR = 3.3, 95% CI [1.7-6.2]) (P < 0.001) (stage C vs stage A-B); Serum creatine (HR = 2.5, 95% CI [1.4-4.3]) (P = 0.001) (Serum creatine > 1.5 mg/dL versus serum creatine < 1.5 mg/dL); MELD score (HR = 2.9, 95% CI [1.63-5.21]) (P < 0.001) (MELD > 21 vs MELD < 21). The area under the curves (AUC) that predict survival was 0.72 and 0.75 at 3 mo (P = 0.68), 0.64 and 0.62 at 6 mo (P = 0.67), 0.69 and 0.64 at 12 mo (P = 0.38) respectively for the CPT score and the MELD score.CONCLUSION: The CPT score displays the sameprognostic significance as does the MELD score in black African patients with cirrhosis. Moreover, its handling appears less cumbersome in clinical practice as compared to the latter. | KA Attia KC Ackoundou-N'guessan AT N’dri-yoman AK Mahassadi E Messou YF Bathaix YH Kissi | 2008 | World Journal of Gastroenterology2008，14，2： | 5 |
| 10 | Cellulose-based Antimicrobial Composites and Applications: A Brief Review显示文摘Cellulose-based antimicrobial composites,typically in the form of functional films and cloth,have received much attention in various applications,such as food,medical and textile industries.Cellulose is a natural polymer,and is highly biodegradable,green,and sustainable.Imparting antimicrobial properties to cellulose,will significantly enhance its applications so that its commercial value can be boosted.In this review paper,the use of cellulose for antimicrobial composites’preparation was discussed.Two different approaches:surface loading/coating and interior embedding,were focused.Three most widely-applied sectors:food,medical and textile industries,were highlighted.Nanocellulose,as a leading-edge cellulose material,its unique application on the antimicrobial composites,was particularly discussed. | Bo Sun Fangong Kong Min Zhang Weijun Wang Birat Singh KC Jimi Tjong Mohini Sain | 2019 | Paper And Biomaterials2019，4，4： | 5 |
| 11 | 对试点社区高血压防治知识系列培训评价方法的研究显示文摘 | 徐继英 KC Tang | 2001 | 中国健康教育2001，17，2： | 4 |
| 12 | 达托霉素用于治疗粒细胞缺乏症患者革兰阳性菌感染显示文摘多中心回顾性观察研究评价达托霉素治疗粒细胞减少症患者革兰阳性菌感染的临床疗效。 | Rolston KV Besece D Lamp KC 秦晓华 汪复 | 2014 | 中国感染与化疗杂志2014，14，6： | 4 |
| 13 | A UNIFIED ENERGY APPROACH TO A CLASS OF MICROMECHANICS MODELS FOR MICROCRACKED SOLIDS显示文摘Micromechanics models have been developed for the determination ofthe elastic moduli of microcracked solids based on different approaches andinterpretations,including the dilute or non-interacting solution,the Mori-Tanakamethod,the self-consistent method,and the generalized self-consistent method.It isshown in the present study that all these micromechanics models can be unified withinan energy-equivalence framework,and that they differ only in the way in which themicrocrack opening and sliding displacements are evaluated.Relevance to thedifferential methods and the verification of these models are discussed. | HUANG, Y HWANG, KC | 1995 | Acta Mechanica Solida Sinica1995，8，2： | 4 |
| 14 | 印度Ganga-Meghna-Brahmaputra平原及周围地区与孟加拉国地下水砷污染及其对健康影响的19年研究显示文摘基于近19年对印度Ganga—Meghna—Brahmaputra(简称GMB)平原(面积569749km^2,人口超过5亿)地下水砷污染的调查,可以确定印度Ganga—Brahmaputra平原(包括北方邦、比哈尔邦、恰尔康得邦、西孟加拉邦、阿萨姆邦)和孟加拉国普遍受到砷的污染。近期的调查研究也表明,除米佐拉姆邦外,其他各邦的地下水也受到不同程度的砷污染。至今为止.已对印度各邦和孟加拧国的175000份和50808份压把井水样进行了含砷量检测。并组织了一支包括皮肤科、神经科和妇产科医生在内的有经验的专家组,对上述地区125000人进行了临床检查,其中9%患有砷导致的皮肤病损症状。至今共采集分析了60000份生物样品。包括发样、指甲、尿样及皮肤鳞屑,其中80%的样品含砷量超过允许值,很多人由此受到砷的亚临床损害。在上述砷暴露地区.19000名儿童经过检查,近1100人患有砷导致的皮肤病损。该调查结果表明.儿童比成人更容易受到砷的毒性损害。在这种状况下.应着力解决饮水安全问题来减轻砷的苊害. | Ahamed S Hossain MA Mukharjee A Sengupta MK Das B Nayak B Pal A Mukherjee SC Pati S Dutta RN Saha KC Quamruzzaman Q Chakraborti D 付松波(译) 孙殿军(审校) | 2007 | 中国地方病学杂志2007，26，1： | 3 |
| 15 | Comparative study between intramedullary interlocking nailing and minimally invasive percutaneous plate osteosynthesis for distal tibia extra-articular fractures显示文摘Purpose:Treatment of distal tibia fractures poses significant challenge to orthopedic surgeon because of poor blood supply and paucity of soft tissue coverage.There is considerable controversy regarding the superior option of treatment for distal tibia fracture between the minimally invasive percutaneous plate osteosynthesis(MIPPO)technique and intramedullary interlocking(IMIL)nailing for extra-articular distal tibia fractures.The aim of our study is to compare the functional outcome between the two treatment methods.Methods:This was the prospective comparative study of 100 patients with distal third tibia fractures divided into two groups.The first group of patients were treated with MIPPO technique while the second group of patients were managed by IMIL nailing.Patients were followed up in outpatient department to assess the functional outcomes,malunion,delayed union,nonunion,superficial and deep infection between the two groups.Statistical analyses were performed using the SPSS software(version 16.0).Results:Average malunion(degrees)in the MIPPO group was 5(3—7)±1.41 vs.10.22(8—14)±2.04 in the IMIL group(p=0.001).Similarly postoperative knee pain in the IMIL group was 10%vs.2%in the MIPPO group(p=0.001).In terms of superficial infection and nonunion,the results were 8%vs.4%and 2%vs.6%for the MIPPO and IMIL group,respectively(p=0.001).Conclusion:Both procedures have shown the reliable method of fixation for distal extra-articular tibia fractures preserving the soft tissue,bony vascularity and fracture hematoma that provide a favourable biological environment for fracture healing.Considering the results of the study,we have slightly more preference for the MIPPO technique. | Kapil Mani KC Bandhu Ram Pangeni Suman Babu Marahatta Arun Sigdel Amuda KC | 2022 | Chinese Journal of Traumatology2022，25，2： | 3 |
| 16 | Plastins regulate ectoplasmic specialization via its actin bundling activity on microfilaments in the rat testis显示文摘Plastins 是在哺乳动物的房间为交叉结合肌动朊微细丝所知的肌动朊绑定蛋白质(ABP ) 的一个家庭,创造必要的肌动朊微细丝捆授与房间极性和房间形状。Plastins 也在环境响应变化支持房间运动,在房间 / 织物生长和开发包含了。他们也响应感染或另外的病理学的条件授与粘性到房间和纸巾(例如,发炎) 。在睾丸,房间房间对在血睾丸障碍(BTB ) 并且在 Sertoli-spermatid 在 Sertoli 房间房间接口被发现的睾丸唯一的抛锚的连接(例如,在老鼠睾丸的 8-19 spermatids ) 基础并且顶端的 ectoplasmic 专门化(ES ) 分别地。ES 是抛锚的 F-actin-rich 最尤其是肌动朊微细丝捆组成的连接。3 关于由 plastin, 3 调整肌动朊微细丝的地位的机制产出一些深刻信息的用明确地将 plastin 击倒的 RNAi 的一份最近的报告经由它的内在的肌动朊细丝捆绑活动在 ES 绑。此处,我们考虑到这份报告在睾丸在 plastins 的角色上提供简短评论,它和这块地里的最近的调查结果,我们建议由哪个 plastins 在老鼠睾丸在肌动朊微细丝组织上经由他们的内在的活动在精子发生的上皮的周期期间调整 ES 功能的一个可能的模型。 | Nan Li Chris KC Wong C Yan Cheng | 2016 | Asian Journal of Andrology2016，18，5： | 3 |
| 17 | The 5-HT2c receptor gene Cys23Ser polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation显示文摘有终生的早泄(LPE ) 的人的坚持的短 intravaginal 射精潜伏时间(IELT ) 与 5-hydroxytryptamine (HT ) 有关是 2C 受体工作,这被要求了。这研究的目的是与 LPE 在人调查 Cys23Ser 5-HT 2C 受体基因多型性和 IELT 的持续时间的关系。因此,未来的研究与 LPE 在 64 个荷兰的白种人人被进行。基线 IELT 被秒表在一个 1 月的时期上在性交期间估计。所有人是为 Cys23Ser 5-HT 2C 受体基因多型性的 genotyped。Cys 的等位基因频率和 5-HT 2C 受体基因多型性的重量的单位变体是坚定的。在 Cys/Cys 和重量的单位 / 重量的单位遗传型和在有 LPE 的人的 IELT 的自然对数之间的协会被调查。作为结果,几何吝啬、中部、自然的吝啬的 IELT 是 25.2, 27.0, 33.9 s 分别地。所有人, 20.0% , 10.8% , 23.1% 和 41.5% 在 10 以内射精,在阴道穿入以后的 10-20, 20-30 和 30-60 s。64 个人,为 5-HT 2C 受体基因的 Cys23Ser 多型性的 Cys/Cys 和重量的单位 / 重量的单位遗传型频率分别地是 81% 和 19% 。wildtypes (Cys/Cys ) 的几何吝啬的 IELT 显著地更低(22.6 s;95% CI 18.3-27.8 s ) 比在男同型结合的异种(重量的单位 / 重量的单位)(40.4 s;95% CI 20.3-80.4 s )(P = 0.03 ) 。Cys23Ser 5-HT 2C 受体基因多型性与 LPE 在人与 IELT 被联系,这被结束。有 Cys/Cys 遗传型的人与重量的单位 / 重量的单位遗传型比人有更短的 IELT。 | Paddy KC Janssen Ron van Schaik Berend Olivier Marcel D Waldinger | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 18 | 保护渣的性能及其对表面质量的影响显示文摘 | Mills,KC 徐长青 | 1993 | 钢铁译文集1993，，2： | 3 |
| 19 | Liver transplantation for a giant mesenchymal hamartoma of the liver in an adult: Case report and review of the literature显示文摘Mesenchymal hamartomas of the liver(MHLs) in adults are rare and potentially premalignant lesions, which present as solid/cystic neoplasms. We report a rare case of orthotopic liver transplantation in a patient with a giant MHL. In 2013, a 34-year-old female sought medical advice after a 2-year history of progressive abdominal distention and respiratory distress. Physical examination revealed an extensive mass in the abdomen. Computed tomography(CT) of her abdomen revealed multiple liver cysts, with the diameter of largest cyst being 16 cm × 14 cm. The liver hilar structures were not clearly displayed. The adjacent organs were compressed and displaced. Initial laboratory tests, including biochemical investigations and coagulation profile, were unremarkable. Tumor markers, including levels of AFP, CEA and CA19-9, were within the normal ranges. The patient underwent orthotopic liver transplantation in November 2013, the liver being procured from a 40-year-old man after cardiac death following traumatic brain injury. Warm ischemic time was 7.5 min and cold ischemic time was 3 h. The recipient underwent classical orthotopic liver transplantation. The recipient operative procedure took 8.5 h, the anhepatic phase lasting for 1 h without the use of venovenous bypass. The immunosuppressive regimen includedintraoperative induction with basiliximab and high-dose methylprednisolone, and postoperative maintenance with tacrolimus, mycophenolate mofetil, and prednisone. The recipient's diseased liver weighed 21 kg(dry weight) and measured 41 cm × 32 cm × 31 cm. Histopathological examination confirmed the diagnosis of an MHL. The patient did not experience any acute rejection episode or other complication. All the laboratory tests returned to normal within one month after surgery. Three months after transplantation, the immunosuppressive therapy was reduced to tacrolimus monotherapy, and the T-tube was removed after cholangiography showed no abnormalities. Twelve months after transplantation, the patient remains well and is fulfilling all normal activities. Adult giant MHL is extremely rare. Symptoms, physical signs, laboratory results, and radiographic imaging are nonspecific and inconclusive. Surgical excision of the lesion is imperative to make a definite diagnosis and as a cure. Liver transplantation should be considered as an option in the treatment of a non-resectable MHL. | Jiang Li Jin-Zhen Cai Qing-Jun Guo Jun-Jie Li Xiao-Ye Sun Zhan-Dong Hu David KC Cooper Zhong-Yang Shen | 2015 | World Journal of Gastroenterology2015，21，20： | 3 |
| 20 | Acute respiratory distress syndrome after kidney transplantation:epidemiology,risk factors,and outcomes显示文摘 | Shorr AF Abbott KC Agadoa LY | 2003 | Critical Care Medicine2003，，05： | 2 |
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