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您的检索式：作者名="Kavin Thinkhamrop"
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| 1 | Repeated praziquantel treatment and Opisthorchis viverrini infection:a population-based cross-sectional study in northeast Thailand显示文摘Background:Opisthorchis viverrini infection is highly prevalent in northeast Thailand.This liver fluke is classified as a carcinogen due to its causal links with cholangiocarcinoma(CCA)development.Although treatment with praziquantel(PZQ)effectively cures O.viverrini infection,the prevalence remains high due to the traditional consumption of raw fish.Therefore,re-infection is common in the endemic community,leading to severe hepatobiliary morbidities including the fatal CCA.In this study,we evaluate the association between the frequency of previous PZQ treatment and current O.viverrini infections among Thai adults living in the endemic area of northeast Thailand.Methods:This study includes all participants who were screened for O.viverrini infection in the Cholangiocarcinoma Screening and Care Program(CASCAP),northeast Thailand.History of PZQ treatment was recorded using a health questionnaire.O.viverrini infections were diagnosed using urine antigen detection.Associations between PZQ and O.viverrini were determined by adjusted odds ratio(aOR)and 95%confidence interval(CI)using multiple logistic regression.Results:Among participants,27.7%had previously been treated once with PZQ,8.2%twice,2.8%three times,and 3.5%more than three times.Current O.viverrini prevalence was 17%(n=524).Compared with participants who never used PZQ,the aOR for infection among those who used the drug once was 1.09(95%CI:0.88-1.37),twice was 1.19(95%CI:0.85-1.68),three times was 1.28(95%C/:0.74-2.21),and more than three times was 1.86(95%C/:1.18-2.93;P=0.007).Conclusions:The population with a frequent history of PZQ use and still continued raw fish consumption showed high levels of repeated reinfection with O.viverrini.They were infected,treated and re-infected repeatedly.These findings suggest that certain participants continue raw fish consumption even after previous infection.This is a particular problem in highly endemic areas for O.viverrni and increases the risk of CCA. | Kavin Thinkhamrop Narong Khuntikeo Paiboon Sithithaworn Wilaiphorn Thinkhamrop Kinley Wangdi Matthew J.Kelly Apiporn T.Suwannatrai Darren J.Gray | 2019 | Infectious Diseases of Poverty2019，8，2： | 0 |
| 2 | Correction to:Repeated praziquantel treatment and Opisthorchis viverrini infection:a population-based crosssectional study in northeast Thailand显示文摘In the original publication of this article[1],there is an error in the section of‘Ethics approval and consent to participate’at the end of the article,the correct Ethics reference number should be HE551404 rather than HE591067. | Kavin Thinkhamrop Narong Khuntikeo Paiboon Sithithaworn Wilaiphorn Thinkhamrop Kinley Wangdi Matthew J.Kelly Apiporn T.Suwannatrai Darren J.Gray | 2019 | Infectious Diseases of Poverty2019，8，3： | 0 |
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