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| 1 | 角膜胶原交联术治疗圆锥角膜的疗效和安全性研究显示文摘目的:研究角膜胶原交联术治疗圆锥角膜的疗效和安全性。方法:对2015-04/2018-08在泰国朱拉隆功国王纪念医院行角膜胶原交联术的圆锥角膜患者病历进行回顾性分析。评估术前和术后1a的视力、屈光度、角膜地形图、高阶像差(HOA)、地形图参数和角膜密度。根据患者年龄是否小于24和30岁、基线角膜最大曲率(Kmax)是否小于55 D、基线最佳矫正视力(BCVA)是否小于0.3 LogMAR分组评估年龄、基线Kmax和BCVA对手术疗效的影响。分析术前Kmax、Kmean、平均等效球镜度数(MRSE)、视力、角膜最薄点厚度值、Kmax的变化以及相关参数的变化与角膜密度测量值变化之间的关系。P<0.05具有统计学意义。结果:共155例患者185眼纳入研究,其中119例男性,36例女性。根据Amsler-Krumeich进行分类,1期和2期占优势(分别为37.84%和35.14%)。术后1a,平均裸眼视力(UCVA)提高0.1 LogMAR(P<0.05)。与基线BCVA较好组(术前BCVA<0.3 LogMAR)相比,基线BCVA较差组(术前BCVA≥0.3 LogMAR)术后BCVA改善大于0.2 LogMAR的眼数较多(78.26%vs 21.74%,P<0.05)。平均Kmax比基线下降2.36 D(P<0.05)。术前Kmax≥55 D的患眼术后Kmax下降超过2.0 D的眼数占比73%。距角膜顶点6 mm处角膜HOA下降0.40(P<0.05)。术后1mo~1a,0~6 mm区角膜密度测量值持续增加。术后1a,角膜密度的增加与最薄点厚度的减少呈线性相关。表面变异指数、高度非对称性指数、圆锥角膜指数、高度轴偏心指数在术后1a时下降(P<0.05)。术后1a,手术成功率为90.24%。术后1wk、1、3、6mo、1a角膜混浊发生率分别为11.35%、30.27%、15.67%、10.27%、2.16%。无角膜水肿发生,但有1例无菌性角膜炎患者。结论:角膜胶原交联术可有效治疗圆锥角膜,使角膜变平、重塑,提高视力、HOA和角膜形态指数,晚期圆锥角膜Kmax也明显降低。 | Yonrawee Piyacomn Ngamjit Kasetsuwan Vilavun Puangsricharern Usanee Reinprayoon Vannarut Satitpitakul Patchima Chantaren | 2021 | 国际眼科杂志2021，21，7： | 5 |
| 2 | Prevalence of ocular demodicosis among patients at Tertiary Care Center,Bangkok,Thailand显示文摘● AIM: To determine the prevalence of ocular demodicosis by both microscopic examination and molecular detection among patients at King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok.● METHODS: One hundred individuals were enrolled in the study and were divided into five age groups. The meibomian gland dysfunction(MGD) score and qualities of cylindrical dandruff(CD) were also determined. Demodex mite infestations of eyelash samples were screened by both microscopic examination and semi-nested polymerase chain reaction(PCR).● RESULTS: The prevalence of ocular demodicosis as determined by microscopic examination was 42% [Demodex folliculorum(D. folliculorum) 41% and Demodex brevis(D. brevis) 1%]. Among patients who had ocular Demodex infestation, 69% have CD and had an average MGD score of 4; in patients without demodicosis, 15.5% had CD and had an average MGD score of 4.12. Prevalence of ocular demodicosis as determined by semi-nested PCR was 79%(D. folliculorum 78% and D. brevis 1%). ● CONCLUSION: This is the first report on the prevalence of ocular demodicosis in Thailand. Patients with CD also had Demodex mites present. Semi-nested PCR is better than microscopy for Demodex infestation detection. An extensive survey with more representative samples is required to determine the prevalence in the country. | Ngamjit Kasetsuwan Kitchaporn Kositphipat Mathu Busayarat Pawanrat Threekhan Kanok Preativatanyou Atchara Phumee Padet Siriyasatien | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 3 |
| 3 | Toxicity of topical anesthetic agents to human keratocytes in vivo显示文摘 | Moreira LB Kasetsuwan N Sanchez D | | 0，，： | 1 |
| 4 | Perfor- mance profile of sodium hyaluronate in patients withlipid tear deficiency: randomised, double-blind, con- trolled, exploratory study显示文摘 | Prabhasawat P Tesavibul N Kasetsuwan N | 2007 | Br J Ophthalmol2007，91，1： | 1 |
| 5 | Incidence and pattern of dry eye after cataract surgery显示文摘 | Kasetsuwan N Satitpitakul V Changul T Jariyakosol S | 2013 | PLoS One2013，8，78： | 1 |
| 6 | Incidence and pat-tern of dry eye after cataract surgery显示文摘 | Kasetsuwan N Satitpitakul V Changul T | 2013 | PLoS 0ne2013，8，78： | 1 |
| 7 | Effect of topical ascorbic acid on free radical tissue damage and inflammatory cell influx in the cornea after excimer laser corneal surgery显示文摘 | Kasetsuwan N Wu FM Hsioh F | 1999 | Arch Ophthalmol1999，117，5： | 1 |
| 8 | Incidence and pattern of dry eye after cataract surgery显示文摘 | Kasetsuwan N Satitpitakul V Changul T | 2013 | PLoS One2013，8，78： | 1 |
| 9 | Real time intraocular pres- sure and lamellar corneal flap thickness in keratomileusis显示文摘 | Kasetsuwan N Pangilinan RT Moreira LL DiMartino DS Shah SS Sehallhorn SC McDonnell PJ | 2001 | Cornea2001，20，： | 1 |
| 10 | Toxicity of topical anesthetic agents to human keratocytes in vivo显示文摘 | Moreira LB Kasetsuwan N Sanchez D | 1999 | J Cataract Refract Surg1999，25，7： | 1 |
| 11 | Alveolar bone changes in autogenous tooth transplantation 显示文摘 | Waikakul A Punwutikorn J Kasetsuwan J | 2011 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2011，111，3： | 1 |
| 12 | Performance profile of sodium hyaluronate in patients with lipid tear deficlency: randomlsed, dou- ble-blind, controlled, exploratory study 显示文摘 | Prabhasawat P Tesavlbul N Kasetsuwan N | 2007 | Br J Ophthalmol2007，91，1： | 1 |
| 13 | Performance profile of sodium hyaluronate in patients with lipid tear deficiency: randomised, double-blind, controlled, exploratory study显示文摘 | Prabhasawat P Tesavibul N Kasetsuwan N | 2007 | Br J Ophthaltool2007，91，1： | 1 |
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