|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oligodendrocytes in Mouse Corpus Callosum are Coupled Via Gap Junction Channels Formed by Connexin47 and Connexin32显示文摘已有的超微结构研究显示,白质中的少突胶质细胞和星形胶质细胞之间存在缝隙连接,但少突胶质细胞之间不存在缝隙连接,虽然体外培养的少突胶质细胞可形成功能性缝隙连接。本文研究新生小鼠胼胝体急性脑片中的少突胶质细胞的功能性连接。以全细胞膜片钳技术用生物胞素(一种可渗透的缝隙连接示踪剂)标记少突胶质细胞。平均61个细胞为链霉亲和素-Cy3标记的生物胞素阳性。约77%的连结细胞表达少突胶质细胞标志蛋白CNPase阳性染色,9%表达星形胶质细胞标志蛋白GFAP阳性,14%为CNPase和GFAP阴性。后者的大部分表达Olig2和一些NG2(少突胶质细胞前体细胞的标志物)。少突胶质细胞表达Cx47、Cx32和Cx29,星形胶质细胞表达Cx43和Cx30。在Cx47敲除小鼠中,连结细胞的数量减少80%。单独删除Cx32或Cx29并不能显著减少连结细胞的数量,但Cx32/Cx47双缺陷小鼠中没有观察到相互连结的细胞。Cx47敲除完全消除了少突胶质细胞与星形胶质细胞间的耦联。在Cx43敲除动物中,少突胶质细胞-星形胶质细胞间连接仍然存在,但与少突胶质细胞前体细胞间的耦联没有被观察到。在Cx43/Cx30双敲除小鼠中,少突胶质细胞-星形胶质细胞连接几乎不存在。解开连结的少突胶质细胞显示为较高的膜输入电阻。本文认为,白质中的少突胶质细胞依靠Cx47和Cx32的表达形成功能性的合胞体,而星形胶质蛋白缝隙连接蛋白的表达能提升此网络的大小。 | Marta Maglione Oliver Tress Brigitte Haas Khalad Karram Jacqueline Trotter Klaus Willecke Helmut Kettenmann | 2010 | 神经损伤与功能重建2010，5，3： | 2 |
| 2 | Periurethral collagen injection for stress incontinence with and without urethral hypermobility 显示文摘 | Steel AC Kohli N Karram MM | 2000 | Obstet Ggncol2000，95，： | 1 |
| 3 | Randomised trial of laparoscopic Burch colposuspension versus tension-free vaginal tape : Long-term follow-up显示文摘 | Jelovsek JE Barber MD Karram MM | 2008 | BJOG2008，115，： | 1 |
| 4 | Ultrasound and hookwire needle placement for localizatian of a hydrocele Of the canal of Nuck 显示文摘 | Miklos JR Karram NN Silver E | 1995 | Obstet Gynecol1995，85，5： | 1 |
| 5 | Implications of the natriuretic peptide system in the pathogenesis of heart failure:diagnostic and therapeutic importance显示文摘 | Abassi Z Karram T Ellaham S | 2004 | Pharmacol Ther2004，102，： | 1 |
| 6 | Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats显示文摘 | Brustle O Choudhary K Karram K | 1998 | Nat Biotechnol1998，16，11： | 1 |
| 7 | Implications of the natriuretic peptide system in the pathogenesis of heart failure:diagnostic and therapeutic importance显示文摘 | Abassi Z Karram T Ellaham S | 2004 | Pharmacol Therapeu2004，102，3： | 1 |
| 8 | Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats 显示文摘 | Brustle O Choudhary K Karram K | 1998 | Nat Biotechnol1998，16，11： | 1 |
| 9 | Are bile acids involved in the renal dysfunction of obstructive jaundice? An experimental study in bile duct ligated rats显示文摘 | Kaler B Karram T Morqan WA | 2004 | Ren Fail2004，26，5： | 1 |
| 10 | NG2 cells: Properties, progeny and origin显示文摘 | Trotter J Karram K Nishiyama A | 2010 | Brain Res Rev2010，63，12： | 1 |
| 11 | NG2-expressing cells in the nervous systera revealed by the NG2-EYFP-knockin mouse显示文摘 | Karram K Goebbels S Schwab M | 2008 | Genesis2008，46，12： | 1 |
| 12 | Are Bile Acids Involved in the Renal Dysfunction of Obstructive Jaundice? An Experimental Study in Bile Duct Ligated Rats显示文摘 | Balwant Kaler Tony Karram Winston A. Morgan Peter H. Bach Ibrahaim M. Yousef Arieh Bomzon | 2004 | Renal Failure2004，，5： | 1 |
| 13 | Poor outcome in radiation induced pericarditis显示文摘 | KARRAM T RINKEVITCH D MARKIEWICZ W | 1993 | Int J Rad Oncol1993，25，3： | 1 |
| 14 | Ultrasound an hookwire needle placement for localizatian of a hydrocele of the canal of Nuck显示文摘 | Miklos JR Karram MM Silver E | 1995 | Obstet Gynecol1995，85，5： | 1 |
| 15 | Laparoscoplc Butch colposuspension versus tension-free vaginal tape: a randomized trial显示文摘 | Paraiso MF Waiters MD Karram MM | 2004 | Obstet Gynecol2004，104，6： | 1 |
| 16 | Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats 显示文摘 | Brustle O Choudhary K Karram K | 1998 | Nat Biotechnol1998，16，11： | 1 |
| 17 | Implications of the natriuretic peptide system in the pathogenesis of heart failure:diagnosis and therapeutic importance显示文摘 | Abassi Z Karram T Ellaham S | 2004 | Pharmacol Ther2004，102，3： | 1 |
| 18 | Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats显示文摘 | Brustle O Choudhary K Karram K | 1998 | Nat Biotechnol1998，16，11： | 1 |
| 19 | In vitro generated neural progenitors participatein mammalian brain in development 显示文摘 | Brustle O Spiro AC Karram K | 1997 | Prox Nail Acad Sci USA1997，94，26： | 1 |
| 20 | Scientific basis for use of grafts during vaginal reconstructive procedures 显示文摘 | Silva WA Karram MM | 2005 | Curr Opin Obstet Gynecol2005，17，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员