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| 1 | After having changed the treatment of heart failure with reduced ejection fraction: what are the latest evidences with sacubitril valsartan?显示文摘1 Introduction Sacubitril/valsartan(SV)is a first in class dual action molecule of the neprilysin(NEP)inhibitor prodrug sacubitril(AHU377)and the angiotensin II receptor(Ang-II)type 1 antagonist valsartanJ11 It is the first angiotensin receptor-neprilysin inhibitor(ARNI)whose pharmacodynamic effects are consistent with a simultaneous stimulation of the natriuretic peptides system(via NEP inhibition)and the blockade of the renin-angiotensin-aldosterone system(valsartan effect)that finally results in systemic vasodilation,increased diuresis and natriuresis,reduction of plasmatic volume and diminution of peripheral vascular resistance. | Edgardo Kaplinsky | 2019 | Journal of Geriatric Cardiology2019，16，2： | 5 |
| 2 | Changing the treatment of heart failure with reduced ejection fraction: clinical use of sacubitril-valsartan combination显示文摘尽管有重要治疗学的进展,有长期的心失败(HF ) 的病人在病态和死亡的高风险留下。Sacubitril valsartan (以前作为 LCZ696 知道) 一个新口头的代理人与减少的喷射在成年人为征兆的长期的心失败的治疗被同意部分。自从它合并 neprilysin 禁止者, sacubitril 和血管收缩素 II,它在班血管收缩素受体 neprilysin 禁止者(ARNI ) 被描述为第一受体对手, valsartan。Neprilysin 是包括 natriuretic 毁坏几 vasoactive 肽的 endopeptidase 肽(NP ) , bradykinin, endothelin 和血管收缩素 II (Ang-II ) 。因此,它的抑制的自然后果是两个, NP 和 Ang-II 的 plasmatic 层次的增加(随相反的生物行动) 。那么,这些的联合抑制两个系统(Sacubitril / valsartan ) 可以在 HF 提高 NP 效果的好处(natriuresis,多尿,等等) 当 Ang-II 受体被禁止时(减少的血管缩小和醛固酮版本) 。在大临床的试用(与 8442 个病人一起的 PARADIGM-HF ) ,这个新代理人被发现显著地减少心血管,所有由于 HF 象住院一样引起死亡(与 enalapril 相比) 。这张手稿为 sacubitril valsartan, dosing 和小心考察临床的证据,在有减少的喷射的 HF 的治疗的未来方向和它的考虑地方部分。 | Edgardo Kaplinsky | 2016 | Journal of Geriatric Cardiology2016，13，11： | 4 |
| 3 | PARADIGM-HF trial: will LCZ696 change the current treatment of systolic heart failure?显示文摘 | Edgardo Kaplinsky | 2015 | Journal of Geriatric Cardiology2015，12，5： | 2 |
| 4 | The Value of Value Chains: Spreading the Gains from Globalization 显示文摘 | Gereftl Gary Kaplinsky Raphael | 2001 | IDS Bulletins2001，，3： | 1 |
| 5 | Globalization and Unequalisation:WhatCanbeLearnedfrom ValueChain Analysis-显示文摘 | Kaplinsky R | 2000 | JournalofDevelopmentStudies2000，37，： | 1 |
| 6 | The Value of Value Chains 显示文摘 | Gereffi G Raphael Kaplinsky | 2001 | IDS Bulletin2001，，： | 1 |
| 7 | Spreading the gains from globalisation: What Can be Learned from Value Chain Analysis?显示文摘 | Kaplinsky R | 2000 | Journal of Development Studies2000，37，11： | 1 |
| 8 | Spreading the Gains from Globalisation:What Can Be Learned from Value Chain Analysis显示文摘 | Kaplinsky R | | 0，，02： | 1 |
| 9 | Globalization and Unequalisation: What Can Be Learned from Value Chain Analysis 显示文摘 | Kaplinsky R | 2000 | Journal of Development Studies2000，37，2： | 1 |
| 10 | Detection of NASBA amplified bacterial tmRNA molecules on SLICSel designed microarray probes显示文摘 | Scheler O Kaplinski L Glynn B | 2011 | BMC Biotechnol2011，11，： | 1 |
| 11 | The stabilityand fate of a spliced intron from vertebrate cells显示文摘 | Clement JQ Qian L Kaplinsky N Wilkinson MF | 1999 | RNA1999，5，2： | 1 |
| 12 | Globalization and Unequalisation: What Can Be Learned from Value Chain Analysis显示文摘 | Kaplinsky R | 2000 | Journal of Development Studies2000，37，2： | 1 |
| 13 | Globalization and Unequalisation: What Can be Learned from Value Chain Analysis? 显示文摘 | Kaplinsky R | 2000 | Journal of Development Studies2000，37，2： | 1 |
| 14 | Putting supply chain leaming into practice显示文摘 | Bessant J Kaplinsky R Lamming R | 2003 | International Journal of Operations & Production Management2003，23，2： | 1 |
| 15 | Is globalization all it is cracked up to be?显示文摘 | Raphael Kaplinsky | 2001 | Review of International Political Economy2001，，1： | 1 |
| 16 | Fime size and technical change in a dynamic context显示文摘 | Kaplinsky R | 1983 | Journal of industrical Economics1983，32，： | 1 |
| 17 | The distinction between coronary and myocardial reperfusion after thrombolytic therapy by clinical markers of reperfusion显示文摘 | Shlomi Matetzky Dov Freimark Pierre Chouraqui Ilya Novikov Oren Agranat Babeth Rabinowitz Elieser Kaplinsky Hanoch Hod | 1998 | Journal of the American College of Cardiology1998，，5： | 1 |
| 18 | Globalisation and Unequalisation: What Can Be Learned from Value Chain Analysis?显示文摘 | R. Kaplinsky | 2000 | Journal of Development Studies2000，，2： | 1 |
| 19 | Frequency and prognostic significance of high-degree atrioventricular block in patients with a first non-Q-wave acute myocardial infarction显示文摘 | Haim M Hod H Kaplinsky E | 1997 | Am J Cardiol1997，47，79： | 1 |
| 20 | Introduction, Globalisati- on, value chains and development显示文摘 | Gereffi G Humphrey J Kaplinsky R | 2001 | IDS bulletin2001，32，3： | 1 |
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