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| 1 | Interleukin-1 receptor antagonist:From synthesis to therapeutic applications显示文摘The cytokine channel’s mechanism for self-regulation involves the application of antagonistic cytokines that are synthesized to connect to the receptors and release soluble cytokine receptors.The very first receptor antagonist of cytokine that was naturally present was interleukin-1 receptor antagonist(IL-1Ra).The IL-1Ra protein forms are disinfected from supernatants of cultured monocytes on stacked IgG.The family of IL-1 consists of IL-1α,IL-1βand IL-1Ra.Human monocytes regulate the production of IL-Ra.IL-Ra takes part in normal physiological functions by using specific antibodies,and acts as an anti-inflammatory agent.IL-Ra is synthesized in the tissues during the period of active disease and can be systematically measured and/or estimated.Maintenance of the levels of IL-Ra and IL-1 is the main factor for host resistance in patients during diseased conditions,as IL-Ra acts as an inherent regulator of various inflammatory responses.In this article,we focuse on how IL-Ra is synthesized and performs its functions once the inflammatory responses are activated. | KANWAL REHMAN AMMARA AFZAAL MUHAMMAD SAJID HAMID AKASH MUHAMMAD IMRAN MOHAMMED A.ASSIRI | 2023 | BIOCELL2023，47，4： | 0 |
| 2 | Biochemical association between the prevalence of genetic polymorphism and myocardial infarction显示文摘Genetic polymorphism has a vital role in the pathogenesis and development of myocardial infarction(MI).Single nucleotide polymorphism at any one of the amino acid sequences can result in a diseased state.A single gene can exhibit genetic polymorphism at more than one position giving rise to different variants.Genetic polymorphism of angiotensinogen(AGT)M235T,AGT T174M,and angiotensin-1-converting enzyme(ACE)I/D,endothelial nitric oxide synthase(eNOS),and methylenetetrahydrofolate reductase(MTHFR)can be a risk factor for MI.However,it is important to study the prevalence of genetic polymorphisms of these genes among different populations.MI is influenced by genetic polymorphism of various genes,including AGT,ACE,eNOS,MTHFR,etc.However,the association of genetic polymorphism of these genes varies among different populations,but different ethnic groups could show contradictory results.These genes have shown a positive association with risks of MI in some populations,whereas the results have not been consistent with every ethnic group.In this article,we have summarized the genetic variations in the aforementioned genes and their association with MI. | MOMINA SHAHID KANWAL REHMAN MUHAMMAD SAJID HAMID AKASH SHALEEM SUHAIL SUMBAL RASHEED MUHAMMAD IMRAN MOHAMMED AASSIRI | 2023 | BIOCELL2023，47，3： | 0 |
| 3 | A Secure and Efficient Cluster-Based Authentication Scheme for Internet of Things(IoTs)显示文摘IPv6 over Low PowerWireless Personal Area Network(6LoWPAN)provides IP connectivity to the highly constrained nodes in the Internet of Things(IoTs).6LoWPANallows nodeswith limited battery power and storage capacity to carry IPv6 datagrams over the lossy and error-prone radio links offered by the IEEE 802.15.4 standard,thus acting as an adoption layer between the IPv6 protocol and IEEE 802.15.4 network.The data link layer of IEEE 802.15.4 in 6LoWPAN is based on AES(Advanced Encryption Standard),but the 6LoWPANstandard lacks and has omitted the security and privacy requirements at higher layers.The sensor nodes in 6LoWPANcan join the network without requiring the authentication procedure.Therefore,from security perspectives,6LoWPAN is vulnerable to many attacks such as replay attack,Man-in-the-Middle attack,Impersonation attack,and Modification attack.This paper proposes a secure and efficient cluster-based authentication scheme(CBAS)for highly constrained sensor nodes in 6LoWPAN.In this approach,sensor nodes are organized into a cluster and communicate with the central network through a dedicated sensor node.The main objective of CBAS is to provide efficient and authentic communication among the 6LoWPAN nodes.To ensure the low signaling overhead during the registration,authentication,and handover procedures,we also introduce lightweight and efficient registration,de-registration,initial authentication,and handover procedures,when a sensor node or group of sensor nodes join or leave a cluster.Our security analysis shows that the proposed CBAS approach protects against various security attacks,including Identity Confidentiality attack,Modification attack,Replay attack,Man-in-the-middle attack,and Impersonation attack.Our simulation experiments show that CBAS has reduced the registration delay by 11%,handoff authentication delay by 32%,and signaling cost by 37%compared to the SGMS(Secure GroupMobility Scheme)and LAMS(Light-Wight Authentication&Mobility Scheme). | Kanwal Imran Nasreen Anjum Abdullah Alghamdi Asadullah Shaikh Mohammed Hamdi Saeed Mahfooz | 2022 | Computers, Materials & Continua2022，，1： | 0 |
| 4 | Cluster-Based Group Mobility Support for Smart IoT显示文摘IPv6 over Low Power Wireless Personal Area Network(6LoWPAN)connects the highly constrained sensor nodes with the internet using the IPv6 protocol.6LoWPAN has improved the scalability of the Internet of Things(IoTs)infrastructure and allows mobile nodes to send packets over the IEEE 802.15.4 wireless network.Several mobility managements schemes have been suggested for handling the registration and handover procedures in 6LoWPAN.However,these schemes have performance constraints,such as increased transmission cost,signalling overhead,registration,and handover latency.To address these issues,we propose a novel cluster-based group mobility scheme(CGM6)for 6LoWPAN.To reduce the signalling cost in the CGM6 scheme,we propose to combine the functions of the Authentication,Authorization and Accounting(AAA)server and Local Mobility Anchor(LMA)in AMAG6(AAA+MAG for 6LoWPAN).AMAG6 acts as a cluster head and exchange its information directly with its neighbouring AMAG6 during the mobility.Furthermore,AMAG6 is responsible for the binding and authentication process.To reduce the transmission cost,we also propose enhancements in registration and Handover procedures.The performance of CGM6 is evaluated through extensive simulations.The simulation results show that CGM6 has reduced the handoff latency by 32%,registration delay by 11%and transmission cost by 37%compared to the state-of-the-art mobility management schemes. | Kanwal Imran Nasreen Anjum Saeed Mahfooz Muhammad Zubair Zhahoui Yang Abdul Haseeb Malik Qazi Ejaz Ali Madeeha Aman | 2021 | Computers, Materials & Continua2021，，8： | 0 |
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