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| 1 | A novel surface molecularly imprinted polymer as the solid-phase extraction adsorbent for the selective determination of ampicillin sodium in milk and blood samples显示文摘Surface molecularly imprinted polymers(SMIPs) for selective adsorption of ampicillin sodium were synthesized using surface molecular imprinting technique with silica gel as a support.The physical and morphological characteristics of the polymers were investigated by scanning electron microscope(SEM),Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),elemental analysis and nitrogen adsorption–desorption test.The obtained results showed that the SMIPs displayed great adsorption capacity(13.5 μg/mg),high recognition ability(the imprinted factor is 3.2) and good binding kinetics for ampicillin sodium.Finally,as solid phase extraction adsorbents,the SMIPs coupled with HPLC method were validated and applied for the enrichment,purification and determination of ampicillin sodium in real milk and blood samples.The averages of spiked accuracy ranged from 92.1% to 107.6%.The relative standard deviations of intra- and inter-day precisions were less than 4.6%.This study provides a new and promising method for enriching,extracting and determining ampicillin sodium in complex biological samples. | Ningli Wu Zhimin Luo Yanhui Ge Pengqi Guo Kangli Du Weili Tang Wei Du Aiguo Zeng Chun Chang Qiang Fu | 2016 | Journal of Pharmaceutical Analysis2016，6，3： | 6 |
| 2 | Engineering practice and economic analysis of ozone oxidation wet denitrification technology显示文摘SO_(2)and NO emitted from coal-fired power plants have caused serious air pollution in China.In this study,a test system for NO oxidation using O_(3)is established.The basic characteristics of NO oxidation and products forms are studied.A separate test system for the combined removal of SO_(2)and NO_(x)is also established,and the absorption characteristics of NO_(x)are studied.The characteristics of NO oxidation and NO_(x)absorption were verified in a 35 t·h^(-1)industrial boiler wet combined desulfurization and denitrification project.The operating economy of ozone oxidation wet denitrification technology is analyzed.The results show that O_(3)has a high rate and strong selectivity for NO oxidation.When O_(3)is insufficient,the primary oxidation product is NO_(2).When O_(3)is present in excess,NO_(2)continues to get oxidized to N_(2)O_(5)or NO_(3).The removal efficiency of NO_(2)in alkaline absorption system is low(only about 15%).NOx removal efficiency can be improved by oxidizing NO_(x)to N_(2)O_(5)or NO_(3)by increasing ozone ratio.When the molar ratio of O_(3)/NO is 1.77,the NOx removal efficiency reaches 90.3%,while the operating cost of removing NO_(x)per kilogram is 6.06 USD(NO_(2)). | Yang Li Defu Che Chenglong Yang Mingyu Yao Tingwen Zhao Kangli Fu Hanchen Zhao | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 3 |
| 3 | Determination of azithromycin in raw materials and pharmaceutical formulations by HPLC coupled with an evaporative light scattering detector显示文摘A simple high-performance liquid chromatography(HPLC)method coupled with an evaporative light scattering detector(ELSD)was developed for the determination of azithromycin in raw materials and pharmaceutical formulations(injections,capsules and tablets)without any pretreatment or derivatization step.Azithromycin,degradation products and formulation ingredients were separated efficiently by using the mobile phase consisted of ammonium acetate(0.05 M,pH 8.0)and acetonitrile(60:40,v/v)in an isocratic mode at 0.8 ml/min flow rate.Parameters of ELSD were 60C for evaporation temperature and 50 psi for pressure of carrier gas(air).A logarithmic calibration curve was obtained from 50.93 to 509.30 mg/ml(r¼0.9996)for azithromycin,with the limit of detection(LOD)of 6.75 mg/ml(S/n¼3)and the limit of quantification of 22.50 mg/ml(S/n¼10).The developed method was validated and applied with satisfactory accuracy and precision for the determination of azithromycin in raw materials and pharmaceutical formulations(recovery 99e102%,RSD<1.2%,n¼3).No significant difference(t-test)was found between the results of the developed HPLCeELSD method and the HPLCeUV or microbiological method. | Aiguo Zeng Xia Liu Siruo Zhang Yan Zheng Ping Huang Kangli Du Qiang Fu | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，2： | 0 |
| 4 | Kunming mouse strain is less susceptible to elastase-induced abdominal aortic aneurysms显示文摘Background:Porcine pancreatic elastase(PPE)is successfully used to induce abdominal aortic aneurysm(AAA)in mice.However,differences between mouse strains in susceptibility to PPE induction have been reported.Kunming mouse is one of the most frequently used strains in China but whether it is suitable for induction of AAA by PPE application remains unclear.Methods:PPE infusion(1.5 units/ml)in temporary controlled aorta was performed to induce AAAs in both C57BL/6J and Kunming mice.Phosphatebuffered saline(PBS)application was used as vehicle control.The aorta diameters of all mice were measured at days 0 and 14 after surgery to evaluate the AAA formation.Results:After 14 days of PPE or PBS infusion,all mice were sacrificed and aorta tissues were collected for histological staining analysis.At the 14th day after infusion,PPE successfully induced aortic dilation in Kunming mice and typical AAA in C57BL/6J mice.The aorta diameter increased by 0.23 mm in Kunming mice after PPE infusion,while it was 0.72 mm in the C57BL/6J strain.PPE induced mild elastin degradation,smooth muscle cell(SMC)depletion and mural leucocyte infiltration in Kunming mice,but in PPE-sensitive C57BL/6J mice,it induced total loss of SMCs,elastin disappearance and diffused infiltrated leucocytes in aortic aneurysmal segments.The effects of PPE in inducing angiogenesis and upregulating matrix metalloproteinase 2 and 9 expression in Kunming mice were also weaker than that in C57BL/6J mice.Conclusion:At the reported dose of PPE,Kunming mouse is not as susceptible to AAA formation as C57BL/6J mice.The failure of PPE to induce AAA formation in Kunming mice may be associated to its inability to boost a strong inflammatory response. | Haole Liu Kangli Tian Congcong Xia Panpan Wei Boyu Xu Weilai Fu Yankui Li Yafeng Li Liang Bai Rong Wang Weirong Wang Baohui Xu Enqi Liu Sihai Zhao | 2022 | Animal Models and Experimental Medicine2022，5，1： | 0 |
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