|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13显示文摘Dendritic cells(DCs)are indispensable for defense against pathogens but may also contribute to immunopathology.Activation of DCs upon the sensing of pathogens by Toll-like receptors(TLRs)is largely mediated by pattern recognition receptor/nuclear factor-κB(NF-κB)signaling and depends on the appropriate ubiquitination of the respective signaling molecules.However,the ubiquitinating and deubiquitinating enzymes involved and their interactions are only incompletely understood.Here,we reveal that the deubiquitinase OTU domain,ubiquitin aldehyde binding 1(OTUB1)is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.Stimulation of DCs with the TLR11/12 ligand T.gondii profilin and the TLR4 ligand lipopolysaccharide induced an increase in NF-κB activation in OTUB1-competent cells,resulting in elevated interleukin-6(IL-6),IL-12,and tumor necrosis factor(TNF)production,which was also observed upon the specific stimulation of TLR2,TLR3,TLR7,and TLR9.Mechanistically,OTUB1 promoted NF-κB activity in DCs by K48-linked deubiquitination and stabilization of the E2-conjugating enzyme UBC13,resulting in increased K63-linked ubiquitination of IRAK1(IL-1 receptor-associated kinase 1)and TRAF6(TNF receptor-associated factor 6).Consequently,DC-specific deletion of OTUB1 impaired the production of cytokines,in particular IL-12,by DCs over the first 2 days of T.gondii infection,resulting in the diminished production of protective interferon-γ(IFN-γ)by natural killer cells,impaired control of parasite replication,and,finally,death from chronic T.encephalitis,all of which could be prevented by low-dose IL-12 treatment in the first 3 days of infection.In contrast,impaired OTUB1-deficient DC activation and cytokine production by OTUB1-deficient DCs protected mice from lipopolysaccharide-induced immunopathology.Collectively,these findings identify OTUB1 as a potent novel regulator of DCs during infectious and inflammatory diseases. | Floriana Mulas Xu Wang Shanshan Song Gopala Nishanth Wenjing Yi Anna Brunn Pia-Katharina Larsen Berend Isermann Ulrich Kalinke Antonio Barragan Michael Naumann Martina Deckert Dirk Schlüter | 2021 | Cellular & Molecular Immunology2021，18，6： | 4 |
| 2 | Combinatorialimmunoglobulin light chain variability creates sufficient B celldiversity to mount protective antibody responses against pathogeninfections 显示文摘 | Senn BM Lopez-Macias C Kalinke U | 2003 | Eur J Immunol2003，33，4： | 1 |
| 3 | Walking pedestrian recognition 显示文摘 | Curio C Edelbrunner J Kalinker T | 2000 | IEEE Transactions on Intelligent Transportation Systems2000，1，3： | 1 |
| 4 | A highly immunogenic and protective middle east respiratory syndrome coro- navirus vaccine based on a recombinant measles virus vaccine platform显示文摘 | Malczyk A H Kupke A Prufer S Scheuplein V A Hutzler S Kreuz D Beissert T Bauer S Hubich Rau S Tondera C Eldin H S Schmidt J Vergara-Alert J Suzer Y Seifried J Hanschmann K M Kalinke U Herold S Sahin U Cichutek K Waibler Z Eickmann M Becker S Muhlebach M D | 2015 | J Virol2015，89，11： | 1 |
| 5 | Walking pe- destrian recognition 显示文摘 | Curio C Edelbrunner J Kalinker T | 2000 | IEEE Transactions on Intelli- gent Transportation Systems2000，1，3： | 1 |
| 6 | Endogenous,or therapeutically induced,type I interferon responses differentially modulate Th1 /Th 17-mediated autoimmunity in the CNS显示文摘 | Kalinke U Prinz M | 2012 | Immunol Cell Biol2012，90，5： | 1 |
| 7 | Walking pedestrian r ecognition显示文摘 | Cur io C Edelbrunner J Kalinker T | | 0，，03： | 1 |
| 8 | The role of anti- body concentration and avidity in antiviral protection 显示文摘 | Bachmann MF Kalinke U Althage A et ol | 1997 | Scie- nce1997，276，5321： | 1 |
| 9 | An image processing system for driver assistance显示文摘 | U Handmann T Kalinke C Tzomakas M.Werner W.v.Seelen | | 0，，： | 1 |
| 10 | An image processing system for driver assistance显示文摘 | Handmann U Kalinke T Tzomakas C | 2000 | Image and Vision Computing2000，18，5： | 1 |
| 11 | The role of anti-,body concentration and avidity in antiviral protection显示文摘 | Bachmann MF Kalinke U Althage A | 1997 | Science1997，276，： | 1 |
| 12 | IFNalpha activates dormant haematopoietic stem cells in vivo显示文摘 | Essers M A Offner S Blanco-Bose W E Waibler Z Kalinke U DuchosaI M A | 2009 | Nature2009，458，： | 1 |
| 13 | An Image Processing System for Driver Assistance显示文摘 | Handmann U Kalinke T Tzomakas C | 2000 | Image and Vision Computing2000，18，5： | 1 |
| 14 | Crystallization Kinetics of Pure and Fiber-reinforced Poly (Phenylene Sulfide) 显示文摘 | Auer C Kalink G Krause TH | 1994 | Journal of Applied Polymer Science1994，51，3： | 1 |
| 15 | Protective role of interferonβ in host defense against influenza A virus显示文摘 | KOERNER I KOCHS G KALINKE U | 2006 | J Virol2006，10，： | 1 |
| 16 | Walking pedestrian recognition显示文摘 | Curio C Edelbrunner J Kalinke T | 2000 | IEEE Transactions on Intelligent Transportation System2000，1，3： | 1 |
| 17 | An Image Process- ing System for Driver Assistanee显示文摘 | Handmann U Kalinke T Tzomakas C | 2000 | Image and Vision Compu- ting2000，18，5： | 1 |
| 18 | Toward Biosimilar Monoclonal Antibodies 显示文摘 | Schneider C K Kalinke U | 2008 | Nature Biotechnology2008，26，9： | 1 |
| 19 | Walking Pedestrian Recognition显示文摘 | Cristobal Curio Johann Edelbrunner Thosmas Kalinke | 2000 | IEEE Transactions on ITS2000，1，3： | 1 |
| 20 | An image processing system for dirver assistance显示文摘 | U Handmann T Kalinke C Tzomakas M Werner and W Seelen | 2000 | image and vision computing2000，18，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员