|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 2 | Response surface analysis and sinulation as tool for bioprocess design and optimization显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，6： | 1 |
| 3 | Response surface analysis and simulation as a tool for bioprocess design and optimization显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，： | 1 |
| 4 | Response surface analysis and simulation as a tool for bioproeess design and optimization 显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Pro- gress Biochemistry2000，35，6： | 1 |
| 5 | Response surface analysis and simulation as a tool for bioprocess design and optimization 显示文摘 | Kalil J Maugeri F Rodrigues M I | 2000 | Process Biochem2000，35，： | 1 |
| 6 | Response surface analysis and simulation as a tool for bioprocess design and optimization显示文摘 | KALIL S J MAUGERI F RODRIGUES M I | 2000 | Process Biochemistry2000，35，： | 1 |
| 7 | Response surface analysis and simulation as a tool for bioprocess design and optimization 显示文摘 | KALIL S J MAUGERI F RODRIGUES M I | 2000 | Proc Biochem2000，35，： | 1 |
| 8 | Response surface analysis and simulation as a tool for bioprocess design and optimization显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，6： | 1 |
| 9 | Response surface analysis and simulation as a tool for bioprocess design and optimization 显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，6： | 1 |
| 10 | Response surface analysis and simulation as a tool for bioprocess design and optimization 显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，6： | 1 |
| 11 | Response surface analysis and simulation as a tool for bioprocess design andoptimization显示文摘 | Kalil SJ Maugeri F Rodrigues M I | 2000 | ProcessBioehemistry2000，35，： | 1 |
| 12 | Response surface analysis and simulation as a tool for bioprocess design and optimization 显示文摘 | KALIL S J MAUGERI F RODRIGUES M I | 2000 | process Biochemistry2000，35，6： | 1 |
| 13 | Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the infectious diseases society of america and the american thoracic society 显示文摘 | Kalil AC Metersky ML Klompas M | 2016 | Clin Infect Dis2016，63，5： | 1 |
| 14 | Response surface analysis and simulation as a tool for bioprocess design and optimization显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | J Process Biochem2000，35，： | 1 |
| 15 | Response surface analysis and simulation as a tool for bioprocess design and optimization 显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Proc Biochem2000，35，： | 1 |
| 16 | Linezolid versus vaneomycin or teicoplanin for nosocomial pneumonia: A systematic review and meta-analysis显示文摘 | Kalil A C Murthy M H Hermsen E D | 2010 | Crit Care Med2010，38，9： | 1 |
| 17 | Response surface analysis and simulation as a tool for bioprocess design and optimization显示文摘 | Kalil S J Maugeri F Rodrigues M I | | 0，，06： | 1 |
| 18 | Response surface analysis and simulation as a tool for bioprocess design and optimization显示文摘 | Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，： | 1 |
| 19 | Response sur- face analysis and simulation as a tool for bioprocess design and optimization 显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，6： | 1 |
| 20 | Induction of immunologictolerance to myelin basic protein prevents central nervous systemautoimmunity and improves outcome after stroke显示文摘 | Gee JM Kalil A Thullbery M | 2008 | Stroke2008，39，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员