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| 1 | ^(18)F-fluorodeoxyglucose positron emission tomography in the diagnosis of small pancreatic cancer显示文摘AIM:To investigate the role of 18 F-fluorodeoxyglucose positron emission tomography(FDG-PET) in the diagnosis of small pancreatic cancer. METHODS:This study involved 31 patients with proven invasive ductal cancer of the pancreas.The patients were divided into 3 groups according to the maximum diameter of the tumor:TS1(maximum tumor size≤2.0 cm) ,TS2(>2.0 cm and≤4.0 cm) or TS3-4(>4.0 cm) .The relationships between the TS and various diagnostic tools,including FDG-PET with dual time point evaluation,were analyzed. RESULTS:The tumors ranged from 1.3 to 11.0 cm in diameter.Thirty of the 31 patients(97%) had a positive FDG-PET study.There were 5 patients classified as TS1,15 as TS2 and 11 as TS3-4.The sensitivity of FDG-PET,computed tomography(CT) and magnetic resonanceimaging(MRI) were 100%,40%,0%in TS1,93%,93%,89%in TS2 and 100%,100%,100%in TS3-4. The sensitivity of FDG-PET was significantly higher in comparison to CT and MRI in patients with TS1(P< 0.032) .The mean standardized uptake values(SUVs) did not show a significant difference in relation to the TS(TS1:5.8±4.5,TS2:5.7±2.2,TS3-4:8.2±3.9) ,respectively.All the TS1 tumors(from 13 to 20 mm) showed higher SUVs in FDG-PET with dual time point evaluation in the delayed phase compared with the early phase,which suggested the lesions were malignant. CONCLUSION:These results indicate that FDG-PET with dual time point evaluation is a useful modality for the detection of small pancreatic cancers with a diameter of less than 20 mm. | Keiichi Okano Keitaro Kakinoki Shintaro Akamoto Masanobu Hagiike Hisashi Usuki Yuka Yamamoto Yoshihiro Nishiyama Yasuyuki Suzuki | 2011 | World Journal of Gastroenterology2011，17，2： | 12 |
| 2 | High total Joule heat increases the risk of post-endoscopic submucosal dissection electrocoagulation syndrome after colorectal endoscopic submucosal dissection显示文摘BACKGROUND We hypothesized that thermal damage accumulation during endoscopic submucosal dissection(ESD)causes the pathogenesis of post-ESD electrocoagulation syndrome(PECS).AIM To determine the association between Joule heat and the onset of PECS.METHODS We performed a retrospective cohort study in patients who underwent colorectal ESD from May 2013 to March 2021 in Japan.We developed a novel device that measures swift coagulation time with a sensor adjacent to the electrosurgical coagulation unit foot switch,which enabled us to calculate total Joule heat.PECS was defined as localized abdominal pain(visual analogue scale≥30 mm during hospitalization or increased by≥20 mm from the baseline)and fever(temperature≥37.5 degrees or white blood cell count≥10000μ/L).Patients exposed to more or less than the median Joule heat value were assigned to the high and low Joule heat groups,respectively.Statistical analyses included Mann-Whitney U and chisquare tests and logistic regression and receiver operating characteristic curve(ROC)analyses.RESULTS We evaluated 151 patients.The PECS incidence was 10.6%(16/151 cases),and all patients were followed conservatively and discharged without severe complications.In multivariate analysis,high Joule heat was an independent PECS risk factor.The area under the ROC curve showing the correlation between PECS and total Joule heat was high[0.788(95%confidence interval:0.666-0.909)].CONCLUSION Joule heat accumulation in the gastrointestinal wall is involved in the onset of PECS.ESD-related thermal damage to the peeled mucosal surface is probably a major component of the mechanism underlying PECS. | Masanori Ochi Ryosuke Kawagoe Toshiro Kamoshida Yukako Hamano Haruka Ohkawara Atsushi Ohkawara Nobushige Kakinoki Yuji Yamaguchi Shinji Hirai Akinori Yanaka Kiichiro Tsuchiya | 2021 | World Journal of Gastroenterology2021，27，38： | 2 |
| 3 | A patient with unresectable advanced pancreatic cancer achieving long-term survival with Gemcitabine chemotherapy显示文摘A 68-year-old female visited a local clinic with epigastralgia. A routine laboratory test revealed jaundice and liver dysfunction. She was referred to this hospital. Abdominal computed tomography (CT) and endoscopic retrograde cholangio-pancreatography (ERCP) revealed that the density of the entire pancreas had decreased,and showed dilatation of the common bile duct (CBD) and the main pancreatic duct (MPD). Pancreatic cancer was diagnosed by cytological examination analyzing the pancreatic juice obtained by ERCP. When jaundice had decreased the tumor was observed via laparotomy. No ascites,liver metastasis,or peritoneal dissemination was observed. The entire pancreas was a hard mass,and a needle biopsy was obtained from the head,body and tail of the pancreas. These biopsies diagnosed a poorly differentiated adenocarcinoma. Hepaticojejunostomy was thus performed,and postoperative progress was good. Chemotherapy with 1000 mg/body per week of gemcitabine was administered beginning 15 d postoperatively. However,the patient suffered relatively severe side effects,and it was necessary to change the dosing schedule of gemcitabine. Abdominal CT revealed a complete response (CR) after 3 treatments. Therefore,weekly chemotherapy was stopped and was changed to monthly administration. To date,for 4 years after chemotherapy,the tumor has not reappeared. | Yoshiki Okamoto Takashi Maeba Keitarou Kakinoki Keiichi Okano Kunihiko Izuishi Hisao Wakabayashi Hisashi Usuki Yasuyuki Suzuki | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 4 | Hand-assisted Laparos- copic splenetomy for thrombocytopenia in patients with cir- rhosis 显示文摘 | Kakinoki K Okano K Suto H | 2013 | Surg Today2013，43，8： | 1 |
| 5 | Pancreatic thickness as a predictive factor for postoperative pancreatic fistula after distal pancreatectomy using an endopath stapler显示文摘 | Okano K Oshima M Kakinoki K | | 0，，2： | 1 |
| 6 | Suture granuloma showing false-positive findings on FDG-PET显示文摘 | Takahara K Kakinoki H Ikoma S | 2013 | Case Rep Urol2013，2013，47： | 1 |
| 7 | Prospective comparisons of intravitreal injections of triameinolone aeetonide and bevaeizumab for maeular oedema due to branch retinal vein occlusion 显示文摘 | Higashiyama T Sawada O Kakinoki M et at | 2013 | Acta Ophthalmol2013，91，： | 1 |
| 8 | Magnetic characterristics of electro-magnetic levitation system for short-radius curve track 显示文摘 | Nomiyama T Kakinoki T Yamaguchi H | 2006 | Electrical Engineering in Japan2006，156，3： | 1 |
| 9 | Second dor- sal metacarpal artery muscle flap: an adjunct in the treatment of chronic phalangeal osteomyelitis显示文摘 | KAKINOKI R LKEGUCHI R NAKAMURA T | 2004 | J Hand Surg Am2004，29，1： | 1 |
| 10 | Hand-assisted laparoscopic splenec- tomy for thrombocytopenia in patients with cirrhosis显示文摘 | Kakinoki k Okano k Suto H | 2013 | Surg Today2013，43，8： | 1 |
| 11 | Preparation of poly-lac- tic acid microspheres containing the angiogenesis inhibitor TNP-470 with medium-chain triglyceride and the in vitro e- valuation of release profiles显示文摘 | Kakinoki S Yasuda C Kaetsu I | 2003 | Eur J Pharm Biopharm2003，55，2： | 1 |
| 12 | Up-regulation of nuclear PP1 alpha and PP1 delta in hepatoma cells 显示文摘 | Imai Y Kakinoki Y Takizawa N | 1999 | Int J Oncol1999，14，： | 1 |
| 13 | Effect of immunothera- py on serum levels of eosinophil cationic protein in perennial al lergic rhinitis显示文摘 | Ohashi Y Nakai Y Kakinoki Y | 1997 | Ann Otol Rhinol Laryngol1997，106，101： | 1 |
| 14 | Predic- tion of ambulation ability following total hip arthroplasty 显示文摘 | Nankaku M Tsuboyama T Kakinoki R | 2011 | J Orthop Sci2011，16，4： | 1 |
| 15 | Vascular endothelial growth factor in the aqueous humour in eyes with myopic cho- roidal neovaseularization 显示文摘 | Sawada O Kawamura H Kakinoki M | 2011 | Acta ()phthalmol2011，89，5： | 1 |
| 16 | Isolation and characterization of bacterial strains that have high ability to degrade 1,4-dioxane as a sole carbon and energy source显示文摘 | Sei K Miyagaki K Kakinoki T | 2013 | Biodegradation2013，24，5： | 1 |
| 17 | Evans syndrome associated with idiopathic mixed-type autoimmune hemolytic anemia显示文摘 | KAKINOKI Y NAGASE M OKADA K | 2008 | Rinsho Ketsueki2008，49，7： | 1 |
| 18 | Pharmacokinetics of bevacizumab and its effect on vascular endothelial growth factor after intravitreal injection of bevacizumab in macaque eyes显示文摘 | Miyake T Sawada O Kakinoki M | 2010 | Invest Ophthalmol Vis Sci2010，51，3： | 1 |
| 19 | Pancreatic thickness as a predictive factor for postoperative pancreatic fistula after distal pancreatectomy using an endopath stapler显示文摘 | Okano K Oshima M Kakinoki K | 2013 | Surg Today2013，43，2： | 1 |
| 20 | Hand-assisted laparoscopic splenectomy for thrombocytopenia in patients with cirrhosis显示文摘 | Kakinoki K Okano K Suto H | 2013 | Surg Today2013，43，8： | 1 |
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