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| 1 | Signaling pathways and therapeutic interventions in gastric cancer显示文摘Gastric cancer(GC)ranks fifth in global cancer diagnosis and fourth in cancer-related death.Despite tremendous progress in diagnosis and therapeutic strategies and significant improvements in patient survival,the low malignancy stage is relatively asymptomatic and many GC cases are diagnosed at advanced stages,which leads to unsatisfactory prognosis and high recurrence rates.With the recent advances in genome analysis,biomarkers have been identified that have clinical importance for GC diagnosis,treatment,and prognosis.Modern molecular classifications have uncovered the vital roles that signaling pathways,including EGFR/HER2,p53,PI3K,immune checkpoint pathways,and cell adhesion signaling molecules,play in GC tumorigenesis,progression,metastasis,and therapeutic responsiveness.These biomarkers and molecular classifications open the way for more precise diagnoses and treatments for GC patients.Nevertheless,the relative significance,temporal activation,interaction with GC risk factors,and crosstalk between these signaling pathways in GC are not well understood.Here,we review the regulatory roles of signaling pathways in GC potential biomarkers,and therapeutic targets with an emphasis on recent discoveries.Current therapies,including signaling-based and immunotherapies exploited in the past decade,and the development of treatment for GC,particularly the challenges in developing precision medications,are discussed.These advances provide a direction for the integration of clinical,molecular,and genomic profiles to improve GC diagnosis and treatments. | Zi-Ning Lei Qiu-Xu Teng Qin Tian Wei Chen Yuhao Xie Kaiming Wu Qianlin Zeng Leli Zeng Yihang Pan Zhe-Sheng Chen Yulong He | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 4 |
| 2 | Single image haze removal using dark channel prior 显示文摘 | He Kaiming Sun Jian Tang Xiaoou | 2011 | IEEE Transac- tions on Pattern Analysis and Machine Intelligence2011，33，12： | 1 |
| 3 | Single image haze removal using dark channel prior显示文摘 | He Kaiming Sun Jian Tang Xiaoou | | 0，，12： | 1 |
| 4 | Single image haze removal using dark channel prior显示文摘 | He Kaiming Sun Jian Tang Xiaoou | 2011 | IEEE Trans on PAMI2011，33，12： | 1 |
| 5 | Guided image filtering显示文摘 | He Kaiming Sun Jian Tang Xiaoou | 2013 | IEEE Transactions on Pattern Analysis and Machine Intelligence2013，35，6： | 1 |
| 6 | Single Image Haze Removal Using Dark Channel Prior 显示文摘 | Kaiming He Jian Sun Xiaoou Tang | 2009 | IEEE Computer Society Conference on Computer Vision and Pattern Recongnition Workshops2009，2009，： | 1 |
| 7 | Guided image filte- ring 显示文摘 | HE Kaiming SUN Jian TANG Xiaoou | 2013 | IEEE Transactions on Pattern Analysis and Machine Intelligence2013，35，6： | 1 |
| 8 | The role of the TLR4 signaling pathway in cognitive deficits followingsurgery in aged rats显示文摘 | Yi Wang Huijuan He Dan Li Wenjing Zhu Kaiming Duan Yuan Le Yan Liao Yangwen Ou | 2013 | Molecular Medicine Reports2013，，： | 1 |
| 9 | Single Image Haze Removal Using Dark Channel Prior显示文摘 | He Kaiming Sun Jian Tang Xiaoou | 2011 | IEEE Transactions on Pattern Analysis and Machine Intelligence2011，33，12： | 1 |
| 10 | Guided Image Filtering显示文摘 | He Kaiming Sun Jian Tang Xiaoou | 2013 | Transactions on Pattern and Machine Intelligence2013，35，6： | 1 |
| 11 | Single image haze removal using dark channel prior 显示文摘 | HE Kaiming SUN Jian TANG Xiaoou | 2011 | Pattern Analysis and Machine Intelligence2011，33，12： | 1 |
| 12 | Single image haze removal using dark channel prior显示文摘 | He Kaiming Sun Jian Tang Xiaoou | 2011 | IEEE Transactions on pattern Analysis and Machine Intelligence2011，33，12： | 1 |
| 13 | Rectanglingpanoramic images via warping 显示文摘 | He Kaiming Chang Huiwen and Sun Jian | 2013 | ACM Transactionson Graphics (S0730-0301)2013，32，4： | 1 |
| 14 | Single image haze removal using dark channel prior 显示文摘 | He Kaiming Sun Jian Tang Xiaoou | 2011 | IEEE Transactions on Pattern Analysis and Machine Intelligence2011，33，12： | 1 |
| 15 | Guided image filte- ring显示文摘 | He Kaiming Sun Jian Tang Xiaoou | 2013 | IEEE Transactions on Pattern Analysis and Ma- chine Intelligence2013，35，6： | 1 |
| 16 | Guided image filtering显示文摘 | He Kaiming Sun Jian Tang Xiaoou | 2013 | IEEE2013，35，6： | 1 |
| 17 | Single Image Haze Removal Using Dark Channel Prior显示文摘 | He Kaiming Sun Jian Tang Xiaoou | 2011 | IEEE Transactions on Pattern Analysis and Machine Intelligence2011，33，12： | 1 |
| 18 | Guided Image Filtering显示文摘 | He Kaiming Sun Jian Tang Xiaoou | 2013 | IEEE Transactions on Pattern Analysis and Machine Intelligence2013，35，6： | 1 |
| 19 | Guided Image Filtering显示文摘 | He Kaiming Sun Jian Tang Xiaoou | 2013 | IEEE Transactions on Pattern Analysis and Machine Intelligence2013，35，6： | 1 |
| 20 | Single Image Haze Removal Using Dark Channel Prior显示文摘 | He Kaiming Sun Jian Tang Xiao | 2011 | IEEE Transactions on Pattern Analysis and Machine Intelligence2011，33，12： | 1 |
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