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| 1 | Generation and functional characterization of a conditional Pumilio2 null allele显示文摘The highly conserved RNA binding protein PUF(Pumilio/FBF) family is present throughout eukaryotes from yeast to mammals, with critical roles in development, fertility and the nervous system. However, the function of the mammalian PUF family members remains underexplored. Our previous study reported that a gene-trap mutation of Purm2 results in a smaller testis but does not impact fertility and viability. Although the gene-trap mutation disrupted the key functional domain of PUM protein-PUM-HD(Pumilio homology domain), but still produced a chimeric Pum2-β-geo protein containing part of PUM2, raising a question if such a chimeric protein may provide any residual function or contribute to the reproductive phenotype. Here, we report the generation of a conditional PUM2 allele,when knocked out, producing no residual PUM2 and hence a complete loss-of-function allele. We also uncovered small but significant reduction of male fertility and viability in the mutants, suggesting requirement of PUM2 for male fertility and viability. | Kaibo Lin Shikun Zhang Jieli Chen Ding Yang Mengyi Zhu Eugene Yujun Xu | 2018 | The Journal of Biomedical Research2018，32，6： | 1 |
| 2 | Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging 显示文摘 | Lin Yuan Lin Weiying Zheng Kaibo | 2013 | Chemical Society Reviews2013，42，： | 1 |
| 3 | Balancing green and grain trade显示文摘 | CHEN Yiping WANG Kaibo LIN Yishan | 2015 | Nature Geoscience2015，8，10： | 1 |
| 4 | Corrigendum to:“Spectrum-tailored random fiber laser towards ICF laser facility”[Matter and Radiation at Extremes 8,025902(2023)]显示文摘The third paragraph in Sec.IV REGENERATIVE AMPLIFICATION erroneously states“In other words,the distribution of spectral components is time-dependent,and the spectral distortion in the amplification process will not change the time-domain shape.” | Mengqiu Fan Shengtao Lin Ke Yao Yifei Qi Jiaojiao Zhang Junwen Zheng Pan Wang Longqun Ni Xingyu Bao Dandan Zhou Bo Zhang Kaibo Xiao Handing Xia Rui Zhang Ping Li Wanguo Zheng Zinan Wang | 2023 | Matter and Radiation at Extremes2023，8，2： | 1 |
| 5 | Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study显示文摘Sorafenib therapy improves overall survival(OS)in patients with FLT3 internal tandem duplication(ITD)acute myeloid leukemia(AML)undergoing allogeneic hematopoietic stem cell transplantation.We explored the efficacy of sorafenib therapy in this population with different concomitant genetic patterns.In this multi-center,cohort study,we enrolled patients with FLT3-ITD AML undergoing allogenic hematopoietic cell transplantation.Patients with sorafenib maintenance post-transplantation for at least four weeks were allocated to the sorafenib group,and otherwise to the control group. | Ruoyang Shao Yu Zhang Jinping He Fen Huang Zhiping Fan Kaibo Yang Yajing Xu Na Xu Yi Luo Lan Deng Xi Zhang Jia Chen Mingzhe Han Xudong Li Sijian Yu Hui Liu Xinquan Liang Xiaodan Luo Pengcheng Shi Zhixiang Wang Ling Jiang Xuan Zhou Ren Lin Yan Chen Sanfang Tu Jing Sun Yu Wang Qifa Liu Li Xuan | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 6 | A description logic based approach to formalizing the information bearing capability of paths in ER schemata显示文摘Purpose–The purpose of this paper is to show how description logics(DLs)can be applied to formalizing the information bearing capability(IBC)of paths in entity-relationship(ER)schemata.Design/methodology/approach–The approach follows and extends the idea presented in Xu and Feng(2004),which applies DLs to classifying paths in an ER schema.To verify whether the information content of a data construct(e.g.a path)covers a semantic relation(which formulates a piece of information requirement),the principle of IBC under the source-bearer-receiver framework is presented.It is observed that the IBC principle can be formalized by constructing DL expressions and examining constructors(e.g.quantifiers).Findings–Description logic can be used as a tool to describe the meanings represented by paths in an ER schema and formalize their IBC.The criteria for identifying data construct distinguishability are also discovered by examining quantifiers in DL expressions of paths of an ER schema.Originality/value–This paper focuses on classifying paths in data schemas and verifying their formalized IBC by using DLs and the IBC principle.It is a new point of view for evaluation of data representation,which looks at the information borne by data but not data dependencies. | Kaibo Xu Junkang Feng Malcolm Crowe Lin Liu | 2015 | International Journal of Intelligent Computing and Cybernetics2015，8，3： | 0 |
| 7 | A retrospective study on 464 bullous pemphigoid patients in Northeast China显示文摘To the Editor:Bullous pemphigoid(BP)is a chronic autoimmune blistering disease characterized by the association with autoantibodies to two hemidesmosomal proteins(BP180 and BP230)interfering with the adhesion of basal epidermal keratinocytes.The global incidence of BP is 2.5 to 75 cases/million per year.[1]Genetic,environmental,and stochastic factors contribute to the susceptibility to BP.We performed a retrospective study on BP in Northeast China to evaluate its clinical characteristics.The data of BP patients from Shenyang Seventh People’s Hospital between January 2015 and January 2020 were analyzed,including 464 BP patients from Northeast China. | Qiang Wang Ruiqun Qi Jianping Li Fengqiu Lin Xianwei Han Xiuyu Liang Xiaodong Sun Yue Feng Kaibo Wang Chunlin Jin Guijuan Xu Tienan Li Changhong Chu | 2022 | Chinese Medical Journal2022，，7： | 0 |
| 8 | Spectrum-tailored random fiber laser towards ICF laser facility显示文摘Broadband low-coherence light is considered to be an effective way to suppress laser plasma instability.Recent studies have demonstrated the ability of low-coherence laser facilities to reduce back-scattering during beam–target coupling.However,to ensure simultaneous low coherence and high energy,complex spectral modulation methods and amplification routes have to be adopted.In this work,we propose the use of a random fiber laser(RFL)as the seed source.The spectral features of this RFL can be carefully tailored to provide a good match with the gain characteristics of the laser amplification medium,thus enabling efficient amplification while maintaining low coherence.First,a theoretical model is constructed to give a comprehensive description of the output characteristics of the spectrum-tailored RFL,after which the designed RFL is experimentally realized as a seed source.Through precise pulse shaping and efficient regenerative amplification,a shaped random laser pulse output of 28 mJ is obtained,which is the first random laser system with megawatt-class peak power that is able to achieve low coherence and efficient spectrum-conformal regenerative amplification. | Mengqiu Fan Shengtao Lin Ke Yao Yifei Qi Jiaojiao Zhang Junwen Zheng Pan Wang Longqun Ni Xingyu Bao Dandan Zhou Bo Zhang Kaibo Xiao Handing Xia Rui Zhang Ping Li Wanguo Zheng Zinan Wang | 2023 | Matter and Radiation at Extremes2023，8，2： | 0 |
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