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136篇 您的检索式:作者名="Kaeberlein"
    题名 作者 年代 出处 被引量
1Rapamycin and Ageing:When,for How Long,and How Much?显示文摘The mechanistic target of rapamycin(mTOR)is a nutrient and growth factor responsive kinase that modulates lifespan in species from yeast to mice(Johnson et al.,2013b).mTOR exists in two complexes within cells,mTOR complexⅠ(mTORC1)and mTOR complex 2(mTORC2)(Laplante and Sabatini,2012).Abundant evidence suggests that mTORC1is the primary mTOR complex involved in regulating longevity:mutations that reduceMatt Kaeberlein 2014Journal of Genetics and Genomics2014,41,9:2
2The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms显示文摘Kaeberlein M McVey M Guarente L 1999Genes Dev1999,13,19:1
3Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone de acetylase显示文摘IMAI SI ARMSTRONG CM KAEBERLEIN M 2000Nature2000,403,6771:1
4Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration显示文摘Lin SJ Kaeberlein M Andalis AA 2002Nature2002,418,6895:1
5Transcriptional silencing and longevity protein Sir2 is an NAD+-dependent histone dcaeetylase显示文摘Imai S Armstrong C M Kaeberlein M 2000Nature2000,403,6771:1
6Transcriptional silen-cing and longevity protein Sir2 is an NAD-dependent histonedeacetylase显示文摘Imai S I Armstrong C M Kaeberlein M 2000Nature2000,403,6771:1
7Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase显示文摘Imai S Armstrong CM Kaeberlein M 2000Nature2000,403,6771:1
8Extension of chronological life span in yeast by de- creased TOR pathway signaling 显示文摘Powers R W Kaeberlein M Caldwell S D 2006Genes Dev2006,20,2:1
9Substrate-specific activation of sirtuins by resveratrol显示文摘KAEBERLEIN M MCDONAGH T HELTWEG B 2005JBiol Chem2005,280,17:1
10Replicative aging in yeast:the means to the end显示文摘Steinkraus KA Kaeberlein M Kennedy BK 0,,:1
11Replicative aging in yeast:the means to the end显示文摘Steinkraus K A Kaeberlein M Kennedy B K 0,,:1
12Transcriptional silenc- ing and longevity protein Sir2 is an NAD-dependent histone deacety- lase 显示文摘Imai S Armstrong CM Kaeberlein M 2000Nature2000,403,6771:1
13Hot topics in aging re- search: protein translation显示文摘Kennedy BK Kaeberlein M 2009Aging Cell2009,8,6:1
14The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharo- myces cerevisiae by two different mechanisms 显示文摘Kaeberlein M McVey M Guarente L 1999Genes Dev1999,13,19:1
15Isolating ' uncultiva- ble' microorganisms in pure culture in a simulated natural environment 显示文摘Kaeberlein T Lewis K Epstein S S 2002Science2002,296,5570:1
16Measuring replicative life span in the budding yeast 显示文摘Steffen K K Kennedy B K Kaeberlein M 2009J Vis Exp2009,25,28:1
17Isolating'uncultivable'microorganisms in pure culture in a simulated natural environment显示文摘Kaeberlein T Lewis K Epstein S S 2002Science2002,296,5570:1
18Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration显示文摘Lin S J Kaeberlein M Andalis A A 2002Nature2002,418,6895:1
19Recent developments in yeast aging显示文摘Steinkraus KA Kaeberlein M Kennedy BK 0,,05:1
20Measuring replicative life span in the budding yeast显示文摘Steffen KK Kennedy BK Kaeberlein M 2009J Vis Exp2009,,28:1
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