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| 1 | Diagnosis and Operative Treatment of Intraforaminal and Extraforaminal Nerve Root Compression显示文摘 | JUN-ICHI KUNOGI MITSUO HASUE | 1991 | Spine1991，，11： | 2 |
| 2 | Gastric submucosa-invasive carcinoma associated with EpsteinBarr virus and endoscopic submucosal dissection: A case report显示文摘BACKGROUND Epstein-Barr virus(EBV)-associated carcinoma is a gastric cancer subtype with a morphology characterized by gastric carcinoma with lymphoid stroma(GCLS).Clinicopathological studies have indicated a better prognosis for GCLS than for common gastric carcinomas.Some previous cases of early gastric cancer associated with EBV had been diagnosed by endoscopic resection.CASE SUMMARY We present two GCLS cases subjected to endoscopic submucosal dissection(ESD)for a definitive diagnosis.A protruded gastric lesion was identified by routine endoscopic examination,but forceps biopsy showed no atypical cells before ESD.The resected specimen showed a poorly differentiated adenocarcinoma with lymphoid cells involving the mucosa and submucosa.The final diagnosis was submucosa-invasive poorly differentiated gastric adenocarcinoma.Accordingly,additional gastrectomy was recommended to obtain a complete cure.One patient underwent additional distal gastrectomy with lymph node dissection,but the other was refused because of cardiovascular complications.Both patients remained in remission for more than half a year.EBV positivity was determined by EBV-encoded RNA in situ hybridization.We also conducted a literature review of cases of early gastric cancer associated with EBV that had been diagnosed by ESD.CONCLUSION Submucosa-invasive GCLS could be dissected using ESD,and EBV positivity should be subsequently assessed to determine whether or not any additional curative surgery is required.Further prospective investigations on the prevalence of lymph node metastasis in EBV-associated carcinoma should be performed to expand the indications for endoscopic resection. | Yu Kobayashi Takehito Kunogi Hiroki Tanabe Yuki Murakami Takuya Iwama Takahiro Sasaki Keitaro Takahashi Katsuyoshi Ando Yoshiki Nomura Nobuhiro Ueno Shin Kashima Kentaro Moriichi Hidehiro Takei Mikihiro Fujiya Toshikatsu Okumura | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 2 |
| 3 | Mesangia cell proliferation inhibitors for the treatment of proliferative glomerular discase显示文摘 | | 2003 | Med Res Rev2003，23，： | 1 |
| 4 | Diagnosis and operative treatment of intraforaminal and extraforaminal nerve root compression显示文摘 | Kunogi J Hasue M | | 0，，1976： | 1 |
| 5 | The efficacy of prostaglandin E1derivat ive in patients with lumbar spinal stenosis显示文摘 | Matsudaira K Seichi A Kunogi J | | 0，，02： | 1 |
| 6 | Diagnosis and operative treatment of intraforaminal and extraforaminal nerve root compression显示文摘 | Kunogi J Hasue M | 1991 | Spine1991，16，11： | 1 |
| 7 | Mesangia cell proliferation inhibitors for the treatment of proliferative glomerular disease显示文摘 | Kunogi Y | 2003 | Med Res Rev2003，23，： | 1 |
| 8 | Diagnosis and operative treatment of intraforminal and extraforminal nerve root compression显示文摘 | Kunogi J Hasue M | | 0，，11： | 1 |
| 9 | Diagnosis and operative treatment of intraforminal and extraforaminal nerve root compression显示文摘 | Kunogi J Hasue M | 1991 | Spine1991，16，11： | 1 |
| 10 | Diagnosis and operative treat- ment of intraforaminal and extraforaminal nerve root compression显示文摘 | Kunogi J Hasue M | 1991 | Spine1991，16，11： | 1 |
| 11 | The efficacy of prosta- glandin E1 derivative in patients with lumbar spinal stenosis 显示文摘 | Matsudaira K Seichi A Kunogi J | 2009 | Spine2009，34，2： | 1 |
| 12 | Mesangia cell proliferation inhibitors for the treatment of proliferative glomerular disease显示文摘 | Kunogi Y | 2003 | Med Res Rev2003，23，： | 1 |
| 13 | Diagnosis and operative treatment of intrafo- raminal and extraforaminal nerve root compression 显示文摘 | Kunogi J Hasue M | 1991 | Spine(Phi- la Pa 1976)1991，16，11： | 1 |
| 14 | Diagnosis and operatfve treatment of intraforaminal and extraforaminal nerve root compres- sion显示文摘 | Kunogi J Hasue M | 1991 | Spine1991，16，11： | 1 |
| 15 | The efficacy of prostaglandin E1 derivative in patients with lumbar spinal stenosis显示文摘 | Matsudaira K Seichi A Kunogi J | 2009 | Spine2009，34，2： | 1 |
| 16 | Mesangia cell proliferation inhibitors for the treatment of proliferative glomerular disease 显示文摘 | Kunogi Y | 2003 | Med Res Rev2003，23，： | 1 |
| 17 | Local recurrence after successful endoscopic submucosal dissection for rectal mucinous mucosal adenocarcinoma:A case report显示文摘BACKGROUND Mucinous adenocarcinoma of the colorectum is a rare histological subtype characterized by an abundant mucinous component.Mucinous tumors are frequently diagnosed at an advanced stage,which indicates an aggressive subtype.However,few case reports have been published,and little information is available concerning genetic alterations in mucinous adenocarcinoma.CASE SUMMARY A 76-year-old man underwent en bloc endoscopic submucosal dissection(ESD)for the management of a type 0-Is+IIa lesion.Histological examination revealed an intramucosal mucinous adenocarcinoma with signet-ring cell carcinoma and well-to-moderately differentiated tubular adenocarcinoma.Three years after the ESD,local recurrence was detected by an endoscopic examination,revealing a new 0-Is+IIa lesion with a phenotype similar to the previously resected lesion.Re-ESD was chosen for the management of the recurrent tumor,and the histological examination showed positive tumor infiltration at the vertical margin.Additional surgical resection was performed for the curative treatment.Genetic analysis showed pathogenic alterations in RNF43 and TP53 in the adenoma and an additional SMAD4 alteration in the carcinoma.CONCLUSION This mucinous mucosal adenocarcinoma case was suggested to have an aggressive phenotype and a careful and close follow-up are required. | Yuki Murakami Hiroki Tanabe Yusuke Ono Yuya Sugiyama Yu Kobayashi Takehito Kunogi Takahiro Sasaki Keitaro Takahashi Katsuyoshi Ando Nobuhiro Ueno Shin Kashima Sayaka Yuzawa Kentaro Moriichi Yusuke Mizukami Mikihiro Fujiya Toshikatsu Okumura | 2023 | World Journal of Gastrointestinal Oncology2023，15，1： | 0 |
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