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| 1 | 高龄对男性生育力的影响显示文摘在过去的几十年里,现代社会的压力和期望使得育龄夫妇生育年龄总体推迟。已知女性在临近40岁时卵母细胞的产生将会明显减少,而高龄对男性精子生成能力的影响还知之甚少。男性生育年龄无明确限制,因而高龄对男性生育能力的影响还不完全清楚。本文将就目前已知的高龄对男性精子质量、生育能力和子代健康的影响进行综述,希望能在医生就男性推迟生育及高龄相关的风险咨询时起到一定的指导作用。 | Jason R Kovac Josephine Addai Ryan P Smith Robert M Coward Dolores J Lamb Larry I Lipshultz | 2013 | Asian Journal of Andrology2013，15，6： | 12 |
| 2 | Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families:Implications for genetic testing显示文摘AIM: To analyze the prevalence of germline MLH1 and MSH2 gene mutations and evaluate the clinical characteristics of Hungarian hereditary non-polyposis colorectal cancer (HNPCC) families. METHODS: Thirty-six kindreds were tested for mutations using conformation sensitive gel electrophoreses, direct sequencing and also screening for genomic rearrangements applying multiplex ligation-dependent probe amplifi cation (MLPA). RESULTS: Eighteen germline mutations (50%) were identifi ed, 9 in MLH1 and 9 in MSH2. Sixteen of these sequence alterations were considered pathogenic, the remaining two were non-conservative missense alterations occurring at highly conserved functional motifs. The majority of the defi nite pathogenic mutations (81%, 13/16) were found in families fulfilling the stringent Amsterdam Ⅰ/Ⅱ criteria, including three rearrangements revealed by MLPA (two in MSH2 and one in MLH1). However, in three out of sixteen HNPCC-suspected families (19%), a disease-causing alteration could be revealed. Furthermore, nine mutations described here are novel, and none of the sequence changes were found in more than one family.CONCLUSION: Our study describes for the f irst time the prevalence and spectrum of germline mismatch repair gene mutations in Hungarian HNPCC and suspected-HNPCC families. The results presented here suggest that clinical selection criteria should be relaxed and detection of genomic rearrangements should be included in genetic screening in this population. | Janos Papp Marietta E Kovacs Edith Olah | 2007 | World Journal of Gastroenterology2007，13，19： | 9 |
| 3 | Systematic review of the old and new concepts in the epithelial-mesenchymal transition of colorectal cancer显示文摘Epithelial-to-mesenchymal transition(EMT) is defined as the transformation of an epithelial cell into a spindle cell with the loss of membrane E-cadherin expression and the gain of mesenchymal markers positivity. In the field of colorectal cancer(CRC), first data about EMT was published in 1995 and more than 400 papers had been written up to March 2016. Most of them are focused on the molecular pathways and experimentally-proved chemoresistance. In the present article, an update in the field of EMT in CRC based on the review of the literature and personal experience of the authors is presented. The information about the molecular and immunohistochemical(IHC) particularities of these processes and their possible role in the prognosis of CRC were also up-dated. This article focuses on the IHC quantification of the EMT, the immunoprofile of tumor buds and on the relation between EMT, angiogenesis, and stem cells activation. The EMT-induced chemoresistance vs chemotherapyor radiotherapy-induced EMT and cellular senescence was also synthesized for both conventional and targeted therapy. As a future perspective, the EMTangiogenesis-stemness link could be used as a possible valuable parameter for clinical follow-up and targeted therapeutic oncologic management of patients with CRC. Association of dexamethasone and angiotensin converting enzyme inhibitors combined with conventional chemotherapies could have clinical benefits in patients with CRC. The main conclusion is that, although many studies have been published, the EMT features are still incompletely elucidated and newly discovered EMT markers provide confusing data in understanding this complicated process, which might have significant clinical impact. | Simona Gurzu Camelia Silveanu Annamaria Fetyko Vlad Butiurca Zsolt Kovacs Ioan Jung | 2016 | World Journal of Gastroenterology2016，22，30： | 8 |
| 4 | 毛皮鞣制中不同铝鞣剂的对比研究显示文摘通过对比试验研究了三甲酸铝和明矾鞣制毛皮的优缺点。试验证明,采用三甲酸铝为鞣剂,成品革在面积得革率、单位面积重量。 | Vasil kovac Dr. H. Francke | 1999 | 中国皮革1999，28，19： | 7 |
| 5 | Family-level leaf nitrogen and phosphorus stoichiometry of global terrestrial plants显示文摘Leaf nitrogen(N) and phosphorus(P) concentrations are critical for photosynthesis, growth, reproduction and other ecological processes of plants. Previous studies on large-scale biogeographic patterns of leaf N and P stoichiometric relationships were mostly conducted using data pooled across taxa, while family/genus-level analyses are rarely reported. Here, we examined global patterns of family-specific leaf N and P stoichiometry using a global data set of 12,716 paired leaf N and P records which includes 204 families, 1,305 genera, and 3,420 species. After determining the minimum size of samples(i.e., 35 records), we analyzed leaf N and P concentrations, N:P ratios and N^P scaling relationships of plants for 62 families with 11,440 records. The numeric values of leaf N and P stoichiometry varied significantly across families and showed diverse trends along gradients of mean annual temperature(MAT) and mean annual precipitation(MAP). The leaf N and P concentrations and N:P ratios of 62 families ranged from 6.11 to 30.30 mg g–1, 0.27 to 2.17 mg g–1, and 10.20 to 35.40, respectively. Approximately 1/3–1/2 of the families(22–35 of 62) showed a decrease in leaf N and P concentrations and N:P ratios with increasing MAT or MAP, while the remainder either did not show a significant trend or presented the opposite pattern. Family-specific leaf N^P scaling exponents did not converge to a certain empirical value, with a range of 0.307–0.991 for 54 out of 62 families which indicated a significant N^P scaling relationship. Our results for the first time revealed large variation in the family-level leaf N and P stoichiometry of global terrestrial plants and that the stoichiometric relationships for at least one-third of the families were not consistent with the global trends reported previously. The numeric values of the family-specific leaf N and P stoichiometry documented in the current study provide critical synthetic parameters for biogeographic modeling and for further studies on the physiological and ecological mechanisms underlying the nutrient use strategies of plants from different phylogenetic taxa. | Di Tian Zhengbing Yan Suhui Ma Yuehong Ding Yongkai Luo Yahan Chen Enzai Du Wenxuan Han Emoke Dalma Kovacs Haihua Shen Huifeng Hu Jens Kattge Bernhard Schmid Jingyun Fang | 2019 | Science China(Life Sciences)2019，62，8： | 7 |
| 6 | Men with a complete absence of normal sperm morphology exhibit high rates of success without assisted reproduction显示文摘在里面结合不孕, 0% 正常形式(NF ) 的反常严格的形态学是一个标准很快继续到在 vitro 授精(IVF ) 。自从没有数据,当前存在,我们与 0% NF 为人调查了结果没有帮助繁殖技术(艺术) 的使用,决定繁殖成功。有 0% NF 的 24 个人的一个队被识别(2010-2013 ) 随机与 ≥ 与 27 选择了人;是的 4% NF 控制。耐心的图表与联系并且管理同意的一块机构的评论板(IRB ) 的人一起被考察查明结果的电话问询表。在 2.5 年的一中部的后续时间以后,有 0% NF 的 29.2% 人没为他们的第一怀孕要求艺术(控制 =55.6% , P ≤0.05 ) 。当所有怀孕一起被分析时,有 0% NF 的人完成了 75% 没要求 IVF 的二十怀孕(控制 = 三十怀孕;76.7% 没要求 IVF ) 。人和女搭挡的平均年龄在有 0% NF 和 ≥ 的人之间是类似的; 4% NF。所有人有正常刺激滤泡的荷尔蒙(FSH ) ,睾丸激素,催乳激素,性别荷尔蒙绑定血球素(SHBG ) ,和 estradiol。尽管,当第一怀孕是一个自然概念(NC ) 时,全球精液参数在有 0% NF 的人是更坏的,有 0% NF (n = 7/7 ) 的人的 100% 并且 37.5% 控制(n = 3/8 ) 继续了经由 NC 有随后的怀孕。没有 IVF,有 0% NF 的人与 55.6% 控制相比在 29.2% 盒子中怀孕了。严格的形态学不应该被用来预言授精,怀孕,或实时出生潜力。在有 0% NF 的人,其他的形式应该被认为 IVF 以前立即。 | Jason R Kovac Ryan P Smith Miguel Cajipe Dolores J Lamb Larry I Lipshultz | 2017 | Asian Journal of Andrology2017，19，1： | 7 |
| 7 | Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections显示文摘Selection of the appropriate donor is essential to a successful allograft recipient outcome for solid organ transplantation. Multiple infectious diseases have been transmitted from the donor to the recipient via transplantation. Donor-transmitted infections cause increased morbidity and mortality to the recipient. In recent years, a series of high-profile transmissions of infections have occurred in organ recipients prompt-ing increased attention on the process of improving the selection of an appropriate donor that balances the shortage of needed allografts with an approach that mitigates the risk of donor-transmitted infection to the recipient. Important advances focused on improving donor screening diagnostics, using previously excluded high-risk donors, and individualizing the selection of allografts to recipients based on their prior infection history are serving to increase the donor pool and improve outcomes after transplant. This article serves to review the relevant literature surrounding this topic and to provide a suggested approach to the selection of an appropriate solid organ transplant donor. | Christopher S Kovacs Jr Christine E Koval David van Duin Amanda Guedes de Morais Blanca E Gonzalez Robin K Avery Steven D Mawhorter Kyle D Brizendine Eric D Cober Cyndee Miranda Rabin K Shrestha Lucileia Teixeira Sherif B Mossad | 2014 | World Journal of Transplantation2014，4，2： | 7 |
| 8 | Emergency department procedural sedation for primary electrical cardioversion — a comparison with procedural sedations for other reasons显示文摘BACKGROUND: Atrial fibrillation(AF) is the most common arrhythmia treated in the emergency department(ED), with primary electrical cardioversion(PEC) the preferred method of rhythm control. Anecdotally, patients undergoing ED procedural sedation(EDPS) for PEC differ from those requiring EDPS for other procedures: they are at higher risk of adverse events, and require fewer drugs and lower doses. We attempt to verify this using an EDPS registry at a Canadian, tertiary care teaching hospital.METHODS: This is a retrospective review of patients that underwent EDPS for the period of June 2006 to September 2014. We compared demographics, medication use and intra-procedural adverse events between those receiving EDPS for PEC for AF compared to that for other indications. We report the asssociation between AEs and predictors using logistic regression.RESULTS: A total of 4 867 patients were included, 714 for PEC for AF and 4 153 for other indications. PEC patients were more likely male(58.5% vs. 47.1%), older(59.5 years vs. 48.1 years), and less likely to be ASA I(46.6% vs. 69.0%). PEC patients received smaller doses of propofol and less likely to receive adjuvant analgesic therapy(11.5% vs. 78.2%). PEC patients were more likely to experience hypotension(27.6% vs. 16.5%) but respiratory AEs(apnea, hypoxia and airway intervention) were not different.CONCLUSION: EDPS for PEC differs from that conducted for other purposes: patients tend to be less healthy, receive smaller doses of medication and more likely to suffer hypotension without an increase in respiratory AEs. These factors should be considered when performing EDPS. | Michael Butler Patrick Froese Peter Zed George Kovacs Robert Mac Kinley Kirk Magee Mary-Lynn Watson Samuel G.Campbell | 2017 | World Journal of Emergency Medicine2017，8，3： | 6 |
| 9 | 血管内皮生长因子受体3通过β抑制蛋白1调节内皮功能显示文摘受体信号转导对于维持血管内皮功能至关重要,其在动脉粥样硬化和肺动脉高压(pulmonary arterial hypertension,PAH)等血管疾病中出现失调。内皮功能相关受体信号包括血管内皮生长因子(vascular endothelial growth factor,VEGF)受体(VEGFR)和G蛋白耦联受体(G protein-coupled receptor,GPCR),激活特异的细胞内信号通路和反应。 | 刘青 叶鹏 Ma Z Yu YR Badea CT Kovacs JJ Xiong X Comhair S Piantadosi CA Rajagopal S | 2019 | 中华高血压杂志2019，27，1： | 5 |
| 10 | 药物涂层支架在冠状动脉介入治疗中的地位和作用显示文摘 | 肖文良 Jan Kovac | 2005 | 临床心血管病杂志2005，21，2： | 5 |
| 11 | Prolonged intestinal mucosal acidosis is associated with multiple organ failure in human acute pancreatitis: Gastric tonometry revisited显示文摘瞄准:评估是否在尖锐胰腺炎(AP ) 的 intramucosal pH (pHi ) 的多重决心病人们能在早住院期间提供疾病严厉的另外的信息。方法:受不了尖锐胰腺炎的 21 个病人被胃的张力测量法在医院承认以后在开始的 72 h 监视。结果:在幸存者组(n = 15 ) 还给正常的开始低的 pHi 值铺平(pHi >
或 = 7.32 ) 在 48 h 以内(中部的 pHi:d1:7.21;d2:7.32;d3:7.33 ) 。相反,在非幸存者的 pHi 值组织 n = 6 ) 固执地,下面或在里面,低正常变化(中部的 pHi 7.12;7.12;7.07 分别地) ,但是二个组之间的 pHi 差别仅仅在 24 h (P<0.01 ) 以后到达了意义。在监视时期期间在任何时间检测的粘膜酸中毒与单个或多重的机关机能障碍(P<0.01 ) 的出现被联系。结论:然而,延长胃的粘膜酸中毒在尖锐胰腺炎与遥远的机关机能障碍和失败被联系与致命的结果的关联变得重要仅仅在承认以后的 24 h。由于它的非侵略的性质,胃的张力测量法可以补充支持 inflammatory 标记完成疾病的滑稽得多的监视。 | Gabor C Kovacs Geza Telek Janos Hamar Jozsef Furesz Janos Regoly-Merei | 2006 | World Journal of Gastroenterology2006，12，30： | 4 |
| 12 | Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001显示文摘For a safe and sustainable environment,effective microbes as biocontrol agents are in high demand.We have isolated a new Bacillus velezensis strain DTU001,investigated its antifungal spectrum,sequenced its genome,and uncovered the production of lipopeptides in HPLC-HRMS analysis.To test the antifungal efficacy,extracts of B.velezensis DTU001 was tested against a range of twenty human or plant pathogenic fungi.We demonstrate that inhibitory potential of B.velezensis DTU001 against selected fungi is superior in comparison to single lipopeptide,either iturin or fengycin.The isolate showed analogous biofilm formation to other closely related Bacilli.To further support the biocontrol properties of the isolate,coculture with Candida albicans demonstrated that B.velezensis DTU001 exhibited excellent antiproliferation effect against C.albicans.In summary,the described isolate is a potential antifungal agent with a broad antifungal spectrum that might assist our aims to avoid hazardous pathogenic fungi and provide alternative to toxicity caused by chemicals. | Sagarika Devi Heiko T.Kiesewalter Renato Kovacs Jens Christian Frisvad Tilmann Weber Thomas Ostenfeld Larsen Akos T.Kovacs Ling Ding | 2019 | Synthetic and Systems Biotechnology2019，4，3： | 4 |
| 13 | On the field method in non-holonomic mechanics显示文摘This paper deals with the generalization of the field method to non-holonomic systems whose motion is subject to either non-linear constraints or those of a higher order, while their motion is modeled by the generalized Lagrange equations of the second kind. Two examples are given to illustrate the theory. | Ivana Kovacic | 2005 | Acta Mechanica Sinica2005，21，2： | 4 |
| 14 | 小形变量轧制下电工钢中立方织构的形成显示文摘尝试了小形变量轧制对立方织构电工钢织构形成的影响.结果表明,对含碳量较低的Fe-3.2%S i铁硅合金的初次再结晶组织施加小形变量形变和退火后,可以得到具有柱状晶结构的晶粒组织,并且得到比较集中的立方织构.柱状晶组织形成过程中伴随着∑5和∑11晶界的减少和最终消失,这种低∑重位晶界的移动主要是由于(100)取向晶粒与基体晶粒之间存在沿〈100〉或〈110〉转动36.9°或50.5°的取向关系. | 王均安 贺英 邱振伟 周邦新 Frantisek Kovac | 2008 | 上海大学学报(自然科学版)2008，14，5： | 4 |
| 15 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 16 | 这里一应俱全:业内大咖纵论门诊部设计新趋势显示文摘随着我国改革开放的深入,市场经济快速发展,建筑技术水平也得到了切实提高,并迈上了新的发展台阶。在许多高层建筑中,剪力墙结构是普遍采用的结构形式,其抗震性高且刚性强度大,能够很好的提高建筑安全性。本文针对建筑剪力墙结构设计进行了分析与研究,阐述了剪力墙设计的应用价值,希望本文能对同行在类似工程中的设计提供借鉴和帮助。 | Jennifer Kovacs Silvis 田晓 | 2016 | 建筑知识2016，0，14： | 3 |
| 17 | 微卫星跨物种交叉PCR扩增的一个新问题:扩增非同源产物(英文)显示文摘微卫星已被广泛应用于群体遗传学、生态学和进化生物学研究。然而,一些物种微卫星尚未克隆。为了节省时间和经费,研究人员往往使用一个物种已发表的微卫星引物扩增其近缘物种的微卫星。该研究对属于3个不同科(Clariidae、Heteropneustidae和Pimelodidae)的7个鲶鱼物种的微卫星跨物种PCR扩增产物进行了序列分析,研究发现扩增非同源(non-orthologous)产物是微卫星跨物种PCR扩增的一个新问题。该研究共采用4对胡子鲶微卫星座位引物对7个鲶鱼物种进行了跨物种PCR扩增。对获得的204个PCR产物的序列分析结果表明,两对微卫星座位引物扩增了所有7个物种的同源特异产物。而其他两个座位的引物扩增了特异但非同源的多态产物,对近缘物种的扩增也获得类似结果。另外,除胡子鲶等位基因大小异源同型(size homoplasy)的特征不明显外,其他物种在3个微卫星座位都具有这一非常明显的特征。这些数据表明,微卫星跨物种间交叉扩增能产生非同源产物;等位基因大小异源同型与微卫星座位本身有关,而与物种间的亲缘关系无明显的相关性。微卫星跨物种扩增产生的非同源产物和等位基因大小异源同型将使系统发育、群体遗传学和进化研究明显复杂化。因此,在应用微卫星跨物种交叉扩增数据以前,最好对跨物种交叉扩增产物进行测序验证。 | 岳根华 Balazs Kovacs Laszlo Orban | 2010 | Zoological Research2010，31，2： | 3 |
| 18 | The role of advanced paternal age in modern reproductive medicine显示文摘 | Christopher Wu Larry I Lipshultz Jason R Kovac | 2016 | Asian Journal of Andrology2016，18，3： | 3 |
| 19 | Characterization of novel Brown midrib 6 mutations affecting lignin biosynthesis in sorghum显示文摘The presence of lignin reduces the quality of lignocellulosic biomass for forage materials and feedstock for biofuels. In C4 grasses,the brown midrib phenotype has been linked to mutations to genes in the monolignol biosynthesis pathway. For example,the Bmr6 gene in sorghum(Sorghum bicolor) has been previously shown to encode cinnamyl alcohol dehydrogenase(CAD),which catalyzes the final step of the monolignol biosynthesis pathway. Mutations in this gene have been shown to reduce the abundance of lignin,enhance digestibility,and improve saccharification efficiencies and ethanol yields. Nine sorghum lines harboring five different bmr6 alleles were identified in an EMS-mutagenized TILLING population. DNA sequencing of Bmr6 revealed that the majority of the mutations impacted evolutionarily conserved amino acids while three-dimensional structural modeling predicted that all of these alleles interfered with the enzyme's ability to bind with its NADPH cofactor. All of the new alleles reduced in vitro CAD activity levels and enhanced glucose yields following saccharification. Further,many of these lines were associated with higher reductions in acid detergent lignin compared to lines harboring the previously characterized bmr6-ref allele. These bmr6 lines represent new breeding tools for manipulating biomass composition to enhance forage and feedstock quality. | Erin D. Scully Tammy Gries Deanna L. Funnell-Harris Zhanguo Xin Frank A. Kovacs Wilfred Vermerris Scott E. Sattler | 2016 | Journal of Integrative Plant Biology2016，58，2： | 3 |
| 20 | Past,present and future of cyanide antagonism research:From the early remedies to the current therapies显示文摘This paper reviews milestones in antidotal therapies for cyanide(CN) spanning early remedies,current antidotal systems and research towards next generation therapies.CN has been a part of plant defense mechanisms for millions of years.It became industrially important in the nineteenth century with the advent of CN assisted gold mining and the use of CN as a pest control agent.The biochemical basis of CN poisoning was actively studied and key mechanisms were understood as early as 1929.These fundamental studies led to a variety of antidotes,including indirect CN binders that generate methemoglobin,direct CN binders such as hydroxocobalamin,and sulfur donors that convert CN to the less toxic thiocyanate.Research on blood gases at the end of the twentieth century shed new light on the role of nitric oxide(NO) in the body.The discovery of NO's ability to compete with CN for enzymatic binding sites provided a previously missed explanation for the rapid efficacy of NO generating antidotes such as the nitrites.Presently used CN therapies include:methemoglobin/NO generators(e.g.,sodium nitrite,amyl nitrite,and dimethyl aminophenol),sulfur donors(e.g.,sodium thiosulfate and glutathione),and direct binding agents [(e.g.,hydroxocobalamin and dicobalt salt of ethylenediaminetetraacetic acid(dicobalt edetate)].A strong effort is being made to explore novel antidotal systems and to formulate them for rapid administration at the point of intoxication in mass casualty scenarios.New antidotes,formulations,and delivery systems are enhancing bioavailability and efficacy and hold promise for a new generation of improved CN countermeasures. | Ilona Petrikovics Marianna Budai Kristof Kovacs David E Thompson | 2015 | World Journal of Methodology2015，5，2： | 3 |
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