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| 1 | Capecitabine for locally advanced and metastatic colorectal cancer:A review显示文摘Capecitabine (Xeloda) is an oral fluoropyrimidine which is produced as a pro-drug of fluorouracil, and shows improved tolerability and intratumor drug concentrations following its tumor-specif ic conversion to the active drug. We have searched the Pubmed and Cochrane databases from 1980 to 2009 with the purpose of reviewing all available information on Capecitabine, focusing on its clinical effectiveness against colorectal cancer. Special attention has been paid to trials that compared Capecitabine with standard folinic acid (leucovorin, LV)-modulated intravenous 5-fluorouracil (5-FU) bolus regimens in patients with metastatic colorectal cancer. Moreover the efficacy of Capecitabine on metastatic colorectal cancer, either alone or in various combinations with other active drugs such as Irinotecan and Oxaliplatin was also assessed. Finally, neoadjuvant therapy con- sisting of Capecitabine plus radiation therapy, for locally advanced rectal cancer was analysed. This combination of chemotherapy and radiotherapy has a special role in tumor down staging and in sphincter preservation for lower rectal tumors. Comparative trials have shown that Capecitabine is at least equivalent to the standard LV-5-FU combination in relation to progression-free and overall survival whilst showing a better tolerability prof ile with a much lower incidence of stomatitis. It is now known that Capecitabine can be combined with other active drugs such as Irinotecan and Oxaliplatin. The combination of Oxaliplatin with Capecitabine represents a new standard of care for metastatic colorectal cancer. Combinating the Capecitabine-Oxaliplatin regimen with promising new biological drugs such as Bevacizumab seems to give a realistic prospect of further improvement in time to progression of metastatic disease. Moreover, preoperative chemo-radiation using oral capecitabine is better tolerated than bolus 5-FU and is more effective in the promotion of both down-staging and sphincter preservation in patients with locally advanced rectal cancer. Finally, the outcomes of recently published trials suggest that capecitabine seems to be more cost effective than other standard treatments for the management of patients with colorectal cancer. | Georgios V Koukourakis Georgios Zacharias John Tsalafoutas Dimitrios Theodoridis Vassilios Kouloulias | 2010 | World Journal of Gastrointestinal Oncology2010，2，8： | 4 |
| 2 | Radiation induced pneumonitis following whole breast radiotherapy treatment in early breast cancer patients treated with breast conserving surgery:a single institution study 显示文摘 | Fragkandrea I Kouloulias V Mavridis P | 2013 | Hippokratia2013，17，3： | 1 |
| 3 | Chemoradiotherapy combined with intracavitary hyperthermia for anal cancer,feasibility and long-term results from a phase Ⅱ randomized trial显示文摘 | Kouloulias V Plataniotis G Kouvaris J | 2005 | Am J Clin Oncol2005，28，1： | 1 |
| 4 | Efficacy and toxicity of radiotherapy for Graves'ophthalmopathy:the University of Athens experience显示文摘 | Kouloulias V Kouvaris J Zygogianni A | | 0，，02： | 1 |
| 5 | Amifostine:The First Selective-Target and Broad-Spectrum Radioprotector显示文摘 | Kouvaris J R Kouloulias V E Vlahos L J | 2007 | The Oncologist2007，12，6： | 1 |
| 6 | Intraoperative hyperthermia in conjunction with multi-schedule chemotherapy(pre-,intra-and pos operative),by-pass surgery,and post-operative radiotherapy for the management of unresectable pancreatic adenocarcinoma显示文摘 | KOULOULIAS V E KOUVARIS J R NIKITA K S | 2002 | Int J Hyperthermia2002，18，3： | 1 |
| 7 | Amifostine: the first selective-target and broad spectrum radioprotector 显示文摘 | Kouvaris J R Kouloulias V E Vlahos L J | 2007 | Oncologist2007，12，6： | 1 |
| 8 | The cytoprotective effect of amifostine in acule radiation dermatitis:a retrospective analysis显示文摘 | Knuvaris J Kouloulias V Kokakis J | | 0，，05： | 1 |
| 9 | Efficacy of the oral fluorouracil pro-drug capecitabine in cancer treatment: a review显示文摘 | Koukourakis GV Kouloulias V Koukourakis M J | 2008 | Molecules2008，13，8： | 1 |
| 10 | Efficacy of the oral fluornuracil pro-drug capecitabine in cancer treatment:a review 显示文摘 | Koukourakis GV Kouloulias V Koukourakis M J | 2008 | Molecules2008，13，8： | 1 |
| 11 | Radiotherapy in conjunction with intravenous inrfsion of 180 mg of disodium pamidronate in management of osteolytic metastases from beast cancer: clinical evaluation, biochemical markers, quality of life, and monitoring of recaliflcation using assessments of gray - level histogram in plain radiographs 显示文摘 | Kouloulias V Matsopoulos G Kouvaris J | 2003 | Int J Radiat Oncol Biol Phys2003，57，1： | 1 |
| 12 | Amifostine :the first selective-target and broad spectrum radioprotec-tor显示文摘 | Kouvaris J R Kouloulias V E Vlahos L J | 2007 | Oncologist2007，12，： | 1 |
| 13 | Efficacy of the oral fluorouracil pro-drug capecitabine in cancer treatment: a review 显示文摘 | Koukourakis G V Kouloulias V Koukourakis M J | 2008 | Molecules2008，13，： | 1 |
| 14 | The cytoprotective effect of amifostine in acute radiation dermatitis:a retrospective analysis显示文摘 | KOUVARIS J KOULOULIAS V KOKAKIS J | 2002 | Eur J Dermatol2002，12，5： | 1 |
| 15 | Effi- cacy of the oral fluorouraeil pro - drug eapeeitabine in eaneer treatment: a review 显示文摘 | Koukourakis GV Kouloulias V Koukourakis MJ | 2008 | Molecules2008，13，： | 1 |
| 16 | Ra- diation induced pneumonitis following whole breast radiotherapy treatment in early breast cancer patients treated with breast con- serving surgery: a single institution study显示文摘 | FRAGKANDREA I KOULOULIAS V MAVRIDIS P | 2013 | Hippokratia2013，17，3： | 1 |
| 17 | Therapeutic inter- ventions targeting organ preservation in muscle - invasive bladder cancer: a review显示文摘 | Koukourakis G Kouloulias V Zacharias G | 2011 | Clin Transl Oncol2011，13，5： | 1 |
| 18 | Therapeutic interventions targeting organ preservation in muscle-invasive bladder cancer:a review显示文摘 | Koukourakis G Kouloulias V Zacharias G | 2011 | Clin Transl Oncol2011，13，5： | 1 |
| 19 | Amifostine: the first selective-target and broad-spectrum radioprotector 显示文摘 | Kouvaris J R Kouloulias V E Vlahos L J | 2007 | Oncologist2007，12，6： | 1 |
| 20 | The treatment out- come and radiation-induced toxicity for patients with head and neck carcinoma in the IMRT era : a systematic review with dosimet- ric and clinical parameters 显示文摘 | Kouloulias V Thalassinou S Platoni K | 2013 | Biomed Res Int2013，2013，40： | 1 |
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