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| 1 | Dynamic Changes of ORF1ab and N Gene Ct Values in COVID-19 Omicron Inpatients of Different Age Groups—Beijing Municipality,China,November-December 2022显示文摘Introduction:In November 2021,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant was identified as the variant of concern and has since spread globally,replacing other cocirculating variants.To better understand the dynamic changes in viral load over time and the natural history of the virus infection,we analyzed the expression of the open reading frames 1ab(ORF1ab)and nucleocapsid(N)genes in patients infected with Omicron.Methods:We included patients initially admitted to the hospital for SARS-CoV-2 infection between November 5 and December 25,2022.We collected daily oropharyngeal swabs for quantitative reverse transcriptase-polymerase chain reaction tests using commercial kits.We depicted the cycle threshold(Ct)values for amplification of ORF1ab and N genes from individual patients in age-specific groups in a time series.Results:A total of 480 inpatients were included in the study,with a median age of 59 years(interquartile range,42 to 78;range,16 to 106).In the<45-year-old age group,the Ct values for ORF1ab and N gene amplification remained below 35 for 9.0 and 11.5 days,respectively.In the≥80-year-old age group,the Ct values for ORF1ab and N genes stayed below 35 for 11.5 and 15.0 days,respectively,which was the longest among all age groups.The Ct values for N gene amplification took longer to rise above 35 than those for ORF1ab gene amplification.Conclusion:The time to test negative varied among different age groups,with viral nucleic acid shedding taking longer in older age groups compared to younger age groups.As a result,the time to resolution of Omicron infection increased with increasing age. | Qing Zhang Zhaomin Feng Yiwei Hao Lirong Wei Aibin Wang Zhixing Han Meimei Tian Sheng Sun Xin'gang Li Tianjiao Xue Xiangjing Kong Baoliang Li Cheng Kou Quanyi Wang Da Huo Linghang Wang | 2023 | China CDC weekly2023，5，8： | 0 |
| 2 | THE POSSIBILITY OF A NEW RESONANCE OF THREE-BODY LINEAR CHAIN STRUCTURE IN THE REACTION ^(12)C+^(16)O AT E_(c.m)≈33.5MeV显示文摘There is a peak in the excitation function of total cross section of low energyα-particles in the reaction ^(12)C+^(16)O at E_(c.m)≈33.5MeV.The experimental distribution of α-particle emitted event has been obtained.The result of theoretical calculation roughly agrees with experimental data,gives an orientation where three-body resonances can be expected,and the information on internal structure of three-body linear chain molecule. | KONG Xiangjing P.L.Li J.J.Kolata A.Morsad L.Goetting R.A.Kryger S.Dixit R.Tighe W.Chune | 1990 | Chinese Physics Letters1990，7，5： | 0 |
| 3 | Difference of Clinical Characteristics in Patients with Omicron and Delta Variants of SARS-CoV-2 in Beijing,China显示文摘Background Delta and Omicron are two main variants that have been prevalent since 2021.However,the Omicron variant of severe acute respiratory syndrome coronavirus 2 shows a less severe clinical presentation and high transmissibility.Therefore,we carried out this retrospective study to evaluate Omicron severity compared with the Delta variant and further comprehend the differences in clinical characteristics in patients with the Omicron variant.Methods We extracted clinical data and compared clinical severity,symptoms,vaccination status,laboratory parameters,viral shedding time,and computed tomography(CT)imaging between the two groups of patients,which included 109 COVID-19 cases with the Delta variant and 183 cases with the Omicron variant,from January 19 to April 1,2022,in Beijing Ditan Hospital.In addition,the Beijing Center for Disease Prevention and Control conducted whole-genome sequencing.Results We obtained 94 strains of variants of concern/Delta and 110 strains of variants of concern/Omicron.For the 110 Omicron strains,three were assigned as BA.1.1,53 as BA.2,and 54 as BA.2.2.Among patients with the Delta variant,54%(59/109)were moderate,which was significantly higher than that of patients with the Omicron variant(7%(12/183),P<0.001).The number of patients with mild symptoms in the Omicron group was significantly higher than in the Delta group(80%vs.35%,P<0.001).Compared with the Omicron group,patients with underlying diseases or obesity,60 years or older,or unvaccinated in the Delta group had more severe disease,and there was a significant difference between the two groups.The viral shedding time in the Omicron group was shorter than in the Delta group((11.9±5.9)vs.(14.0±5.8)days,P=0.003).Among the 183 patients in the Omicron group,104(57%)had dry or sore throat symptoms,more than those in the Delta group(34%(37/109);P<0.001).In the Delta group,patients in the moderate group had more fever and cough symptoms than those in the mild group.The remission time of CT imaging in the Omicron group was shorter than in the Delta group((9.0±5.2)vs.(13.2±4.2)days,P=0.018).Conclusions Patients with Delta variants are more likely to have pneumonia,mainly with fever and cough symptoms,while patients with the Omicron variant are mostly mild,with more prominent dry or sore throat symptoms.In addition,patients with the Omicron variant have a short viral shedding time and rapid absorption of pneumonia. | Di Tian Yang Pan Ziruo Ge Xiangjing Kong Yao Zhang Qing Zhang Aibin Wang Peng Yang Zhihai Chen | 2023 | Infectious Diseases & Immunity2023，3，2： | 0 |
| 4 | A stable Co(Ⅱ)-based metal-organic framework with dual-functional pyrazolate-carboxylate ligand:Construction and CO_(2) selective adsorption and fixation显示文摘By taking the functional adva ntages of both pyrazolate and carboxylate ligands,a unique dual-functional pyrazolate-carboxylate ligand acid,4-(3,6-di(pyrazol-4-yl)-9-carbazol-9-yl)benzoic acid(H3PCBA) was designed and synthesized.Using it,a new Co(Ⅱ)-based metal-organic framework(MOF),Co_(3)(PCBA)_(2)(H_(2)O)_(2)(BUT-75) has been constructed.It revealed a(3,6)-connected net based on the 6-connected linear trinuclear metal node,and showed good chemical stability in a wide pH range from 3 to 12 at room temperature,as well as in boiling water.Due to the presence of rich exposed Co(Ⅱ) sites in pores,BUT-75 presented high selective CO_(2) adsorption capacity over N2 at 298 K.Simultaneously,it demonstrated fine catalytic performance for the cycloaddition of CO_(2) with epoxides into cyclic carbonates under ambient conditions.This work has not only enriched the MOF community through integrating diverse functio nalities into one ligand but also contributed a versatile platform for CO_(2) fixation,thereby pushing MOF chemistry forward by stability enhancement and application expansion. | Guangrui Si Xiangjing Kong Tao He Wei Wu Linhua Xie Jianrong Li | 2021 | Chinese Chemical Letters2021，32，2： | 0 |
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