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| 1 | Fourier Transform Infrared Spectroscopic Analysis of Protein Secondary Structures显示文摘红外线的光谱学是为多肽和蛋白质的二级结构的分析的最旧、好的确定的试验性的技术之一。它是方便的,非破坏性,要求更少的样品准备,和罐头在 ofconditions.This 评论介绍的一个宽变化下面被使用在 Fourier 的最近的开发转变红外线(FTIR ) 光谱学技术和它的应用到蛋白质结构的研究。在 FTIR 分光镜的乐队和蛋白质二级结构部件之间的 experimentals 杀死,数据分析,和关联被讨论。到分析, conformational 变化,结构的动力学和稳定性蛋白质学习的二级结构的 FTIR 的应用也被讨论。 | Jilie KONG Shaoning YU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，8： | 81 |
| 2 | Outline of the Report on Cardiovascular Disease in China,2010显示文摘Major and profound changes have taken place in China over the past 30 years.Rapid socioeconomic progress has exerted a great impact on lifestyle,ranging from food,clothing,working and living conditions,and means of transportation to leisure activities and entertainment.At the same time,new health problems have emerged,and health services are facing new challenges.Presently,cardiovascular diseases (CVD) are among the top health problems of the Chinese people,and pose a serious challenge to all engaged in the prevention and control of these diseases.An epidemic of CVD in China is emerging as a result of lifestyle changes,urbanization and longevity.Both national policy decision-making and medical practice urgently need an authoritative report which comprehensively reflects the trends in the epidemic of CVD and current preventive measures.Since 2005,guided by the Bureau of Disease Prevention of the Ministry of Health of the People's Republic of China and the National Center for Cardiovascular Diseases of China,nationwide experts in the fields of epidemiology,clinical medicine and health economics in the realms of CVD,cerebrovascular disease,diabetes and chronic kidney disease,completed the Report on Cardiovascular Diseases in China every year.The report aims to provide a timely review of the trend of the epidemic and to assess the progress of prevention and control of CVD.In addition,as the report is authoritative,representative and readable,it will become an information platform in the CVD field and an important reference book for government,academic institutes,medical organizations and clinical physicians.This publication is expected to play a positive role in the prevention and control of CVD in China.We present an abstract from the Report on Cardiovascular Diseases in China (2010),including trends in CVD,morbidity and mortality of major CVDs,up-to-date assessment of risk factors,as well as health resources for CVD,and a profile of medical expenditure,with the aim of providing evidence for decision-making in CVD prevention and control programs in China,and of delivering the most authoritative information on CVD prevention and control for all citizens. | HUSheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Wen WANG Yong Jun WU Zhao Su CHEN Wei Wei LIU Ming Bo For the editorial board | 2012 | Biomedical and Environmental Sciences2012，25，3： | 93 |
| 3 | Long-term trend and abrupt events of the Holocene Asian monsoon inferred from a stalagmiteδ^(18)O record from Shennongjia in Central China显示文摘A high-resolution oxygen-isotope record from a thorium-uranium-dated stalagmite from Shanbao Cave at Shennongjia reflects variations in the amount of monsoon precipitation for the period from 11.5 to 2.1 ka (1 ka = 1000 cal aBP). Between 11.5 and 9.3 ka, a sharp decrease in δ18O indicates a rapid increase in monsoon precipitation. An interval of generally high monsoon precipitation is observed between 9.3 and 4.4 ka. An arid period has prevailed between 4.4 and 2.1 ka. The long-term trend of Shanbao record appears to follow summer insolation at 33°N latitude. An abrupt decrease in monsoon precipitation around 4.3 ka is synchronous with the collapse of Neolithic culture in central China. This abrupt change could have resulted from the amplifi- cation of the gradually decreased summer insolation by the positive vegetation-atmosphere-aerosol feed- back. The weakened Asian monsoon events were in concert with decreased Greenland temperature dur- ing the early Holocene, centered at 8.2, 8.6, 9.3, 10.2 and 11.0 ka. This correlation suggests that changes in low-latitude monsoon are connected with climate change in high-latitude polar region. | SHAO Xiaohua WANG Yongjin CHENG Hai KONG Xinggong WU Jiangying EDWARDS R. Lawrence | 2006 | Chinese Science Bulletin2006，51，2： | 64 |
| 4 | China's lakes at present:Number,area and spatial distribution显示文摘Based on 11004 satellite images from CBERS CCD and Landsat TM/ETM,changes in the spatial characteristics of all lakes in China were determined following pre-established interpretation rules.This dataset was supported by 6843 digital raster images(1:100000 and 1:50000),a countrywide digital vector dataset(1:250000),and historical literature.Comparative data were corrected for seasonal variations using precipitation data.There are presently 2693 natural lakes in China with an area greater than 1.0 km2,excluding reservoirs.These lakes are distributed in 28 provinces,autonomous regions and municipalities and have a total area of 81414.6 km2,accounting for-0.9% of China's total land area.In the past 30 years,the number of newly formed and newly discovered lakes with an area greater than 1.0 km2 is 60 and 131,respectively.Conversely,243 lakes have disappeared in this time period. | MA RongHua YANG GuiShan DUAN HongTao JIANG JiaHu WANG SuMin FENG XueZhi LI AiNong KONG FanXiang XUE Bin WU JingLu LI ShiJie | 2011 | Science China Earth Sciences2011，54，2： | 79 |
| 5 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 6 | First flush of storm runoff pollution from an urban catchment in China显示文摘暴风雨流量污染过程在 China.The 结果的武汉城市里与 1.3 km2 的 anarea 在城市的集水被调查显示 8 的在所有的流动山峰监视了的污染物质集中 peakspreceded 袭击在污染山峰 andflow 山峰之间的 events.The 间隔在有在起始的时期的更高的紧张的雨事件是更短的比 thosewith ,污染负担的更低的 intensity.The 部分搬运了由开始的30%流量体积( FF30 )是为全部的 suspende 的 52.2%-72.1 % | LI Li-qing YIN Cheng-qing HE Qing-ci KONG Ling-li | 2007 | Journal of Environmental Sciences2007，19，3： | 51 |
| 7 | 氯吡格雷的使用与药物洗脱支架植入后远期临床结果显示文摘背景:近来的冠状动脉内药物洗脱支架研究提示,现行的抗血小板治疗方案可能并不足以预防后期支架内血栓形成。目的:于接受药物洗脱支架(drug-eluting stents,DESs)和裸金属支架(bare-metal stents,BMSs)治疗的冠状动脉病患者中评估氯吡格雷使用与患者远期结果的关系。设计、地点及患者:于连续患者中进行观察性研究。患者于2000年1月1日至2005年7月31日在杜克心脏治疗中心(一家位于北卡罗来纳州达累姆市的三级治疗中心)接受冠状动脉内支架治疗。于6、12、24个月时进行随访,直至2006年9月7日。研究人群包括4666例最初接受BMS(n=3165)或DES(n=1501)经皮冠状动脉介入治疗的患者。对随访6和12个月没有事件(没有死亡、心肌梗死或血管重建手术)的患者进行界标分析(landmark analysis)。在这些时间点上根据支架类型以及自我报告之氯吡格雷的使用情况将患者分为4组:DES使用氯吡格雷组、DES不用氯吡格雷组、BMS使用氯吡格雷组以及BMS不用氯吡格雷组。主要观测指标:随访24个月时死亡、非致命性心肌梗死以及死亡或心肌梗死之复合终点。结果:在6个月时没有事件发生的DES组患者(637例使用、579例未使用氯吡格雷)中,氯吡格雷的使用是随访24个月校正死亡率较低(使用2.0%比未使用5.3%;差异,-3.3%;95%CI,-6.3%至-0.3%;P=0.03)以及死亡或心肌梗死发生率较低(3.1%比7.2%;差异,-4.1%;95%CI,-7.6%至-0.6%;P=0.02)的显著预测指标。然而,在BMS组患者中(417例使用、1976例未用氯吡格雷),死亡(3.7%比4.5%;差异,-0.7%;95%CI,-2.9%至1.4%;P=0.50)以及死亡或心肌梗死发生率(5.5%比6.0%;差异,-0.5%;95%CI,-3.2%至2.2%;P:0.70)没有差异。在12个月随访没有事件发生的DES组患者(252例使用、276例未用氯吡格雷)中,氯吡格雷的使用依然可以预测24个月死亡(0%比3.5%;差异,-3.5%;95%CI,-5.9%至-1.1%;P=0.004)以及死亡或心肌梗死发生率(0%比4.5%;差异,-4.5%;95%CI,-7.1%至-1.9%;P〈0.001)较低。然而,在BMS组患者中(346例使用、1644例未用氯吡格雷),在死亡(3.3%比2.7%;差异,0.6%;95%CI,1.5%至2.8%;P=0.57)以及死亡或心肌梗死(4.7%比3.6%;差异,1.0%;95%CI,-1.6%至3.6%;P=0.44)发生方面,依然没有差异。结论:在接受DES治疗的患者中,延长氯吡格雷的使用可以使死亡以及死亡或心肌梗死的发生率下降。然而,使用氯吡格雷的适宜期限只能通过大型临床随机试验确定。 | Eric L Eisenstein, DBA Kevin J. Anstrom, PhD David F. Kong, MD Linda K. Shaw, MS Robert H. Tuttle, MSPH Daniel B. Mark, MD, MPH Judith M. Kramer, MD, MS Robert A. Harrington, MD David B. Matchar, MD David E. Kandzari, MD 1 Eric D. Peterson, MD, MPH Kevin A. Schulman, MD Robert M. Califf, MD 李呈亿(译) David E. Kandzari, MD | 2007 | 美国医学会杂志(中文版)2007，26，3： | 60 |
| 8 | SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion显示文摘Bone marrow mesenchymal stem cells(MSCs)are considered as a promising cell source to treat the acute myocardial infarction.However,over 90%of the stem cells usually die in the first three days of transplantation.Survival potential,migration ability and paracrine capacity have been considered as the most important three factors for cell transplantation in the ischemic cardiac treatment.We hypothesized that stromal-derived factor-1(SDF-1)/CXCR4 axis plays a critical role in the regulation of these processes.In this study,apoptosis was induced by exposure of MSCs to H2O2 for 2 h.After re-oxygenation,the SDF-1 pretreated MSCs demonstrated a significant increase in survival and proliferation.SDF-1 pretreatment also enhanced the migration and increased the secretion of pro-survival and angiogenic cytokines including basic fibroblast growth factor and vascular endothelial growth factor.Western blot and RT-PCR demonstrated that SDF-1 pretreatment significantly activated the pro-survival Akt and Erk signaling pathways and up-regulated Bcl-2/Bax ratio.These protective effects were partially inhibited by AMD3100,an antagonist of CXCR4.We conclude that the SDF-1/CXCR4 axis is critical for MSC survival,migration and cytokine secretion. | Xiaolei Liu Biyan Duan Zhaokang Cheng Xiaohua Jia Lina Mao Hao Fu Yongzhe Che Lailiang Ou Lin Liu Deling Kong | 2011 | Protein & Cell2011，2，10： | 53 |
| 9 | Treatment Efficiencies of Constructed Wetlands for Eutrophic Landscape River Water显示文摘The efficiencies of two types of constructed wetlands for the treatment of low-concentration polluted eutrophic land- scape river water were studied in the western section of the Qingyuan River at the Minhang campus of Shanghai Jiaotong University.The first wetland was a single-stage system using gravel as a filtration medium,and the second was a three- stage system filled with combinations of gravel,zeolite,and fly ash.Results from parallel operations of the wetlands showed that the three-stage constructed wetland could remove organics,nitrogen, and phosphorus successfully.At the same time,it could also decrease ammoniacal odour in the effluent.Compared to the single-stage constructed wetland,it had better nutrient removal efficiencies with a higher removal of 19.37%-65.27% for total phosphorus (TP) and 21.56%- 62.94% for total nitrogen (TN),respectively,during the operation period of 14 weeks.In terms of removal of chemical oxygen demand (COD), turbidity,and blue-green algae,these two wetland systems had equivalent performances.It was also found that in the western section of the test river,in which the two constructed wetlands were located, the water quality was much better than that in the eastern and middle sections without constructed wetland because COD,TN, and TP were all in a relatively lower level and the eutrophication could be prevented completely in the western section. | HE Sheng-Bing YAN Li KONG Hai-Nan LIU Zhi-Ming WU De-Yi HU Zhan-Bo | 2007 | Pedosphere2007，17，4： | 50 |
| 10 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 11 | Transition-metal doped edge sites in vertically aligned MoS2 catalysts for enhanced hydrogen evolution显示文摘为象氢进化反应那样的电气化学的反应的高度活跃、便宜的催化剂(她的) 为有效精力的发展是关键的变换和存储技术。理论模拟在揭示在材料和他们的催化活动的电子结构之间的关联是有帮助的,并且指导改进催化剂的预言和发展。然而,在精确地设计需要的原子地点的困难在做在试验性、理论的结果之间的直接比较导致挑战。在瞬间 < 潜水艇 class= “ a-plus-plus ” > 2 , 而薹是惰性的,瞬间边被表明了为她活跃。用一条计算基于描述符的途径,我们预言由合并转变金属原子(Fe,公司, Ni,或 Cu ) ,薹地点应该也成为她活跃。垂直地站的、终止边的瞬间 < 潜水艇 class= “ a-plus-plus ” > 2 nanofilms 为验证这些预言提供一个明确的模型系统。转变金属做了瞬间 < 潜水艇 class= “ a-plus-plus ” > 2 nanofilms 表演交换水流密度由的增加至少双重,与理论计算一致。这个工作为由把倡导者合并到特别原子地点改进电气化学的催化剂,并且为使用明确的系统以便理解提升效果的起源开创进一步的机会。 | Haotian Wang Charlie Tsai Desheng Kong Karen Chan Frank Abild-Pedersen Jens K. Norskov Yi Cui | 2015 | Nano Research2015，8，2： | 41 |
| 12 | A Novel QTL qTGW3 Encodes the GSK3/ SHAGGY-Like Kinase OsGSK5/OsSK41 that Interacts with OsARF4 to Negatively Regulate Grain Size and Weight in Rice显示文摘谷物尺寸和形状在米饭是谷物重量和产量的重要决定因素。这里,我们报导一个新主要量的特点在米饭的地点(QTL ) , qTGW3,那种控制谷物尺寸和重量。这个地点, qTGW3,编码 OsSK41 (也作为 OsGSK5 知道) , GLYCOGEN SYNTHASE KINASE 3/SHAGGY-like 家庭的一个成员。带 OsSK41 的 loss-of-function 等位基因的瑞斯 near-isogenic 线增加了谷物长度和重量。我们证明那 OsSK41 交往与并且 phosphorylates 植物生长素反应因素 4 (OsARF4 ) 。有 OsARF4 的 OsSK41 的合作表示在米饭原物增加 OsARF4 的累积。OsARF4 的功能的损失导致更大的米饭谷物。定序 RNA 分析建议 OsARF4 和 OsSK41 镇压下游的基因的一个普通集合的表示, ? 包括一些植物生长素应答的基因,在米饭谷物开发期间。在 qTGW3 的 OsSK41 的 loss-of-function 形式代表没被指向的基因编辑或 QTL 节节上升广泛地在 OsSK41 功能的米饭 breeding.?Suppression 利用了的稀罕等位基因提高米饭谷物尺寸和重量。因此,我们的学习在米饭谷物开发揭示 OsSK41 的重要角色 ?? 并且在另外的谷物庄稼在米饭并且也许为谷物产量的基因改进提供新候选人基因。 | Zejun Hu Sun-Jie Lu Mei-Jing Wang Haohua He Le Sun Hongru Wang Xue-Huan Liu Ling Jiang Jing-Liang sun Xiaoyun Xin Wei Kong Chengcai Chu Hong-Wei Xue Jinshui Yang Xiaojin Luo Jian-Xiang Liu | 2018 | Molecular Plant2018，11，5： | 47 |
| 13 | Why are social network transactions important? Evidence based on the concentration of key suppliers and customers in China显示文摘Based on a new institutional economy framework,this study examines the formation and economic consequences of social networks(guanxi)from the perspective of key suppliers and customers in China.Results show that commercial activities which depend on networks are determined by the institutional environment.For example,companies that have lower accumulated social capital(less trust among people)and are subject to more government invention depend more on social network transactions than on the market.In addition,this study shows that network transactions can provide benefits to firms,especially in weak institutional environments.Networks can reduce transaction costs by reducing information asymmetry,i.e.,increased network dependence is associated with lower credit costs and lower advertising and sales costs.Networks can also reduce the effect of industry shocks,especially negative shocks,by creating a bonding mechanism.This study contributes to our understanding of social networks in emerging markets by providing evidence on network transactions with key suppliers and customers and their influence on firms'accounting behavior. | Xiang Kong | 2011 | China Journal of Accounting Research2011，，3： | 46 |
| 14 | Anatomical and chemical characteristics associated with lodging resistance in wheat显示文摘Anatomical and chemical characteristics of stems affect lodging in wheat(Triticum aestivum L.) cultivars. Traits associated with lodging resistance, such as plant height, stem strength, culm wall thickness, pith diameter, and stem diameter, were extensively investigated in earlier studies. However, the solid stem trait was rarely considered. In this study, we measured a range of anatomical and chemical characteristics on solid and hollow stemmed wheat cultivars. Significant correlations were detected between resistance to lodging and several anatomical features, including width of mechanical tissue, weight of low internodes, and width of stem walls. Morphological features that gave the best indication of improved lodging resistance were increased stem width, width of mechanical tissue layer, and stem density. Multiple linear regression analysis showed that 99% of the variation in lodging resistance could be explained by the width of the mechanical tissue layer, suggesting that solid stemmed wheat has several anatomical features for increasing resistance to lodging. In addition, microsatellite markers GWM247 and GWM340 were linked to a single solid stem QTL on chromosome 3BL in a population derived from the cross Xinongshixin(solid stem)/Line 3159(hollow stem). These markers should be valuable in breeding wheat for solid stem. | Eryan Kong Dongcheng Liu Xiaoli Guo Wenlong Yang Jiazhu Sun Xin Li Kehui Zhan Dangqun Cui Jinxing Lin Aimin Zhang | 2013 | The Crop Journal2013，1，1： | 43 |
| 15 | Abscisic acid dynamics, signaling, and functions in plants显示文摘Abscisic acid(ABA)is an important phytohormone regulating plant growth,development,and stress responses.It has an essential role in multiple physiological processes of plants,such as stomatal closure,cuticular wax accumulation,leaf senescence,bud dormancy,seed germination,osmotic regulation,and growth inhibition among many others.Abscisic acid controls downstream responses to abiotic and biotic environmental changes through both transcriptional and posttranscriptional mechanisms.During the past 20 years,ABA biosynthesis and many of its signaling pathways have been well characterized.Here we review the dynamics of ABA metabolic pools and signaling that affects many of its physiological functions. | Kong Chen Guo-Jun Li Ray ABressan Chun-Peng Song Jian-Kang Zhu Yang Zhao | 2020 | Journal of Integrative Plant Biology2020，62，1： | 46 |
| 16 | Major complications after radiofrequency ablation for liver tumors:Analysis of 255 patients显示文摘AIM:To investigate the major complications after radiofrequency ablation(RFA) for the treatment of liver tumors and analyze possible risk factors that precipitate these complications.METHODS:From March 2001 to April 2008,255 patients with liver tumors(205 male,50 female;age range,18-89 years;mean age,56.0 years) who received RFA were enrolled in this study.Of these patients,212 had hepatocellular carcinoma,39 had metastatic liver tumors and four had cholangiocellular carcinoma.One hundred and forty eight patients had a single tumor,and 107 had multiple tumors.Maximum diameter of the tumors ranged 1.3-20 cm(mean,5.1 cm).All patients were treated with a cooled-tip perfusion electrode attached to a radiofrequency generator(Radionics,Burlington,MA,USA).RFA was performed via the percutaneous approach(n = 257),laparoscopy(n = 7),or open surgical treatment(n = 86).The major complications related to RFA were recorded.The resultant data were analyzed to determine risk factors associated these complications.RESULTS:Among the 255 patients,425 liver tumors were treated and 350 RFA sessions were performed.Thirty-seven(10%) major complications were observed which included 13 cases of liver failure,10 cases of hydrothorax requiring drainage,three casesof tumor seeding,one case of upper gastrointestinal bleeding,one case ofintrahepatic abscess,one case of bile duct injury,one case of cardiac arrest,and five cases of hyperglycemia.Seven patients had more than two complications.Liver failure was the most severe complication and was associated with the highest mortality.Eleven patients died due to worsening liver decompensation.Child-Pugh classification(P = 0.001) and choice of approach(P = 0.045) were related to post-treatment liver failure,whereas patient age,tumor size and number were not significant factors precipitating this complication.CONCLUSION:RFA can be accepted as a relatively safe procedure for the treatment of liver tumors.However,attention should be paid to possible complications even though the incidences of these complications are rare.Careful patient selection and the best approach choice(percutaneous,laparoscopy,or laparotomy) will help to minimize the incidence and morbidity rate of complications which occur after RFA. | Wen-Tao Kong Wei-Wei Zhang Yu-Dong Qiu Tie Zhou Jun-Lan Qiu Wei Zhang Yi-Tao Ding | 2009 | World Journal of Gastroenterology2009，15，21： | 35 |
| 17 | Ginsenoside Rbl protects cardiomyocytes against CoCl2-induced apoptosis in neonatal rats by inhibiting mitochondria permeability transition pore opening显示文摘 | Hong-liang KONG Zhan-quan LI Ying-jun ZHAO Shu-mei ZHAO Li ZHU Tong LI Yao FU Hui-jun LI | 2010 | Acta Pharmacologica Sinica2010，31，6： | 35 |
| 18 | Double contrast-enhanced two-dimensional and three-dimensional ultrasonography for evaluation of gastric lesions显示文摘AIM:To investigate the value of two-dimensional(2D) and three-dimensional(3D) double contrast-enhanced ultrasonography(DCUS) imaging for evaluation of gastric lesions.METHODS:2D and 3D DCUS imaging with both oral and intravenous administrations of contrast agents was used to assess gastroscopiclly-confirmed gastric lesions in 46 patients with benign and malignant diseases.Initially,liquid-based ultrasound contrast agent(Xinzhang) was given orally at dose of 500-600 mL for conventional ultrasound examination of the gastric lesions,and then a microbubble-based contrast agent(SonoVue) was injected intravenously at dose of 1.2-2.4 mL in bolus fashion to assess the perfusion pattern of the lesions using contrast imaging modes.The parameters derived from time-intensity curves including the arrival time(AT),time to peak(TTP),peak intensity(PI) and enhanced intensity(EI) were measured on the 2D DCUS imaging.3D DCUS of the lesions was acquired to demonstrate the value of this imaging mode.RESULTS:There were 22 cases with benign lesions including chronic gastritis(n = 5),gastric ulcer(n = 9),gastric polyps(n = 3),gastric stromal tumors(n = 5),and 24 cases with malignant lesions including gastric cancer(n = 20),gastric cardia carcinoma(n = 3) and post-operative recurrent gastric cancer(n = 1) in the study.The oral contrast-enhanced ultrasonography(CEUS) imaging of the stomach clearly demonstrated the anatomy of the stomach and morphologic features of gastric lesions.With optimal scanning window and imaging display under oral CEUS,intravenous CEUS clearly showed the perfusion of gastric lesions with various characteristic manifestations.Both 2D and 3D DCUS images clearly demonstrated normal gastric wall as a three-layer structure,from the inside out,hyperechoic mucosa,hypoechoic muscularis and hyperechoic serosa,respectively.There were statistical significant differences of AT(8.68 ± 2.06 vs 10.43 ± 2.75,P = 0.017),PI(34.64 ± 6.63 vs 29.58 ± 8.22,P = 0.023) and EI(29.72 ± 6.69 vs 22.66 ± 7.01,P = 0.001) between malignant lesions and normal gastric wall.However,no differences of AT,PI and EI between benign lesions and normal gastric wall tissue were found.3D DCUS could intuitively display morphological features and vascularities of the lesions with multiplanar and volume views.3D DCUS imaging provided comprehensive information complementary to 2D imaging.The crater or wellhead appearances and feeding vessels as well as distorted nourishing vasculature of gastric carcinoma were better seen with 3D imaging than 2D imaging.CONCLUSION:DCUS imaging can simultaneously display the anatomic and perfusion features of gastric lesions.3D DCUS can provide additional information to 2D DCUS for evaluation of gastric lesions. | Hong Shi Xiu-Hua Yu Xin-Zhang Guo Yuan Guo Hong Zhang Bin Qian Zhang-Rui Wei Li Li Xian-Chen Wang Zi-Xiang Kong | 2012 | World Journal of Gastroenterology2012，18，31： | 36 |
| 19 | Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis显示文摘Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously, the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days. The results were as follows:(1) Electron microscopy revealed shrunken mitochondria in the spinal cord injury group.(2) The Basso, Beattie and Bresnahan locomotor rating score showed that recovery of the hindlimb was remarkably better in the Deferoxamine group than in the spinal cord injury group.(3) The iron concentration was lower in the Deferoxamine group than in the spinal cord injury group after injury.(4) Western blot assay revealed that, compared with the spinal cord injury group, GPX4, xCT, and glutathione expression was markedly increased in the Deferoxamine group.(5) Real-time polymerase chain reaction revealed that, compared with the Deferoxamine group, mRNA levels of ferroptosis-related genes Acyl-CoA synthetase family member 2(ACSF2) and iron-responsive element-binding protein 2(IREB2) were up-regulated in the Deferoxamine group.(6) Deferoxamine increased survival of neurons and inhibited gliosis. These findings confirm that Deferoxamine can repair spinal cord injury by inhibiting ferroptosis. Targeting ferroptosis is therefore a promising therapeutic approach for spinal cord injury. | Xue Yao Yan Zhang Jian Hao Hui-Quan Duan Chen-Xi Zhao Chao Sun Bo Li Bao-You Fan Xu Wang Wen-Xiang Li Xuan-Hao Fu Yong Hu Chang Liu Xiao-Hong Kong Shi-Qing Feng | 2019 | Neural Regeneration Research2019，14，3： | 35 |
| 20 | Safety and Efficacy of Low Dosage of Urokinase for Catheter-directed Thrombolysis of Deep Venous Thrombosis显示文摘 | Xiao-Long Du Ling-Shang Kong Qing-You Meng Aimin Qian Wen-Dong Li Hong Chen Xiao-Qiang Li Cheng-Long Li | 2015 | Chinese Medical Journal2015，，13： | 35 |
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