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| 1 | Molecular aspects of carcinogenesis in pancreatic cancer显示文摘BACKGROUND:Pancreatic cancer(PCa)is one of the most aggressive human solid tumors,with rapid growth and metastatic spread as well as resistance to chemotherapeutic drugs,leading rapidly to virtually incurable disease.Over the last 20 years,however,significant advances have been made in our understanding of the molecular biology of PCa,with a focus on the cytogenetic abnormalities in PCa cell growth and differentiation. DATA SOURCES:A MEDLINE search and manual cross- referencing were utilized to identify published data for PCa molecular biology studies between 1986 and 2008, with emphasis on genetic alterations and developmental oncology. RESULTS:Activation of oncogenes,deregulation of tumor suppressor and genome maintenance genes,upregulation of growth factors/growth factor receptor signaling cascade systems,and alterations in cytokine expression,have been reported to play important roles in the process of pancreatic carcinogenesis.Alterations in the K-ras proto- oncogene and the p16INK4a,p53,FHIT,and DPC4 tumor suppressor genes occur in a high percentage of tumors. Furthermore,a variety of growth factors are expressed at increased levels.In addition,PCa often exhibits alterations in growth inhibitory pathways and evades apoptosis through p53 mutations and aberrant expression of apoptosis-regulating genes,such as members of the Bcl family.Additional pathways in the development of an aggressive phenotype,local infiltration and metastasis are still under ongoing genetic research.The present paper reviews recent studies on the pathogenesis of PCa,and includes a brief reference to alterations reported for other types of pancreatic tumor. CONCLUSIONS:Advances in molecular genetics and biology have improved our perception of the pathogenesis of PCa.However,further studies are needed to better understand the fundamental changes that occur in PCa,thus leading to better diagnostic and therapeutic management. | Alexandros Koliopanos Constantinos Avgerinos Constantina Paraskeva Zisis Touloumis Dionisisa Kelgiorgi Christos Dervenis | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 4 |
| 2 | Radical resection of pancreatic cancer显示文摘BACKGROUND: Pancreatic adenocarcinoma (PCa) is a disease with dismal prognosis, and the only possibility of cure, albeit small, is based on the combination of complete resection with negative histopathological margins (R0 resection) with adjuvant treatment. Therefore, a lot of effort has been made during the last decade to assess the role of extensive surgery in both local recurrence and survival of patients with PCa. DATA SOURCES: Medline search and manual cross- referencing were utilized to identify published evidence- based data for PCa surgery between 1973 and 2006, with emphasis to feasibility, efficacy, long-term survival, disease free survival, recurrence rates, pain relief and quality of life. RESULTS: Extended surgery is safe and feasible in high volume surgical centers with comparable short-term results. Organ preserving surgery is a main goal because of quality of life reasons and is performed whenever possible from the tumor extent. Concerning long-term survival major vein resection does not adversely affect outcome. To date, there are no changes in long-term survival attributed to the extended lymph node dissection. However, there is a benefit in locoregional control with fewer local recurrences and extended lymphadenectomy allows better staging for the disease. CONCLUSIONS: Extended PCa surgery is safe and feasible despite the inconclusive results in patient's survival benefit. In the future, appropriately powered randomized trials of standard vs. extended resections may show improved outcomes for PCa patients. | Alexander Koliopanos C Avgerinos Athanasios Farfaras C Manes Christos Dervenis | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，1： | 4 |
| 3 | Esophageal Doppler (ODM Ⅱ)Improves Intraoperative hemodynamic monitoring during laparoscopic surgery 显示文摘 | KOLIOPANOS A ZOGRAFOS G SKIATHITIS S | 2005 | Surg Laparosc Endosc Percutan Tech2005，15，6： | 1 |
| 4 | H eparanase expression in primary and metastatic pancreatic cancer显示文摘 | Koliopanos A Friess H Kleeff J | 2001 | Cancer Res2001，61，： | 1 |
| 5 | He-paranase Expression in Primary and Metastatic Pancreatic Cancer显示文摘 | Alexander Koliopanos Helmut Friess J rg Kleeff | 2001 | Cancer Research2001，61，12： | 1 |
| 6 | Syndecan-1 expression is up-regulated in pancreatic but not in other gastrointestinal cancers显示文摘 | Conejo JR Kleeff J Koliopanos A | 2000 | Int J Cancer2000，88，1： | 1 |
| 7 | Heparanase expression in primary and metastatic Pancreatic cancer显示文摘 | Koliopanos A Friess H | 2001 | Cancer Res2001，61，12： | 1 |
| 8 | Esophageal Doppler (OMDII) improves intraoperative hemodynamic monitoring during laparoscopic surgery显示文摘 | Koliopanos A Zografos G Skiathitis S | | 0，，06： | 1 |
| 9 | Heparanase expression in primary and metastatic pancreatic cancer 显示文摘 | Koliopanos A Friess H Kleeff J | 2001 | Cancer Res2001，61，12： | 1 |
| 10 | Heparanase expression in primary and metastatic pancreatic cancer显示文摘 | Koliopanos A Friess H Kleeff J | 2001 | Cancer Res2001，61，12： | 1 |
| 11 | Heparanase expression in primary and metastatic pancreatic cancer显示文摘 | Koliopanos A Friess H Kleeff J | 2001 | Cancer Res2001，61，12： | 1 |
| 12 | Heparanase Expression in Primary and Metastatic Pancreatic Cancer显示文摘 | KOLIOPANOS A FRIESS H KLEEFF J | 2001 | Cancer Res2001，61，： | 1 |
| 13 | Esophageal Doppler (OMDII)improves intraoperative hemodynamic monitoring during laparoscopic surgery 显示文摘 | Koliopanos A Zografos G Skiathitis S | 2005 | Surg La- parosc Endosc Percutan Tech2005，15，6： | 1 |
| 14 | Heparanase expression in primary and metastatic pancreatic cancer显示文摘 | KOLIOPANOS A HELMUT F KLEEFF J | 2001 | Cancer Res2001，61，： | 1 |
| 15 | Heparanase expression in primary and metastatic pancreatic cancer显示文摘 | Koliopanos A Friess H | 2001 | Cancer Res2001，61，12： | 1 |
| 16 | Heparanase expression in primary and metastatic pancreatic cancer显示文摘 | Koliopanos A Friess H Kleeff J | 2001 | Cancer Res2001，61，12： | 1 |
| 17 | Cyclooxygenase-2 expression in chronic pancreatitis:correlation with stage of the disease and diabetes mellitus显示文摘 | Koliopanos A Friess H Kleeff J | 2001 | Digestion2001，64，4： | 1 |
| 18 | Connective tissue growth factor gene expression alters tumor progression in esophageal cancer显示文摘 | KOLIOPANOS A FRIESS H DI MOLA FF | | 0，，04： | 1 |
| 19 | Heparanase expression in primary and metastatic pancreatic cancer显示文摘 | Koliopanos A Friess H Kleeff J | 2001 | Cancer Res2001，61，12： | 1 |
| 20 | Heparanase expression in primary and metastatic pancreatic cancer显示文摘 | Nadav L Eidor A | 2001 | Cancer Res2001，61，： | 1 |
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