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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Epidemiology of clinical benign prostatic hyperplasia显示文摘Clinical benign prostatic hyperplasia(BPH)is one of the most common diseases in ageing men and the most common cause of lower urinary tract symptoms(LUTS).The prevalence of BPH increases after the age of 40 years,with a prevalence of 8%-60% at age 90 years.Some data have suggested that there is decreased risk among the Asians compared to the western white population.Genetics,diet and life style may play a role here.Recent reports suggest the strong relationship of clinical BPH with metabolic syndrome and erectile dysfunction,as well as the possible role of inflammation as a cause of the prostatic hyperplasia.Lifestyle changes including exercise and diet are important strategies in controlling this common ailment. | Kok Bin Lim | 2017 | Asian Journal of Urology2017，4，3： | 26 |
| 3 | Current research and treatment for gastrointestinal stromal tumors显示文摘Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumors of the gastrointestinal tract and have gained considerable research and treatment interest,especially in the last two decades. GISTs are driven by mutations commonly found in the KIT gene and less commonly in the platelet-derived growth factor receptor alpha gene,BRAF gene and succinate dehydrogenase gene. GISTs behave in a spectrum of malignant potential,and both the tumor size and mitotic index are the most commonly used prognostic criteria. Whilst surgical resection can offer the best cure,targeted therapy in the form of tyrosine kinase inhibitors(TKIs) has revolutionized the management options. As the first-line TKI,imatinib offers treatment for advanced and metastatic GISTs,adjuvant therapy in high-risk GISTs and as a neoadjuvant agent to downsize large tumors prior to resection. The emergence of drug resistance has altered some treatment options,including prolonging the first-line TKI from 1 to 3 years,increasing the dose of TKI or switching to second-line TKI. Other newer TKIs,such as sunitinib and regorafenib,may offer some treatment options for imatinib-resistant GISTs. New molecular targeted therapies are being evaluated,such as inhibitors of BRAF,heat shock protein 90,glutamine and mitogenactivated protein kinase signaling,as well as inhibitors of apoptosis proteins antagonist and even immunotherapy. This editorial review summarizes the recent research trials and potential treatment targets that may influence our future patient-specific management of GISTs. The current guidelines in GIST management from Europe,North America and Asia are highlighted. | Kheng Tian Lim Kok Yang Tan | 2017 | World Journal of Gastroenterology2017，23，27： | 23 |
| 4 | Association of smoking, alcohol drinking and dietary factors with esophageal cancer in high- and low-risk areas of Jiangsu Province, China显示文摘瞄准:到环境的 main 和在食道的癌症(EC ) 说明地区性的差别的生活方式因素在江苏省的低风险、高风险的区域冒的风险的学习,中国。方法:自从 2003,基于人口的盒子控制研究同时被进行了在低风险(Ganyu 县) 并且高风险(Dafeng 县) 江苏省的区域,中国。使用相同协议和 pre-tested 标准化了问询表,跟随写的知情同意,合格题目被询问他们 EC 的潜在的决定因素的详细信息包括人口统计的信息,社会经济的地位,生活条件,疾病历史,家庭癌症历史,吸烟,酒精喝酒,饮食的习惯,频率,食物摄取的数量,等等。有最大的可能性评价的有条件的逻辑回归被用来获得机会比率(或) 并且 95 % 信心间隔(95% CI ) ,在为潜力的调整以后,反对失败。结果:在进行中的学习的初步的分析,我们招募了在 Ganyu 的在 Dafeng 的 291 个盒子和 240 个盒子和控制分别地。在低风险、高风险的区域, EC 相反地与社会经济的地位被联系,例如教育的水平,经过经济地位和身体团索引。然而,这疾病在有癌症的家庭历史或在过去的 10 年里遇到了不幸的那些之中是更经常的。EC 在吸烟者,白酒喝酒者和快食客之中也是更经常的。而且,有在吸烟,酒精喝酒和尽管有在低风险、高风险的区域的这些风险因素的类似的流行的 EC 风险之间的协会的一个地理变化。吸烟并且吸烟的剂量反应关系联系了变量,例如首先吸烟,持续时间和数量的年龄在高风险的区域仅仅是明显的。相反,在 EC 上喝的酒精的效果上的一种剂量反应关系仅仅在低风险的区域被观察。结论:环境风险因素,可能和基因因素和基因环境的相互作用是为在江苏省的这个高风险的坡度的主要原因,中国。 | Ming Wu Jin-Kou Zhao Xiao-Shu Hu Pei-Hua Wang Yu Qin Yin-Chang Lu Jie Yang Ai-Min Liu De-Lin Wu Zuo-Feng Zhang Kok J Frans Pieter van't Veer | 2006 | World Journal of Gastroenterology2006，12，11： | 18 |
| 5 | Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain显示文摘Coronaviruses 开发了各种各样的措施躲避天生的免疫。我们以前证明了那严重急性呼吸症候群(SARS ) coronavirus M 蛋白质压制类型我由阻碍功能的包含 TRAF3 的形成的干扰素(IFN ) 生产复杂。在这研究,我们证明反对 IFN 活动对 SARS coronavirus M 蛋白质特定并且通过它在 N 终点定位的第一个 transmembrane 领域(TM1 ) 被调停。从人的 coronavirus HKU1 的 M 蛋白质不禁止 IFN 生产。而 SARS coronavirus M 蛋白质的连接 N 的 glycosylation 没在 IFN 对抗上有影响, TM1 为 IFN 生产的抑制是不可缺少的。TM1 目标 SARS coronavirus M 蛋白质和 heterologous 蛋白质到 Golgi 仪器,然而, Golgi 本地化被要求然而并非为 IFN 足够对抗。机械学地, TM1 能够有 RIG-I, TRAF3, TBK1 和 IKKε 的绑定;,并且与它的下游的受动器阻止 TRAF3 的相互作用。我们的工作定义为天生的抗病毒的反应的抑制要求的 SARS coronavirus M 蛋白质的分子的建筑学。 | Kam-Leung Siu Chi-Ping Chan Kin-Hang Kok Patrick Chiu-Yat Woo Dong-Yan Jin | 2014 | Cellular & Molecular Immunology2014，11，2： | 13 |
| 6 | Therapeutic and prevention strategies against human enterovirus 71 infection显示文摘Human enterovirus 71(HEV71) is the cause of hand,foot and mouth disease and associated neurological complications in children under five years of age.There has been an increase in HEV71 epidemic activity throughout the Asia-Pacific region in the past decade,and it is predicted to replace poliovirus as the extant neurotropic enterovirus of highest global public health significance. To date there is no effective antiviral treatment and no vaccine is available to prevent HEV71 infection. The increase in prevalence, virulence and geographic spread of HEV71 infection over the past decade provides increasing incentive for the development of new therapeutic and prevention strategies against this emerging viral infection. The current review focuses on the potential, advantages and disadvantages of these strategies. Since the explosion of outbreaks leading to large epidemics in China, research in natural therapeutic products has identified several groups of compounds with anti-HEV71 activities. Concurrently, the search for effective synthetic antivirals has produced promising results. Other therapeutic strategies including immunotherapy and the use of oligonucleotides have also been explored. A sound prevention strategy is crucial in order to control the spread of HEV71. To this end the ultimate goal is the rapid development, regulatory approval and widespread implementation of a safe and effective vaccine. The various forms of HEV71 vaccine designs are highlighted in this review. Given the rapid progress of research in this area, eradication of the virus is likely to be achieved. | Chee Choy Kok | 2015 | World Journal of Virology2015，4，2： | 12 |
| 7 | Report on Childhood Obesity in China (5) Body Weight, Body Dissatisfaction, and Depression Symptoms of Chinese Children Aged 9-10 Years显示文摘Objective To investigate the relationship between body weight, body dissatisfaction and depression symptoms among Chinese children. Methods The fasting body weight and height of the third and fourth grade students (n=3886, aged 9 or 10 years) from 20 schools in Beijing, China, were measured, and the students were asked to choose the figures of body image and to complete the self-reported children’s depression inventory (CDI) questionnaire. Results The CDI Cronbach’s alpha was 0.81. The total CDI score was 9.60±7.50, 13.2% of children (boys 16.7% vs girls 9.5%) were at risk of developing depression symptoms. Overweight girls, but not boys, had significantly higher total CDI score than their normal weight counteparts. Both obese girls and boys showed a higher negative self-esteem score. More than one fifth underweight girls still wanted to be thinner while more than one third obese boys still wanted to be heavier. Children who wanted to be thinner showed slightly higher scores of ineffectiveness and negative self-esteem. After introducing the body dissatisfaction into the model, overweight was still associated with total CDI score among girls and obesity was still associated with negative self-esteem among both boys and girls. Conclusion Overweight girls show a significantly higher depression symptom score than their normal weight counterparts, which maybe partially explained by body dissatisfaction. Obese boys and girls are both more likely to suffer from low self-esteem, which is partially explained by body dissatisfaction. | YAN-PING LI GUAN-SHENG MA EVERT G. SCHOUTEN XIAO-QI HU ZHAO-HUI CUI DONG WANG FRANS J. KOK | 2007 | Biomedical and Environmental Sciences2007，20，1： | 10 |
| 8 | 空气湿度对东方百合生长和切花品质的影响显示文摘以东方百合(Liliumspp.)品种‘凝视星空’和‘巴希亚布兰卡’为材料,种植于温室进行不同湿度栽培试验,设置60%、75%和90%相对湿度水平。结果表明:湿度对两个东方百合品种的植株生长和发育有显著影响,高湿度增加了叶面积,但是推迟了开花期,缩短了切花瓶插寿命,加速了叶片衰老。高湿度下气孔增大,密度减小,叶片气孔导度和蒸腾速率提高,气孔在叶片失水后的反应迟钝,关闭速度慢于低湿度下生长的叶片。高湿度下植株茎流也慢,水分吸收少于低湿度植株。高湿度下生长的百合切花在瓶插期发生了纸叶病。 | 尤伟忠 Hans Kok 房伟民 成海钟 | 2009 | 园艺学报2009，36，4： | 10 |
| 9 | Biogreen Synthesis of Carbon Dots for Biotechnology and Nanomedicine Applications显示文摘Over the past decade, carbon dots have ignited a burst of interest in many different fields, including nanomedicine, solar energy, optoelectronics, energy storage,and sensing applications, owing to their excellent photoluminescence properties and the easiness to modify their optical properties through doping and functionalization. In this review, the synthesis, structural and optical properties,as well as photoluminescence mechanisms of carbon dots are first reviewed and summarized. Then, we describe a series of designs for carbon dot-based sensors and the different sensing mechanisms associated with them.Thereafter, we elaborate on recent research advances on carbon dot-based sensors for the selective and sensitive detection of a wide range of analytes, including heavy metals, cations, anions, biomolecules, biomarkers,nitroaromatic explosives, pollutants, vitamins, and drugs.Lastly, we provide a concluding perspective on the overall status, challenges, and future directions for the use of carbon dots in real-life sensing. | Kok Ken Chan Stephanie Hui Kit Yap Ken-Tye Yong | 2018 | Nano-Micro Letters2018，10，4： | 9 |
| 10 | 内皮-氧化氮合酶基因多态性与糖尿病肾病关系的研究显示文摘目的 探讨内皮一氧化氮合酶(eNOS)基因内含子4的多态性与糖尿病肾病的关系,以及其在中国人、马来西亚人和印度人中的分布。方法 选择258例病程在10年以上的2型糖尿病患者作为观察对象,其中中国人150例、马来西亚人71例、印度人37例。从患者全血中提取DNA,然后,进行聚酶链反应(PCR)、克隆及测序。结果 以往认为该基因有2种等位基因(a和b),而本研究发现3种等位基因,并对第3种多态(等位基因c)基因进行了序列分析;统计分析显示,等位基因a、b和c均与糖尿病肾病无显著相关性。结论 eNOS基因内含子4上的多态性有3种等位基因;该基因多态性与糖尿病肾病无显著相关性。 | 廖琳 赵家军 Lim Min Chen Chan Shzu-Wei Lee Kok Onn | 2004 | 中华检验医学杂志2004，27，5： | 7 |
| 11 | Intrahepatic vascular changes in non-alcoholic fatty liver disease: potential role of insulin-resistance and endothelial dysfunction显示文摘Metabolic syndrome is a cluster of several clinical conditions characterized by insulin-resistance and high cardiovascular risk. Non-alcoholic fatty liver disease is the liver expression of the metabolic syndrome, and insulin resistance can be a frequent comorbidity in several chronic liver diseases, in particular hepatitis C virus infection and/or cirrhosis. Several studies have demonstrated that insulin action is not only relevant for glucose control, but also for vascular homeostasis. Insulin regulates nitric oxide production, which mediates to a large degree the vasodilating, antiinflammatory and antithrombotic properties of a healthy endothelium, guaranteeing organ perfusion. The effects of insulin on the liver microvasculature and the effects of IR on sinusoidal endothelial cells have been studied in animal models of non-alcoholic fatty liver disease. The hypotheses derived from these studies and the potential translation of these results into humans are critically discussed in this review. | Marcos Pasarín Juan G Abraldes Eleonora Liguori Beverley Kok Vincenzo La Mura | 2017 | World Journal of Gastroenterology2017，23，37： | 6 |
| 12 | IVF或ICSI周期卵巢过度刺激获取大量卵子并不会导致妊娠率降低显示文摘Objective: To investigate the possible negative effects of a strong ovarian response on oocyte quality.Design: Retrospective study.Setting: Tertiary academic center.Patient(s): A total of 1, 894 women (IVF, n = 1, 544; ICSI, n = 350) who underwent their first ovarian stimulation cycle during the period 1995- 2002.Intervention(s): Standardized controlled ovarian stimulation with urinary FSH or recombinant FSH after pituitary down- regulation, followed by IVF/intracytoplasmic sperm injection (ICSI) and ET.Main Outcome Measure(s): Fertilization rate, fraction of high- quality embryos, and implantation rate.Result(s): Using multivariate logistic regression, we analyzed the effect, expressed as an odds ratio (OR), of the number of oocytes obtained (i.e., ovarian response) on the outcome measures.No effect of the response on the ongoing implantation rate or fraction of high- quality embryos was observed.Both in IVF (OR = 0.81, 95% confidence interval [CI] 0.75- 0.87) and in ICSI (OR = 0.88, 95% CI 0.76- 1.00), a negative effect of increasing ovarian response was seen on the fertilization rate per oocyte obtained.However, no negative effect was observed on the fertilization rate per oocyte injected in ICSI (OR = 1.00, 95% CI 0.87- 1.14).The fraction of immature oocytes rises from 3.9% , in women with ≤ 3 oocytes, to 26% in women with > 20 oocytes.Conclusion(s): Oocytes from high responders contain a greater fraction of immature oocytes, but pregnancy outcome is not impaired. | Kok J.D. Looman C.W.N. Weima S.M. Te Velde E.R. 朱亮 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，2，9： | 5 |
| 13 | Report on Childhood Obesity in China(8):Effects and Sustainability of Physical Activity Intervention on Body Composition of Chinese Youth显示文摘Objectives To determine whether a large-scale physical activity intervention could affect body composition in primary school students in Beijing,China.Methods The study design was one-year cluster randomized controlled trial of physical activity intervention(20 min of daily exercise in the classroom) with an additional year of follow-up among 4 700 students aged 8-11 years at baseline.Results After the one-year intervention,BMI increased by 0.56 kg/m^2(SD 1.15) in the intervention group and by 0.72 kg/m^2(SD 1.20) in the control group,with a mean difference of-0.15 kg/m^2(95%CI:-0.28 to-0.02).BMI z score decreased by-0.05(SD 0.44) in the intervention group,but increased by 0.01(SD 0.46) in the control group,with a mean difference of-0.07(-0.13 to-0.01).After another year of follow up,compared to the control group,children in the intervention group had significantly lower BMI(-0.13,-0.25 to-0.01),BMI z score(-0.05,-0.10 to-0.01),fat mass(-0.27 kg,-0.53 to-0.02) and percent body fat(-0.53,-1.00 to-0.05).The intervention had a more pronounced effect on weight,height,BMI,BMI z score,and body composition among obese children than among normal weight or overweight children.Compared to the control group,the intervention group had a significantly higher percentage of children who maintained or reduced their BMI z score at year 1(P=0.008) and year 2(P=0.04).Conclusions These findings suggest that 20 min of daily moderate to vigorous physical activity during the school year is a feasible and effective way to prevent excessive gain of body weight,BMI,and body fatness in primary school students. | YAN-PING LI XIAO=QI HU EVERT G. SCHOUTEN AI-LING LIU SONG-MING DU LIN-ZHONG LI ZHAO-HuI CUI DONG WANG FRANS J KOK FRANK B HU GUAN-SHENG MA | 2010 | Biomedical and Environmental Sciences2010，23，3： | 5 |
| 14 | Cerebrospinal fluid phosphorylated tau,visinin-like protein-1,and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease显示文摘Background:Visinin-like protein-1(VILIP-1)and chitinase-3-like protein 1(CHI3L1 or YKL-40)in cerebrospinal fluid(CSF)are newly discovered markers indicating neuronal damage and microglial activation,respectively.Phosphorylated tau(p-tau)reflects the neuropathology of Alzheimer’s disease(AD)and is useful as diagnostic markers for AD.However,it is unknown whether these biomarkers have similar or complementary information in AD.Methods:We stratified 121 participants from the Alzheimer’s Disease Neuroimaging Initiative(ADNI)database into cognitively normal(CN),stable mild cognitive impairment(sMCI),progressive MCI(pMCI),and dementia due to AD.Analysis of covariance(ANOVA)and chi-square analyses,Spearman correlation,and logistic regression models were performed to test the demographic,associations between biomarkers,and diagnostic accuracies,respectively.Linear mixed-effects models were used to evaluate the effects of CSF amyloid-β(Aβ)on above biomarkers within diagnostic groups,the combination of diagnostic group and Aβstatus as predictor,and CSF biomarkers as predictors of AD features,including cognition measured by Mini–Mental State Examination(MMSE)and brain structure and white matter hyperintensity(WMH)measured by magnetic resonance imaging(MRI).Results:P-tau,VILIP-1,and YKL-40 were all predictors of AD diagnosis,but combinations of biomarkers did not improve the diagnostic accuracy(AUC 0.924 for p-tau,VILIP-1,and YKL-40)compared to p-tau(AUC 0.922).P-tau and VILIP-1 were highly correlated(r=0.639,p<0.001)and strongly associated with Aβpathology across clinical stages of AD,while YKL-40 was correlated with Aβpathology in CN and AD groups.VILIP-1 was associated with acceleration of cognitive decline,hippocampal atrophy,and expansion of ventricles in longitudinal analyses.YKL-40 was associated with hippocampal atrophy at baseline and follow-up,while p-tau was only associated with worsening WMH at baseline.Conclusions:CSF levels of p-tau,VILIP-1,and YKL-40 may have utility for discriminating between cognitively normal subjects and patients with AD.Increased levels of both VILIP-1 and YKL-40 may be associated with disease degeneration.These CSF biomarkers should be considered for future assessment in the characterization of the natural history of AD. | Hua Zhang Kok Pin Ng Joseph Therriault Min Su Kang Tharick APascoal Pedro Rosa-Neto Serge Gauthier the Alzheimer’s Disease Neuroimaging Initiative | 2018 | Translational Neurodegeneration2018，7，1： | 5 |
| 15 | HIV/AIDS in Asia:The Shape of Epidemics and Their Molecular Epidemiology显示文摘The Asia-Pacific region is a home to 60% of the population in the world and to approximately one quarter of people with HIV/AIDS. Close to a million of people has been infected and a half million people died of AIDS annually in Asia,becoming the second largest epicenter of global AIDS epidemic. Molecular epidemiology has been useful tool to track a course of HIV spread. In-depth knowledge from the studies on molecular epidemiology elucidates the dynamics of HIV spread and the interrelationship of epidemics in the different regions in Asia. | Rie Uenishi Saiki Hase Tee Kok Keng Shigeru Kusagawa Yutaka Takebe | 2007 | Virologica Sinica2007，22，6： | 4 |
| 16 | Can intravesical prostatic protrusion predict bladder outlet obstruction even in men with good flow?显示文摘Objective:Men with benign prostate hyperplasia(BPH)with good urinary flow may still have bladder outlet obstruction(BOO).Intravesical prostatic protrusion(IPP)has been shown to be able to predict BOO.We aim to investigate the use of IPP to predict BOO in men with good urinary flow.Methods:One hundred and fourteen consecutive men(>50 years old)presenting with lower urinary tract symptoms suggestive of BPH were recruited in 2001 and 2002.They were evaluated with serum prostate specific antigen(PSA),uroflowmetry and transabdominal ultrasound measurement of IPP and prostate volume(PV).Pressure-flow urodynamic studies were performed on all men and BOO was defined by BOO index>40.Men with Qmax12.0 mL/s were considered to have good flow.Results:Among the 114 men,61 patients had good urinary flow.Their median age,PV and Qmax were 66 years,32.9 mm3 and 14.5 mL/s respectively.14/61(23.0%)patients had BOO and their distribution of IPP were as follows:Grade 1 e 0/20(0%)obstructed,Grade 2 e 6/22(27.3%)and Grade 3 e 8/19(42.1%).Sensitivity of Grade 2/3 IPP for BOO was 100% while specificity of Grade 3 IPP was 76.6%.The area-under-curve(AUC)for IPP was greater than that for PV(0.757 vs.0.696).Conclusion:Even in men with good flow,high grades of IPP were more likely to have BOO and hence,may be a useful adjunct to predict BOO. | Alvin Lee Han Jie Lee Kok Bin Lim Hong Hong Huang Henry Ho Keong Tatt Foo | 2016 | Asian Journal of Urology2016，3，1： | 4 |
| 17 | Reducing risk of transjugular intrahepatic portosystemic shunt using ultrasound guided single needle pass显示文摘Delayed liver laceration following transjugular intrahepatic portosystemic shunt (TIPS) is a serious and likely underdiagnosed complication. It is however an important complication following TIPS, which remains one of the most technically challenging interventional procedures performed. In addition to laceration, a number of complications regarding bleeding and perforation are well described following TIPS procedures. We feel the adoption of techniques such as ours and that of other authors described in the literature using an ultrasoundguided percutaneous transhepatic approach with a small caliber needle provides a safer and less traumatic procedure and should reduce complications of bleeding and almost completely eliminate the risk of liver laceration. Our procedure was successfully performed under conscious sedation rather than general anaesthesia further reducing the overall procedural risk to the patient. | Sum Leong Hong Kuan Kok Pradeep Govender William Torreggiani | 2013 | World Journal of Gastroenterology2013，19，22： | 4 |
| 18 | A Dual-driven Intelligent Combination Control of Heat Pipe Space Cooling System显示文摘Effective thermal control systems are essential for reliable operation of spacecraft.A dual-driven intelligent combination control strategy is proposed to improve the temperate control and heat flux tracking effects.Both temperature regulation and heat flux tracking errors are employed to generate the final control action;their contributions are adaptively adjusted by a fuzzy fusing policy of control actions.To evaluate the control effects,describe a four-nodal mathematical model for analyzing the dynamic characteristics of the controlled heat pipe space cooling system(HP-SCS) consisting of an aluminum-ammonia heat pipe and a variable-emittance micro-electromechanical-system(MEMS) radiator.This dynamical model calculates the mass flow-rate and condensing pressure of the heat pipe working fluid directly from the systemic nodal temperatures,therefore,it is more suitable for control engineering applications.The closed-loop transient performances of four different control schemes have been numerically investigated.The results conclude that the proposed intelligent combination control scheme not only improves the thermal control effects but also benefits the safe operation of HP-SCS. | LI Yunze LI Mingmin LEE Kok Meng | 2012 | Chinese Journal of Aeronautics2012，25，4： | 4 |
| 19 | 关于一类不可微规划问题的对偶性显示文摘作者构造了一类不可微规划问题的一阶和二阶对偶模型,其目标函数含有紧凸集的支撑函数项。利用FritzJohn最优性必要条件,在适当条件下建立了这两类一阶和二阶对偶模型的弱和逆对偶性定理。 | 杨新民 KOK LAY TEO | 2005 | 重庆师范大学学报(自然科学版)2005，22，3： | 3 |
| 20 | Viral respiratory infections among Hajj pilgrims in 2013显示文摘Middle East respiratory syndrome coronavirus(MERS-Co V) has emerged in the Arabian Gulf region, with its epicentre in Saudi Arabia, the host of the ‘Hajj' which is the world's the largest mass gathering. Transmission of MERS-Co V at such an event could lead to its rapid worldwide dissemination. Therefore, we studied the frequency of viruses causing influenza-like illnesses(ILI) among participants in a randomised controlled trial at the Hajj 2013. We recruited 1038 pilgrims from Saudi Arabia, Australia and Qatar during the first day of Hajj and followed them closely for four days. A nasal swab was collected from each pilgrim who developed ILI. Respiratory viruses were detected using multiplex RT-PCR. ILI occurred in 112/1038(11%) pilgrims. Their mean age was 35 years, 49(44%) were male and 35(31%) had received the influenza vaccine pre-Hajj. Forty two(38%) pilgrims had laboratory-confirmed viral infections; 28(25%) rhinovirus, 5(4%) influenza A, 2(2%) adenovirus, 2(2%) human coronavirus OC43/229 E, 2(2%) parainfluenza virus 3, 1(1%) parainfluenza virus 1, and 2(2%) dual infections. No MERS-Co V was detected in any sample. Rhinovirus was the commonest cause of ILI among Hajj pilgrims in 2013. Infection control and appropriate vaccination are necessary to prevent transmission of respiratory viruses at Hajj and other mass gatherings. | Osamah Barasheed Harunor Rashid Mohammad Alfelali Mohamed Tashani Mohammad Azeem Hamid Bokhary Nadeen Kalantan Jamil Samkari Leon Heron Jen Kok Janette Taylor Haitham El Bashir Ziad A.Memish Elizabeth Haworth Edward C.Holmes Dominic E Dwyer Atif Asghar Robert Booy | 2014 | Virologica Sinica2014，29，6： | 3 |
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