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| 1 | Effect of serum γ-glutamyltranferase and albumin levels on the response to cardiac resynchronization therapy in the elderly显示文摘Background Several liver function tests have been identified as predictors of hospitalization for heart failure(HF) and death in patients with chronic HF. The relationship between serum γ-glutamyltranferase(GGT) and albumin(SA) levels with the response to cardiac resynchronization therapy(CRT) has not been reliably determined. The aim of the study was to evaluate the impact of liver function tests on the results of CRT in the elderly. Methods Baseline GGT and SA were assessed before CRT device implantation in the elderly(> 70-year-old) patients. The endpoints were:(1) CRT response defined as > 5% left ventricular ejection fraction improvement and no hospitalization for HF or cardiovascular death;(2) hospitalizations;and(3) mortality. Results Eighty of 138(58%) included patients were responders at nine months. Compared to responders, the SA levels were not significantly different(35.1 ± 5.4 vs. 33.6 ± 5.5 g/L, P = 0.103);but the GGT levels, higher(81.6 ± 69.3 vs. 54.7 ± 49.6 U/L, P = 0.013) in non-responders to CRT. GGT level was independently associated with non-response to CRT(P < 0.001, OR = 0.17;95% CI: 0.08–0.38, P < 0.001). GGT cut-off value ≥ 55 U/L was highly predictive of non-response [AUC = 0.65, 64% Sensitivity, 69% Specificity(95% CI: 0.56–0.74)]. GGT ≥ 55 U/L was also associated with higher risk of hospitalization for atrial fibrillation(AF)(95% vs. 83%, P = 0.024). Both SA and GGT had no impact on overall(P = 0.220, P = 0.723) mortality. Conclusions Higher level of GGT is an independent predictor of non-response to CRT in patients over age 70 years and is associated with higher risk of hospitalization for AF. Baseline serum levels of albumin and GGT and have no impact on mortality in elderly patients undergoing CRT. | Maciej Kubala Alexis Hermida Otilia Buiciuc Pierre-Marc Lallemand Geneviève Bertaina Frédéric Anselme Didier Klug Momar Diouf Jean-Sylvain Hermida | 2020 | Journal of Geriatric Cardiology2020，17，6： | 3 |
| 2 | Computer Simulation and Rapid Prototyping for the Reconstruction of the Mandible显示文摘 | Philipp Juergens Zdzislaw Krol Hans-Florian Zeilhofer Joerg Beinemann Kurt Schicho Rolf Ewers Clemens Klug | 2009 | Journal of Oral and Maxillofacial Surgery2009，，10： | 2 |
| 3 | Non-occlusive mesenteric ischemia: Diagnostic challenges and perspectives in the era of artificial intelligence显示文摘Acute mesenteric ischemia(AMI)is a severe condition associated with poor prognosis,ultimately leading to death due to multiorgan failure.Several mechanisms may lead to AMI,and non-occlusive mesenteric ischemia(NOMI)represents a particular form of AMI.NOMI is prevalent in intensive care units in critically ill patients.In NOMI management,promptness and accuracy of diagnosis are paramount to achieve decisive treatment,but the last decades have been marked by failure to improve NOMI prognosis,due to lack of tools to detect this condition.While real-life diagnostic management relies on a combination of physical examination,several biomarkers,imaging,and endoscopy to detect the possibility of several grades of NOMI,research studies only focus on a few elements at a time.In the era of artificial intelligence(AI),which can aggregate thousands of variables in complex longitudinal models,the prospect of achieving accurate diagnosis through machine-learning-based algorithms may be sought.In the following work,we bring you a state-of-the-art literature review regarding NOMI,its presentation,its mechanics,and the pitfalls of routine work-up diagnostic exams including biomarkers,imaging,and endoscopy,we raise the perspectives of new biomarker exams,and finally we discuss what AI may add to the field,after summarizing what this technique encompasses. | Simon Bourcier Julian Klug Lee S Nguyen | 2021 | World Journal of Gastroenterology2021，27，26： | 2 |
| 4 | Arrangement of subunits in flagellar microtubules 显示文摘 | Amos L A Klug A | 1974 | J Cell Sci1974，14，： | 2 |
| 5 | DNA synthesis and multinucleation in embryonic stem cell-derived cardiomyocytes显示文摘 | SOONPAA M H FIELD L J | 1995 | Am J Physiol1995，269，62： | 1 |
| 6 | The prevalence of human papillomavirus genotypes in nonmelanoma skin cancers of nonimmunosuppressed individuals identifies high-risk genital types as possible risk factors显示文摘 | Iftner A Klug SJ Garbe C | 2003 | Cancer Res2003，63，12： | 1 |
| 7 | Cocaine experience controls bidirectional synaptic plasticity in the nudeus accumbens显示文摘 | Kourrich S Rothwell PE Klug JR | 2007 | J Neurosci2007，27，30： | 1 |
| 8 | A radioimmuno assay using a monoelonal antibody to monitor the eouse of epithelial ovarian cancer显示文摘 | Bast RC Jr Klug TL St John E | 1983 | N Engl J Med1983，309，： | 1 |
| 9 | Formation and Decomposition Mecha- nisms for Clathrate Hydrates 显示文摘 | Tse J S Klug D D | 2002 | J Supramolecular Chem2002，2，45： | 1 |
| 10 | Risk factors related to infections of implanted pacemakers and cardioverter-defibrillators: results of a large prospective study显示文摘 | Klug D Balde M Pavin D | 2007 | Circulation2007，116，： | 1 |
| 11 | Com- plications of permanent cardiac pacing 显示文摘 | Klug D Marqui6 C Laeroix D | 2003 | Arch Mal Coeur Vaiss2003，7，： | 1 |
| 12 | Repetitive zinc-binding domains in the protein transcription factor ⅢA from Xenopus oocytes显示文摘 | Miller J McLachlan A D Klug A | | 0，，6： | 1 |
| 13 | Alterations in liver mitoehondrial function as a Result of fasting and exhaustive exercise 显示文摘 | KLUG G A | 1984 | Bioehim Acta1984，764，： | 1 |
| 14 | Repetitive zinc-binding domains in the protein transcription factor ⅢA from Xenopus ooeytes显示文摘 | MCLACHLAN A D KLUG A | 1985 | EMBO J1985，，4： | 1 |
| 15 | Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium显示文摘 | Soonpaa MH Koh GY Klug MG | 1994 | Science1994，264，1： | 1 |
| 16 | Analysis of factors affecting the accuracy,reproducibility and interpretation of microbial community carbon source utilization patterns显示文摘 | Haack S K Garchow H Klug M J | 1995 | Appl Environ Microbiol1995，61，： | 1 |
| 17 | TP53 polymorphism,HPV infection and risk of cervical cancer显示文摘 | KLUG SJ WILMOTTE R SANTOS C | 2001 | Cancer Epdemiol Biomarkers Prey2001，10，9： | 1 |
| 18 | Recrystallization in Oxide-Dispersion Strengthened Mechanically Alloyed Sheet Steel显示文摘 | Klug R C Krauss G Matlock D K | 1996 | Metallurgical and Materials Transactions1996，27，： | 1 |
| 19 | Sex pheromone of Egyptian cotton leafworm (Spodoptera littoralis) Its chemical transformation under field conditions 显示文摘 | SHANI A AND KLUG J T | 1980 | Journal of Chemical Ecology1980，8，4： | 1 |
| 20 | Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes显示文摘 | MILLER J MCLACHLAN A D KLUG A | 1985 | The Embo Journal1985，4，6： | 1 |
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