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| 1 | Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus:a retrospective cohort study显示文摘AIM To assess the incidence of hepatocellular carcinoma(HCC) in chronic liver disease due to hepatitis B virus(HBV) or hepatitis C virus(HCV) coinfected with human immunodeficiency virus(HIV).METHODS A retrospective cohort study was performed, including patients with chronic liver disease due to HBV or HCV, with and without HIV coinfection. Patients were selected in the largest tertiary public hospital complex in southern Brazil between January 2007 and June 2014. We assessed demographic and clinical data, including lifestyle habits such as illicit drug use or alcohol abuse, in addition to frequency and reasons for hospital admissions via medical records review.RESULTS Of 804 patients were included(399 with HIV coinfection and 405 monoinfected with HBV or HCV). Coinfected patients were younger(36.7 ± 10 vs 46.3 ± 12.5, P < 0.001). Liver cirrhosis was observed in 31.3% of HIV-negative patients and in 16.5% of coinfected(P < 0.001). HCC was diagnosed in 36 patients(10 HIV coinfected and 26 monoinfected). The incidence density of HCC in coinfected and monoinfected patients was 0.25 and 0.72 cases per 100 patient-years(95%CI: 0.12-0.46 vs 0.47-1.05)(long-rank P = 0.002), respectively. The ratio for the HCC incidence rate was 2.98 for HIV-negative. However, when adjusting for age or when only cirrhotic are analyzed, the absence of HIV lost statistical significance for the development of HCC. CONCLUSION In this study, the presence of HIV coinfection in chronic liver disease due to HBV or HCV showed no relation to the increase of HCC incidence. | Patrícia dos Santos Marcon Cristiane Valle Tovo Dimas Alexandre Kliemann Patrícia Fisch Angelo Alves de Mattos | 2018 | World Journal of Gastroenterology2018，24，5： | 6 |
| 2 | Investigation of modal interaction and its effects on control performance in stressed power systems using normal forms of vector fields显示文摘 | Lin C M Vittal V Kliemann W | 1996 | IEEE Transactions on Power Systems1996，11，2： | 1 |
| 3 | Stability Boundary Approximation of a Power Sustem Using the Real Normal Form of Vector Fields显示文摘 | Saha S Fouad A A Kliemann W H | 1997 | IEEE Trans on Power Systems1997，12，2： | 1 |
| 4 | Investigation of model interaction and its effect on control performance in stressed power system using normal forms of vector fields显示文摘 | Chih Ming Lin Vittal V Kliemann W | 1996 | IEEE Trans on Power Systems1996，11，2： | 1 |
| 5 | Application of the Normal form of Vector Fields to Predict Interarea Separation in Power Systems显示文摘 | Thapar J Vittal V Kliemann W | 1997 | IEEE Trans on Power Systems1997，12，2： | 1 |
| 6 | Quantitative analyses of bone composition in acetylcholine receptor M3R and alpha7 knockout mice显示文摘 | Kliemann K Kneffel M Bergen I | 2012 | Life Sci2012，91，21122： | 1 |
| 7 | Analyzing dynamic performance of power systems over parameter space using normal forms of vector fields-PartⅠ:identification of vulnerable regions显示文摘 | Songzhe Zhu Vijay Vittal Wolfgang Kliemann | 2001 | IEEE Transactions on Power Systems2001，16，3： | 1 |
| 8 | An improved technique to determine the controlling unstable equilibrium point in a power system显示文摘 | ROGER T T VITTAL V KLIEMANN W | 1996 | IEEE Transactions on Circuits and Systems-I:Fundamental Theory and Applications1996，43，4： | 1 |
| 9 | Nonlinear jodal interaction in HVDC/AC power system with DC power modulation显示文摘 | Ni Y X Vital V Kliemann W | 1996 | IEEE Trans on Power Systems1996，11，4： | 1 |
| 10 | Stability Boundaty Approximation of a Power System Using the Real Normal Form of Vector Fields显示文摘 | Saha S A A Fouad Kliemann W H | | 0，，： | 1 |
| 11 | Re-treatment of Children With Chronic Hepatitis C Who Did Not Respond to Interferon-α Treatment显示文摘 | Patrick Gerner Juliane Hilbich Tobias G Wenzl Rolf Behrens Frank Walther Guido Kliemann Axel Enninger Stefan Wirth | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，2： | 1 |
| 12 | Application of the normal form of vector fields to predict interarea separation in power system 显示文摘 | Thapar J Vittal V Kliemann W | 1997 | IEEE Trans on Power Systems1997，12，2： | 1 |
| 13 | Minimal cold knife conization height for high-grade cervical squamous intraepi- thelial lesion treatment显示文摘 | Kliemann LM Silva M Reinheimer M | 2012 | Eur J Obstet Gynecol Reprod Bi- oi2012，165，2： | 1 |
| 14 | Part Ⅰ: General theory and precedure显示文摘 | Jang G Vittal V Kliemann W Effect of nonlinear modal interavtion on control performance: Use of normal forms technique in control design | 1998 | IEEE Trans PWRS1998，13，5： | 1 |
| 15 | Analyzing dynamic performance of power systems over parameter space using normal forms of vector fields-part 2:comparison of the system structure显示文摘 | ZHU S VITTAL V KLIEMANN W | 2001 | IEEE Transactions on Power Systems2001，16，3： | 1 |
| 16 | Effect of nonlinear modal interaction on control performance:use of normal forms technique in control design,Part Ⅰ:General theory and procedure显示文摘 | Jang Gilsoo Vittal Vijiay Kliemann Wolfgang | 1998 | IEEE Trans on Power Systems1998，13，2： | 1 |
| 17 | Polymorphisms and resistance mutations of hepatitis C virus on sequences in the European hepatitis C virus database显示文摘AIM To evaluate the occurrence of resistant mutations in treatment-na?ve hepatitis C virus(HCV) sequences deposited in the European hepatitis C virus database(euH CVdb). METHODS The sequences were downloaded from the eu HCVdb(http://gffzzc7adb7d73a2545c0sbxpc5uwb0ufn6nbc.ffgz.tsg.suse.edu.cn/eu HCVdb/). The search was performed for full-length NS3 protease, NS5 A and NS5 B polymerase sequences of HCV, separated by genotypes 1a, 1b, 2a, 2b and 3a, and resulted in 798 NS3, 708 NS5 A and 535 NS5 B sequences from HCV genotypes1a, 1b, 2a, 2b and 3a, after the exclusion of sequences containing errors and/or gaps or incomplete sequences, and sequences from patients previously treated with direct antiviral agents(DAA). The sequence alignment was performed with MEGA 6.06 MAC and the resulting protein sequences were then analyzed using the BioE dit 7.2.5. for mutations associated with resistance. Only positions that have been described as being associated with failure in treatment in in vivo studies, and/or as conferring a more than 2-fold change in replication in comparison to the wildtype reference strain in in vitro phenotypic assays were included in the analysis.RESULTS The Q80 K variant in the NS3 gene was the most prevalent mutation, being found in 44.66% of subtype 1a and 0.25% of subtype 1b. Other frequent mutations observed in more than 2% of the NS3 sequences were: I170V(3.21%) in genotype 1a, and Y56F(15.93%), V132I(23.28%) and I170V(65.20%) in genotype 1b. For the NS5 A, 2.21% of the genotype 1a sequences have the P58 S mutation, 5.95% of genotype 1b sequences have the R30 Q mutation, 15.79% of subtypes 2a sequences have the Q30 R mutation, 23.08% of subtype 2b sequences have a L31 M mutation, and in subtype 3a sequences, 23.08% have the M31 L resistant variants. For the NS5 B, the V321 L RAV was identified in 0.60% of genotype 1a and in 0.32% of genotype 1b sequences, and the N142 T variant was observed in 0.32% of subtype 1b sequences. The C316 Y, S556 G, D559 N RAV were identified in 0.33%, 7.82% and 0.32% of genotype 1b sequences, respectively, and were not observed in other genotypes.CONCLUSION HCV mutants resistant to DAAs are found in low frequency, nevertheless they could be selected and therapy could fail due resistance substitutions in HCV genome. | Dimas Alexandre Kliemann Cristiane Valle Tovo Ana Beatriz Gorini da Veiga Angelo Alves de Mattos Charles Wood | 2016 | World Journal of Gastroenterology2016，22，40： | 1 |
| 18 | Analyzing dynamic performance of power systems over parameter space using normal forms of vector fields:Part one identification of vulnerable regions显示文摘 | SONGZHE Z VITTAL V KLIEMANN W | | 0，，03： | 1 |
| 19 | DNA damage in children and adolescents with cardiovascular disease risk factors显示文摘 | Kliemann M Pra D Muller LL | 2012 | An Acad Bras Cienc2012，84，3： | 1 |
| 20 | A Stochastic Dynamical Model for the Characterization of the Geometrical Structure of Dendritic Processes显示文摘 | Kliemann W | 1987 | Bulletin of Mathematical Biology1987，49，2： | 1 |
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