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| 1 | 星形胶质细胞通过分泌IL-23促进黑色素瘤脑转移显示文摘黑色素瘤是最主要皮肤致死性恶性肿瘤,黑色素瘤患者死亡的主要原因是远处转移,常为脑转移。微环境在肿瘤的发生和转移中起着关键的作用,为了治疗或预防转移,必须阐明播散的肿瘤细胞与转移性器官微环境之间的相互作用。然而,大脑间质细胞在促进转移性生长中的作用却知之甚少。星形胶质细胞的主要功能是大脑损伤后修复和形成胶质瘢痕,部分因为通过介导神经炎症,但是星形胶质细胞在黑色素瘤脑转移中的作用却不清楚。 | Klein A Schwartz H Sagi-Assif O 陈达阳 王行富 | 2015 | 临床与实验病理学杂志2015，31，11： | 4 |
| 2 | 2型糖尿病患者及其一级亲属和非糖尿病者骨骼肌的胰岛素信号传导显示文摘2型糖尿病与骨骼肌和其他组织的葡萄糖利用能力下降有关。胰岛素抵抗可能与遗传因素和糖尿病本身的代谢异常如高血糖或非脂化脂肪酸(NEFA)升高有关。遗传因素和继发的胰岛素抵抗代谢异常可能是由于调节葡萄糖代谢的胰岛素受体和受体后信号传导的改变引起。胰岛素与其受体结合后,受体自身磷酸化,受体激酶活化,一些细胞间的底物磷酸化,其中在骨骼肌细胞中胰岛素受体底物-1(IRS-1)最重要。酪氨酸磷酸化的IRS与脂肪激酶磷脂酚肌醇3’(PI3’) | Meyer MM Levin K Grimmsmann T Beck-Nielsen H Klein HH Diabetologia 叶华 | 2003 | 中国糖尿病杂志2003，11，2： | 3 |
| 3 | Histological analysis of pollen-pistil interactions in sour passion fruit plants (Passiflora edulis Sims)显示文摘The success of sexual plant reproduction is directly influenced by specific interactions between the pollen and pistil.Light,fluorescence and scanning electron microscopy techniques were used to evaluate the steps of pollination in sour passion fruit plants(Passiflora edulis Sims).In the compatible interaction,pollen tubes grow through stigma projections towards the ovary.The pollen grain surface was found to be spheroidal and to consist of heteroreticulate exine with six colpi.Furthermore,analysis in vivo of pollenpistil interactions indicated that stigmas of flowers 24 hours before anthesis are unable to discriminate compatible(genetically unrelated)and incompatible(genetically related)pollen grains.Taken together,these results provide insight into the cellular mechanisms underlying pollination in passion fruit plants. | HÉRIKA CHAGAS MADUREIRA TELMA NAIR SANTANA PEREIRA MAURA DA CUNHA DENISE ESPELLET KLEIN | 2012 | BIOCELL2012，36，2： | 2 |
| 4 | Induction of T helper cell type 1 response and elidriation of HBeAg during treatineni with IL-12 in a patiat with therapy refractory chronic hepatitis B显示文摘 | Barth H Klein R Berg PA | 2001 | Hepatogastroenterology2001，48，： | 2 |
| 5 | A study on the photoresponses in GaAs n-channel optical detectors显示文摘 | WEI C J KLEIN H J | 1982 | IEEE Transactions on Electron Devices1982，29，9： | 2 |
| 6 | 中国甘肃省中铺地区下白垩统河口群的兽脚类与蜥脚类足迹组合(英文)显示文摘近年来,中国西北部兰州-民和盆地的中铺地区河口群发现了一批恐龙骨骼化石和足迹化石。中铺地区的蜥脚类与兽脚类足迹组合相对丰富,但大多数标本保存较差。大夏足迹点发现了保存较好的类似亚洲足迹的跷脚龙类足迹(Asianopodus-like grallatorid tracks),足迹有着中趾弱前凸(weak mesaxony)。李家沟一号点的足迹组合包括了较大的兽脚类足迹和大型的、非三趾型四足类足迹,后者可能是蜥脚类足迹。李家沟二号点的足迹为多层的蜥脚类足迹,这表明了这类恐龙的活跃性,巨龙类的骨骸也可能来自同一层位。虽然中铺足迹组合不如同属河口群的盐锅峡足迹组合那么具有多样化与得以充分暴露,但依然体现了该地区以及中国早白垩世地层的典型足迹组合。 | 邢立达 李大庆 Lockley M G 张建平 尤海鲁 Klein H Marty D Persons IV W S 彭措 | 2014 | 古生物学报2014，53，3： | 2 |
| 7 | Efficient 3D modeling of vibration isolation by open trenches显示文摘 | Klein R Antes H LeHouedec D | 1997 | Computers and Structures1997，64，： | 1 |
| 8 | Autologous bone marrow stem cell transplantation for myocardial regeneration显示文摘 | Stamm C Westphal B Kleine H D | 2003 | Lancet2003，361，9351： | 1 |
| 9 | Burnout in mental health professionals in psychiatric hospitals显示文摘 | Messenzehl M Lukesch H Klein HE | 2007 | Psychiatr Prax2007，，： | 1 |
| 10 | Numerical simulation of crack growth in an isotropic solid with randomized internal cohesive bonds 显示文摘 | Gao H Klein P | 1998 | Journal of the Mechanics and Physics of Solids1998，46，2： | 1 |
| 11 | Proliferative cell activity in correlatio n to human chorionic gonadotrophin release of trophoblast tissue of tubal pregnancy显示文摘 | Kiss H Klein M Egarter C | 1998 | J Reprod Med1998，43，： | 1 |
| 12 | Prevention of left ventricular remodeling with granulocyte colony-stimulating factor after acute myocardial infarction:final 1-year results of the front-integrated revascularization and stem cell liberation in evolving acute myocardial infarction by granulocyte colony-stimulating factor (FIRSTLINE-AMI) trial显示文摘 | Ince H Petzsch M Kleine HD | 2005 | Circulation2005，112，9： | 1 |
| 13 | 显示文摘 | Wang Peng Klein C Baker R H | 2005 | J Am Chem Soc2005，，127： | 1 |
| 14 | Antibodies in HIV-1 vaccine development and therapy显示文摘 | Klein F Mouquet H Dosenovic P | 2013 | Science2013，341，6151： | 1 |
| 15 | DLR PSP system intensity and lifetime measurements显示文摘 | Engler R H Klein Chr | 1997 | Instrumentation in Aerospace Simulation Facilities1997，29，2： | 1 |
| 16 | Benign sym- metrical lipomatosis (Madelungs disease) complicated by involvement of the facial nerve显示文摘 | Raguse'J D menneking H Klein M | 2004 | Eur J plast surg2004，27，9： | 1 |
| 17 | New primary prevention trials of sudden cardiac death in patients with left ventrieular dysfunction : SCD-HEFT and MADIT- II 显示文摘 | Klein H Auricehio A Reek S | 1999 | Am J Cardiol1999，83，5： | 1 |
| 18 | Genetic heterogeneity of single disseminated turnout cells in minimal residual cancer显示文摘 | Klein C A Blankenstein T J Schmidt-Kittler O Petronio M Polzer B Stoecklein N H | 2002 | Lancet2002，2360，： | 1 |
| 19 | Reconstruction of the contracted ocular socked with free full - thickness mucosa graft显示文摘 | Klein M Menneking H Bier J | 2000 | Int J Orla Maxillofac Surg2000，29，2： | 1 |
| 20 | The F-PEC Scale of Family Influence: Construction, Validation, and Further Implication Firm Theory 显示文摘 | KLEIN S B ASTRACHAN J H SMYRNIOS K X | 2005 | Entrepreneurship Theory and Practice2005，29，3： | 1 |
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