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| 1 | Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1显示文摘AIM:To evaluate the protective effects of fucoidan on oxidative stress-induced barrier disruption in human intestinal epithelial cells.METHODS:In Caco-2 cell monolayer models,the disruption of barrier function by oxidative stress is mediated by H2O2.The integrity of polarized Caco-2 cell monolayers was determined by measuring the transepithelial resistance(TER)and permeability was estimated by measuring the paracellular transport of FITC-labeled4-kDa dextran(FD4).The protective effects of fucoidan on epithelial barrier functions on polarized Caco-2 cell monolayers were evaluated by TER and FD4 flux.The expression of tight junction(TJ)proteins was assessed using reverse-transcription polymerase chain reaction(RT-PCR)and immunofluorescence staining.RESULTS:Without H2O2treatment,fucoidan significantly increased the TER compared to control(P<0.05),indicating a direct enhancement of intestinal epithelial barrier function.Next,H2O2disrupted the epithelial barrier function in a time-dependent manner.Fucoidan prevented the H2O2-induced destruction in a dosedependent manner.Fucoidan significantly decreased H2O2-induced FD4 flux(P<0.01),indicating the prevention of disruption in paracellular permeability.RTPCR showed that Caco-2 cells endogenously expressed claudin-1 and-2,and occludin and that H2O2reduced the mRNA expression of these TJ proteins.Treatment with fucoidan attenuated the reduction in the expressions of claudin-1 and claudin-2 but not occludin.Immunofluorescence staining revealed that the expression of claudin-1 was intact and high on the cell surface.H2O2disrupted the integrity of claudin-1.Treatment with fucoidan dramatically attenuated the expression of claudin-1.CONCLUSION:Fucoidan enhanced intestinal epithelial barrier function by upregulating the expression of claudin-1.Thus,fucoidan may be an appropriate therapy for the treatment of inflammatory bowel diseases. | Atsushi Iraha Hiroshi Chinen Akira Hokama Takumi Yonashiro Tetsu Kinjo Kazuto Kishimoto Manabu Nakamoto Tetsuo Hirata Nagisa Kinjo Futoshi Higa Masao Tateyama Fukunori Kinjo Jiro Fujita | 2013 | World Journal of Gastroenterology2013，19，33： | 15 |
| 2 | Diagnosis of intestinal tuberculosis using a monoclonal antibody to Mycobacterium tuberculosis显示文摘AIM:To investigate the utility of immunohistochemical(IHC) staining with an antibody to Mycobacterium tuberculosis(M.tuberculosis) for the diagnosis of intestinal tuberculosis(TB).METHODS:We retrospectively identified 10 patients(4 males and 6 females;mean age = 65.1 ± 13.6 years) with intestinal TB.Clinical characteristics,including age,gender,underlying disease,and symptoms were obtained.Chest radiograph and laboratory tests,including sputum Ziehl-Neelsen(ZN) staining,M.tuberculosis culture,and sputum polymerase chain reaction(PCR) for tubercle bacilli DNA,as well as Tuberculin skin test(TST) and QuantiFERON-TB gold test(QFT),were examined.Colonoscopic records recorded on the basis of Sato's classification were also reviewed,in addition to data from intestinal biopsies examined for histopathological findings,including hematoxylin and eosin staining,and ZN staining,as well as M.tuberculosis culture,and PCR for tubercle bacilli DNA.For the present study,archived formalin-fixed paraffin-embedded(FFPE) intestinal tissue samples were immunohistochemically stained using a commercially available species-specific monoclonal antibody to the 38-kDa antigen of the M.tuberculosis complex.These sections were also stained with the pan-macrophage marker CD68 antibody.RESULTS:From the clinical data,we found that no patients were immunocompromised,and that the main symptoms were diarrhea and weight loss.Three patients displayed active pulmonary TB,six patients(60%) had a positive TST,and 4 patients(40%) had a positive QFT.Colonoscopic findings revealed that all patients had type 1 findings(linear ulcers in a circumferential arrangement or linear ulcers arranged circumferentially with mucosa showing multiple nodules),all of which were located in the right hemicolon and/or terminal ileum.Seven patients(70%) had concomitant healed lesions in the ileocecal area.No acid-fast bacilli were detected with ZN staining of the intestinal tissue samples,and both M.tuberculosis culture and PCR for tubercle bacilli DNA were negative in all samples.The histopathological data revealed that tuberculous granulomas were present in 4 cases(40%).IHC staining in archived FFPE samples with anti-M.tuberculosis monoclonal antibody revealed positive findings in 4 patients(40%);the same patients in which granulomas were detected by hematoxylin and eosin staining.M.tuberculosis antigens were found to be mostly intracellular,granular in pattern,and primarily located in the CD68 + macrophages of the granulomas.CONCLUSION:IHC staining with a monoclonal antibody to M.tuberculosis may be an efficient and simple diagnostic tool in addition to classic examination methods for the diagnosis of intestinal TB. | Yasushi Ihama Akira Hokama Kenji Hibiya Kazuto Kishimoto Manabu Nakamoto Tetsuo Hirata Nagisa Kinjo Haley L Cash Futoshi Higa Masao Tateyama Fukunori Kinjo Jiro Fujita | 2012 | World Journal of Gastroenterology2012，18，47： | 12 |
| 3 | Immunological Effects of Silica and Asbestos显示文摘Silicosis patients(SILs) and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders. In particular,SIL sometimes complicates autoimmune diseases such as systemic scleroderma,rheumatoid arthritis(known as Caplan syndrome) ,and systemic lupus erythematoses. In addition,malignant complications such as lung cancer and malignant mesothelioma often occurr in patients exposed to asbestos,and may be involved in the reduction of tumor immunity. Although silica-induced disorders of autoimmunity have been explained as adjuvant-type effects of silica,more precise analyses are needed and should reflect the recent progress in immunomolecular findings. A brief summary of our investigations related to the immunological effects of silica/asbestos is presented. Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica. Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors,respectively. In addition,immunological analyses may lead to the development of new clinical tools for the modification of the pathophysiological aspects of diseases such as the regulation of autoimmunity or tumor immunity using cell-mediated therapies,various cytokines,and molecule-targeting therapies. In particular,as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer of 2005 in Japan,efforts should be focused on developing a cure for these diseases to eliminate nationwide anxiety. | Takemi Otsuki Megumi Maeda Shuko Murakami Hiroaki Hayashi Yoshie Miura Masayasu Kusaka Takashi Nakano Kazuya Fukuoka Takumi Kishimoto Fuminori Hyodoh Ayako Ueki Yasumitsu Nishimura | 2007 | Cellular & Molecular Immunology2007，4，4： | 9 |
| 4 | Endoscopic and radiographic features of gastrointestinal involvement in vasculitis显示文摘Vasculitis is an inflammation of vessel walls,followed by alteration of the blood flow and damage to the dependent organ.Vasculitis can cause local or diffuse pathologic changes in the gastrointestinal (GI) tract.The variety of GI lesions includes ulcer,submucosal edema,hemorrhage,paralytic ileus,mesenteric ischemia,bowel obstruction,and life-threatening perforation.The endoscopic and radiographic features of GI involvement in vasculitisare reviewed with the emphasis on small-vessel vasculitis by presenting our typicalcases,including Churg-Strauss syndrome,HenochSch nlein purpura,systemic lupus erythematosus,and Beh et's disease.Important endoscopic features are ischemic enterocolitis and ulcer.Characteristic computed tomographic findings include bowel wall thickening with the target sign and engorgement of mesenteric vessels with comb sign.Knowledge of endoscopic and radiographic GI manifestations can help make an early diagnosis and establish treatment strategy. | Akira Hokama Kazuto Kishimoto Yasushi Ihama Chiharu Kobashigawa Manabu Nakamoto Tetsuo Hirata Nagisa Kinjo Futoshi Higa Masao Tateyama Fukunori Kinjo Kunitoshi Iseki Seiya Kato Jiro Fujita | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，3： | 9 |
| 5 | Tuning of band gaps for a two-dimensional piezoelectric phononic crystal with a rectangular lattice显示文摘In this paper,the elastic wave propagation in atwo-dimensional piezoelectric phononic crystal is studiedby considering the mechanic-electric coupling.The gener-alized eigenvalue equation is obtained by the relation of themechanic and electric fields as well as the Bloch-Floquet the-orem.The band structures of both the in-plane and anti-planemodes are calculated for a rectangular lattice by the plane-wave expansion method.The effects of the lattice constantratio and the piezoelectricity with different filling fractionsare analyzed.The results show that the largest gap width isnot always obtained for a square lattice.In some situations,a rectangular lattice may generate larger gaps.The band gapcharacteristics are influenced obviously by the piezoelectric-ity with the larger lattice constant ratios and the filling frac-tions. | Yize Wang Fengming Li Yuesheng Wang Kikuo Kishimoto Wenhu Huang | 2009 | Acta Mechanica Sinica2009，25，1： | 8 |
| 6 | A body mass index ≥25 kg/m2 is associated with a poor prognosis in patients with acute pancreatitis: a study of Japanese patients显示文摘BACKGROUND:In Asian population, there is limited infor mation on the relevance between obesity and poor outcomes in acute pancreatitis(AP). The objective of this study was to examine the clinical impact of obesity based on body mass index(BMI) on prognosis of AP in Japanese patients.METHODS:A total of 116 patients with AP were enrolled in this study. Univariate and multivariate logistic regression analyses were performed to examine relations between BMI and patients' outcomes. Additionally, to investigate whether including obesity as a prognostic factor improved the predic tive accuracy of a Japanese prognostic factor score(PF score)a receiver-operating characteristic(ROC) curve analysis of mortality was conducted.RESULTS:Multiple logistic regression analyses revealed that BMI ≥25 kg/m^2 was associated with a significant higher mor tality [odds ratio(OR)=15.8; 95% confidence interval(CI):1.1-227; P=0.043]. The area under the ROC curve(AUC) for the combination of PF score and BMI ≥25 kg/m^2(AUC=0.881;95% CI:0.809-0.952) was higher than that for the PF score alone(AUC=0.820; 95% CI:0.713-0.927)(P=0.034).CONCLUSIONS:The negative impact of a high BMI on the prognosis of AP was confirmed in a Japanese population Including BMI ≥25 kg/m2 as an additional parameter to PF score enhanced the predictive value of the PF score for AP-related mortality. | Tsukasa Ikeura Kota Kato Makoto Takaoka Masaaki Shimatani Masanobu Kishimoto Kenichiro Nishi Shuji Kariya Kazuichi Okazaki | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，6： | 8 |
| 7 | EFFECT OF TRIAXIAL STRESS CONSTRAINT ON THE DEFORMATION AND FRACTURE OF POLYMERS显示文摘One purpose of this paper is to give a brief overview on the researchstatus of deformation,fracture and toughening mechanisms of polymers,includingexperimental,theoretical and numerical studies.Emphasis is on the more recentprogresses of micromechanics of rubber particle cavitation and crazing,and the de-velopment of fracture criteria for ductile polymers.The other purpose is to study the effect of triaxial stress constraint on the deforma-tion and fracture behavior of polymers.Polycarbonate(PC),acrylonitrile-butadiene-styrene(ABS)and PC/ABS alloy are considered in this investigation.A series ofcircumferentially blunt-notched bars are used to experimentally generate different tri-axial stress fields.The fracture surfaces of specimens with different notch radius areexamined by scanning electron microscope(SEM)to study the fracture and tough-ening mechanisms of polymer alloy.It is shown that the triaxial stress constrainthas a significant effect on the deformation,fracture and toughening of PC,ABS andPC/ABS alloy.We will also discuss the extent to which a micromechanies criterionproposed by the first author can serve as a fracture criterion for ductile polymers.A new ductile fracture parameter is emphasized,which can be employed to evaluatethe fracture ductility of polymers.Stress state independence of the parameter for thePC,ABS and PC/ABS alloy has been experimentally verified. | 王铁军 Kikno Kishimoto Mitsuo Notomi | 2002 | Acta Mechanica Sinica2002，18，5： | 6 |
| 8 | 胃肠的淀粉样变性病的内视镜、组织病理学说的特征显示文摘 Amyloidosis is a rare disorder, characterized by the extracellular deposition of an abnormal fibrillar protein, which disrupts tissue structure and function. Amyloidosis can be acquired or hereditary, and systemic or localized to a single organ, such as the gastrointestinal (GI) tract. Clinical manifestations may vary from asymptomatic to fatal forms. Primary amyloidosis (monoclonal immunoglobulin light chains, AL) is the most common form of amyloidosis. AL amyloidosis has been associated with plasma cell dyscrasias, such as, mul- tiple myeloma. Secondary amyloidosis is caused by the deposition of fragments of the circulating acute-phase reactant, serum amyloid A protein (SAA). Common causes of AA amyloidosis are chronic inflammatory dis-orders. Although GI symptoms are usually nonspecific, histopathological patterns of amyloid deposition are associated with clinical and endoscopic features. Amyloid deposition in the muscularis mucosae, submucosa, and muscularis propria has been dominant in AL amyloidosis, leading to polypoid protrusions and thickening of the valvulae conniventes, whereas granular amyloid deposition mainly in the propria mucosae has been related to AA amyloidosis, resulting in the fine granular appearance, mucosal friability, and erosions. As a result, AL amyloidosis usually presents with constipation, mechanical obstruction, or chronic intestinal pseudoobstruction while AA amyloidosis presents with diarrhea and malabsorption Amyloidotic GI symptoms are mostly refractory and have a negative impact on quality of life and survival. Diagnosing GI amyloidosis requires high suspicion of evaluating endoscopists. Because of the absence of specific treatments for reducing the abundance of the amyloidogenic precursor protein, we should be aware of certain associations between patterns of amyloid deposition and clinical and endoscopic features. | Akira Hokama Kazuto Kishimoto Manabu Nakamoto Chiharu Kobashigawa Tetsuo Hirata Nagisa Kinjo Fukunori Kinjo Seiya Kato Jiro Fujita | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，8： | 6 |
| 9 | An electron moir■ method for a common SEM显示文摘在电子 moir é方法,一个高周波的栅栏被用来测量显微镜的变丑,它在材料的显微镜的分析为方法答应重要潜在的应用。然而,扫描控制设备的一根特殊横梁被要求生产一个栅栏并且为扫描电子显微镜(SEM ) 产生一个 moir é穗模式。因为仅仅在材料科学研究使用的一些 SEM 与这台设备被装备,电子 moir é方法的使用是有限的。在这研究,为没有横梁控制设备的普通 SEM 的一个电子 moir é方法被介绍。一个栅栏在任何观察模式基于一个多扫描的概念被制作。一个即时 moir é模式能也在 SEM 或一个光过滤系统被产生。没有横梁控制设备,是一个前提,电子 moir é方法能更广泛地被使用。从 SEM 的三种不同类型的试验性的结果证明有一致的线和更少的沥青错误的高质量的栅栏能被这个方法,和 moir é模式制作能正确地也被产生。 | Y. M. Xing S. Kishimoto Y. R. Zhao | 2006 | Acta Mechanica Sinica2006，22，6： | 6 |
| 10 | Histological mixed-type as an independent prognostic factor in stageⅠgastric carcinoma显示文摘AIM: To evaluate the clinicopathological features of mixed-type gastric cancer and their influence on prognosis of mixed-type stageⅠgastric cancer.METHODS: We analyzed 446 patients who underwent curative gastrectomy for stageⅠgastric cancer between 1999 and 2009. The patients were divided into two groups: those with differentiated or undifferentiated cancer(non-mixed-type, n = 333) and those with a mixture of differentiated and undifferentiated cancers(mixed-type, n = 113).RESULTS: The overall prevalence of mixed-type gastric cancer was 25.3%(113/446). Compared with patients with non-mixed-type gastric cancer, those with mixedtype gastric cancer tended to be older at onset(P = 0.1252) and have a higher incidence of lymph node metastasis(P = 0.1476). They also had significantly larger tumors(P < 0.0001), more aggressive lymphatic invasion(P = 0.0011), and deeper tumor invasion(P < 0.0001). In addition, they exhibited significantly worse overall survival rates than did patients with non-mixedtype gastric cancer(P = 0.0026). Furthermore, mixedtype gastric cancer was independently associated with a worse outcome in multivariate analysis [P = 0.0300, hazard ratio = 11.4(1.265-102.7)].CONCLUSION: Histological mixed-type of gastric cancer contributes to malignant outcomes and highlight its usefulness as a prognostic indicator in stageⅠgastric cancer. | Shuhei Komatsu Daisuke Ichikawa Mahito Miyamae Hiroki Shimizu Hirotaka Konishi Atsushi Shiozaki Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Eigo Otsuji | 2015 | World Journal of Gastroenterology2015，21，2： | 6 |
| 11 | PPAR-γ ligands inhibit the expression of inflammatory cytokines and attenuate autoimmune myocarditis显示文摘 | 袁祖贻 刘艳 刘豫 张继军 Chiharu Kishimoto 王燕妮 马爱群 刘治全 | 2004 | Chinese Medical Journal2004，，8： | 6 |
| 12 | 血流介导的血管舒张,硝酸甘油诱导的血管舒张,基线肱动脉直径,充血剪切应力与心血管病危险因素之间的相关性显示文摘血流介导的血管舒张功能(flow-mediated vasodilation,FMD)已被用于评估内皮功能。充血性剪切应力(hyperemic shear stress,HSS,一种FMD的刺激因素)、硝酸甘油诱导的血管舒张(nitroglycerine-induced vasodilation,NID,非内皮依赖性血管舒张指数)以及基线肱动脉直径(brachial artery diameter,BAD)也参与血管舒张反应。 | 刘青 叶鹏 Maruhashi T Iwamoto Y Kajikawa M Oda N Kishimoto S Matsui S Hashimoto H Aibara Y Yusoff FM Hidaka T Kihara Y Chayama K Noma K Nakashima A Goto C Hida E Higashi Y | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 13 | WAVE LOCALIZATION IN RANDOMLY DISORDERED PERIODIC PIEZOELECTRIC RODS WITH INITIAL STRESS显示文摘在有起始的应力的混乱的周期的压电的杆的有弹性的波浪本地化用转移矩阵和 Lyapunov 代表方法被学习。电场作为伪静电干扰被接近。乐队差距特征上的起始的压力的效果被调查。本地化因素和本地化长度的数字计算被执行。它能从结果被观察乐队结构能被施加合适的起始的压力调节。为压电的杆长度和有弹性的常数的不同价值,乐队结构和本地化现象是很不同的。更大的混乱度能导致更多的明显的本地化现象。 | Yize Wang Fengming Li Kikuo Kishimoto Yuesheng Wang Wenhu Huang | 2008 | Acta Mechanica Solida Sinica2008，21，6： | 5 |
| 14 | Endoscopic submucosal dissection for large laterally spreading tumors involving the ileocecal valve and terminal ileum显示文摘Endoscopic submucosal dissection is a challenging technique that enables en-bloc resection for large colorectal tumors, as laterally spreading tumors, particularly difficult, if the ileocecal valve and terminal ileum is involved. Herein, we report on one of 4 cases. The procedures, using a bipolar needle knife (B-Knife) to reduce the perforation risk and carbon dioxide instead of conventional air insufflation for patient comfort, achieved curative resections without any complications. | Gustavo Kishimoto Yutaka Saito Hajime Takisawa Haruhisa Suzuki Taku Sakamoto Takeshi Nakajima Takahisa Matsuda | 2012 | World Journal of Gastroenterology2012，18，3： | 5 |
| 15 | Comparison of percutaneous radiofrequency ablation and CyberKnife®for initial solitary hepatocellular carcinoma:A pilot study显示文摘AIM To compare therapeutic outcomes and adverseevents in initial solitary hepatocellular carcinoma(HCC) treated with radiofrequency ablation (RFA) andCyberKnife?.METHODS: Seventy three consecutive patients withinitial solitary HCC treated with RFA (38 patients;RFA group) and CyberKnife (35 patients; CK group)were enrolled in this study. Background factorswere compared between the two groups. Local andintrahepatic distant recurrence control, and cumulativesurvival rates were compared between the two groups.These were determined using the Kaplan-Meier method,and the significance of differences was analyzed by log-rank test. The presence of more grade 3 on CTCAE ver.4.0 early and late adverse events was investigated.RESULTS: In background factors, age was significantlyhigher (P = 0.005) and the tumor diameter wassignificantly larger (P = 0.001) in the CK group. The1-year local recurrence control rates were 97.4%and 97.1% in the RFA and CK groups, respectively (P= 0.71); the 1-year intrahepatic distant recurrencecontrol rates were 85.6% and 86.1%, respectively (P= 0.91); and the 1-year cumulative survival rates were100% and 95.2%, respectively (P = 0.075), showingno significant difference in any rate between the twogroups. There were no late adverse event in the RFAgroup, but 11.4% in the CK group had late adverseevents. In the CK group, the Child-Pugh score at 12 moafter treatment was significantly higher than that in theRFA group (P = 0.003) and significantly higher than thescore before treatment (P = 0.034).CONCLUSION: The occurrence of adverse events is aconcern, but CyberKnife treatment is likely to becomean important option for local treatment of early HCC. | Kazue Shiozawa Manabu Watanabe Takashi Ikehara Yasushi Matsukiyo Michio Kogame Yui Kishimoto Yusuke Okubo Hiroyuki Makino Nobuhiro Tsukamoto Yoshinori Igarashi Yasukiyo Sumino | 2015 | World Journal of Gastroenterology2015，21，48： | 4 |
| 16 | WAVE PROPAGATION IN TWO-DIMENSIONAL DISORDERED PIEZOELECTRIC PHONONIC CRYSTALS显示文摘波浪繁殖用有限差别的时间域(FDTD ) 在二维的混乱压电的 phononic 晶体被学习方法。为混乱的不同的格,传播系数是计算的。乐队差距上的混乱的影响被调查。结果证明在压电的 phononic 晶体的混乱比在高频率在低频率区域在乐队差距上有更重要的影响。在乐队差距和位置混乱的方向的宽度之间的关系也被讨论。当位置混乱沿着对波浪传播垂直的方向时,压电的 phononic 晶体比沿着波浪传播方向的位置混乱的案例在低频率区域有更宽的乐队差距。乐队差距上的尺寸混乱的效果类似于地点混乱的,这能也被发现。当不安系数大时,它更多比在压电的 phononic 晶体与尺寸和地点混乱在压电的 phononic 晶体在通行证乐队上读了效果与单个混乱。在更高的频率区域,压电的效果减少传播系数。要不是更大的混乱度,压电的效果将被减少。 | Jinqiang Li Fengming Li Yuesheng Wang Kikuo Kishimoto | 2008 | Acta Mechanica Solida Sinica2008，21，6： | 4 |
| 17 | Overexpression of a reversion-related protein in the revertant RR cells显示文摘The cDNA insert of the plasmid p14-6[1] is found to be the 3’-untranslatcd region (3’-UTR) of the transcription factor for human interleukin-6, NF-IL6. This 3’ -DTK is actively transcribed in the revertant cell line RR, which contains the p14-6 plasmid integrated into its genomic DNA. Simultaneously a protein specifically bound to this 3’-UTR is expressed in significantly larger amounts. Its overexpression is apparently related to the reversion of the malignant cellular phenotype. The properties of this protein, named BNF, and possible reasons for its overexpression are discussed, and hypothesis on the mechanism of reversion of the RR cells is proposed. | 刘定干 李载平 Shizuo Akira Tadamitsu Kishimoto | 1996 | Science China(Life Sciences)1996，39，3： | 4 |
| 18 | Endoscopic and histopathological study on the duodenum of Strongyloides stercoralis hyperinfection显示文摘AIM:To investigate endoscopic and histopathological findings in the duodenum of patients with Strongyloides stercoralis(S.stercoralis)hyperinfection. METHODS:Over a period of 23 years(1984-2006),we investigated 25 patients withS.stercoralis hyperinfection who had had an esophagogastroduodenoscopy before undergoing treatment for strongyloidiasis.The clinical and endoscopic findings were analyzed retrospectively. RESULTS:Twenty-four(96%)of the patients investigated were under immunocompromised condition which was mainly due to a human T lymphotropic virus type 1(HTLV-1)infection.The abnormal endoscopic findings,mainly edematous mucosa,white villi and erythematous mucosa,were observed in 23(92%) patients.The degree of duodenitis including villous atrophy/destruction and inflammatory cell infiltration corresponded to the severity of the endoscopic findings. The histopathologic yield for identifying larvae was 71.4% by duodenal biopsy.The endoscopic findings of duodenitis were more severe in patients whose biopsies were positive for larvae than those whose biopsies were negative(Endoscopic severity score:4.86±2.47vs 2.71 ±1.38,P<0.05). CONCLUSION:Our study clearly demonstrates that,in addition to stool analysis,endoscopic observation and biopsies are very important.We also emphasize that S.stercoralis and HTLV-1 infections should be ruled out before immunosuppressive therapy is administered in endemic regions. | Kazuto Kishimoto Akira Hokama Tetsuo Hirata Yasushi Ihama Manabu Nakamoto Nagisa Kinjo Fukunori Kinjo Jiro Fujita | 2008 | World Journal of Gastroenterology2008，14，11： | 4 |
| 19 | Permeabilities of rebamipide via rat intestinal membranes and its colon specific delivery using chitosan capsule as a carrier显示文摘AIM: To investigate the permeability characteristics of rebamipide across intestinal mucosa, and examine the effects of some absorption enhancers on the permeability across the colonic tissue. Another purpose is to demonstrate the colon-specific delivery of rebamipide with or without absorption enhancers using chitosan capsule as a carrier. METHODS: The permeability of rebamipide was evaluated using an in vitro diffusion chamber system, and the effects of some absorption enhancers on the permeability via colon were further investigated. The release of rebamipide from chitosan or gelatin capsule was studied by Japan Pharmacopoeia rotating basket method. The colonic and plasma concentrations were analyzed by high performance liquid chromatography (HPLC) to evaluate colon-targeting action after oral administration of various dosage forms, and rebamipide with absorption enhancers in chitosan dosage forms. RESULTS: The permeability of rebamipide across the jejunal or ileal membranes was higher than the colonic membranes. Both sodium laurate (C12) and labrasol signifi cantly increased permeability across the colon membranes. On the other hand, the release of rebamipide from chitosan capsule was less than 10%totally within 6 h. The area under concentration-time profile of drug in the colon mucosa using chitosan capsules (AUCLI, 1 6011.2 ng·h/g) was 2.5 times and 4.4 times greater than using gelatin capsules and CMC suspension, respectively. Meanwhile, the area under concentration-time profile of drug in the plasma (AUCPL) was 1016.0 ng·h/mL for chitosan capsule, 1887.9 ng·h/mL for CMC suspension p and 2163.5 ng·h/mL for gelatin capsule. Overall, both AUCLI and AUCPL were increased when C12 was co-administrated, but the increase of AUCLI was much greater; the drug delivery index (DDI) was more than 1 compared with simple chitosan capsule group. CONCLUSION: There was a regional difference in the permeability of Rabamipide across the jejunum, ileum and the colon, and passive diffusion seems to be one of the major transport mechanisms of rebamipide. Absorption enhancers can increase the permeability of rebamipide across the colon tissue signifi cantly. In addition, chitosan capsule may be a useful carrier to deliver rebamipide to the colon specifi cally and the co-administration of C12 with rebamipide may also be very useful in local treatment. | Bei-Bei Huang Guo-Feng Li Jing-Hui Luo Lian Duan Kishimoto Nobuaki Yamamoto Akira | 2008 | World Journal of Gastroenterology2008，14，31： | 3 |
| 20 | Impact of dendritic cell vaccines pulsed with Wilms’ tumour-1 peptide antigen on the survival of patients with advanced non-small cell lung cancers显示文摘 | Hidenori Takahashi Masato Okamoto Shigetaka Shimodaira Shun-ichi Tsujitani Masaki Nagaya Takefumi Ishidao Junji Kishimoto Yoshikazu Yonemitsu | 2012 | European Journal of Cancer2012，，： | 3 |
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