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| 1 | A systematic study on efficiency enhancements in phosphorescent green, red and blue microcavity organic light emitting devices显示文摘A systematic study has been conducted on microcavity organic light emitting diodes(OLEDs)based on green,red and blue phosphorescent emitters to elucidate the microcavity effects for different color emitters.We found that the luminance output is determined by the reflectivity of the semitransparent electrode and the photopic response of the green,red and blue emitters.While the luminance enhancements of blue and red phosphorescent microcavity devices are small,a current efficiency as high as 224 cd A21 is obtained in the green phosphorescent microcavity OLEDs. | Chaoyu Xiang Wonhoe Koo Franky So Hisahiro Sasabe Junji Kido | 2013 | Light(Science & Applications)2013，2，1： | 12 |
| 2 | Roles of the Y chromosome genes in human cancers显示文摘男性和女性由他们的各自的性染色体作文遗传上不同,也就是说同样男性的 XY 和 XX 作为女性。尽管 X 和 Y 染色体从正染色体的一样的祖先对演变, Y 染色体怀有男性特定的基因,它在各种各样的纸巾的男性决心,细菌房间区别,和 masculinization 起枢轴的作用。决定性的基因的删除或 translocation, SRY,从 Y,染色体引起性开发的混乱(以前作为一个间性条件称为) 与劣生的性腺。gonadal 开发的失败不孕导致不仅,而且在细菌房间肿瘤(GCT ) 的增加的风险,例如 gonadoblastoma 和阴囊的 GCT 的各种各样的类型。最近的研究证明 Y 染色体或 Y 染色体基因的宫外的表示的任何一个损失仔细与各种各样的偏导男性的疾病被联系,包括选择体的癌症。这些观察比期望建议连接 Y 的基因经常在更多涉及男健康和疾病。尽管仅仅编码蛋白质的基因的一个小数字在 Y 染色体的男性特定的区域是在场的,人的疾病上的 Y 染色体基因的影响大部分仍然是未知的,由于缺乏在在人和啮齿类动物的 Y 染色体之间的 vivo 模型和差别。在这评论,我们在人在癌症开发加亮选择 Y 染色体基因的参与。 | Tatsuo Kido Yun-Fai Chris Lau | 2015 | Asian Journal of Andrology2015，17，3： | 8 |
| 3 | Utility of tricalcium phosphate and osteogenic matrix cell sheet constructs for bone defect reconstruction显示文摘AIM: To determine the effects of transplanting osteogenic matrix cell sheets and beta-tricalcium phosphate(TCP) constructs on bone formation in bone defects.METHODS: Osteogenic matrix cell sheets were prepared from bone marrow stromal cells(BMSCs), and a porous TCP ceramic was used as a scaffold. Three experimental groups were prepared, comprised of TCP scaffolds(1) seeded with BMSCs;(2) wrapped with osteogenic matrix cell sheets; or(3) both. Constructs were implanted into a femoral defect model in rats and bone growth was evaluated by radiography, histology, biochemistry, and mechanical testing after 8 wk. RESULTS: In bone defects, constructs implanted with cell sheets showed callus formation with segmentalor continuous bone formation at 8 wk, in contrast to TCP seeded with BMSCs, which resulted in bone nonunion. Wrapping TCP constructs with osteogenic matrix cell sheets increased their osteogenic potential and resulting bone formation, compared with conventional bone tissue engineering TCP scaffolds seeded with BMSCs. The compressive stiffness(mean ± SD) values were 225.0 ± 95.7, 30.0 ± 11.5, and 26.3 ± 10.6 MPa for BMSC/TCP/Sheet constructs with continuous bone formation, BMSC/TCP/Sheet constructs with segmental bone formation, and BMSC/TCP constructs, respectively. The compressive stiffness of BMSC/TCP/Sheet constructs with continuous bone formation was significantly higher than those with segmental bone formation and BMSC/TCP constructs.CONCLUSION: This technique is an improvement over current methods, such as TCP substitution, and is useful for hard tissue reconstruction and inducing earlier bone union in defects. | Tomoyuki Ueha Manabu Akahane Takamasa Shimizu Yoshinobu Uchihara Yusuke Morita Naoya Nitta Akira Kido Yusuke Inagaki Kenji Kawate Yasuhito Tanaka | 2015 | World Journal of Stem Cells2015，7，5： | 7 |
| 4 | Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment显示文摘A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin,and her HCV-RNA became negative at wk 12,but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH. | Takayuki Kogure Yoshiyuki Ueno Koji Fukushima Futoshi Nagasaki Jun Inoue Eiji Kakazu Yasunori Matsuda Osamu Kido Yu Nakagome Osamu Kimura Noriyuki Obara Yuta Wakui Takao Iwasaki Tooru Shimosegawa | 2007 | World Journal of Gastroenterology2007，13，32： | 5 |
| 5 | A case of mucosa-associated lymphoid tissue lymphoma of the gastrointestinal tract showing extensive plasma cell differentiation with prominent Russell bodies显示文摘A 73-year-old Japanese woman was hospitalized for detailed examination of nausea, diarrhea and loss of appetite. Atypical erosion in the ileum was found on endoscopy. Biopsy of this erosion showed proliferation of cells containing numerous Russell bodies. Differential diagnoses considered were Russell body enteritis, crystal-storing histiocytosis, Mott cell tumor, immunoproliferative small intestinal disease(IPSID) and mucosaassociated lymphoid tissue(MALT) lymphoma. The cells containing prominent Russell bodies showed diffuse positivity for CD79 a and CD138, but negative results for CD20, CD3, UCHL-1, CD38 and CD68. Russell bodies were diffusely positive for lambda light chain, but negative for kappa light chain, and immunoglobulin(Ig)G, Ig A and Ig M. Based on these findings, Russell body enteritis, crystal-storing histiocytosis and IPSID were ruled out. As the tumor formed no mass lesions and was restricted to the gastrointestinal tract, MALT lymphoma with extensive plasma cell differentiation was finally diagnosed. The patient showed an unexpectedly aggressive clinical course. The number of atypical lymphocytes in peripheral blood gradually increased and T-prolymphocytic leukemia(T-PLL) emerged. The patient died of T-PLL 7 mo after admission. Autopsy was not permitted. | Keita Kai Masaharu Miyahara Yasunori Tokuda Shinich Kido Masanori Masuda Yukari Takase Osamu Tokunaga | 2013 | World Journal of Clinical Cases2013，1，5： | 4 |
| 6 | Relationship between urinary cadmium and mortality in habitants of a cadmium-polluted area: a 22-year follow-up study in Japan显示文摘背景几研究建议了到镉( Cd )的暴露从肾的疾病,心血管的疾病和恶意的瘤增加了死亡,在住在 弄脏Cd 的区域和工厂 workers.This 学习的居民之中包括肺癌症和前列腺癌症试图在住在一个区域的居民的长期的结果上估计环境暴露的影响到 Cd 由 Cd.Methods A 弄脏22年的后续学习与 3119 个居民( 1403 个男人和 1716 个女人)一起被进行 1.64 ( 95 C/ 1.17-2.28 )并且 1.78 ( 95 C/ 1.27-2.50 )为 women.The 大多数,死亡的经常的原因是恶意的在男人的瘤和在 women.The 的心血管的疾病为心血管的疾病的死亡风险的重要增加与 10 g/g 在这些题目被观察在为男人的两 sexes:1.79 的 Cr ( 95 Cl 1.02-3.12 )并且 2.38 为女人( 95 CI 1.11-5.07 ) .When 这些题目被划分成 2 个范畴( 20 g/g Cr 和 20 g/g Cr ),为肾炎和肾变病的尿 Cd 20 g/g Cr 组的 HR 是 4. | LI Qian Muneko Nishijo Hideaki Nakagawa Yuko Morikawa Masaru Sakurai Koshi Nakarnura Teruhiko Kido Koji Nogawa DAI Min | 2011 | Chinese Medical Journal2011，，21： | 3 |
| 7 | Hyperammonemia crisis following parturition in a female patient with ornithine transcarbamylase deficiency显示文摘Ornithine transcarbamylase deficiency(OTCD) is an X-linked disorder,with an estimated prevalence of 1 per 80000 live births.Female patients with OTCD develop metabolic crises that are easily provoked by non-predictable common disorders,such as genetic(private mutations and lyonization) and external factors;however,the outcomes of these conditions may differ.We resuscitated a female patient with OTCD from hyperammonemic crisis after she gave birth.Hyperammonemia after parturition in a female patient with OTCD can be fatal,and this type of hyperammonemia persists for an extended period of time.Here,we describe the cause and treatment of hyperammonemia in a female patient with OTCD after parturition.Once hyperammonemia crisis occurs after giving birth,it is difficult to improve the metabolic state.Therefore,it is important to perform an early intervention before hyperammonemia occurs in patients with OTCD or in carriers after parturition. | Jun Kido Tatsuya Kawasaki Hiroshi Mitsubuchi Hidenobu Kamohara Takashi Ohba Shirou Matsumoto Fumio Endo Kimitoshi Nakamura | 2017 | World Journal of Hepatology2017，9，6： | 3 |
| 8 | Identification of a TSPY co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers显示文摘Testis specific protein Y-encoded(TSPY) is a Y-located proto-oncogene predominantly expressed in normal male germ cells and various types of germ cell tumor. Significantly, TSPY is frequently expressed in somatic cancers including liver cancer but not in adjacent normal tissues, suggesting that ectopic TSPY expression could be associated with oncogenesis in non-germ cell cancers. Various studies demonstrated that TSPY expression promotes growth and proliferation in cancer cells; however, its relationship to other oncogenic events in TSPY-positive cancers remains unknown. The present study seeks to correlate TSPY expression with other molecular features in clinical cancer samples, by analyses of RNA-seq transcriptome and DNA methylation data in the Cancer Genome Atlas(TCGA) database. A total of 53 genes,including oncogenic lineage protein 28 homolog B(LIN28B) gene and RNA-binding motif protein Y-linked(RBMY) gene, are identified to be consistently co-expressed with TSPY, and have been collectively designated as the TSPY co-expression network(TCN). TCN genes were simultaneously activated in subsets of liver hepatocellular carcinoma(30%) and lung adenocarcinoma(10%) regardless of pathological stage, but only minimally in other cancer types. Further analysis revealed that the DNA methylation level was globally lower in the TCN-active than TCN-silent cancers. The specific expression and methylation patterns of TCN genes suggest that they could be useful as biomarkers for the diagnosis,prognosis and clinical management of cancers, especially those for liver and lung cancers, associated with TSPY co-expression network genes. | Tatsuo Kido Yun-Fai Chris Lau | 2016 | Journal of Genetics and Genomics2016，43，10： | 2 |
| 9 | Wilson disease developing osteoarthritic pain in severe acute liver failure: A case report显示文摘BACKGROUND Wilson disease (WD) is a rare copper metabolism disorder with symptoms including hepatic disorders, neuropsychiatric abnormalities, Kayser-Fleischer rings, and hemolysis in association with acute liver failure (ALF). Osteoarthritis is a rare manifestation of WD. We experienced a case of WD with arthritic pain in the knee and liver cirrhosis. Here, we report the clinical course in a WD patient with arthritic pain and liver cirrhosis receiving combination therapy with Zn and a chelator and discuss the cause of arthritic pain. CASE SUMMARY We present an 11-year-old boy who developed osteoarthritis symptoms and ALF, with a New Wilson Index Score (NWIS) of 12. He was diagnosed with WD with decreased serum ceruloplasmin and copper levels, increased urinary copper excretion, and ATP7B gene mutations detected on gene analysis. There was improvement in the liver cirrhosis, leading to almost normal liver function and liver imaging, one year after receiving combination therapy with Zn and a chelator. Moreover, his arthritic pain transiently deteriorated but eventually improved with a decrease in the blood alkaline phosphatase levels following treatment. CONCLUSION Patients with WD who develop ALF with an NWIS > 11 may survive after treatment with Zn and chelators, without liver transplantation, when they present with mild hyperbilirubinemia and stage ≤ II hepatic encephalopathy. Osteoarthritis symptoms may improve with long-term Zn and chelator therapy without correlation of liver function in WD. | Jun Kido Shirou Matsumoto Keishin Sugawara Kimitoshi Nakamura | 2019 | World Journal of Hepatology2019，11，7： | 2 |
| 10 | A possible anorthositic continent of early Mars and the role of planetary size for the inception of Earth-like life显示文摘The Moon has an anorthositic primordial continental crust. Recently anorthosite has also been discovered on the Martian surface. Although the occurrence of anorthosite is observed to be very limited in Earth's extant geological record,both lunar and Martian surface geology suggest that anorthosite may have comprised a primordial continent on the early Earth during the first 600 million years after its formation. We hypothesized that differences in the presence of an anorthositic continent on an Earthlike planet are due to planetary size. Earth likely lost its primordial anorthositic continent by tectonic erosion through subduction associated with a kind of proto-plate tectonics(PPT). In contrast, Mars and the Moon, as much smaller planetary bodies, did not lose much of their anorthositic continental crust because mantle convection had weakened and/or largely stopped, and with time, they had appropriately cooled down. Applying this same reasoning to a super-Earth exoplanet suggests that, while a primordial anorthositic continent may briefly form on its surface, such a continent will be likely transported into the deep mantle due to intense mantle convection immediately following its formation. The presence of a primordial continent on an Earth-like planet seems to be essential to whether the planet will be habitable to Earth-like life. The key role of the primordial continent is to provide the necessary and sufficient nutrients for the emergence and evolution of life. With the appearance of a 'trinity' consisting of(1) an atmosphere,(2) an ocean, and(3) the primordial continental landmass, material circulation can be maintained to enable a 'Habitable Trinity' environment that will permit the emergence of Earth-like life. Thus, with little likelihood of a persistent primordial continent, a super-Earth affords very little chance for Earth-like life to emerge. | James M.Dohm Shigenori Maruyama Motoyuki Kido Victor R.Baker | 2018 | Geoscience Frontiers2018，9，4： | 2 |
| 11 | Secretory leukoprotease inhibitor and pulmonary surfactant serve as principal defenses against influenza A virus infection in the airway and chemical agents up-regulating their levels may have therapeutic potential显示文摘 | Hiroshi Kido Yuushi Okumura Hiroshi Yamada Dai Mizuno Youichirou Higashi Mihiro Yano | 2004 | Biological Chemistry2004，，11： | 2 |
| 12 | Homeostasis model assessment of insulin resistance and the risk of cardiovascular events in middle-aged non-diabetic Japanese men显示文摘 | K. Nakamura M. Sakurai K. Miura Y. Morikawa M. Ishizaki K. Yoshita T. Kido Y. Naruse H. Nakagawa | 2010 | Diabetologia2010，，9： | 2 |
| 13 | Self-care practices and health-seeking behavior among older persons in a developing country:Theories-based research显示文摘Purpose:The aim of this study was to examine the self-care practices and health-seeking behaviours of older adults in urban Indonesia.Methods:The cross-sectional study was performed from January to March 2014 in the Tammua sub-district of Indonesia.At the time of the study,273 older adults resided in Tammua,and half of them(51.2%)participated in this study.Data collection was carried out including self-care practices,health literacy,self-efficacy and basic conditioning factors.Results:It was found that most respondents(124;88.6%)always ate various protein sources daily.However,many participants never limited consumption of sugar(55;39.3%)or salt(40;28.6%),and more than half of respondents(96;68.6%)did not regularly visit MHCs.Health status(p<0.05),health maintenance(p<0.01)and salt limitation(p<0.05)were all significantly associated with salt limitation.It was found that respondents with higher selfefficacy,those who did not want to get information,and those of younger ages are less likely to visit MHCs regularly.Conclusion:An understanding of self-care practices and self-efficacy is needed to improve health care in developing countries.High self-efficacy should be promoted along with adequate health literacy.Older persons should learn the importance of regular health examinations to promote health,prevent diseases,and slow the progress of chronic diseases.The number of respondents who never limit their sugar and salt intake was especially surprising.An intervention program should be developed to limit salt and sugar intake of Indonesian elderly and to motivate older persons to use primary health services. | Andi Masyitha Irwan Mayumi Kato Kazuyo Kitaoka Teruhiko Kido Yoshimi Taniguchi Miho Shogenji | 2016 | International Journal of Nursing Sciences2016，3，1： | 2 |
| 14 | Oxy-fuel combustion and its impact on refractories in glass melting tank furnaces显示文摘 | Nobuyuki Kido | 2008 | Journal of the Association of Refractories2008，28，1： | 1 |
| 15 | Multilayer white light-emitting organic electroluminescent device显示文摘 | Kido J Kimura M Nagai K | 1995 | Science1995，267，： | 1 |
| 16 | Differential myocardial gene delivery by recombinant serotype-specific adeno-associated viral vectors显示文摘 | Du L Kido M Lee DV | 2004 | Mol Ther2004，10，： | 1 |
| 17 | Examination of the fine interstitial changes of pneumocortiosis with high resolution computed tomography (HR-CT) 显示文摘 | Kido M Miyazaki N Harada S | 1986 | J UOEH1986，20，： | 1 |
| 18 | Multilayer white light- emitting organic electroluminescent devices 显示文摘 | Kido J Kimura M Nagai K | 1995 | Science1995，267，： | 1 |
| 19 | 查看详情显示文摘 | J Kido C Ohtaki K. Hongawa K. Okuyama and K.Nagai Jpn | | 0，，： | 1 |
| 20 | Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2 显示文摘 | Kido Y Burks D J Withers D | 2000 | J Clin Invest2000，105，： | 1 |
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