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| 1 | 槟榔子中抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分(英文)显示文摘目的:研究槟榔子(Areca catechu)粗提取物中所含的抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分及其作用机制。方法:使用70%甲醇水溶液对槟榔子进行粗提取。使用生物发光血小板凝集仪在富血小板血浆中测定槟榔子粗提取物的抗血小板聚集作用,使用分光光度计在试管内测定槟榔子粗提取物对乙酰胆碱酯酶活性的抑制作用。检测槟榔子中的多种化合物以测定槟榔子中抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分。结果:槟榔子粗提取物能够抑制花生四烯酸、二磷酸腺苷、血小板活化因子、肾上腺素及钙离子载体引起的血小板聚集,尤其对二磷酸腺苷及钙离子载体引起的血小板聚集的抑制最为明显;槟榔子粗提取物能够显著抑制乙酰胆碱酯酶的活性。在所检测的槟榔子所含化合物中,只有儿茶素对肾上腺素引起的血小板聚集有显著的抑制作用,而这种抑制作用显著弱于槟榔子粗提取物,提示槟榔子中的其他成分参与了这种抑制作用;鞣酸、没食子酸、薯蓣皂苷元和异去甲槟榔次碱能够抑制乙酰胆碱酯酶的活性,其中鞣酸的抑制作用强于槟榔子粗提取物。结论:槟榔子中含有抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分,而发挥这些功效的确切成分有待进一步的研究证实。 | Muhammad Nabeel Ghayur Syed Faraz Kazim Huma Rasheed Asaad Khalid Maliha Iqbal Jumani Muhammad Iqbal Choudhary Anwarul Hassan Gilani | 2011 | 中西医结合学报2011，9，6： | 4 |
| 2 | A new coumarin from Murraya paniculata显示文摘 | CHOUDHARY MUHAMMAD IQBAL AZIZUDDIN KHALID ASAAD | 2002 | Planta Medica2002，68，1： | 1 |
| 3 | New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids显示文摘 | Atta-ur-Rahman Khalid Asaad Sultana Nighat | 2006 | Journal of Enzyme Inhibition and Medicinal Chemistry2006，21，6： | 1 |
| 4 | Antioxidant,antimicrobial,and α-glucosidase inhibitory activities of saponin extracts from walnut(Juglans regia L.) leaves显示文摘Objective:To investigate the relationship between triterpenoid saponin content and antioxidant,antimicrobial,and α-glucosidase inhibitory activities of 70%ethanolic,butanolic,aqueous,supernate and precipitate extracts of Juglans regia leaves.Methods:Triterpenoid saponins of different Juglans regia leaf extracts were measured by the vanillin method.Antioxidant activity was evaluated against DPPH and ABTS free radicals.We also assessed α-glucosidase inhibitory and antimicrobial activities of the leaf extracts.Pearson’s correlation coefficient was evaluated to determine the correlation between the saponin content and biological activities.Results:The butanolic extract was most effective against DPPH with an IC50of 6.63μg/mL,while the aqueous extract showed the highest scavenging activity against ABTS free radical with an IC50of 42.27μg/mL.Pearson’s correlation analysis indicated a strong negative correlation (r=-0.956) between DPPH radical scavenging activity (IC50) and the saponin content in the samples examined.In addition,the aqueous extract showed the best α-glucosidase inhibitory activity compared with other extracts.All the extracts had fair antibacterial activity against Bacillus subtilis,Escherichia coli,and Klebsiella pneumoniae except for the aqueous extract.Conclusions:Juglans regia extracts show potent antioxidant,antimicrobial,and α-glucosidase inhibitory activities.There is a correlation between saponin levels in Juglans regia leaf extracts and the studied activities.However,additional research is required to establish these relationships by identifying the specific saponin molecules responsible for these activities and elucidating their mechanisms of action. | Youssef Elouafy Adil El Yadini Salma Mortada Mohamed Hnini Hicham Harhar Asaad Khalid Ashraf NAbdalla Abdelhakim Bouyahya Khang Wen Goh Long Chiau Ming My El Abbes Faouzi Mohamed Tabyaoui | 2023 | Asian Pacific Journal of Tropical Biomedicine2023，13，2： | 1 |
| 5 | New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids显示文摘 | Atta-ur -Rahman Asaad Khalid Nighat Sultana M. Nabeel Ghayur M. Ahmed Mesaik M. Riaz Khan Anwar H. Gilani M. Iqbal Choudhary | 2006 | Journal of Enzyme Inhibition and Medicinal Chemistry2006，，6： | 1 |
| 6 | Perceptions of emergency medicine residents on the quality of residency training in the United States and Saudi Arabia显示文摘BACKGROUND: We compare educational environments(i.e. physical, emotional and intellectual experiences) of emergency medicine(EM) residents training in the United States of America(USA) and Saudi Arabia(SA).METHODS: A cross-sectional survey study was conducted using an adapted version of the validated Postgraduate Hospital Educational Environment Measure(PHEEM) survey instrument from April 2015 through June 2016 to compare educational environments in all emergency medicine residency programs in SA and three selected programs in the USA with a history of training Saudi physicians. Overall scores were compared across programs, and for subscales(autonomy, teaching, and social Support), using chi-squared, t-tests, and analysis of variance.RESULTS: A total of 219 surveys were returned for 260 residents across six programs(3 SA, 3 USA), with a response rate of 84%. Program-specific response rates varied from 79%–100%. All six residencies were qualitatively rated as 'more positive than negative but room for improvement'. Quantitative PHEEM scores for the USA programs were significantly higher: 118.7 compared to 109.9 for SA, P=0.001. In subscales, perceptions of social support were not different between the two countries(P=0.243); however, role autonomy(P<0.001) and teaching(P=0.005) were better in USA programs. There were no significant differences by post-graduate training year.CONCLUSION: EM residents in all three emergency medicine residency programs in SA and the three USA programs studied perceive their training as high quality in general, but with room for improvements. USA residency programs scored higher in overall quality. This was driven by more favorable perceptions of role autonomy and teaching. Understanding how residents perceive their programs may help drive targeted quality improvement efforts. | Ahmad Aalam Mark Zocchi Khalid Alyami Abdullah Shalabi Abdullah Bakhsh Asaad Alsufyani Abdulrahman Sabbagh Mohammed Alshahrani Jesse M.Pines | 2018 | World Journal of Emergency Medicine2018，9，1： | 1 |
| 7 | In-silico identification of the binding mode of synthesized adamantyl derivatives inside cholinesterase enzymes显示文摘目的: 调查有约束力的模式坚定不移地综合了在用分子的停靠的胆碱酯酶酶以内的衍生物模拟。 | Amal AL-ABOUDI Raed A AL-QAWASMEH Alaa SHAHWAN Uzma MAHMOOD Asaad KHALID Zaheer UbHAQ | 2015 | Acta Pharmacologica Sinica2015，36，7： | 0 |
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